RE: Waiting to hear if I have CML -- couple of questions about what my doc said

[Guest guest]

At 12:38 AM 8/13/06 +0000, you wrote:

>I had an appointment yesterday and he said that all of my blood

>tests were normal except for one abnormality. He said -- and this

>is where it gets cloudy and I cannot rcall exactly what he said --

>something about how there were two " mutations " for CML and that my

>blood tested positive for one and negative for the other and that

>the positive test was at the " very low levels. "

>

>I asked him what he would " guess " if he had to, and he said he would

>guess that I do not have it, but that we should do another blood

>test and bone marrow biopsy to be sure. He actually too the bone

>marrow right there and then (and the blood). Now I am waiting.

Hi ,

The definitive diagnosis for CML is the presence of the Philadelphia

chromosome....which is a translocation between chromosomes 9 and 22. You

find this when you do a bone marrow biopsy and do a cytogenetic analysis.

When you are looking just at blood, maybe with a FISH test, you are looking

for the BCR-ABL which is a marker for CML........I don't know exactly what

test was done with your blood? You should get a complete answer from the

bone marrow biopsy. Usually they will look at 20 dividing cells and see if

any have the 9/22 translocation and if they do, what % have it. Good luck

with your test.

C.

[Guest guest]

Hi ,

Hope all is well with you.

I was wondering about this message from . I get the individual

emails from and haven't seen his original post yet.

Zavie

Re: [ ] Waiting to hear if I have CML -- couple of

questions about what my doc said

At 12:38 AM 8/13/06 +0000, you wrote:

>I had an appointment yesterday and he said that all of my blood

>tests were normal except for one abnormality. He said -- and this

>is where it gets cloudy and I cannot rcall exactly what he said --

>something about how there were two " mutations " for CML and that my

>blood tested positive for one and negative for the other and that

>the positive test was at the " very low levels. "

>

>I asked him what he would " guess " if he had to, and he said he would

>guess that I do not have it, but that we should do another blood

>test and bone marrow biopsy to be sure. He actually too the bone

>marrow right there and then (and the blood). Now I am waiting.

Hi ,

The definitive diagnosis for CML is the presence of the Philadelphia

chromosome....which is a translocation between chromosomes 9 and 22. You

find this when you do a bone marrow biopsy and do a cytogenetic

analysis.

When you are looking just at blood, maybe with a FISH test, you are

looking

for the BCR-ABL which is a marker for CML........I don't know exactly

what

test was done with your blood? You should get a complete answer from the

bone marrow biopsy. Usually they will look at 20 dividing cells and see

if

any have the 9/22 translocation and if they do, what % have it. Good

luck

with your test.

C.