RE: 'Toxic trio’ in celiac disease pinpointed after analysis of 2,700 gluten peptides – Vaccine trial underway

[Guest guest]

Yeah right! While it May allow them to eat gluten atack products you are still

doing damage to your body. And what about those of us that are allergic to

Gluten? We arent considered Celiac because it doesnt show up in our blood & /or

intestin...so May times our allergy isnt even acknowledged.

I'll eat a GF diet thank you very much. It's not as hard as people think it

is...I'm discovering, the hard part is cooking baked goods or breads from

scratch or buying the GF foods which arent always that great. They are getting

better but are way pricey. As long as I cook like grandma used to - it's not

that hard. Who needs processed crap?

Carlena

'Toxic trio’ in celiac disease pinpointed after analysis

of 2,700 gluten peptides – Vaccine trial underway

Attachments: imstp_animation_monkey_en_020908.gif (41 KB)

When I heard the report on this, it was presented with the statement that,

with this vaccine, coeliacs would be able to eat anything they liked....

I really believe that!

http://www.prohealth.com/library/showarticle.cfm?libid=15495

'Toxic trio’ in celiac disease pinpointed after analysis of 2,700 gluten

peptides – Vaccine trial underway

July 26, 2010

“The holy grail in celiac disease research has been to identify the toxic

peptide components of gluten; and that's what we've done.”

Scientists in Australia and the UK have identified the three protein

fragments that make gluten - the main protein in wheat, rye and barley –

toxic to people with celiac disease.

Their discovery opens the way for a new generation of diagnostics,

treatments, prevention strategies and food tests for the millions of people

worldwide with celiac disease, with immunotherapy trials already underway.

When people with celiac disease eat products containing gluten their body's

immune response is switched on and the lining of the small intestine is

damaged, hampering their ability to absorb nutrients. The disease is

currently treated by permanently removing gluten from the patient's diet.

Dr. Bob , head of the Walter and Eliza Hall Institute's celiac

disease research laboratory in , Australia, said it had been 60

years since gluten was discovered to be the environmental cause of celiac

disease.

" In the years since, the holy grail in celiac disease research has been to

identify the toxic peptide components of gluten; and that's what we've done,

Dr said.

The research, done in collaboration with Dr. Tye-Din, Dr. Dromey

Dr. Stuart Mannering, Dr. and Dr. Tim Beissbarth from the

institute as well as Professor Rossjohn at Monash University and

Professor Jim McCluskey at the University of Melbourne, was published July

21 in the international journal Science Translational Medicine.

The study was started by Professor nine years ago and has involved

researchers in Australia and the UK as well as more than 200 celiac disease

patients.

The patients, recruited through the Celiac Society of and the

Celiac Clinic at Radcliffe Hospital, UK, ate bread, rye muffins or

boiled barley. Six days later, blood samples were taken to measure the

strength of the patients' immune responses to 2,700 different gluten

fragments. The responses identified 90 fragments as causing some level of

immune reaction, but three gluten fragments (peptides) were revealed as

being particularly toxic.

" These three components account for the majority of the immune response to

gluten that is observed in people with celiac disease, " Dr. said.

This knowledge has already been used by Melbourne-based biotech company,

Nexpep Pty Ltd, to develop a 'peptide-based' immunotherapy that aims to

desensitize people with celiac disease to the toxic effects of gluten.

Nexpep's Phase 1 trials of the therapy were completed in June and final

results are expected in coming months.

The immunotherapy works by exposing people with celiac disease to small

amounts of the three toxic peptides and is based upon the same principles as

desensitization for allergies.

Dr said that although celiac disease could be managed with a

gluten-free diet, compliance with the diet is often challenging, and nearly

half the people on the diet still have residual damage to their small

intestine. " Consequently, the immunotherapy and three other drugs are under

development to help people with celiac disease. "

Source: Walter and Eliza Hall Institute press release, Jul 21, 2010