WOW! Acute disseminated encephalomyelitis with probable measles vaccine failure.

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Pediatr Neurol. 1999 May;20(5):399-402. Related Articles, Links

Acute disseminated encephalomyelitis with probable measles vaccine

failure.

Nagai K, Mori T.

Department of Pediatrics, Otaru Kyokai Hospital, Hokkaido, Japan.

The patient is a 10-year-old male who experienced somnolence and

incomplete quadriplegia after headache and vomiting, without

exanthema, for 3 days. The clinical course and magnetic resonance

imaging findings of the brain and spinal cord were compatible with

acute disseminated encephalomyelitis. The serologic examination

revealed that the patient had rubeola because titers of IgM and IgG

antibody to measles virus measured by enzyme immunoassay were 0.91

and 40 (cutoff = 0.80 and 2), respectively, at 5 weeks after the

onset, the IgM titer had become negative (0.56), and the IgG titer

had decreased to 17.7 at 13 weeks after the onset. Because the

patient had received a measles-mumps-rubella vaccine at 12 months of

age, the acute disseminated encephalomyelitis was thought to be

attributed to the modified measles resulting from measles vaccine

failure.

Publication Types:

Case Reports

PMID: 10371390 [PubMed - indexed for MEDLINE]