Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 In a message dated 10/23/2006 7:00:37 PM Central Daylight Time, marvindamartian05@... writes: Did you treat with Peg-Intron? Looks like that's what I will be on ---the infamous RediPen. Or was it something else? OH wanted to let everyone know that my second shot of intron was much easier..so it was a bad one the first time..when I went to get my tummy scope I asked my gastro about it and he said it should be easy...oh my scope went fine too..some redness by the belly so he uped the little purple pill to two a day and I havent had any heart burn since..thank God..geri Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 cool bunch of us Arkys..we should get together somewhere...if we can drive..LOL..geri Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 Thank You all I am sorry everyone is sick but I feel better knowing I am not alone. Robbie From: Sheena <mom4possums2002@...>Reply-Hepatitis C To: Hepatitis C Subject: Re: Another questionDate: Sun, 22 Oct 2006 09:53:03 -0700 (PDT) My symptoms match yours exactly, Robbie. I have not yet started treatment. I am STILL waiting to see the GI Specialist for the first visit, 8 days to go now.. I will see a Alternative/Holistic MD this coming week for a consultation.. I couldn't even make a Support Group meeting that I badly wanted to attend, but then my youngest daughter backed out last minute and everyone else is way too busy with their own lives.. All we can really do is one day at a time.. Hang In.. Sheena Robbie J <robbiej4hotmail> wrote: I have another question for everyone. I am extremly tired all the time and sick at my stomach and just general malaise most days it is all I can do to get the kids to school go to work and cook dinner. Is this common did anyone else feel badly before treatment? I have read a lot about people being sick during tx but not alot about people being sick before tx. Some times I think I am just a big weenie and if I just buck up I will be alright. Robbie Try the new Live Search today! Get your own web address for just $1.99/1st yr. We'll help. Small Business. Try the new Live Search today! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 I WISH that were true,, no I have ended up with severe left over side effects and it takes 60 mg of morphine and 200 mg of provigil to get me out of bed EVERY DAY! The fatigue is UN-relenting... Im usually only out of bed 3-6 hours per day,,, I always hesitate to tell this but its the truth and I dont want anyone to be discouraged from treating,, because I WOULD do it all over again....I WOULD TX even knowing that I would end up totally disabled from the tx,, because the hep is gone!marvindamartian05 <marvindamartian05@...> wrote: Jackie, so you don't get them anymore, or you just don't notice it as much? > > You are showing the signs of chronic hep c sweetie , nausea > and fatigue are right up there as the most common signs . So your > not being a weenie , your just feeling the icky effects of hep c > > Re: Another question> > > > > > I have another question for everyone. I am extremly > tired all the time and sick at my stomach and just general malaise > most days it is all I can do to get the kids to school go to work > and cook dinner. Is this common did anyone else feel badly before > treatment? I have read a lot about people being sick during tx but > not alot about people being sick before tx. Some times I think I > am just a big weenie and if I just buck up I will be alright. > > Robbie> > > > > > > > > > > > > > ---------------------------------> > All-new - Fire up a more powerful email and get > things done faster.> >> > > > > > > Jackie>Jackie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 I am so sorry to hear that, and it is very scary. Bless your heart for dealing with all of my naive questions (and those who came before me, and the mulittudes who will come after)while you are hurting! Did you treat with Peg-Intron? Looks like that's what I will be on --- the infamous RediPen. Or was it something else? > > > You are showing the signs of chronic hep c sweetie , nausea > > and fatigue are right up there as the most common signs . So your > > not being a weenie , your just feeling the icky effects of hep c > > > Re: Another question > > > > > > > > > I have another question for everyone. I am extremly > > tired all the time and sick at my stomach and just general malaise > > most days it is all I can do to get the kids to school go to work > > and cook dinner. Is this common did anyone else feel badly before > > treatment? I have read a lot about people being sick during tx but > > not alot about people being sick before tx. Some times I think I > > am just a big weenie and if I just buck up I will be alright. > > > Robbie > > > > > > > > > > > > > > > > > > > > > --------------------------------- > > > All-new - Fire up a more powerful email and get > > things done faster. > > > > > > > > > > > > > > > > > Jackie > > > > > > > > > Jackie > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 I do still have these spells, short lived. I'm a homebody and I often just lie on the couch for 15 minutes and feel better. If you're out and about, I guess all you can do is what you do, just breathe and let it pass. I can only get one good day of housework, most of the time and then I'm tired the next. I was running around with mega energy for a few months, but that seems to have passed. I think of it as a cycle, and I believe my energy runs in cycles. Now, I work in short spurts to get the yard and house work done and don't mind having a nap. I'm thankful I don't go to work anymore. The last few years were very hard to keep going. Sharonmarvindamartian05 <marvindamartian05@...> wrote: Is it normal to get spells of fatigue so bad that you feel like you're gonna die? I have them sometimes, and then it turns into a panic attack. Of course, after the "heart attack scare" of last week, I know what is really happening so I sit down and breathe. Seems to help, and then the "spell" is over. Just had it at the mall and I feel badly because my kids get worried!...susan> You are showing the signs of chronic hep c sweetie , nausea and fatigue are right up there as the most common signs . So your not being a weenie , your just feeling the icky effects of hep c > Re: Another question> > > I have another question for everyone. I am extremly tired all the time and sick at my stomach and just general malaise most days it is all I can do to get the kids to school go to work and cook dinner. Is this common did anyone else feel badly before treatment? I have read a lot about people being sick during tx but not alot about people being sick before tx. Some times I think I am just a big weenie and if I just buck up I will be alright. > Robbie> > > Talk is cheap. Use Messenger to make PC-to-Phone calls. Great rates starting at 1¢/min. