Re: SOD and CATALASE in cfs ?

[Guest guest]

Hi

I think we are all familar with glutathione helping in CFS - Does anyone

know SODs and Catalse's role in cfs?

Regards

CS

[Guest guest]

CS,

Wednesday, April 12, 2006, 10:13:36 PM, you wrote:

> I think we are all familar with glutathione helping in CFS - Does anyone

> know SODs and Catalse's role in cfs?

I don't know about CFS, but Dr. Grace Ziem (M.D.) has found low levels

of superoxide dismutase (SOD) in her multiple chemical sensitivity

(MCS) patients.

" Biomarkers of MCS

Abnormal Medical Tests and Physical Signs Associated with Multiple

Chemical Sensitivity

[...]

Detoxification: impaired function of Phase I (cP450) and/or Phase II

detox pathway (Ziem 1997); caffeine clearance, salicylic acid

conversion, paracetamol conversion (Monro 1997); low sulphoxidation

and low glutathione (Scadding 1988, McFadden 1996, Ziem 1997), low

superoxide dismutase and glutathione peroxidase (Ziem, unpublished) "

( http://www.mcsrr.org/resources/biomarkers.html )

" Medical Evaluation and Treatment of Patients with Chemical Injury and

Sensitivity, " by Dr. Grace Ziem:

" Medical testing was conducted on 30 consecutive toxic injury new

patients seen in the author’s medical practice. These patients

typically had toxic encephalophathy with reactive airways disease.

Other abnormalities were quantified by testing, and included adrenal

cortisol changes with frequent deficiency; protein deficiency with

greatest deficiency in detoxification-related amino acids; changes in

Phase II detoxification following challenge, with deficiency of

glutathione and superoxide dismutase and increase of lipid peroxides

and other free radicals; changes in cell membrane lipid composition to

a proinflammatory status; Secretory IgA deficiency with frequent

parasites and/or Candida; pancreatic digestive enzyme (chymotrypsin)

deficiency; food intolerances; intracellular essential mineral

deficiency; reduced antioxidant function; altered energy metabolism;

and other nutrient deficiency, the most prevalent being B 12 (involved

with myelin synthesis). Toxic exposures inducing illness were

symptomatic (and repeated, except one patient from a massive propane

leak). Other causal agents were solvents, pesticides

(organophosphates, pyrethroid, chlordane, benzyl benzoate, other),

vehicle exhaust in a building, “sick building” volatiles, adhesives,

inorganic chlorines, formaldehyde and glutaraldehyde. "

( http://www.mcs-global.org/Documents/PDFs/RICERCA_2001_ZIEM.pdf )

--

Best regards,

Bubba mailto:mcsei@...

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[Guest guest]

Hi CS,

I have low or impaired SOD. That leaves me with big problems

detoxifying pesticides & herbicides.

I believe SOD is often very low, along with glutathione, in people

with multiple chemical sensitivities, so at least a subset of CFS

people.

SOD is dependant on good supplies of Zinc (yes Zinc again!), and

Manganese I think. Perhaps other minerals too, if I find out more

I'll add to this thread.

I had my SOD drastically upregulated (think that is the correct term)

by the use of Hyperbaric Oxygen therapy, but the benefit was

temporary. IE the SOD stayed high and effective (very effective,

quite amazing really!) during the therapy but not afterwards.

Hope that helps a bit.

Anne.

>

> Hi

>

> I think we are all familar with glutathione helping in CFS - Does

anyone

> know SODs and Catalse's role in cfs?

>

>

> Regards

> CS

>

>

>