Guest guest Posted December 24, 2004 Report Share Posted December 24, 2004 Hi Rich, I sent you an e-mail last week, I was wondering if you received it? Take care, _R Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 24, 2004 Report Share Posted December 24, 2004 Hi, . Yes, I received your e-mail, and this is the reply I sent you (maybe you didn't receive it): Hi, . Thanks for sending me your oxidative stress test results. It seems clear that your selenium level is very much too high. Since Brazil nuts are very high in selenium, I think that your former consumption of them " a couple of days a week " explains this high level. I'm glad that you have stopped eating Brazil nuts and also stopped taking the supplement that contains selenium. I'm wondering if you have observed any of the symptoms of selenium toxicity. The most frequently observed ones are brittleness and loss of hair and nails. Other symptoms of selenium toxicity are skin rash, garlic-like breath odor, fatigue, irritability, nausea and vomiting. Since selenium is known to form an insoluble complex with copper, I think your high selenium level explains why your copper level is low. I note that your glutathione peroxidase activity is on the low end of the normal range. This may explain why you don't have as much oxidized glutathione as normal. This would also raise your concentration of hydrogen peroxide, and that may explain why your ratio of vitamin C to ascorbyl radical is low, since the vitamin C may be having to pick up more of the load of dealing with the hydrogen peroxide, particularly since your total amount of vitamin C is on the low end of normal. It may also explain your other indicators of oxidative stress being high (oxidized protein and DNA, and antibodies to oxidized LDL). This leaves us with the question of why your glutathione peroxidase activity is low, even though you have a very elevated level of selenium, which is the cofactor for these enzymes. Perhaps you have a genetic variation in your glutathione peroxidase enzymes that make them less active, and even though you have plenty of selenium, it still isn't sufficient to get the activity of the glutathione peroxidase up high enough. As I said, I'm glad that you have decreased your intake of selenium, because that can be toxic. I think that raising your intake of vitamin C and bioflavonoids would be a good idea, and also taking alpha lipoic acid. Perhaps these would be able to pick up more of the load for water-soluble antioxidant activity from the glutathione peroxidase, which appears not to be functioning as well as it should. Rich In a message dated 12/16/2004 4:15:58 PM Eastern Standard Time, " Rubben " <kevin.rubben@...> writes: >Hi Rich, > >it´s here from the cfs groups. I received my oxidative >stress test results and I thought you might be interested in them. > >I have elevated selenium and beta-carotene. I stopped taking a >supplement that contains beta-carotene, I usually eat a few raw carrots >a week, so maybe that explains it. >I was taking Transfer Factor Essentials from immunesupport.com and it >contains 25 mcg selenium, I also eat brazil nuts on a couple of days a >week. I stopped taking the Transfer Factor 3 weeks before the test and >stopped eating the brazil nuts a week before the test. >Copper was slightly too low. > >Vitamin C and E are at the low side of normal. The text with the results >said that there is oxidation of vitamin C because of the elevated level >of the ascorbyl radical. >It also said that the vitamin E is too low in regards to the level of >cholesterol and that there is not enough protection of the lipids >because of this. Q10 was normal. > >What appears weird to me is that the level of reduced glutathione is >actually elevated, I didn´t take any supplements to build glutathione in >the last four or six months before having the test done, only magnesium >and malic acid and hydroxocobalamin injections, Transfer factor and some >green tea extract. >The level of oxidized glutathione was normal, the level of glutathione >peroxidase was at the lowest value of normal. > >In the oxidative stress markers the oxidized lipids was normal, there >was elevation of oxidized proteins and oxidized DNA. The level of >antibodies against oxidized LDL was highly elevated too. > >I will scan the results and attach them to this mail, the terms are in >French, most of them are the same as in English, but some of them are >different, I will translate those: >- the CATH is the hydrophilic antioxidant capacity, CATL is the >lipophilic antioxidant capacity >-acide urique is uric acid >- cuivre is copper >- peroxydes lipidiques is lipid peroxidation ; ADN oxydé is oxidized DNA >; proteins oxydées is oxidized proteins >- anticorps contre ox & #150; LDL is antibodies against oxidized LDL >- fer is iron ; fer sérique is serum iron ; coeff satur Fe transferrine >is iron saturation capacity of transferring >- habitudes alimentaires is eating habits > >They also did an omega acids test, I will also give the results if you >are interested in those too. > >I´d be curious to know your thoughts on the results of this test and >what supplements you would suggest that would be helpful. > >I really appreciate all of your help in the and the effort >that you put into the research of cfs. > >Take care, > Rubben > > Hi Rich, > > I sent you an e-mail last week, I was wondering if you received it? > > Take care, > _R Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 26, 2004 Report Share Posted December 26, 2004 Hi Rich, thanks for your post, I don´t know why I didn´t receive your reply, but lately I have had some troubles with receiving e-mails. I had read that too much selenium can be toxic and I thought that the 25mcg in the Transfer Factor would be quite safe because many people, including Lester Packer recommend taking 200mcg of selenium per day. I ate maybe 12 unshelled brazil nuts a day a couple of days a week, I read that this would be safe. This makes you wonder about the people who take 200mcg of selenium each day and the safety of this, seeing how the little dose I took resulted in a too high blood value. I certainly didn´t feel any worse while taking the Transfer Factor, and out of all the symptoms you mention of selenium toxicity I have only gotten some bald patches in my beard and eyebrows since starting the Transfer Factor. I was tired too but no more then before starting eating brazil nuts and taking the Transfer Factor. I am going to start taking supplements again now that I have the