Guest guest Posted September 26, 2006 Report Share Posted September 26, 2006 At 07:38 AM 9/26/06 -0700, you wrote: >What does that mean? Did i loose my Gleevec option? Should i begin to look >for a donor for the transplantation? I'm really afraid, and waiting for >your answers.. > >Thnx.. > >Yusuf Cipe Hi Yusuf, Often when someone has this kind of change early on (like at 6 months) it may mean that you have a mutation to treat. Here is how it happens.....the Gleevec kills off all the typical cml ph+ cells and then you are left with just the 'abnormal, mutated' cml cells and they are uncontrolled by Gleevec....so the WBC count would then increase. Where are you treated? what you need is a mutation test, which is done mainly at research centers, so they can determine if and what mutation you have. The new drug Sprycel (BMS) will treat most of the mutaitons. There is one mutation (T-315I) that is harder to treat. There scenario might not be what is happening to you......but it needs to be checked out. My best wishes to you. Let us know what your doctor is suggesting. Are you in the US and can you get to one of the cml specialty centers (like OHSU, MDACC or UCLA among others). C. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 26, 2006 Report Share Posted September 26, 2006 Dear Yusuf, You may be loosing your Gleevic but there is new drugs that were approved for the repalsed gleevic patients, disitanib i think is one option. Check with your doc first! regards Jamal --- yusuf ÿffffe7ipe <cipeyusuf@...> wrote: > Hello to all; > > I'm using Gleevec for 6 months. Everything was ok. > My blood counts were normal, my PCR was 0.0068 three > months ago. It was 0.145 when i was diagnosed. > > Today i went to the hospital for the 6th month > tests. Doctor took sample from my bone marrow and > wanted blood test. I've just learned the blood test > results and i'm totaly shocked. > > WBC= 27.7 > PLT=101 > others are normal > > What does that mean? Did i loose my Gleevec > option? Should i begin to look for a donor for the > transplantation? I'm really afraid, and waiting for > your answers.. > > Thnx.. > > Yusuf Cipe > Dx 01/03/06 > 400 mg gleevec > > > > > --------------------------------- > Do you ? > Everyone is raving about the all-new . > > [Non-text portions of this message have been > removed] > > Jamal Hurani e-mail : jamalhurani@... __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2006 Report Share Posted September 28, 2006 At 09:48 AM 9/28/06 -0700, you wrote: >Thanks God, a big mistake from the hospital. My doctor asked me to make a >new test and today i made a new blood test and everything is ok. The >machine counted my blood wrong. Now i'm the happiest man in the world but >very angry to the hospital. Hooray.......and a good reminder for us all not to panic and that mistakes are made in the lab. So, maybe the first recourse for any big changes in test results are to have the test re-done. You might talk to the doctor about whether there is a better place to have the testing done?? Take care and be well, C. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 17, 2006 Report Share Posted November 17, 2006 When Gleevec stops working, oncologists usually switch to Dasatinib made by Bristol-Meyers Squibb [www.bms.com] which I am on right now. It usually works on CML that doesnt respond to gleevec! Xyzzy > > > Hello to all; > > > > I'm using Gleevec for 6 months. Everything was ok. > > My blood counts were normal, my PCR was 0.0068 three > > months ago. It was 0.145 when i was diagnosed. > > > > Today i went to the hospital for the 6th month > > tests. Doctor took sample from my bone marrow and > > wanted blood test. I've just learned the blood test > > results and i'm totaly shocked. > > > > WBC= 27.7 > > PLT=101 > > others are normal > > > > What does that mean? Did i loose my Gleevec > > option? Should i begin to look for a donor for the > > transplantation? I'm really afraid, and waiting for > > your answers.. > > > > Thnx.. > > > > Yusuf Cipe > > Dx 01/03/06 > > 400 mg gleevec > > > > > > > > > > --------------------------------- > > Do you ? > > Everyone is raving about the all-new . > > > > [Non-text portions of this message have been > > removed] > > > > > > > Jamal Hurani > e-mail : jamalhurani@... > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 17, 2006 Report Share Posted November 17, 2006 When Gleevec stops working, oncologists usually switch to Dasatinib made by Bristol-Meyers Squibb [www.bms.com] which I am on right now. It usually works on CML that doesnt respond to gleevec! Xyzzy > > > Hello to all; > > > > I'm using Gleevec for 6 months. Everything was ok. > > My blood counts were normal, my PCR was 0.0068 three > > months ago. It was 0.145 when i was diagnosed. > > > > Today i went to the hospital for the 6th month > > tests. Doctor took sample from my bone marrow and > > wanted blood test. I've just learned the blood test > > results and i'm totaly shocked. > > > > WBC= 27.7 > > PLT=101 > > others are normal > > > > What does that mean? Did i loose my Gleevec > > option? Should i begin to look for a donor for the > > transplantation? I'm really afraid, and waiting for > > your answers.. > > > > Thnx.. > > > > Yusuf Cipe > > Dx 01/03/06 > > 400 mg gleevec > > > > > > > > > > --------------------------------- > > Do you ? > > Everyone is raving about the all-new . > > > > [Non-text portions of this message have been > > removed] > > > > > > > Jamal Hurani > e-mail : jamalhurani@... > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
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