Guest guest Posted March 19, 2004 Report Share Posted March 19, 2004 Has this group discussed the issue of whether or not MMP activity is proteolytic to immuno-globulins (Ig)? Please excuse me if you have...I'm not very proficient at searching these groups. I noticed a discussion of gamma-globulins and was wondering if a deficiency is noted. If so is it lack of production, or increased degeneration, increased usage or possibly all of the above? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 19, 2004 Report Share Posted March 19, 2004 I don't remember having that discussion. Many of us who have taken GG have a sub class deficiency. But personally I was never given any tests beyond that to say if it is lack of production, increased usage, etc. CFS research has not focused much on GG. The few studies that were done said it didn't work (because only SOME of the people got better). The studies I have seen are old, before people started realizing that nothing works for everyone, but that doesn't mean it is not an effective treatment for some. Still most doctors cling to that research and say that GG does not work. Doris ----- Original Message ----- Has this group discussed the issue of whether or not MMP activity is proteolytic to immuno-globulins (Ig)? ...I noticed a discussion of gamma-globulins and was wondering if a deficiency is noted. If so is it lack of production, or increased degeneration, increased usage or possibly all of the above? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 21, 2004 Report Share Posted March 21, 2004 A reason I brought this up is because I was thinking that since elastase can digest T4 binding globulin, could MMPs digest IGs? If the MMPs can digest them, this would explain why many of the serological tests for diseases such as ELISA & western blot for chronic LD are so unreliable. It's also likely the immune-dysfunction caused by chronic LD plays a role in this too. But, I hadn't thought of the MMPs proteolytic activity on IGs until recently. > I don't remember having that discussion. Many of us who have taken GG have a sub class deficiency. But personally I was never given any tests beyond that to say if it is lack of production, increased usage, etc. CFS research has not focused much on GG. The few studies that were done said it didn't work (because only SOME of the people got better). The studies I have seen are old, before people started realizing that nothing works for everyone, but that doesn't mean it is not an effective treatment for some. Still most doctors cling to that research and say that GG does not work. > Doris > ----- Original Message ----- > > Has this group discussed the issue of whether or not MMP activity is > proteolytic to immuno-globulins (Ig)? > > ...I noticed a discussion of gamma-globulins and was wondering if a > deficiency is noted. If so is it lack of production, or increased > degeneration, increased usage or possibly all of the above? > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 21, 2004 Report Share Posted March 21, 2004 Work such as this give a little support that this idea might have merit: J Exp Med. 1983 Apr 1;157(4):1184-96. Related Articles, Links Selective proteolysis of immunoglobulins by mouse macrophage elastase. Banda MJ, EJ, Werb Z. Mouse macrophage elastase, a metalloproteinase secreted by inflammatory macrophages, catalyzed the limited proteolysis of selected subclasses of mouse immunoglobulins, including monomeric IgG2a, IgG3, and some forms of IgG2b. Mouse IgG1 was resistant to elastase degradation; however, human IgG1 was degraded. IgG3 in immune complexes was cleaved in a manner similar to that of monomeric IgG3. Degradation by macrophage elastase was limited to the heavy chain, resulting in products that did not compete for binding to the macrophage Fc receptor. Macrophage elastase usually produced a pepsin-like rather than a papain-like pattern of proteolysis, resulting in the release of F(ab')2 and Fc' subfragments. This degradation of IgG differed from the papain-like cleavage of IgG by granulocyte elastase. Macrophage elastase degraded papain-generated Fc fragments of IgG2a into multiple fragments. Therefore, macrophage elastase at concentrations found in culture medium has the potential to regulate some aspects of cellular events associated with immunoglobulins. > > I don't remember having that discussion. Many of us who have > taken GG have a sub class deficiency. But personally I was never > given any tests beyond that to say if it is lack of production, > increased usage, etc. CFS research has not focused much on GG. The > few studies that were done said it didn't work (because only SOME of > the people got better). The studies I have seen are old, before > people started realizing that nothing works for everyone, but that > doesn't mean it is not an effective treatment for some. Still most > doctors cling to that research and say that GG does not work. > > Doris > > ----- Original Message ----- > > > > Has this group discussed the issue of whether or not MMP > activity is > > proteolytic to immuno-globulins (Ig)? > > > > ...I noticed a discussion of gamma-globulins and was wondering > if a > > deficiency is noted. If so is it lack of production, or > increased > > degeneration, increased usage or possibly all of the above? > > > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.