Re: herbs that protect against mycotoxins - rosmarinic acid

[Guest guest]

Kurt

THe heavy hitter in this group would be ROsemary.... followed by the others.

mjh

" The Basil Book "

_http://foxhillfarm.us/FireBasil/_ (http://foxhillfarm.us/FireBasil/)

_herbs that protect against mycotoxins _

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Posted by: " Kurt R " _kurt@... _ (mailto:kurt@...?Subject=Re:

herbs%20that%20protect%20against%20mycotoxins) _kurtrowley _

(kurtrowley)

Sat Jul 29, 2006 8:41 am (PST)

Here is an interesting study that finds herbs with rosmarinic acid

protect against some mycotoxin damage:

Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-Effects

cell damage in a human hepatoma cell line (Hep G2).

J Appl Toxicol. 2004 Jul-Aug;24(4)J Appl To

Recent findings have suggested that oxidative damage might contribute to

the cytotoxicity and carcinogenicity of aflatoxin B(1). The induction of

oxidative stress also plays an important role in the toxicity of another

mycotoxin: ochratoxin A. In this study, the protective effect of

rosmarinic acid against AFB(1) and OTA-induced cytotoxicity was

investigated in a human hepatoma-derived cell lin. Rosmarinic acid, a

natural phenolic compound contained in many Lamiaceae herbs such as

Perilla frutescens, sage, basil and mint, inhibits complement-dependenP

inflammatory processes and may have therapeutic potential. The ability

of Rosmarinic acid to reduce radical oxygen species production, protein

and DNA synthesis inhibition and apoptosis caused by the two mycotoxins

was also investigated. Our experiments proved the significant

cytoprotective effect of Rosmarinic acid in vitro from OTA- and

AFB(1)-induced cell damage. Moreover, Rosmarinic acid dose dependently

attenuated ROS production and DNA and protein synthesis inhibition

induced by both of the toxins. Similarly, apoptosis cell death was

prevented, as demonstrated by reduction of DNA fragmentation and

inhibition of caspase-3 activation.

So, maybe people battling some mycotoxins could benefit from sage,

basil, and maybe some mint tea..

--Kurt