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 I am lucky I have a desk job. I don't envy those who have to do physical work with this disease and/or tx! > > You are showing the signs of chronic hep c sweetie , nausea > and fatigue are right up there as the most common signs . So your > not being a weenie , your just feeling the icky effects of hep c > > Re: Another question > > > > > > I have another question for everyone. I am extremly > tired all the time and sick at my stomach and just general malaise > most days it is all I can do to get the kids to school go to work > and cook dinner. Is this common did anyone else feel badly before > treatment? I have read a lot about people being sick during tx but > not alot about people being sick before tx. Some times I think I > am just a big weenie and if I just buck up I will be alright. > > Robbie > > > > > > > > > --------------------------------- > Talk is cheap. Use Messenger to make PC-to-Phone calls. Great rates starting at 1¢/min. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 Robbie I am in Roxane (with one "n")Misery is OptionalHello ID -- nanaroxane 479-366-7017http://search.ebay.com/_W0QQfgtpZ1QQfrppZ25QQsassZroxanemccartney roxanemccartney@...rmmccartney@...srmccartney@...roxanemccartney@... Re: Re: Another question Geri, I am in NW Arkansas where are you? Robbie From: us4heavenbound@...Reply-Hepatitis C To: Hepatitis C Subject: Re: Re: Another questionDate: Sun, 22 Oct 2006 19:31:42 EDT In a message dated 10/22/2006 2:05:21 PM Central Daylight Time, marvindamartian05 writes: Saddleback church, my husband just went to the seminar there for Celebrate Recovery..they are starting a group at his church in Oregon..I am going to start going here in Arkansas in about 3 weeks..my sons football games are on Friday nights..geri Add a contact to Windows Live Messenger for a chance to win a free trip! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 SEVERE body aches, severe joint pains, and fatigue that wont quit.. IBS, vision problems that are caused by sarcoidosis from INF treatment, sleep problems, and sometimes without the provigil, I cannot wake upus4heavenbound@... wrote: In a message dated 10/23/2006 6:42:38 PM Central Daylight Time, redjaxjm writes: I WISH that were true,, no I have ended up with severe left over side effects and it takes 60 mg of morphine and 200 mg of provigil to get me out of bed EVERY DAY! what kinda sx do you have now..geri Jackie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 I treated with Scherring Peg Intron,, no redipen, I had to draw up the saline and mix it myself, then draw it up and inject it myself.. it was ok,, I think I liked it better because I liked to push the meds real s l o w l y so it didnt sting... I did a full 48 shots of Peg Intron and then did 6 shots of Pegasys.. in my attemtpt to do a full 60 weeks.... No problem hon,, you ask ANY question you want and I will try to answer it and if I dont know,, I can always ask Liz or Janet,, lol,, Im glad you are here!marvindamartian05 <marvindamartian05@...> wrote: I am so sorry to hear that, and it is very scary. Bless your heart for dealing with all of my naive questions (and those who came before me, and the mulittudes who will come after)while you are hurting!Did you treat with Peg-Intron? Looks like that's what I will be on ---the infamous RediPen. Or was it something else?> > > You are showing the signs of chronic hep c sweetie , nausea > > and fatigue are right up there as the most common signs . So your > > not being a weenie , your just feeling the icky effects of hep c > > > Re: Another question> > > > > > > > > I have another question for everyone. I am extremly > > tired all the time and sick at my stomach and just general malaise > > most days it is all I can do to get the kids to school go to work > > and cook dinner. Is this common did anyone else feel badly before > > treatment? I have read a lot about people being sick during tx but > > not alot about people being sick before tx. Some times I think I > > am just a big weenie and if I just buck up I will be alright. > > > Robbie> > > > > > > > > > > > > > > > > > > > > ---------------------------------> > > All-new - Fire up a more powerful email and get > > things done faster.> > >> > > > > > > > > > > > > > Jackie> >> > > > > > > Jackie>Jackie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 Sounds very complicated, like something I could easily screw up. I'm thinking Geri's RediPen sounds like more fun. :)lol Seriously, whatever I have to do, I will do! > > > > You are showing the signs of chronic hep c sweetie , nausea > > > and fatigue are right up there as the most common signs . So your > > > not being a weenie , your just feeling the icky effects of hep c > > > > Re: Another question > > > > > > > > > > > > I have another question for everyone. I am extremly > > > tired all the time and sick at my stomach and just general > malaise > > > most days it is all I can do to get the kids to school go to work > > > and cook dinner. Is this common did anyone else feel badly before > > > treatment? I have read a lot about people being sick during tx > but > > > not alot about people being sick before tx. Some times I think I > > > am just a big weenie and if I just buck up I will be alright. > > > > Robbie > > > > > > > > > > > > > > > > > > > > > > > > > > > > --------------------------------- > > > > All-new - Fire up a more powerful email and get > > > things done faster. > > > > > > > > > > > > > > > > > > > > > > > > > Jackie > > > > > > > > > > > > > > > > > Jackie > > > > > > > > > Jackie > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 24, 2006 Report Share Posted October 24, 2006 I used to live in Tulsa,Okla a mere hour and half drive to Fayettvile. Now I live in Altus, Okla. A lot further. If you Arky's get together let me know, I might go and visit too. Love Janetus4heavenbound@... wrote: In a message dated 10/23/2006 6:15:12 PM Central Daylight Time, robbiej4hotmail writes: Geri, I am in NW Arkansas where are you? Robbie Cool..I am in Beebe...about 40 miles N of LR...are you in Fayettville..go hogs! geri Take the ordinary things of life, and make them your own. Do the impossible with a smile Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 24, 2006 Report Share Posted October 24, 2006 Well when I treated they did not have the redipen,, but it was easy, you just drew up the fluid from the bottle, squirt it into the other bottle that has the dry poweder it in, and roll it gently until it mixed, got a new needle , drew it up and then just injected it.. Im coming up on my 4 year anniversary in Feb,, and Im hoping that Im still clear, but if not, Ill do tx again...I responded once, I would again... You are gonna do just fine hon!!marvindamartian05 <marvindamartian05@...