aspirin and nitric oxide

[Guest guest]

" Usual doses of Aspirin increases Nitric Acid Formation in Human's " ,Hennekens,

,Circulation,Nov 09. All doses of aspirin increase nitric oxide.Nitric

oxide is released from the blood vessel wall (arterial)and may decrease the

development and progression of plaques leading to heart attacks and

strokes.Hennekens was the first to demonstrate that aspirin can prevent a first

heart attack or a first stroke.

Dr. Louis Ignarro, a nobel prize winner, has a book " No more Heart Disease "

which talks about preventing a heart attack or stroke by increasing NO levels by

increasing daily l-arginine(4,000-6,000 mg),l-citrullene(400-600mg),taking

Vitamin E (50IU)and vitamin C(500mg),minimizing saturated fat,eating more

fiber,doing aerobic exercise(at least 20 min 3x/week).

Also there is a paper relating attacks on the mitochondrial protein Drp1 by

the free radical nitric oxide -which causes S-nitrosylation-mediates

neurodegeneration associated with Alzheimer's

disease.(Science,2009;324(5923)102-105).Also I have heard about No being related

to C.O.P.D.

It would be nice to know how much we might be increasing NO by taking ASA and

whether it is a good idea to increase NO level further by some of the above ie.

benefit vs risk with respect to Heart and stroke prevention versus Alzheimers or

COPD?