Clinical Trial of BMS-354825

[Guest guest]

Hello all,

I had not posted for some time but am surely reading most of the posts!

I wanted to give you all some updates about my wellbeing and some news.

Having been diagnosed with CML on 1 March 2005 and taken Hydrea for 28

days, thereafter I was prescriped Gleevec 400 which brought my

bloodcount and my health almost back to normal for a while.

When I say for a while I mean I had ended up in Hospital due to high

Fever because my white blood cells took a tumble.

I was advised from my Doctor to stop taking Gleevec alltogether for 2

weeks and when I start again to take one 400 mg every second day.

My Liver were showing signs of poisening, my headaches gotten out of

control and in the end I took Gleevec only ever 3th day.

My Bloodtests did not show any improvement in regards to my Liver

Enzymes, my headache was persistant and my Onc asked me if I wanted to

take part in a trial for the BMS-354825.

Of course my Liver had to recover first and I was taken off Gleevec

all together. I'm off Gleevec since January 8th.

I'm not taking any other medication, stopped my HRT as well to give

the liver a Break and time to recover.

I was made aware that if my liver would not get back to normal I would

not get into the trial.

Today I went again to the MacCallum Cancer Centre in Melbourne,

met my new Doctor Seymour and was accepted for the trial since my

latest Blood test showed further improvement of the liver.

I had another Blood test and a chest xray done today, and will be

having my 3th BMB since dxd, this coming thursday.

If nothing unforseen comes inbetween I will be starting with the trial

on the 28th this month.

I have been informed about the possible side effects and also about

other possibilites if I cannot take the drug.

As for me I will and do not consider a BMT, there are other ways,

always other medications.

After all I do consider myself lucky to live today and not some 20 or

30 years ago.

Well, that's all for this time, I keep on reading your posts, even

though I do not understand all the medical jargon

I wish you all well!

Ursula

Melbourne, Australia

CML dxd 1 March 2005

off Gleevec since 8 January 2006

BMS-354825 Trial pending