> wrote: Sounds very complicated, like something I could easily screw up. I'm thinking Geri's RediPen sounds like more fun. :)lolSeriously, whatever I have to do, I will do!> > > > You are showing the signs of chronic hep c sweetie , nausea > > > and fatigue are right up there as the most common signs . So your > > > not being a weenie , your just feeling the icky effects of hep c > > > > ----- Original Message ----- > > > > From: Robbie J > > > > Hepatitis C > > > > Sent: Sunday, October 22, 2006 8:38 AM> > > > Subject: Re: Another question> > > > > > > > > > > > I have another question for everyone. I am extremly > > > tired all the time and sick at my stomach and just general > malaise > > > most days it is all I can do to get the kids to school go to work > > > and cook dinner. Is this common did anyone else feel badly before > > > treatment? I have read a lot about people being sick during tx > but > > > not alot about people being sick before tx. Some times I think I > > > am just a big weenie and if I just buck up I will be alright. > > > > Robbie> > > > > > > > > > > > > > > > > > > > > > > > > > > > ---------------------------------> > > > All-new - Fire up a more powerful email and get > > > things done faster.> > > >> > > > > > > > > > > > > > > > > > > > > Jackie> > >> > > > > > > > > > > > > > Jackie> >> > > > > > > Jackie>Jackie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 24, 2006 Report Share Posted October 24, 2006 Thanks for the vote of confidence, and I WILL do whatever I have to do. I had a bad day today - all of the vaccinations caught up with me and I felt flu-ish - but I had a long phone conversation with a former co-worker who has Parkinsons. I never even knew...she told me after I confided about my hep c. She had been sober for 10 years and then she was diagnosed with Parkinson's at 35 years of age. She takes about 50 pills a day, most of them are to treat the sides of the actual Parkinsons meds! So she could relate to the chronic illness mental state...I told her about this group and she said that it's a great thing to plug into, because no one REALLY understands what you're going through unless they have been there. Jax, I am curious, what is (was) your genotype? ... > > > > > You are showing the signs of chronic hep c sweetie , nausea > > > > and fatigue are right up there as the most common signs . So > your > > > > not being a weenie , your just feeling the icky effects of hep > c > > > > > Re: Another question > > > > > > > > > > > > > > > I have another question for everyone. I am extremly > > > > tired all the time and sick at my stomach and just general > > malaise > > > > most days it is all I can do to get the kids to school go to > work > > > > and cook dinner. Is this common did anyone else feel badly > before > > > > treatment? I have read a lot about people being sick during tx > > but > > > > not alot about people being sick before tx. Some times I think > I > > > > am just a big weenie and if I just buck up I will be alright. > > > > > Robbie > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > --------------------------------- > > > > > All-new - Fire up a more powerful email and get > > > > things done faster. > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Jackie > > > > > > > > > > > > > > > > > > > > > > > > > Jackie > > > > > > > > > > > > > > > > > Jackie > > > > > > > > > Jackie > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2006 Report Share Posted October 25, 2006 You are welcome hon,,, and I know that with the great attitude you have, you will do just fine,, Personally and its only my opinion,, attitude is almost 90 % of anything,, lol,, I was unfortunate enough to have geno 1a.. it was so funny because I had read about genotypes and was sooooo afraid I was gonna be 1 B,,, and was so relieved when I saw that I was A,, my doc just smiled and said,," ya know what Jackie,, geno 1 is geno 1".. and then he told me we were gonna beat it,,, and he was right! why do you ask? What geno are you? Im sure you told me but I have a serious memory problem and I will probably ask you that many more times,, lol,,marvindamartian05 <marvindamartian05@...> wrote: Thanks for the vote of confidence, and I WILL do whatever I have to do. I had a bad day today - all of the vaccinations caught up with me and I felt flu-ish - but I had a long phone conversation with a former co-worker who has Parkinsons. I never even knew...she told me after I confided about my hep c. She had been sober for 10 years and then she was diagnosed with Parkinson's at 35 years of age. She takes about 50 pills a day, most of them are to treat the sides of the actual Parkinsons meds! So she could relate to the chronic illness mental state...I told her about this group and she said that it's a great thing to plug into, because no one REALLY understands what you're going through unless they have been there.Jax, I am curious, what is (was) your genotype? ...> > > > > You are showing the signs of chronic hep c sweetie , nausea > > > > and fatigue are right up there as the most common signs . So > your > > > > not being a weenie , your just feeling the icky effects of hep > c > > > > > Re: Another question> > > > > > > > > > > > > > > I have another question for everyone. I am extremly > > > > tired all the time and sick at my stomach and just general > > malaise > > > > most days it is all I can do to get the kids to school go to > work > > > > and cook dinner. Is this common did anyone else feel badly > before > > > > treatment? I have read a lot about people being sick during tx > > but > > > > not alot about people being sick before tx. Some times I think > I > > > > am just a big weenie and if I just buck up I will be alright. > > > > > Robbie> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > ---------------------------------> > > > > All-new - Fire up a more powerful email and get > > > > things done faster.