Re: Published Study on Isoprinosine (Imunovir)

[Guest guest]

I have the JCFS and plan to read it. They are pretty tight with their

copyrights, so it's hard to find on the net.

Jim

[Guest guest]

Al,

How can we find this study to read? I did a search on the journal of

chonic fatigue syndrome but no journal link came up.

Bob

> A study on Isoprinosine(Imunovir), a drug Dr. Cheney uses for his

CFS

> patients, is reported to be in the CFS Journal referenced below.

>

> Al

>

>

> > EDITORIAL

> > [Journal of Chronic Fatigue Syndrome, Vol. 11(2) 2003, pp. 1-5]

> >

> > This issue of the journal has a group of articles on the

> > 2',5'-oligoadenylate-dependent ribonuclease L system in ME/CFS

and a

> review

> > of the pathways and its activities as well as the prevalence of

> potentially

> > important pathogens in the morbidity of ME/CFS. A pilot study is

also

> > presented which assesses the use of Isoprinosine® in a single

blinded

> > placebo controlled study on immune cell and cytokines levels.

>

> (Majority of posting Edited out bercause it was too long. Al)

>

> > ---------------------------------------------

> > Too much mail? Try a digest version.

> > See http://www.co-cure.org/digest.htm

> > Send posts to mailto:CO-CURE@l...

> > Join or leave the list at http://www.co-cure.org/sub.htm

> > ---------------------------------------------

[Guest guest]

Note that this is a 2000 conference presentation, but may have been

the basis of the 2003 publication

Lance

--

Clinical Improvement In Chronic Fatigue Syndrome Is Associated

With Enhanced Natural Killer Cell Mediated Cytotoxicity

The Results Of A Pilot Study With Isoprinosine

A. Kumar 1, E. Turgonyi 2, B. Hyde 3, C. Galvis 1, W. Lim 1 and

F. -Mitoma 1

1- Departments of Pediatrics, Division of Virology, Children's

Hospital of Eastern Ontario, University of Ottawa, Ottawa;

2- Newport Pharmaceuticals Ltd. , Ireland; and

3- Nightingale Research Foundation, Ottawa, Ontario, Canada.

Chronic fatigue syndrome (CFS) is associated with several immune

abnormalities, such as decreased natural killer (NK) cell mediated

cytotoxicity and dysregulated production of cytokines. The clinical

impact of Isoprinosine (immunomodulator/antiviral) on various immune

functions in a total of 16 CFS patients diagnosed according to the CDC

CFS definition was evaluated.

Patients were followed for 28 weeks. Clinical improvement based on the

clinical staging was observed in 6 out of 10 patients (60% ). CFS

patients at baseline compared to normal controls exhibited a

significantly decreased NK activity as well as decreased

mitogen-induced production of IL-10, IL-12 and IFN-y in PBMC. The

clinically improved patients showed a significantly enhanced NK

activity [LU (5 and 15%)/10x5th which correlated with the duration of

the treatment (p< 0.03). A significant increase in IL-12 production by

T cell mitogen stimulated PBMC was observed in clinically improved

patients treated for 28 weeks compared to the patients on placebo (p <

0.02).

Treatment with Isoprinosine for 12 weeks did not appreciably influence

the production of IL-1 a. and lL-10. However, discontinuation of

treatment resulted in enhanced production of both IL-1 a an IL-10 only

in clinically improved patients. When treatment was started again at

week 16, significantly decreased production of these two cytokines was

observed. Treatment with Isoprinosine for prolonged periods (28 weeks)

also resulted in the enhanced number of CD4+ T helper cells and CD4+,

HLA-DR+ T cell number in peripheral blood only in clinically improved

patients. These resu1ts suggest the clinical efficacy of Isoprinosine

and its potential to enhance NK cell activity. In view of the small

number of patients, further studies are required to investigate the

contribution of Isoprinosine -mediated immune effects to the

pathogenesis of CFS.

