Guest guest Posted July 28, 2004 Report Share Posted July 28, 2004 Here is the case history that mirrors my son's case. The sulfites seem to be the culprits, but looking further it would appear that excess copper and the subsequent deficiency of molybdenum caused a lack of sulfite oxidase (enzyme that metabolizes sulfites). I would love to see if there is any similar mechanism that could trigger achalasia. My husband is having his first-ever achalasia attack right now...after eating an Oriental Chicken Salad at a restaurant. Wonder if the lettuce was sulfited?? Hasn' t been able to swallow a bite of food since this afternoon. This is scary. m Entrez PubMed Nucleotide Protein Genome Structure OMIM PMC Journals Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes Conserved Domains 3D Domains Gene GEO Profiles GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard Details About EntrezText VersionEntrez PubMed OverviewHelp | FAQTutorialNew/NoteworthyE-UtilitiesPubMed ServicesJournals DatabaseMeSH DatabaseSingle Citation MatcherBatch Citation MatcherClinical QueriesLinkOutCubbyRelated ResourcesOrder DocumentsNLM GatewayTOXNETConsumer HealthClinical AlertsClinicalTrials.govPubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Profile Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: 5 10 20 50 100 200 500 Sort Author Journal Pub Date Text File Clipboard E-mail Order 1: Ann Allergy Asthma Immunol. 2003 Sep;91(3):314-7. Related Articles, Links Hepatic metabisulfite sensitivity in a patient with sclerosing cholangitis.Stormont JM, Flaherty M, Condemi J.University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. stormymd@...BACKGROUND: Primary sclerosing cholangitis is an uncommon chronic cholestatic liver disease with a poor prognosis in symptomatic cases. Genetic and immunologic alterations have been identified, and many possible etiologies have been entertained. Most treatments have limited benefit, and primary sclerosing cholangitis is a common cause for liver transplantation. OBJECTIVE: To describe a patient with documented primary sclerosing cholangitis associated with chronic ulcerative colitis, who developed hepatic toxicity following ingestion of metabisulfite. RESULTS: A placebo-controlled oral challenge suggested metabisulfite hypersensitivity with liver toxicity. He was treated with cobalamin (to prevent sulfite toxicity), low-sulfite diet, steroids, and antibiotics and has had an unusually benign course for 19 years. CONCLUSIONS: The hypersensitivity to oral metabisulfite in our patient appeared to be a significant trigger to flare-ups of his disease. Controlling the response to metabisulfite (along with recurrent antibiotic and steroid therapy) may have contributed significantly to the remarkably good outcome in this patient.PMID: 14533666 [PubMed - indexed for MEDLINE] Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Profile Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: 5 10 20 50 100 200 500 Sort Author Journal Pub Date Text File Clipboard E-mail Order Write to the Help Desk NCBI | NLM | NIH Department of Health & Human Services Privacy Statement | Freedom of Information Act | Disclaimer Jul 27 2004 13:14:01 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 10, 2004 Report Share Posted September 10, 2004 Cindi wrote: As always, Notan, thank you for being the voice of intelligent reason! lol! Lol indeed! ;-) And I have to ask you, is your name really Notan? My son pointed out that you are " Not an Ostrich " . It is not my real name. It does mean " not an " , not to be confused with " nut in " as in " Nutin Candy " , or " no tan " as in " Notan White " (What happened to the Hawaiian dude with the tan)? Here's my 2 cents I will raise you 2 more, and I agree with everything you said. Also, God makes us each very unique! What a blessing! But that also means there will probably not be a conclusive cause, treatment or even symptoms for every case of A. It may even be because we are very unique that we get A. my kids deserve a healthy mom who can be treated by a group of people who specialize in this area of the body and know more about it than I ever will understand. Yes it often comes down to something like that. In my case, my achalasia has not been a problem for my family. For a while it did scare them, but they have gotten passed that. I would have been interested to hear more from Bernard, if he had more. Maybe he did, maybe he didn't. I can understand that he made people feel uncomfortable though. notan Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 10, 2004 Report Share Posted September 10, 2004 It may even be because we are very unique that we get A. I totally agree with this statement notan! Sandi Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 11, 2004 Report Share Posted September 11, 2004 --- Cindi, If no one has told you yet, YOU, my dear, ARE THE TRUE VOICE OF REASON. I love the way you get to the point of it all without subjecting everyone to so much medical jargon and brouhaha. The heller fixed me too. Period. The fork in the " A " road points to surgery or no surgery. From reading the messages written by Bernard, my take on it is working on the ability to control the ANS by anxiety control--I know that is a simple way of it and I respect what you are saying about this therapy. I hope it really works. This world needs to learn how to slow down anyway. I'm medically oriented and am quick to make decisions based on my own personal experience as a nurse. I chose the heller, and I didn't spend my time wondering if it was right or not. It had to be done. Cindi, like you, my family deserved a wife, mother, daughter in good condition. My swallowing is not perfect and never will be again. Oh well, c'est la vie. My favorite saying is: get over it, get on with it. Life is too short. So Cindi, thanks again. You're awesome. Jo from South Florida In achalasia , " Cindi Wilmot " <cindiscandles@s...> wrote: > As always, Notan, thank you for being the voice of intelligent reason! > lol! And I have to ask you, is your name really Notan? My son pointed out > that you are " Not an Ostrich " . Just have been wondering! > > Here's my 2 cents on the whole " alternative medicine thing " , for what it is > worth.... I'm one who personally researches things like this before > subjecting myself to treatment. When I was diagnosed, I literally read > hundreds of articles online before finding this group. I don't think the > medical community in general is completely ignorant of this problem.... > though many doctors & nurses are. A has been researched and there are still > not a lot of answers. The same goes for cancer, Alzheimer's, AIDS and so on > ...many complicated problems, many without complete answers. > > Also, God makes us each very unique! What a blessing! But that also means > there will probably not be a conclusive cause, treatment or even symptoms > for every case of A. > > So, I came to the conclusion awhile ago that I might try something if it > were minimally invasive or not going to cause a long -term unrelated problem > (like, taking magnesium....no biggie; trying to drink soda to get things > down - works since my Heller!). but if I found a treatment for A that was > 93% effective, would I try it? YES! That treatment, in my case, was a > Heller. I have positively no regrets. My swallowing is not perfect & I > will guess I will have to go back at some point to have a dilation or even > further surgery as I'm only 39 yrs. old. But at the same time, if I hadn't > had it, I would be very, very ill right now. And my kids deserve a healthy > mom who can be treated by a group of people who specialize in this area of > the body and know more about it than I ever will understand. > > Cindi in PA Quote Link to comment Share on other sites More sharing options...
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