RE: Re: Reananlysis of the Wickham Survey

[Guest guest]

OOPS, and OOPS again indeedy !!!

Luv - Sheila

OOPs

>

> J Clin Endocrinol

> <javascript:AL_get(this,%20'jour',%20'J%20Clin%20Endocrinol%20Metab.');>

> Metab. 2010 Feb 11. [Epub ahead of print]

>

>

> The <http://www.ncbi.nlm.nih.gov/pubmed/20150579>

Incidence of Ischemic

> Heart Disease and Mortality in People with Subclinical Hypothyroidism:

> Reanalysis of the Whickham Survey Cohort.

>

>

> Razvi

> <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Razvi%20S%22%5BAuthor%5D & itool=E

> ntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract> S,

> Weaver

> <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Weaver%20JU%22%5BAuthor%5D & itool

> =EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract>

JU,

> Vanderpump

> <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Vanderpump%20MP%22%5BAuthor%5D & i

> tool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract>

> MP, Pearce

> <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Pearce%20SH%22%5BAuthor%5D & itool

> =EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract>

SH.

>

> Department of Endocrinology (S.R., J.U.W.), Gateshead Health National

Health

> Service Foundation Trust, Gateshead NE9 6SX, United Kingdom; Institute of

> Human Genetics (S.R., J.U.W., S.H.S.P.), Newcastle University, Newcastle

> upon Tyne NE1 7RU, United Kingdom; and Department of Endocrinology

(M.P.V.),

> Royal Free Hospitals National Health Service Trust, London NW3 2PF, United

> Kingdom.

>

> Context: The Whickham Survey evaluated vascular events over 20 yr in

> community-dwelling subjects stratified by thyroid function and thyroid

> autoantibody status. No association between ischemic heart disease (IHD)

and

> a composite autoimmune thyroid disease group, comprising individuals with

> subclinical hypothyroidism (SCH), with positive thyroid antibodies or

those

> using levothyroxine, was found. This result appears to be at odds with the

> findings of other cohort studies. Objective: The objective of the study

was

> to evaluate incident IHD and mortality in participants in relation to their

> thyroid status. Outcomes, Design, and Participants: Data were reanalyzed

> assessing incident IHD events and mortality during 20 yr of follow-up in

> individuals with endogenous SCH (n = 97; TSH 6.0-15 mIU/liter) vs. the

> euthyroid group (n = 2279), who were IHD free at baseline. Results:

Incident

> IHD was significantly higher in the SCH group [adjusted hazard ratio 1.76

> (95% confidence interval 1.15-2.71); P = 0.01]. IHD mortality was also

> increased in the SCH group [hazard ratio of 1.79 (1.02-3.56); P = 0.05].

> These findings lost their significance when subsequent treatment with

> levothyroxine was excluded from the regression model. There was no

> difference in all-cause mortality between the groups. Conclusion: In the

> Whickham Survey, there is an association between incident IHD events and

> IHD-related mortality with SCH over the 20 yr of follow-up. Furthermore,

> subsequent treatment of SCH with levothyroxine appears to attenuate

> IHD-related morbidity and mortality, and this may explain why some other

> longitudinal studies of SCH have not shown such an association; properly

> designed controlled trials of treatment of SCH are required to answer this

> question definitively.

>

> PMID: 20150579 [PubMed - as supplied by publisher]

>

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