Re: Weight Loss and Gleevec

[Guest guest]

Hi ,

What dose of Gleevec are you taking? Have you ever tried splitting

up the dose throughout the day? Say, if you were on 400 mg.. taking

200 at lunch and 200 at dinner.

It's very important that you eat a well balanced meal with Gleevec.

Some people can get away with a light meal, but I always feel crummy

unless I take it with my largest meal of the day. I always drink a

lot of water with it too.

Hope this helps.

Lynn

Dx'd 12/03

PCRU 400 mg.

>

> I am a lurker to this group, I read post and I don't question very

> often but I have a concern. I have been on gleevec since 2002 and

have

> had a wonderful response. Last fish and quantative pcr has been

> negative. The difficutly is that I struggle with nausea, vomiting

and

> and other side effects of gleevec, somedays it is so bad I can

barely

> eat or I have to force myself to eat something. This past year I

have

> dropped 35 + pounds without trying. My Dr. feels that gleevec is

not

> the cause and that other things are causing it. Has anyone else

> expereinced this? I have seen a GI dr and everything is always

normal,

> they have no explanation for any of this.

>

> I don't feel depressed, nor do I think it is psychological. I just

fell

> so ill somedays and it is hard. Any one have any comments or

> suggestions that could help me? I am at a loss and really fustrated

> with the whole bit.

>

> Thanks for listening

>

> in Pa

>

[Guest guest]

hi i dont think it is the gleevec i am 36 and i have been on it for 4

mouths on 800mg aand i am 52and 112pds i did not get any side affect w/it

Lynn & Pete <petenlynn@...> wrote:

Hi ,

What dose of Gleevec are you taking? Have you ever tried splitting

up the dose throughout the day? Say, if you were on 400 mg.. taking

200 at lunch and 200 at dinner.

It's very important that you eat a well balanced meal with Gleevec.

Some people can get away with a light meal, but I always feel crummy

unless I take it with my largest meal of the day. I always drink a

lot of water with it too.

Hope this helps.

Lynn

Dx'd 12/03

PCRU 400 mg.

>

> I am a lurker to this group, I read post and I don't question very

> often but I have a concern. I have been on gleevec since 2002 and

have

> had a wonderful response. Last fish and quantative pcr has been

> negative. The difficutly is that I struggle with nausea, vomiting

and

> and other side effects of gleevec, somedays it is so bad I can

barely

> eat or I have to force myself to eat something. This past year I

have

> dropped 35 + pounds without trying. My Dr. feels that gleevec is

not

> the cause and that other things are causing it. Has anyone else

> expereinced this? I have seen a GI dr and everything is always

normal,

> they have no explanation for any of this.

>

> I don't feel depressed, nor do I think it is psychological. I just

fell

> so ill somedays and it is hard. Any one have any comments or

> suggestions that could help me? I am at a loss and really fustrated

> with the whole bit.

>

> Thanks for listening

>

> in Pa

>

[Guest guest]

I take 400 mg, I never thought of splitting it. Maybe I wll try and do that.

Thaks for the suggestion.

Thanks

Lynn & Pete <petenlynn@...> wrote:

Hi ,

What dose of Gleevec are you taking? Have you ever tried splitting

up the dose throughout the day? Say, if you were on 400 mg.. taking

200 at lunch and 200 at dinner.

It's very important that you eat a well balanced meal with Gleevec.

Some people can get away with a light meal, but I always feel crummy

unless I take it with my largest meal of the day. I always drink a

lot of water with it too.

Hope this helps.

Lynn

Dx'd 12/03

PCRU 400 mg.

>

> I am a lurker to this group, I read post and I don't question very

> often but I have a concern. I have been on gleevec since 2002 and

have

> had a wonderful response. Last fish and quantative pcr has been

> negative. The difficutly is that I struggle with nausea, vomiting

and

> and other side effects of gleevec, somedays it is so bad I can

barely

> eat or I have to force myself to eat something. This past year I

have

> dropped 35 + pounds without trying. My Dr. feels that gleevec is

not

> the cause and that other things are causing it. Has anyone else

> expereinced this? I have seen a GI dr and everything is always

normal,

> they have no explanation for any of this.

>

> I don't feel depressed, nor do I think it is psychological. I just

fell

> so ill somedays and it is hard. Any one have any comments or

> suggestions that could help me? I am at a loss and really fustrated

> with the whole bit.

>

> Thanks for listening

>

> in Pa

>

---------------------------------

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[Guest guest]

At 01:29 PM 9/13/06 +0000, you wrote:

> The difficutly is that I struggle with nausea, vomiting and

>and other side effects of gleevec, somedays it is so bad I can barely

>eat or I have to force myself to eat something. This past year I have

>dropped 35 + pounds without trying. My Dr. feels that gleevec is not

>the cause and that other things are causing it. Has anyone else

>expereinced this? I have seen a GI dr and everything is always normal,

>they have no explanation for any of this.

Hi ,

These are definitely Gleevec side effects for some people, but at the

extreme. You might ask your doctor about switching to Sprycel (approved

now) and see if that is a better drug for you. Some folks who had a lot of

problems on Gleevec are doing much better on Sprycel.