> > > > >> > > > > > > > > > > > > > > > > > > > > > > > > > > > Jackie> > > >> > > > > > > > > > > > > > > > > > > > > Jackie> > >> > > > > > > > > > > > > > Jackie> >> > > > > > > Jackie>Jackie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2006 Report Share Posted October 25, 2006 Thanks, Jax. I am the dreaded 1b, and I am trying to find out how many 1b's in the group have cleared so I can keep them in front of my mind instead of all of the information that I only have a 50% chance of clearing after a year of treatment! -- In Hepatitis C , Jackie on <redjaxjm@...> wrote: > > You are welcome hon,,, and I know that with the great attitude you have, you will do just fine,, Personally and its only my opinion,, attitude is almost 90 % of anything,, lol,, > I was unfortunate enough to have geno 1a.. it was so funny because I had read about genotypes and was sooooo afraid I was gonna be 1 B,,, and was so relieved when I saw that I was A,, my doc just smiled and said,, " ya know what Jackie,, geno 1 is geno 1 " .. and then he told me we were gonna beat it,,, and he was right! > why do you ask? What geno are you? Im sure you told me but I have a serious memory problem and I will probably ask you that many more times,, lol,, > > marvindamartian05 <marvindamartian05@...> wrote: > Thanks for the vote of confidence, and I WILL do whatever I have to > do. I had a bad day today - all of the vaccinations caught up with me > and I felt flu-ish - but I had a long phone conversation with a > former co-worker who has Parkinsons. I never even knew...she told me > after I confided about my hep c. She had been sober for 10 years and > then she was diagnosed with Parkinson's at 35 years of age. She takes > about 50 pills a day, most of them are to treat the sides of the > actual Parkinsons meds! So she could relate to the chronic illness > mental state...I told her about this group and she said that it's a > great thing to plug into, because no one REALLY understands what > you're going through unless they have been there. > > Jax, I am curious, what is (was) your genotype? ... > > > > > > > > You are showing the signs of chronic hep c sweetie , nausea > > > > > and fatigue are right up there as the most common signs . So > > your > > > > > not being a weenie , your just feeling the icky effects of > hep > > c > > > > > > Re: Another question > > > > > > > > > > > > > > > > > > I have another question for everyone. I am extremly > > > > > tired all the time and sick at my stomach and just general > > > malaise > > > > > most days it is all I can do to get the kids to school go to > > work > > > > > and cook dinner. Is this common did anyone else feel badly > > before > > > > > treatment? I have read a lot about people being sick during > tx > > > but > > > > > not alot about people being sick before tx. Some times I > think > > I > > > > > am just a big weenie and if I just buck up I will be alright. > > > > > > Robbie > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > --------------------------------- > > > > > > All-new - Fire up a more powerful email and get > > > > > things done faster. > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Jackie > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Jackie > > > > > > > > > > > > > > > > > > > > > > > > > Jackie > > > > > > > > > > > > > > > > > Jackie > > > > > > > > > Jackie > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2006 Report Share Posted October 25, 2006 hon,, all geno 1's only have a 50% chance,, but ,,, YOU CAN DO IT!!! I know its frustrating,, but you have to believe!!!marvindamartian05 <marvindamartian05@...> wrote: Thanks, Jax. I am the dreaded 1b, and I am trying to find out how many 1b's in the group have cleared so I can keep them in front of my mind instead of all of the information that I only have a 50% chance of clearing after a year of treatment!-- In Hepatitis C , Jackie on <redjaxjm@...> wrote:>> You are welcome hon,,, and I know that with the great attitude you have, you will do just fine,, Personally and its only my opinion,, attitude is almost 90 % of anything,, lol,,> I was unfortunate enough to have geno 1a.. it was so funny because I had read about genotypes and was sooooo afraid I was gonna be 1 B,,, and was so relieved when I saw that I was A,, my doc just smiled and said,," ya know what Jackie,, geno 1 is geno 1".. and then he told me we were gonna beat it,,, and he was right!> why do you ask? What geno are you? Im sure you told me but I have a serious memory problem and I will probably ask you that many more times,, lol,,> > marvindamartian05 <marvindamartian05@...> wrote:> Thanks for the vote of confidence, and I WILL do whatever I have to > do. I had a bad day today - all of the vaccinations caught up with me > and I felt flu-ish - but I had a long phone conversation with a > former co-worker who has Parkinsons. I never even knew...she told me > after I confided about my hep c. She had been sober for 10 years and > then she was diagnosed with Parkinson's at 35 years of age. She takes > about 50 pills a day, most of them are to treat the sides of the > actual Parkinsons meds! So she could relate to the chronic illness > mental state...I told her about this group and she said that it's a > great thing to plug into, because no one REALLY understands what > you're going through unless they have been there.> > Jax, I am curious, what is (was) your genotype? ...> > > > > > > > You are showing the signs of chronic hep c sweetie , nausea > > > > > and fatigue are right up there as the most common signs . So > > your > > > > > not being a weenie , your just feeling the icky effects of > hep > > c > > > > > > Re: Another question> > > > > > > > > > > > > > > > > > I have another question for everyone. I am extremly > > > > > tired all the time and sick at my stomach and just general > > > malaise > > > > > most days it is all I can do to get the kids to school go to > > work > > > > > and cook dinner. Is this common did anyone else feel badly > > before > > > > > treatment? I have read a lot about people being sick during > tx > > > but > > > > > not alot about people being sick before tx. Some times I > think > > I > > > > > am just a big weenie and if I just buck up I will be alright. > > > > > > Robbie> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > ---------------------------------> > > > > > All-new - Fire up a more powerful email and get > > > > > things done faster.