Guest guest Posted August 21, 2006 Report Share Posted August 21, 2006 Hi, Lu. I gather from what you've posted that you formerly nebulized glutathione and that didn't cause you fatigue, but now that you have added hydroxocobalamin, it is causing you fatigue, is that correct? I don't know anything about your case. I assume you must have multiple chemical sensitivities, is that correct? Do you also have chronic fatigue syndrome? I think I would need to know a little more about your case before I could suggest what might be going on. In particular, it would be helpful to know what your answers might be to the questions I posed to in message number 105083. Rich > > Any ideas on why nebulizing hydroxycobalamine B12 with glutathione is causing me > tremendous fatigue? > > Thanks, > > Lu > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 21, 2006 Report Share Posted August 21, 2006 Hi, Lu. I gather from what you've posted that you formerly nebulized glutathione and that didn't cause you fatigue, but now that you have added hydroxocobalamin, it is causing you fatigue, is that correct? I don't know anything about your case. I assume you must have multiple chemical sensitivities, is that correct? Do you also have chronic fatigue syndrome? I think I would need to know a little more about your case before I could suggest what might be going on. In particular, it would be helpful to know what your answers might be to the questions I posed to in message number 105083. Rich > > Any ideas on why nebulizing hydroxycobalamine B12 with glutathione is causing me > tremendous fatigue? > > Thanks, > > Lu > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 22, 2006 Report Share Posted August 22, 2006 Thank you for your answer. I have cfs, fibro, and am chemically sensitive. I've been nebulzing glutathione for several years and, yes, the only thing I added was the hydroxycobalamine B12. The additional supplements compounded by Key Pharm made me ill and I quit taking them after several days (the Zeim, Pall, Seymour protocol). I usually get B12 and folic acid shots once a week; I do not know the form of B12. They always help me with the fatigue. I am not sensitive to sulfur-containing foods. My body responds well to protein. I do have problems sleeping and have much pain daily. I have no problems with my moods or constipation, but do have general digestive ailments (I had h-pylori and haven't been the same since). Regarding cysteine or methionine, I am fine with whey protein, but not with NAC. I have not tried SAMe. I did not respond well to 5-HTP (cannot remember exact response). My body seems to loves magnesium. My homocysteine level was checked in the last 7 months and is normal. I do not know the plasma sulfate concentration or 24-hour urinary creatinine excretion. My glutathione level has never been measured, but my body seems to love it. I was very ill when I first started nebulizing and feel much better on it. I have not been tested for mercury or other heavy metals. I have not had a urinary organic acids tests. I am a middle-aged woman trying to work and get well at the same time. I have an MD who is not a research doctor, but is open to any info I bring to him. Any help you can provide is appreciated. Thanks. Lu > > > > Any ideas on why nebulizing hydroxycobalamine B12 with glutathione > is causing me > > tremendous fatigue? > > > > Thanks, > > > > Lu > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 22, 2006 Report Share Posted August 22, 2006 Hi, Lu. Based on what you've reported, I would guess that you have glutathione depletion and a methylation cycle block, but I don't think you have a CBS upregulation SNP. I don't know why you don't do well with NAC, given that you can handle whey protein and glutathion alright. I suspect that the reason why nebulizing the combination of glutathione and hydroxocobalamine makes you fatigued, while you do fine with nebulized glutathione and some type of B12 injections is that when hydroxocobalamin is mixed directly with glutathione, it forms glutathionylcobalamin. This is the intermediate in the conversion of either cyanocobalamin or hydroxocobalamin to the active forms of B12, which are methylcobalamin and adenosylcobalamin. Since more rapid formation of adenosylcobalamin would be more likely to give you more energy than to make you fatigued (because it assists in the conversion of methylmalonate to succinate, which feeds energy into the Krebs cycle, I suspect that the fatigue must be coming from more rapid conversion to methylcobalamin, which would tend to unblock the methylation cycle. You also mentioned that the other supplements in the Ziem-Pall- Seymour protocol made you ill. There are quite a few substances in them, so it's difficult to say for sure what caused this. However, these supplements include several that would act on the methylation cycle, the folate metabolism, and the transsulfuration pathway. My best guess is that these supplements were too much, too fast. If your methylation cycle is indeed, blocked, as I suspect it is, taking all these things at once would likely have been quite a jolt to your metabolism. You might try taking smaller amounts of the hydroxocobalamin in the glutathione, unless you're already doing just one drop. You might also try taking smaller amounts of the other supplements. If this doesn't work, then I would suggest getting the Yasko panel run to see what your SNPs are. It's available at http://www.testing4health.com. Once you know them, you could try to compensate them in a slower and more systematic manner. That might work better for you. Rich > > > > > > Any ideas on why nebulizing hydroxycobalamine B12 with glutathione > > is causing me > > > tremendous fatigue? > > > > > > Thanks, > > > > > > Lu > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 23, 2006 Report Share Posted August 23, 2006 Thank you very much for the reply. Yes, the NAC is a puzzler since my body loves glutathione. I did not nebulize the B-12 today and feel SO much better (I was only adding a drop to the glut). I am going to discontinue it. Also, I am not going to take any of the supplements. My body rejected them and you are right, there are too many ingredients to know which one (s) cause me problems. Why on earth would someone give me so many supplements? I have a history of being easily overwhelmed. I am very sensitive/deficient. When I have more energy, I'll tackle my health problems again. Presently, I'm trying to recuperate from this protocol, which I am abandoning. I need to be more productive at work and can limp along as I have for years w/o adding anything new. Lu > > > > > > > > Any ideas on why nebulizing hydroxycobalamine B12 with > glutathione > > > is causing me > > > > tremendous fatigue? > > > > > > > > Thanks, > > > > > > > > Lu > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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