Did the GI doctor do an endoscopy to look at your esophagus, stomach, etc.

to see if Gleevec has caused any damage. I had a lot of acid reflux when I

was on Gleevec but did overcome it (with lots of juicing to offset the acid

in the drug).........now I am on Sprycel and it is much easier to take and

easier on the stomach.

C.

[Guest guest]

I have asked my Dr. about the new drug but she really didn't say much about

it. I do have an appointment for a follow up consult with the Gi Dr. They

are looking at doing a scope sometime soon but I don't when. Hopefully i

will have some answers soon.

Thanks

>From: Cogan <ncogan@...>

>Reply-

>

>Subject: Re: [ ] Weight Loss and Gleevec

>Date: Wed, 13 Sep 2006 13:04:00 -0700

>

>At 01:29 PM 9/13/06 +0000, you wrote:

> > The difficutly is that I struggle with nausea, vomiting and

> >and other side effects of gleevec, somedays it is so bad I can barely

> >eat or I have to force myself to eat something. This past year I have

> >dropped 35 + pounds without trying. My Dr. feels that gleevec is not

> >the cause and that other things are causing it. Has anyone else

> >expereinced this? I have seen a GI dr and everything is always normal,

> >they have no explanation for any of this.

>

>

>Hi ,

>These are definitely Gleevec side effects for some people, but at the

>extreme. You might ask your doctor about switching to Sprycel (approved

>now) and see if that is a better drug for you. Some folks who had a lot of

>problems on Gleevec are doing much better on Sprycel.

>

>Did the GI doctor do an endoscopy to look at your esophagus, stomach, etc.

>to see if Gleevec has caused any damage. I had a lot of acid reflux when I

>was on Gleevec but did overcome it (with lots of juicing to offset the acid

>in the drug).........now I am on Sprycel and it is much easier to take and

>easier on the stomach.

>

> C.

>

>

[Guest guest]

It's funny I have the exact opposite problem! Before being diagnosed last

summer I had dropped 35 pounds in about a month and a half but once I started

taking gleevec the weight came right back no problem, and then some. Trust me,

I needed to keep that 35 pounds off, I'm 5'3 and my last weigh in in I was 176

pounds. I have not reached zero on my FISH yet. I was at 3.4% last November

after being 98% at diagnosis in August 2005. My local onc started messing with

my dose because my white count was always so low. So by February 2006 my white

count looked pretty good but my platelets were getting real high again then my

Mayo doc got concerned scheduled me for another bmb and Fish and my FISH had

showed 28% in March, by the end of May it was 68%. I had gone from 300 mgs of

gleevec a day back to 400 mgs in March then to 600 mgs in May then to 800 mgs in

June. My last FISH showed 3.8%. I have noticed that I have more bouts with

diarreha but definitely no weight loss. I

guess I should just be happy that the gleevec is working for me even though I

seem to still get monthly neulasta shots because I become neutropenic, but what

I wouldn't give to be a size 6 again! My husband and kids say they'd rather

have me fat and alive than the other!

Take care,

Sheila

leukican <leukican@...> wrote:

I am a lurker to this group, I read post and I don't question very

often but I have a concern. I have been on gleevec since 2002 and have

had a wonderful response. Last fish and quantative pcr has been

negative. The difficutly is that I struggle with nausea, vomiting and

and other side effects of gleevec, somedays it is so bad I can barely

eat or I have to force myself to eat something. This past year I have

dropped 35 + pounds without trying. My Dr. feels that gleevec is not

the cause and that other things are causing it. Has anyone else

expereinced this? I have seen a GI dr and everything is always normal,

they have no explanation for any of this.

I don't feel depressed, nor do I think it is psychological. I just fell

so ill somedays and it is hard. Any one have any comments or

suggestions that could help me? I am at a loss and really fustrated

with the whole bit.

Thanks for listening

in Pa

---------------------------------

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[Guest guest]

> I am a lurker to this group, I read post and I don't

question very

> often but I have a concern. I have been on gleevec since 2002 and

have

> had a wonderful response. Last fish and quantative pcr has been

> negative. The difficutly is that I struggle with nausea, vomiting

and

> and other side effects of gleevec, somedays it is so bad I can

barely

> eat or I have to force myself to eat something. This past year I

have

> dropped 35 + pounds without trying. My Dr. feels that gleevec is

not

> the cause and that other things are causing it. Has anyone else

> expereinced this? I have seen a GI dr and everything is always

normal,

> they have no explanation for any of this.

>

> I don't feel depressed, nor do I think it is psychological. I just

fell

> so ill somedays and it is hard. Any one have any comments or

> suggestions that could help me? I am at a loss and really

fustrated

> with the whole bit.

>

> Thanks for listening

>

> in Pa

>

> in Pa

I have been on gleevec since jan. 03 when I was diagnosed. I have

> taken my gleevec in the morning had nausea tried 200 mg in

> the morning and 200 at dinner then I tried taking it at bedtime

> that has worked really well but I have to make sure I drink

6-8oz. of water then I go to sleep and usually no nausea.

in IL

> ---------------------------------

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