Re: FYI: Article: Gleevec Interferes With Bone Growth

May 11, 2006

At 11:03 PM 5/10/06 -0500, you wrote:

>I thought you might find this of interest. I still get annoyed by

>articles that state that Gleevec has minimal to no side effects -- and

>then you have studies like this one showing that Gleevec is working in

>more ways than thought. Remember when Gleevec first was in development

>(us oldbies here) and some of the " experts " said it was so targeted that

>it had no effect on other organ systems? Years later, they clearly are

>still finding out that is not the case. (Also, note the blurb here about

> " protrusion of the eyes " -- Huh??? For pete's sake; someone got

>confused.)

Hi ,

Thanks for sharing this interesting information.

Maybe we will all eventually look like pugs!

Parents of younger children on Gleevec have mentioned on various lists that

some kids are having slower growth....so maybe this is involved in that.

You might post this infor on Jerry's Childhood CML list. There have also

been a few people who have had odd x-ray changes while on Gleevec???? The

kinase enzyme is very active in the body I think....so these other

involvements are understandable. When I first went on Gleevec, I had a bone

density done (the full dexa scan) because there was some ??question or

concern about calcium and Gleevec I think???? my bones are hard as rocks.

I see Dr. Druker tomorrow and if I have a chance, I will ask him about this.

C.

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