The paper was presented at the MI Immunology 2000 Conference in

Seattle,WA, May 2000.

> > A study on Isoprinosine(Imunovir), a drug Dr. Cheney uses for his

> CFS

> > patients, is reported to be in the CFS Journal referenced below.

> >

> > Al

> >

> >

> > > EDITORIAL

> > > [Journal of Chronic Fatigue Syndrome, Vol. 11(2) 2003, pp. 1-5]

> > >

> > > This issue of the journal has a group of articles on the

> > > 2',5'-oligoadenylate-dependent ribonuclease L system in ME/CFS

> and a

> > review

> > > of the pathways and its activities as well as the prevalence of

> > potentially

> > > important pathogens in the morbidity of ME/CFS. A pilot study is

> also

> > > presented which assesses the use of Isoprinosine® in a single

> blinded

> > > placebo controlled study on immune cell and cytokines levels.

> >

> > (Majority of posting Edited out bercause it was too long. Al)

> >

> > > ---------------------------------------------

> > > Too much mail? Try a digest version.

> > > See http://www.co-cure.org/digest.htm

> > > Send posts to mailto:CO-CURE@l...

> > > Join or leave the list at http://www.co-cure.org/sub.htm

> > > ---------------------------------------------

[Guest guest]

hi all,

interesting that a cfids md i know only found it useful on about 20

% of their patients in their informal studies....

i am now taking it but as i had no baseline lab data , it will take

time to see if it works and what happens if and when i stop using it.

al...i would love to see a copy of the article if u get it from the

manufactuer.....

thanx somish.

[Guest guest]

In a message dated 8/25/2003 8:19:40 PM Mountain Standard Time,

melillo3@... writes:

> The Journal of CFS is published by Haworth Press, I think their

> website is: www.haworthpress.com ; they charge for their articles,

> some medical libraries might subscribe to the journal, so that is one

> way to get it free. I going to see if the rep I know at Rivex, who

> distributes the it has a copy of the article I can get for free by

> email or fax. I'll let you know if I can get it, if it's not free I

>

> In my state the public library has special subsidies to pay for interlibrary

> loans to get medical information. I do not recall what the name of the

> program is, but I have used it. I was informed of it by the librarian at the

> hospital. This is not well known, and probably underutilized.That's all I

know.

> Adrienne

[Guest guest]

> Al,

>

> How can we find this study to read? I did a search on the journal

of

> chonic fatigue syndrome but no journal link came up.

>

> Bob

Hi Bob,

The Journal of CFS is published by Haworth Press, I think their

website is: www.haworthpress.com ; they charge for their articles,

some medical libraries might subscribe to the journal, so that is one

way to get it free. I going to see if the rep I know at Rivex, who

distributes the it has a copy of the article I can get for free by

email or fax. I'll let you know if I can get it, if it's not free I

wont' get it.

Al

[Guest guest]

ISOPRINOSINE STUDY --

" Clinical Improvement In Chronic Fatigue Syndrome Is Associated

With Enhanced Natural Killer Cell Mediated Cytotoxicity:

The Results Of A Pilot Study With Isoprinosine "

This brief report can be found at Message# 40299

> In a message dated 8/25/2003 8:19:40 PM Mountain Standard Time,

> melillo3@e... writes:

>

> > The Journal of CFS is published by Haworth Press, I think their

> > website is: www.haworthpress.com ; they charge for their articles,

> > some medical libraries might subscribe to the journal, so that is one

> > way to get it free. I going to see if the rep I know at Rivex, who

> > distributes the it has a copy of the article I can get for free by

> > email or fax. I'll let you know if I can get it, if it's not free I

>

>

>

> >

> > In my state the public library has special subsidies to pay for interlibrary

> > loans to get medical information. I do not recall what the name of the

> > program is, but I have used it. I was informed of it by the librarian at the

> > hospital. This is not well known, and probably underutilized.That's all I

know.

> > Adrienne

>

>

>

>