> > > > > >> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Jackie> > > > >> > > > > > > > > > > > > > > > > > > > > > > > > > > > Jackie> > > >> > > > > > > > > > > > > > > > > > > > > Jackie> > >> > > > > > > > > > > > > > Jackie> >> > > > > > > Jackie>Jackie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2006 Report Share Posted October 25, 2006 Wow all these locals I am in Springdale just north of Fayetteville. From: us4heavenbound@...Reply-Hepatitis C To: Hepatitis C Subject: Re: Re: Another questionDate: Mon, 23 Oct 2006 22:11:27 EDT In a message dated 10/23/2006 6:15:12 PM Central Daylight Time, robbiej4hotmail writes: Geri, I am in NW Arkansas where are you? Robbie Cool..I am in Beebe...about 40 miles N of LR...are you in Fayettville..go hogs! geri Try Search Survival Kits: Fix up your home and better handle your cash with Live Search! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 Oh, Robbie, you are lucky, you get to quit in June! But, of course you will be one of the tx buddies! We can commiserate for at least 6 months! Can I join the tx buddies I think I will start in January as well I want to get past the holidays before starting. I am only on 6 months of treatment. Robbie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 9, 2006 Report Share Posted November 9, 2006 I have a question, too, one that I've never really had answered, or else I didn't understand. As of right now, which drug company has had the better results with obtaining remission in Genotype "1"s, Schering-Plough or Roche? I am still struggling along here.. right along, I'm sure with a few others... Thanks in Advance, Sheena <marvindamartian05@...> wrote: hat does SAE stand for? -- In Hepatitis C , "elizabethnv1"<elizabethnv1@...> wrote:>> PegIntron/RBV Effective for >65 Year Olds> > Reported by Jules Levin> AASLD, Oct 27-31, 2006, Boston, MA> > “Pegylated Interferon alfa-2b + Ribavirin Is Equally Efficacious > and Well Tolerated in Patients >65 Years Old in Comparison to Other > Age Groups: Subanalysis of a Randomized, Controlled Study (WIN-R > Trial)â€> > S. L. Flamm,1 I. M. son,2 R. S. Brown,3 B. Freilich,4 N. > Afdhal,5 P. Kwo,6 J. Santoro,7 S. Becker,8 A. Wakil,9 D. Pound,10 J. > Harvey,11 L. H. Griffel,11 C. A. Brass11> 1Northwestern University, Chicago, Illinois; 2Weill Medical College > of Cornell University, New York, New York; 3Columbia University > College of Medicine, New York, New York; 4Baptist Medical Center, > Kansas City, Missouri;> 5Beth Israel Deaconness Medical Center, Boston, Massachusetts; > 6Indiana University School of Medicine, Indianapolis, Indiana; > 7Atlantic Gastroenterology, Egg Harbor Township, New Jersey; 8Austin > Gastroenterology, PA, Austin, Texas;> 9California Pacific Medical Center, San Francisco, California; > 10Indianapolis Gastroenterology, RSCH, Indianapolis, Indiana; > 11Schering-Plough Research Institute, Kenilworth, New Jersey> > AUTHOR CONCLUSIONS> Patients 18 to 25 years of age had the highest SVR rate (57%) among > the 6 age groups.> > The SVR rate in patients older than 65 years (46%) was similar to the > SVR rates observed in younger age groups (41%-57%).> > Although elderly patients tended to experience more AEs, the rate of > SAEs was similar in all groups, and the incidence of treatment > discontinuation in elderly patients was similar to or less than that > of younger patients.> > Data from this subanalysis of the WIN-R trial strongly suggest that > patients should not be denied antiviral therapy based on age alone.> > > Abstract*> Background: Peg interferon (IFN) + ribavirin are the standard of care > for chronic HCV. There is reluctance to administer anti-viral > medications to older populations due to a fear of side effects and > possible decreased efficacy. Limited data is available on pts. age > >65 due to ineligibility for clinical trials. The role of age in > determining response to IFN-based antiviral therapy for chronic HCV > has not been clearly defined.> > Aim: To determine if age is an independent predictor of sustained > virological response (SVR) or medication tolerability within a > randomized, controlled clinical trial of treatment-naive pts. with > HCV. Patient age grps studied: 18-25 yrs., n=69; 26-35 yrs., n=350; > 36-45 yrs., n=1866; 46-55 yrs., n=2200; 56-65 yrs., n=368; and >65 > yrs., n=55.> > Methods: A retrospective review of the multi-center WIN-R trial > database was undertaken. Pts. were randomized to receive PEG IFN 2b > (1.5 g/kg/wk) + either ribavirin 800 mg/d or ribavirin 800mg-1400 > mg/d based on body wt. Pts. with HCV GT1/4 received 48 wks of therapy > while pts with HCV GT 2/3 were randomized to 24 or 48 wks of therapy. > 4913 pts. received at least 1 dose of medication and are included in > this analysis. Although pts. age >65 yrs. were ineligible, 55 such > pts. Were enrolled as protocol exceptions. Logistic regression > analyses of SVR comparing two age categories were performed. The > potential influence of demographic variables on SVR was evaluated > using the chi square test (two-way frequency table).> > Results: > The overall SVR was 44%. > > SVR rates for the grps were: > 18-25 yrs. = 57%, > 26-35 yrs. = 41% (p=0.02 vs 18-25),> 36-45 yrs. = 44% (p=0.03 vs 18-25), > 46-55 yrs. = 42%, > 56-65 yrs. = 40% (p=0.01 vs 18-25) and for > >65 yrs. SVR = 45%.> > There was no difference in SVR in any other pt. age grps including > pts. age >65 yrs. > > There were no differences in SAEs between all age groups. Pts. age 26-> 35 yrs., 36-45 yrs. and 46-55 yrs. had fewer AEs than those in the 56-> 65 yrs. and the >65 yrs. age groups. > > Treatment discontinuations were significantly higher among the 26-35 > yrs. group when compared to two groups but there was no difference in > the treatment discontinuations in the >65 yrs. group compared with > any other.> > Conclusions: > 1) Adults age 18-25 yrs. had significantly increased chances of > obtaining SVR than most other age groups.