candida pantethine molybendum and acne (was alcohol)

[Guest guest]

I was trying to put together the information from a couple of candida

articles posted recently regarding alcohol intolerance and 's post about

coenzyme A and acne. The company that makes the Co-enzyme A supplement also

make a supplement with pantethine and niacin called Clear Skin Image that is

supposed to help reduce oil production in the pores. I think the quotes below

infer these supplements also help to create energy from co-enzyme A. Did Rich

have a post on this subject previously?

I think it is saying below that pantethine helps create coenzyme A which

breaks down the waste products of candida (acetaldehyde) and other toxins

(formaldyhe, perfumes) with molybendum. So I am thinking our bodies use up and

run out of molybendum and pantethine trying to deal with candida and chemical

fumes, and adding these supplements would help. I don't understand all of

's post below. The last line says megadosing on b5 may have cause a case

of cfs, but I thought it would break down the products of candida or be washed

out. I''m starting these supplements. Am i getting it right? Also someone

asked on another list the following question and I wondered if it was related.

kathy p

Does anyone besides me have this phenomenon with CFIDS? I've always had oily

hair and skin but this is now a huge problem. I could go 24 hours before

another shower and hairwashing.

Now I'm washing my hair and showering twice a day and two hours later again

appears the problem.

It seems to get worse with allergies and with CFIDS symptoms.

Does anyone have this problem? And if so, what do you do?

http://www.candidapage.com/aldehyde.shtml from anne_likes_red

Acetaldehyde is a paraticularly toxic substance which, in addition to being

produced by threonine and ethanol, is a product of the metabolism (i.e.

fermentation) of carbohydrate in yeast -- hence the Candida connection.

Acetaldehyde is thought to be the major source of tissue damage in alcoholics

rather than ethanol itself. The conversion of acetaldehyde into acetic acid " for

this reaction to occur, threonine to acetaldehyde to acetic acid to acetyl

coenzyme A, NAD (niacine amide) is required, and aldehyde oxidase is dependent

of riboflavin, iron, and molybdenum. These forgoing nutrients could be helpful

to Candida albicans patients, and others who are sensitive to various fragrances

and airborne odors. Those patients with aldehyde sensitivity are incredibly

sensitive to any type of fragrance....

And from another source comes another connection -- from Dr. Atkins'

newsletter: Dr. Atkins is writing about Pantethine which he prescribes to his

Crohn's Disease and Colitis patients, with acknowledgement to Dr. Melvin Werbach

for Dr. Werbach's study that demonstrated that people with colitis have markedly

decreased Coenzyme A activity if the mucosal surface of their colons, even when

the blood levels of pantothenic acid are normal. Dr. Atkins concluded, based on

his success with these patients of his, that Pantethine bypasses the block in

converting Vitamin B5 (Pantothenic Acid) to Coenzyme A. But also, that

Pantethine is a growth factor for lactobacillus bulgaricus and bifidobacterium

that we know help control yeast overgrowth (and Dr. Cooter also speaks of it in

his book). Candida, according to antibody studies done at the Atkins Center, is

involved in more than 80 percent of all cases of Crohn's and Colitis.

And for autoimmune problems, Dr. Atkins states, " For all conditions that a

doctor might prescribe prednisone -- allergies, asthma, rheumatoid arthritis,

psoriasis, lupus, and olther autoimmune diseases, pantethine can be safely,

effectively substituted. I routinely use it for all of those conditions on

hundreds of my patients, and it's valuable in weaning them off steroidal drugs,

or certainly in allowing a lower dose....

By upping body levels of a body enzyme, pantethine counteracts brain fog,

certain allergic sensitivities, and some consequences of alcoholism. (And here

it is --) ... In people with candidiasis, the enzyme fights off a toxic

byproduct called acetaldehyde, which is thought to cause brain fog,

often-suffered but rarely diagnosed.... Acetaldehyde also is suspected of being

responsible for some symptoms of alcoholism, including alcoholic heart muscle

disease. The pantethine-stimulated enzyme also detoxifies formaldehyde, an all

too frequent offender for chemically sensitive individuals. "

In summary, Dr. Atkins is saying that Pantethine, without toxic consequences,

can reduce cholesterol, counuteract oxidation, stimulate the growth of friendly

bacteria, and fight allergies, inflammation, autoimmune disruptions, and

alcoholism.

