Guest guest Posted February 7, 2004 Report Share Posted February 7, 2004 Hi Rich I was wondering if there is any connection between glutathione levels, thyroid and adrenals. The reason I ask is that my thyroid seems to have gone into a bit of overdrive recently and I have come off the Prednisone recently and am justing taking 2.5mg hydrocortisone for the adrenals because they seem to have recovered. I don't understand why this has happened, the only things I have been doing differently lately is the Kane detox protocol (not all the supplements and only oral doses) but I have also been taking 1 1/2 tablespoons of undenatured whey powder for 3 1/2 weeks now. In the past 14 months whenever I have tried to come off the adrenal support I have suffered very bad symptoms straight away but this just hasn't happened this time. Thanks for your help Rich, much appreciated as always Pam Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 7, 2004 Report Share Posted February 7, 2004 Hi, Pam. It's good to hear about the improvement in your adrenals. How do you know that your thyroid has " gone into overdrive " ? Is it based on experience with how it feels if you take too much thyroid hormone? I don't have a very definite answer to your question. I do know that the adrenals and the thyroid are linked, and that if the thyroid goes down it is often necessary to support both the thyroid and the adrenals, or the adrenals will also go down. So it seems reasonable to me that you might get improvement in both of them together. It also seems reasonable that building glutathione would help these organs, since all the cells use it. I don't know the priority with which the thyroid and adrenals utilize the raw materials for making glutathione. I do know that the liver and the heart have greater priority than the skeletal muscles. Are you taking any thyroid hormone now? Rich > Hi Rich > > I was wondering if there is any connection between glutathione > levels, thyroid and adrenals. > > The reason I ask is that my thyroid seems to have gone into a bit of > overdrive recently and I have come off the Prednisone recently and > am justing taking 2.5mg hydrocortisone for the adrenals because they > seem to have recovered. > > I don't understand why this has happened, the only things I have > been doing differently lately is the Kane detox protocol > (not all the supplements and only oral doses) but I have also been > taking 1 1/2 tablespoons of undenatured whey powder for 3 1/2 weeks > now. In the past 14 months whenever I have tried to come off the > adrenal support I have suffered very bad symptoms straight away but > this just hasn't happened this time. > > Thanks for your help Rich, much appreciated as always > > Pam Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 7, 2004 Report Share Posted February 7, 2004 > Hi, Pam. > > It's good to hear about the improvement in your adrenals. How do > you know that your thyroid has " gone into overdrive " ? Is it based > on experience with how it feels if you take too much thyroid hormone? > > I don't have a very definite answer to your question. I do know > that the adrenals and the thyroid are linked, and that if the > thyroid goes down it is often necessary to support both the thyroid > and the adrenals, or the adrenals will also go down. So it seems > reasonable to me that you might get improvement in both of them > together. > > It also seems reasonable that building glutathione would help these > organs, since all the cells use it. I don't know the priority with > which the thyroid and adrenals utilize the raw materials for making > glutathione. I do know that the liver and the heart have greater > priority than the skeletal muscles. > > Are you taking any thyroid hormone now? > > Rich > Hi Rich Yes, I noticed these past few weeks that my bp is often a lot higher than it ever used to be and also that my pulse was always in the 80s whenever I took it. I have also been having really bad sweating episodes. It was a few nights ago that I was woken up about 3 am pouring with sweat plus my pulse was pounding, I guess in the 90s. I realised this has happened on a few occasions recently but hadn't realised that the pulse was so high. I put 2 and 2 together and remembered this has happened before when my thyroid has gone slightly hyper. I had been taking 3 grains of Armour since 8 December after previously being on 2 grains. However I had started getting symptoms of being hypo (very chilled and aching muscles) during November so upped it to 3 grains. Its only been the past couple of weeks that I realised things had changed yet again. Tomorrow I am going to stop the h/c altogether because I just don't think I need it now (just 2.5 h/c yesterday and today and I have cut back to 2 grains of Armour since Thursday. Already my pulse was in the 70s when I took it today and bp was also lower 120/60. Muscles in the legs have been a bit sore but I guess it will take a little time for them to get used to the changes but in general I do feel better in myself. I do have antibodies to my thyroid and know that they do seem to cause changes as I have had to change my dose of Armour many times in the past year. It would be interesting to know whether glutathione did affect the working of the thyroid or not or whether it could be all the extra EFAs plus phosphotidylchlorine that has helped the uptake of the thyroid hormones. Pam Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 7, 2004 Report Share Posted February 7, 2004 Pam, Maybe the abstract below will shed some light on your question. The thyroid gland makes a lot of hydrogen peroxide to carry out its reactions in making thyroid hormones. Glutathione is used to quench hydrogen peroxide. If there isn't enough glutathione in the thyroid, perhaps the hydrogen peroxide produces a condition of oxidative stress and damages the thyroid cells. Here's the abstract: " Biochimie. 1999 May;81(5):527-33. The trace element selenium and the thyroid gland. Kohrle J. Abteilung fur Molekulare Innere Medizin und Klinische Forschergruppe der Medizinischen Poliklinik der Universitat Wurzburg, Germany. Apart from the essential trace element iodine, which is the central constituent of thyroid hormones, a second essential trace element, selenium, is required for appropriate thyroid hormone synthesis, activation and metabolism. The human thyroid gland has the highest selenium content per gram of tissue among all organs. Several selenocysteine-containing proteins respectively enzymes are functionally expressed in the thyroid, mainly in thyrocytes themselves: three forms of glutathione peroxidases (cGPx, pGPx, and PH-GPx), the type I 5-deiodinase, thioredoxin reductase and selenoprotein P. The thyroidal expression of type II 5-deiodinase still is controversial. As thyrocytes produce H2O2 continuously throughout life an effective cell defense system against H2O2 and reactive oxygen intermediates derived thereof is essential for maintenance of normal thyroid function and protection of the gland. In experimental animal models long-term and strong selenium deficiency leads to necrosis and fibrosis after high iodide loads. Combined iodide and selenium deficiency such as in central Zaire is thought to cause the myxedematous form of endemic cretinism. Inadequate selenium supply and prediagnostically low serum selenium levels are significantly correlated with the development of thyroid carcinoma and other tumors. Though selenium supply controls expression and translation of selenocysteine-containing proteins no direct correlation is found between selenium tissue content and expression of various thyroidal selenoproteins, indicating that other regulatory factors contribute to or override selenium- dependent expression control, e.g., in thyroid adenoma, carcinoma or autoimmune disease. As both trace elements, iodine and selenium, were washed out from the upper layers of the soil during and after the ice ages in many regions of the world adequate supply with these essential compounds needs to be provided either by a balanced diet or supplementation. " Rich > > It would be interesting to know whether glutathione did affect the > working of the thyroid or not or whether it could be all the extra > EFAs plus phosphotidylchlorine that has helped the uptake of the > thyroid hormones. > > Pam Quote Link to comment Share on other sites More sharing options...
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