> 2) Pts. >65 had similar SVR to all other age groups. > 3) Although there were more AEs in the older age groups, the rate of > SAEs was the same and treatment drop-outs were the same or less than > the younger age groups. > 4) Pts. should not be denied anti-viral therapy based upon age alone.> > *Poster presents data updated since abstract submission.> > > The Weight-Based Dosing of Peginterferon alfa-2b and Ribavirin (WIN-> R) study was a prospective, multicenter, community and academic-> based, open-label, investigator-initiated, US clinical trial that > evaluated the efficacy and safety of PEG-IFN alfa-2b plus flat-dose > or weight-based ribavirin in treatment-naive patients with chronic > hepatitis C.> - Overall SVR rates were 44% in the weight-based ribavirin arm and > 41% in the flat-dose ribavirin arm (P = .020).3> - SVR rates in patients with chronic hepatitis C caused by hepatitis > C virus (HCV) genotype 1 (G1) were 34% and 29%, respectively (P > =.004).3> - Weight-based ribavirin dosing was associated with higher rates of > dose reduction for anemia but not with higher rates of > discontinuation.3> Everyone is raving about the all-new beta. 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Guest guest Posted November 9, 2006 Report Share Posted November 9, 2006 To be honest the stats are pretty much the same when it comes to peg or pegasys , but if you used something like Infergen it has higher success rates . Re: Re: Another Question I have a question, too, one that I've never really had answered, or else I didn't understand. As of right now, which drug company has had the better results with obtaining remission in Genotype "1"s, Schering-Plough or Roche? I am still struggling along here.. right along, I'm sure with a few others... Thanks in Advance, Sheena <marvindamartian05 > wrote: hat does SAE stand for? -- In Hepatitis C , "elizabethnv1"<elizabethnv1@...> wrote:>> PegIntron/RBV Effective for >65 Year Olds> > Reported by Jules Levin> AASLD, Oct 27-31, 2006, Boston, MA> > “Pegylated Interferon alfa-2b + Ribavirin Is Equally Efficacious > and Well Tolerated in Patients >65 Years Old in Comparison to Other > Age Groups: Subanalysis of a Randomized, Controlled Study (WIN-R > Trial)â€> > S. L. Flamm,1 I. M. son,2 R. S. Brown,3 B. Freilich,4 N. > Afdhal,5 P. Kwo,6 J. Santoro,7 S. Becker,8 A. Wakil,9 D. Pound,10 J. > Harvey,11 L. H. Griffel,11 C. A. Brass11> 1Northwestern University, Chicago, Illinois; 2Weill Medical College > of Cornell University, New York, New York; 3Columbia University > College of Medicine, New York, New York; 4Baptist Medical Center, > Kansas City, Missouri;> 5Beth Israel Deaconness Medical Center, Boston, Massachusetts; > 6Indiana University School of Medicine, Indianapolis, Indiana; > 7Atlantic Gastroenterology, Egg Harbor Township, New Jersey; 8Austin > Gastroenterology, PA, Austin, Texas;> 9California Pacific Medical Center, San Francisco, California; > 10Indianapolis Gastroenterology, RSCH, Indianapolis, Indiana; > 11Schering-Plough Research Institute, Kenilworth, New Jersey> > AUTHOR CONCLUSIONS> Patients 18 to 25 years of age had the highest SVR rate (57%) among > the 6 age groups.> > The SVR rate in patients older than 65 years (46%) was similar to the > SVR rates observed in younger age groups (41%-57%).> > Although elderly patients tended to experience more AEs, the rate of > SAEs was similar in all groups, and the incidence of treatment > discontinuation in elderly patients was similar to or less than that > of younger patients.> > Data from this subanalysis of the WIN-R trial strongly suggest that > patients should not be denied antiviral therapy based on age alone.> > > Abstract*> Background: Peg interferon (IFN) + ribavirin are the standard of care > for chronic HCV. There is reluctance to administer anti-viral > medications to older populations due to a fear of side effects and > possible decreased efficacy. Limited data is available on pts. age > >65 due to ineligibility for clinical trials. The role of age in > determining response to IFN-based antiviral therapy for chronic HCV > has not been clearly defined.> > Aim: To determine if age is an independent predictor of sustained > virological response (SVR) or medication tolerability within a > randomized, controlled clinical trial of treatment-naive pts. with > HCV. Patient age grps studied: 18-25 yrs., n=69; 26-35 yrs., n=350; > 36-45 yrs., n=1866; 46-55 yrs., n=2200; 56-65 yrs., n=368; and >65 > yrs., n=55.> > Methods: A retrospective review of the multi-center WIN-R trial > database was undertaken. Pts. were randomized to receive PEG IFN 2b > (1.5 g/kg/wk) + either ribavirin 800 mg/d or ribavirin 800mg-1400 > mg/d based on body wt. Pts. with HCV GT1/4 received 48 wks of therapy > while pts with HCV GT 2/3 were randomized to 24 or 48 wks of therapy. > 4913 pts. received at least 1 dose of medication and are included in > this analysis. Although pts. age >65 yrs. were ineligible, 55 such > pts. Were enrolled as protocol exceptions. Logistic regression > analyses of SVR comparing two age categories were performed. The > potential influence of demographic variables on SVR was evaluated > using the chi square test (two-way frequency table).> > Results: > The overall SVR was 44%. > > SVR rates for the grps were: > 18-25 yrs. = 57%, > 26-35 yrs. = 41% (p=0.02 vs 18-25),> 36-45 yrs. = 44% (p=0.03 vs 18-25), > 46-55 yrs. = 42%, > 56-65 yrs. = 40% (p=0.01 vs 18-25) and for > >65 yrs. SVR = 45%.> > There was no difference in SVR in any other pt. age grps including > pts. age >65 yrs. > > There were no differences in SAEs between all age groups. Pts. age 26-> 35 yrs., 36-45 yrs. and 46-55 yrs. had fewer AEs than those in the 56-> 65 yrs. and the >65 yrs. age groups. > > Treatment discontinuations were significantly higher among the 26-35 > yrs. group when compared to two groups but there was no difference in > the treatment discontinuations in the >65 yrs. group compared with > any other.> > Conclusions: > 1) Adults age 18-25 yrs. had significantly increased chances of > obtaining SVR than most other age groups.> 2) Pts. >65 had similar SVR to all other age groups. > 3) Although there were more AEs in the older age groups, the rate of > SAEs was the same and treatment drop-outs were the same or less than > the younger age groups. > 4) Pts. should not be denied anti-viral therapy based upon age alone.