In case you wondered, Dr. Cooter and Dr. Schmtt suggest 300 micrograms of

Molybdenum in three divided doses per day, and further suggests staying on it

for at least 4 months.. Dr. Atkins suggests 450 to 900 miligrams daily of

Pantethine with an equal amount of Pantethenic Acid.

http://www.mall-net.com/cooter/moly.html

Date: Sun, 31 Jul 2005 19:01:21 -0000 from

/

From: " jasonlbreckenridge " <jasonlbreckenridge@>

Subject: isotrention induced CFS & vitamin b5/coenzyme A pathway in CFS

Many ancedental reports of accutance or other anti-acne med induced

CFS has been reported. Acne results from increased sebum production

in the skin due to the body's stores of coenzyme A choosing between

sex hormone steroid synthesis over fatty acid metabolism resulting

in an outflow in the skin of the fatty acids (often @ puberty).

Coenzyme A needs vitamin b5 (which also can stop sebum production &

acne interestingly)and COA is the top of the citric acid cycle

(krebs) for all energy in cells. It goes down something like this i

think:

cholesterol -> pregnanolone -> 1) DHEA -> androgens/estrogens 2)

cortisol & progesterone

the body prioritizes which pathway from to make, DHEA or cortisol

and then further optimizes it.

The disruption in CFS may very well be from the top of this pathway

down somewhere in disruption in either feedback inhibition of coA or

different variants of coA/genes or perhaps vitamin b5 metabolism.

Vitamin b12 may be used up in CFS because of this step in b5

metabolism (possibly a hyper-coA , or b5 state).

(IE: Propionyl CoA or methylmalonyl CoA or CoA, the result of the

metabolism of cOA in the citric acid cycle requires b12 and biotin

to " control " this. That s why methylmalonic acid is a good indicator

of b12 defienecy.

It was also shown that increased beta alinine in urine of CFS, beta

alinine happens to be the precursor to pantothenate(b5).

" Pantothenic acid(b5 also) is the amide of beta-alanine and pantoic

acid and under normal conditions, beta-alanine is metabolized into

acetic acid (vinegar) which can be made to form cholesterol. "

someone asked before , polycystic ovary syndrome and male pattern

baldness share near identical patterns in hormones, which is why i

said men can have a PCOS type process going. I am going to make a

huge assumption that PCOS in women (often undiganosed since no

actual cysts are involved on the ovaries) and in men with premature

balding is probably an indicator of a possible CFS type

dysregulation, though many dont progress to CFS itself, but diabetes

and other autoimmune disease instead, or sometimes nothing it all

depends.

now statins probably arent the key for fixing this pathway since

they work further down. We need to start @ the top where coenzyme a,

its feedback, control, metabolism and relation to vitamin b5 is

involved.

What im thinking is inducing increased fatty acid metabolism through

the skin like in puberty is the indicator of the

DHEA /progesterone/cortisol th1/th2 shift and " fix " switch possibly

because LDN is doing this whole oily skin to me whereas i had dry

skin before.

Read this interesting story :

possibly CFS induced by megadosing on vitamin b5 for successful acne

cure :

http://groups-beta.google.com/group/sci.med.nutrition/tree/browse_frm/thread/989\

42e49a479c9cd/fb5a564cff4e5641?rnum=1 & hl=en & q=Pantothenic+acid+overdose & _done=%2\

Fgroup%2Fsci.med.nutrition%2Fbrowse_frm%2Fthread%2F98942e49a479c9cd%2Ffb5a564cff\

4e5641%3Ftvc%3D1%26q%3DPantothenic+acid+overdose%26hl%3Den%26#doc_fb5a564cff4e56\

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