FYI: Article: Thwarting CML mutation

[Guest guest]

Hi all,

FYI:

Research News from the Medical Institute

Studies Reveal How New Drug May Overcome Deadly Mutation that Causes

Leukemia

HHMI researchers have discovered how a new generation of drugs thwarts a

deadly mutation that causes chronic myelogenous leukemia.

Using x-ray crystallography, the scientists produced detailed molecular

images that reveal how VX-680, a drug developed by Vertex

Pharmaceuticals and Merck, deftly sidesteps a deadly mutation that

blunts the effectiveness of Gleevec and a second generation drug called

dasatinib.

Research published in the January 15, 2006, issue of Cancer Research.

Kuriyan, Ph.D., HHMI investigator

University of California, Berkeley

L. Sawyers, M.D., HHMI investigator

University of California, Los Angeles

For the full story, go to

<http://www.hhmi.org//news/kuriyan20050115.html>

http://www.hhmi.org//news/kuriyan20050115.html

G.

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