> > *Poster presents data updated since abstract submission.> > > The Weight-Based Dosing of Peginterferon alfa-2b and Ribavirin (WIN-> R) study was a prospective, multicenter, community and academic-> based, open-label, investigator-initiated, US clinical trial that > evaluated the efficacy and safety of PEG-IFN alfa-2b plus flat-dose > or weight-based ribavirin in treatment-naive patients with chronic > hepatitis C.> - Overall SVR rates were 44% in the weight-based ribavirin arm and > 41% in the flat-dose ribavirin arm (P = .020).3> - SVR rates in patients with chronic hepatitis C caused by hepatitis > C virus (HCV) genotype 1 (G1) were 34% and 29%, respectively (P > =.004).3> - Weight-based ribavirin dosing was associated with higher rates of > dose reduction for anemia but not with higher rates of > discontinuation.3> Everyone is raving about the all-new beta. 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Guest guest Posted November 9, 2006 Report Share Posted November 9, 2006 Who makes Infergen? > > > > PegIntron/RBV Effective for >65 Year Olds > > > > Reported by Jules Levin > > AASLD, Oct 27-31, 2006, Boston, MA > > > > â?oPegylated Interferon alfa-2b + Ribavirin Is Equally Efficacious > > and Well Tolerated in Patients >65 Years Old in Comparison to Other > > Age Groups: Subanalysis of a Randomized, Controlled Study (WIN-R > > Trial)â? > > > > S. L. Flamm,1 I. M. son,2 R. S. Brown,3 B. Freilich,4 N. > > Afdhal,5 P. Kwo,6 J. Santoro,7 S. Becker,8 A. Wakil,9 D. Pound,10 J. > > Harvey,11 L. H. Griffel,11 C. A. Brass11 > > 1Northwestern University, Chicago, Illinois; 2Weill Medical College > > of Cornell University, New York, New York; 3Columbia University > > College of Medicine, New York, New York; 4Baptist Medical Center, > > Kansas City, Missouri; > > 5Beth Israel Deaconness Medical Center, Boston, Massachusetts; > > 6Indiana University School of Medicine, Indianapolis, Indiana; > > 7Atlantic Gastroenterology, Egg Harbor Township, New Jersey; 8Austin > > Gastroenterology, PA, Austin, Texas; > > 9California Pacific Medical Center, San Francisco, California; > > 10Indianapolis Gastroenterology, RSCH, Indianapolis, Indiana; > > 11Schering-Plough Research Institute, Kenilworth, New Jersey > > > > AUTHOR CONCLUSIONS > > Patients 18 to 25 years of age had the highest SVR rate (57%) among > > the 6 age groups. > > > > The SVR rate in patients older than 65 years (46%) was similar to the > > SVR rates observed in younger age groups (41%-57%). > > > > Although elderly patients tended to experience more AEs, the rate of > > SAEs was similar in all groups, and the incidence of treatment > > discontinuation in elderly patients was similar to or less than that > > of younger patients. > > > > Data from this subanalysis of the WIN-R trial strongly suggest that > > patients should not be denied antiviral therapy based on age alone. > > > > > > Abstract* > > Background: Peg interferon (IFN) + ribavirin are the standard of care > > for chronic HCV. There is reluctance to administer anti-viral > > medications to older populations due to a fear of side effects and > > possible decreased efficacy. Limited data is available on pts. age > > >65 due to ineligibility for clinical trials. The role of age in > > determining response to IFN-based antiviral therapy for chronic HCV > > has not been clearly defined. > > > > Aim: To determine if age is an independent predictor of sustained > > virological response (SVR) or medication tolerability within a > > randomized, controlled clinical trial of treatment-naive pts. with > > HCV. Patient age grps studied: 18-25 yrs., n=69; 26-35 yrs., n=350; > > 36-45 yrs., n=1866; 46-55 yrs., n=2200; 56-65 yrs., n=368; and >65 > > yrs., n=55. > > > > Methods: A retrospective review of the multi-center WIN-R trial > > database was undertaken. Pts. were randomized to receive PEG IFN 2b > > (1.5 g/kg/wk) + either ribavirin 800 mg/d or ribavirin 800mg- 1400 > > mg/d based on body wt. Pts. with HCV GT1/4 received 48 wks of therapy > > while pts with HCV GT 2/3 were randomized to 24 or 48 wks of therapy. > > 4913 pts. received at least 1 dose of medication and are included in > > this analysis. Although pts. age >65 yrs. were ineligible, 55 such > > pts. Were enrolled as protocol exceptions. Logistic regression > > analyses of SVR comparing two age categories were performed. The > > potential influence of demographic variables on SVR was evaluated > > using the chi square test (two-way frequency table). > > > > Results: > > The overall SVR was 44%. > > > > SVR rates for the grps were: > > 18-25 yrs. = 57%, > > 26-35 yrs. = 41% (p=0.02 vs 18-25), > > 36-45 yrs. = 44% (p=0.03 vs 18-25), > > 46-55 yrs. = 42%, > > 56-65 yrs. = 40% (p=0.01 vs 18-25) and for > > >65 yrs. SVR = 45%. > > > > There was no difference in SVR in any other pt. age grps including > > pts. age >65 yrs. > > > > There were no differences in SAEs between all age groups. Pts. age 26- > > 35 yrs., 36-45 yrs. and 46-55 yrs. had fewer AEs than those in the 56- > > 65 yrs. and the >65 yrs. age groups. > > > > Treatment discontinuations were significantly higher among the 26-35 > > yrs. group when compared to two groups but there was no difference in > > the treatment discontinuations in the >65 yrs. group compared with > > any other. > > > > Conclusions: > > 1) Adults age 18-25 yrs. had significantly increased chances of > > obtaining SVR than most other age groups. > > 2) Pts. >65 had similar SVR to all other age groups. > > 3) Although there were more AEs in the older age groups, the rate of > > SAEs was the same and treatment drop-outs were the same or less than > > the younger age groups. > > 4) Pts. should not be denied anti-viral therapy based upon age alone. > > > > *Poster presents data updated since abstract submission. > > > > > > The Weight-Based Dosing of Peginterferon alfa-2b and Ribavirin (WIN- > > R) study was a prospective, multicenter, community and academic- > > based, open-label, investigator-initiated, US clinical trial that > > evaluated the efficacy and safety of PEG-IFN alfa-2b plus flat-dose > > or weight-based ribavirin in treatment-naive patients with chronic > > hepatitis C. > > - Overall SVR rates were 44% in the weight-based ribavirin arm and > > 41% in the flat-dose ribavirin arm (P = .020).3 > > - SVR rates in patients with chronic hepatitis C caused by hepatitis > > C virus (HCV) genotype 1 (G1) were 34% and 29%, respectively (P > > =.004).3 > > - Weight-based ribavirin dosing was associated with higher rates of > > dose reduction for anemia but not with higher rates of > > discontinuation.3 > > > > > > > > > -------------------------------------------------------------------- ---------- > Everyone is raving about the all-new beta. