DMSO + Prostate Cancer

[Guest guest]

Hi,

An interesting chemical is DMSO, made from the sap of trees.

This drug is widely available and very low in toxicity. Apart from its

anti-cancer properties

it is used to enhance the effects of other drugs. It does this by modifying cell

permeability.

If you pour some ink on you skin you can wash it off, but if you mix DMSO with

the ink

and pour it on the skin you may get a permanent tattoo. So DMSO can carry things

into

tissues.

I have an interest in the ability of DMSO to carry cancer killing oxygen

products,

like H2O2, into tissues.

Prostate 1989;15(2):123-33

Effect of DMSO and DFMO on rat prostate tumor growth.

Carvalho L, Foulkes K, Mickey DD

Department of Surgery, University of North Carolina, Chapel Hill 27599-7235.

An anaplastic, metastatic subline of the Dunning rat tumor was exposed to

non-cytodestructive doses of the cellular differentiation agents

dimethylsulfoxide and difluoromethylornithine. Copenhagen rats hosting prostate

tumors were evaluated by comparing solid tumor growth resulting from injection

of treated cells with solid tumor growth of untreated control cells. Results

showed significantly slower solid tumor growth after a 15 day in vitro exposure

of cells to either agent, after oral treatment of host animals for 20 days with

either agent before injection of untreated tumor cells, and after oral treatment

of host animals with either agent initiated on the day of untreated tumor cell

injection. Treatment of animals with established tumors with either agent also

had an inhibitory effect on tumor growth, and the effect was related to the

length of treatment. Thus, exposure of these highly malignant rat prostate

carcinoma cells to non-cytotoxic doses of either agent induced slower tumor

growth rates. Treatment with either agent could have selected for a slower

growing population of tumor cells. Since a slowing of cell cycle transit times

is an early indicator of cellular differentiation, these results could reflect

an increase in the capacity of the malignant cells to differentiate.

PMID: 2508071, UI: 90017079