results of the test. I will take vitamins C and E (mixed tocopherols, high in gamma tocopherol)because the accompanying text with the test said they weren´t high enough to give cardiovascular and lipid and cholesterol protection. I will also take tocotrienols for the elevated level of antibodies against oxidized LDL. In order to try and raise the glutathione peroxidase I will take alpha lipoic acid and NAC. I will also take Q10 and acetyl-L-carnitine. I was also planning on taking a low dose of a multivitamin every other day but seeing as that would still amount to 60mcg of selenium it is maybe best to take that only once or twice a week? I am guessing the elevated level of oxidized proteins and DNA will go down with those supplements I will take? Was my oxidative stress test kind of what you would expect it to be for a cfs patient? The fatty acid test said the ratio of omega 6 to omega 3 was 4 to 1 which is normal, however it also said there is formation of inflammatory prostaglandins from AA to the detriment of the anti- inflammatory prostaglandins of EPA. It mentions the use of fish oil supplements for this, but they also warn that those are very susceptible to lipid peroxidation and you need a good antioxidant defense if you take them. So I don´t quite know if I should take fish oil supplements or not. Thanks again for your help Rich. Take care, > > Hi, . > > Yes, I received your e-mail, and this is the reply I sent you (maybe > you didn't receive it): > > Hi, . > > Thanks for sending me your oxidative stress test results. > > It seems clear that your selenium level is very much too high. > Since Brazil nuts are very high in selenium, I think that your > former consumption of them " a couple of days a week " explains this > high level. I'm glad that you have stopped eating Brazil nuts and > also stopped taking the supplement that contains selenium. I'm > wondering if you have observed any of the symptoms of selenium > toxicity. The most frequently observed ones are brittleness and > loss of hair and nails. Other symptoms of selenium toxicity are > skin rash, garlic-like breath odor, fatigue, irritability, nausea > and vomiting. > > Since selenium is known to form an insoluble complex with copper, I > think your high selenium level explains why your copper level is low. > > I note that your glutathione peroxidase activity is on the low end > of the normal range. This may explain why you don't have as much > oxidized glutathione as normal. This would also raise your > concentration of hydrogen peroxide, and that may explain why your > ratio of vitamin C to ascorbyl radical is low, since the vitamin C > may be having to pick up more of the load of dealing with the > hydrogen peroxide, particularly since your total amount of vitamin C > is on the low end of normal. It may also explain your other > indicators of oxidative stress being high (oxidized protein and DNA, > and antibodies to oxidized LDL). > > This leaves us with the question of why your glutathione peroxidase > activity is low, even though you have a very elevated level of > selenium, which is the cofactor for these enzymes. Perhaps you have > a genetic variation in your glutathione peroxidase enzymes that make > them less active, and even though you have plenty of selenium, it > still isn't sufficient to get the activity of the glutathione > peroxidase up high enough. > > As I said, I'm glad that you have decreased your intake of selenium, > because that can be toxic. I think that raising your intake of > vitamin C and bioflavonoids would be a good idea, and also taking > alpha lipoic acid. Perhaps these would be able to pick up more of > the load for water-soluble antioxidant activity from the glutathione > peroxidase, which appears not to be functioning as well as it should. > > Rich Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 28, 2004 Report Share Posted December 28, 2004 Hi, . > > > > Hi, . > > > > Yes, I received your e-mail, and this is the reply I sent you > (maybe > > you didn't receive it): > > > > Hi, . > > > > Thanks for sending me your oxidative stress test results. > > > > It seems clear that your selenium level is very much too high. > > Since Brazil nuts are very high in selenium, I think that your > > former consumption of them " a couple of days a week " explains this > > high level. I'm glad that you have stopped eating Brazil nuts and > > also stopped taking the supplement that contains selenium. I'm > > wondering if you have observed any of the symptoms of selenium > > toxicity. The most frequently observed ones are brittleness and > > loss of hair and nails. Other symptoms of selenium toxicity are > > skin rash, garlic-like breath odor, fatigue, irritability, nausea > > and vomiting. > > > > Since selenium is known to form an insoluble complex with copper, > I > > think your high selenium level explains why your copper level is > low. > > > > I note that your glutathione peroxidase activity is on the low end > > of the normal range. This may explain why you don't have as much > > oxidized glutathione as normal. This would also raise your > > concentration of hydrogen peroxide, and that may explain why your > > ratio of vitamin C to ascorbyl radical is low, since the vitamin C > > may be having to pick up more of the load of dealing with the > > hydrogen peroxide, particularly since your total amount of vitamin > C > > is on the low end of normal. It may also explain your other > > indicators of oxidative stress being high (oxidized protein and > DNA, > > and antibodies to oxidized LDL). > > > > This leaves us with the question of why your glutathione > peroxidase > > activity is low, even though you have a very elevated level of > > selenium, which is the cofactor for these enzymes. Perhaps you > have > > a genetic variation in your glutathione peroxidase enzymes that > make > > them less active, and even though you have plenty of selenium, it > > still isn't sufficient to get the activity of the glutathione > > peroxidase up high enough. > > > > As I said, I'm glad that you have decreased your intake of > selenium, > > because that can be toxic. I think that raising your intake of > > vitamin C and bioflavonoids would be a good idea, and also taking > > alpha lipoic acid. Perhaps these would be able to pick up more of > > the load for water-soluble antioxidant activity from the > glutathione > > peroxidase, which appears not to be functioning as well as it > should. > > > > Rich Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.