RE : RE: Re: CML and Atrial Fibrillation

[Guest guest]

Hi Zavie And Tracey,

I was first treated for AF (Atrial Fibrillation) at Saint-Luc

hospital in June 2003 (51 years old). After I was treated for TE (thrombocytemia

essential) since August 2004 at Sacré-Coeur Hospital. In January 2005, my

platelets went to 1,400,000. So, I took six pills of Hydrea and 3 pills of

Agrylin. My platelets drop to 100,000. In June 2005 the BCR/ABL test came

positive and I started Gleevec (400mg). Actually, I go to Royal

hospital for my treatment and my new CML doctor is Dr Pierre Laneuville. My dose

of Gleevec is always 400 mg.

August 2004 - Hydrea ------- Sacré-Coeur hospital

January 2005 - Hydrea + Agrylin ------- Sacré-Coeur hospital

June 2005 ------ Start Gleevec -------- Sacré-Coeur hospital

November 2005 -- -log 2.0 -------- Royal- Hosp.

February 2006 ---- -log 2,7 -------- Royal- Hosp.

May 2006 ----------- -log 1,5 -------- Royal- Hosp.

June 2006 ----------- -log 2,1 -------- Royal- Hosp.

August 2006 -------- -log 2,3 -------- Royal- Hosp.

November 2006 ???? - ------- Royal- Hosp.

In August 2006, I made a lot of Atrial fibrillation episodes. My

cardiologist double the Rythmol pills to 600 mg. Now my heart is stable

(sinusal). But actually I have trouble with my kidneys ( creatine factor > 100,

between 120-130), My INR is very stable between 2,0 and 2,8. But some days (for

2-3 days), the INR jump to 4,0 and return to normal.

I am worried about the interaction of Rythmol with Gleevec. I knew

that some people had trouble with Coumadin.

Thank you to answer me back so rapidly,

Salutations

Gilles

diag 08/2004

Zavie <zmiller@...> a écrit :

Salut Gilles,

Welcome to our CML family.

Gleevec interacts with Coumadin. It tends to enhance the effect of Coumadin.

In my personal case I was on Coumadin since 1991 and my INR counts were very

steady. In 2001 I started taking Gleevec, and my INR counts were no longer

stable. I check it every 2-3 weeks and make adjustments in my Coumadin dose.

There is a CML support group that meets in Montreal on a regular basis. I

try and join them as often as I can. Both Tracey and I were born in Montreal

and we now live in Ottawa. We have a CML group that meets here on a regular

basis.

Can you tell at what level your CML is at. I ask this question because I am

always looking for new members in my Zero Club. Also, where do you go for

treatment and who is you CML doctor.

I hope this helps,

Zavie

Zavie (age 68)

67 Shoreham Avenue

Ottawa, Canada, dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

PCRU 5/02 at RVH (Questionable)

2.8 log reduction Sep/05

3.0 log reduction Jan/06

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

----Original Message Follows----

From: " Tracey " <traceyincanada@...>

Reply-

Subject: [ ] Re: CML and Atrial Fibrillation

Date: Fri, 15 Dec 2006 21:58:59 -0000

Hi Gilles,

Bienvenu a notre group. Yes there are a couple of people I know of

who started with A-Fib then found out they had CML although I don't

think the two are related. Hopefully you'll hear from some of them.

I know from our group has both and Zavie takes Coumadin as do a

couple of others for a variety issues.

Take care,

Tracey

dx Jan 2002

--- In , " Gilles Cousineau " <cousineaugilles@...>

wrote:

>

> Since June 2005, I took Gleevec (400) mg. First I was diagnosed AF

> Atrial fibrillation in June 2003. Actually I take to control AF,

three

> medicaments ( Coumadin, Monocor and Rythmol). I don't know if there

is

> some interaction between these medicaments. Is the there somebody in

> the same situation than me? I am 53 years old. I lived in Montreal

> (Canada).

>