Undermethylation Dr. Enlander & Dr. Schaller WAS Re: SAMe/homocysteine issue

[Guest guest]

Hello Dr. Enlander & Dr. Schaller

There have been a few reports on this forum from PWCs that benefit

from methyl donor supplementation: a few test undermethylated, others

have bypassed the testing.

One or two reports (afaik) that methyl donor supp has subsequently

allowed GSH precursor/building/supplementation (again, some test low

in GSH, others not tested), when previously not tolerated.

A few reported improvements following the DAN protocol (seemingly

implying that a CFGF diet also helps)

Have you found a significant subset of your patient cohort that

responds similarly?

Should plasma _and_ urine AA tests always be run (if patient

presentation indicates), concurrently? along with a 24 hr urine and

possibly sulfation?

Do you rely heavily on the test results/lab accuracy/ref ranges, or do

you trial patients with various ttmt modalities, more in context with

patient presentation (and possibly contrary to lab results).

Thank you for your time,

Lance

CA

>

> Important material.

>

> We have a transdermal SAMe and just like the oral it works for mood

issues but it DOES drop B vitamins. So folks have been supplementing

with a B complex and this prevents an increased homocysteine which is

not good. It increases clots etc.

>

>

> JL Schaller, MD

> www.personalconsult.com

>

> Re: [ Methylation

cycle and homocysteine

>

>

>

> I have been asked to comment on homocysteine and methylation cycle

>

>

> Homocysteine is converted back to methionine in the methylation

cycle

> This step is thought to be vitamin B12-dependent and possibly

folic acid

> dependent.

>

> S-adenosylmethionine (SAM)

>

> SAM ----> SAH ----> Homocysteine --------> Methionine -------> SAM

> / \ \

> RH R-CH3 ATP

>

>

> Enlander MD

> New York

>

>

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>