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 9, 2006 Report Share Posted November 9, 2006 Please excuse all of the endless questions, but I am now even further confused. Are there some studies somewhere that backs this up..and if so, where can they be found? I do see this is a different company and headquarters are in my backyard.. Thanks, Sheena elizabethnv1 <elizabethnv1@...> wrote: To be honest the stats are pretty much the same when it comes to peg or pegasys , but if you used something like Infergen it has higher success rates . Re: Re: Another Question I have a question, too, one that I've never really had answered, or else I didn't understand. As of right now, which drug company has had the better results with obtaining remission in Genotype "1"s, Schering-Plough or Roche? I am still struggling along here.. right along, I'm sure with a few others... Thanks in Advance, Sheena <marvindamartian05 > wrote: hat does SAE stand for? -- In Hepatitis C , "elizabethnv1"<elizabethnv1@...> wrote:>> PegIntron/RBV Effective for >65 Year Olds> > Reported by Jules Levin> AASLD, Oct 27-31, 2006, Boston, MA> > “Pegylated Interferon alfa-2b + Ribavirin Is Equally Efficacious > and Well Tolerated in Patients >65 Years Old in Comparison to Other > Age Groups: Subanalysis of a Randomized, Controlled Study (WIN-R > Trial)â€> > S. L. Flamm,1 I. M. son,2 R. S. Brown,3 B. Freilich,4 N. > Afdhal,5 P. Kwo,6 J. Santoro,7 S. Becker,8 A. Wakil,9 D. Pound,10 J. > Harvey,11 L. H. Griffel,11 C. A. Brass11> 1Northwestern University, Chicago, Illinois; 2Weill Medical College > of Cornell University, New York, New York; 3Columbia University > College of Medicine, New York, New York; 4Baptist Medical Center, > Kansas City, Missouri;> 5Beth Israel Deaconness Medical Center, Boston, Massachusetts; > 6Indiana University School of Medicine, Indianapolis, Indiana; > 7Atlantic Gastroenterology, Egg Harbor Township, New Jersey; 8Austin > Gastroenterology, PA, Austin, Texas;> 9California Pacific Medical Center, San Francisco, California; > 10Indianapolis Gastroenterology, RSCH, Indianapolis, Indiana; > 11Schering-Plough Research Institute, Kenilworth, New Jersey> > AUTHOR CONCLUSIONS> Patients 18 to 25 years of age had the highest SVR rate (57%) among > the 6 age groups.> > The SVR rate in patients older than 65 years (46%) was similar to the > SVR rates observed in younger age groups (41%-57%).> > Although elderly patients tended to experience more AEs, the rate of > SAEs was similar in all groups, and the incidence of treatment > discontinuation in elderly patients was similar to or less than that > of younger patients.> > Data from this subanalysis of the WIN-R trial strongly suggest that > patients should not be denied antiviral therapy based on age alone.> > > Abstract*> Background: Peg interferon (IFN) + ribavirin are the standard of care > for chronic HCV. There is reluctance to administer anti-viral > medications to older populations due to a fear of side effects and > possible decreased efficacy. Limited data is available on pts. age > >65 due to ineligibility for clinical trials. The role of age in > determining response to IFN-based antiviral therapy for chronic HCV > has not been clearly defined.> > Aim: To determine if age is an independent predictor of sustained > virological response (SVR) or medication tolerability within a > randomized, controlled clinical trial of treatment-naive pts. with > HCV. Patient age grps studied: 18-25 yrs., n=69; 26-35 yrs., n=350; > 36-45 yrs., n=1866; 46-55 yrs., n=2200; 56-65 yrs., n=368; and >65 > yrs., n=55.> > Methods: A retrospective review of the multi-center WIN-R trial > database was undertaken. Pts. were randomized to receive PEG IFN 2b > (1.5 g/kg/wk) + either ribavirin 800 mg/d or ribavirin 800mg-1400 > mg/d based on body wt. Pts. with HCV GT1/4 received 48 wks of therapy > while pts with HCV GT 2/3 were randomized to 24 or 48 wks of therapy. > 4913 pts. received at least 1 dose of medication and are included in > this analysis. Although pts. age >65 yrs. were ineligible, 55 such > pts. Were enrolled as protocol exceptions. Logistic regression > analyses of SVR comparing two age categories were performed. The > potential influence of demographic variables on SVR was evaluated > using the chi square test (two-way frequency table).> > Results: > The overall SVR was 44%. > > SVR rates for the grps were: > 18-25 yrs. = 57%, > 26-35 yrs. = 41% (p=0.02 vs 18-25),> 36-45 yrs. = 44% (p=0.03 vs 18-25), > 46-55 yrs. = 42%, > 56-65 yrs. = 40% (p=0.01 vs 18-25) and for > >65 yrs. SVR = 45%.> > There was no difference in SVR in any other pt. age grps including > pts. age >65 yrs. > > There were no differences in SAEs between all age groups. Pts. age 26-> 35 yrs., 36-45 yrs. and 46-55 yrs. had fewer AEs than those in the 56-> 65 yrs. and the >65 yrs. age groups. > > Treatment discontinuations were significantly higher among the 26-35 > yrs. group when compared to two groups but there was no difference in > the treatment discontinuations in the >65 yrs. group compared with > any other.> > Conclusions: > 1) Adults age 18-25 yrs. had significantly increased chances of > obtaining SVR than most other age groups.> 2) Pts. >65 had similar SVR to all other age groups. > 3) Although there were more AEs in the older age groups, the rate of > SAEs was the same and treatment drop-outs were the same or less than > the younger age groups. > 4) Pts. should not be denied anti-viral therapy based upon age alone.> > *Poster presents data updated since abstract submission.> > > The Weight-Based Dosing of Peginterferon alfa-2b and Ribavirin (WIN-> R) study was a prospective, multicenter, community and academic-> based, open-label, investigator-initiated, US clinical trial that > evaluated the efficacy and safety of PEG-IFN alfa-2b plus flat-dose > or weight-based ribavirin in treatment-naive patients with chronic > hepatitis C.> - Overall SVR rates were 44% in the weight-based ribavirin arm and > 41% in the flat-dose ribavirin arm (P = .020).3> - SVR rates in patients with chronic hepatitis C caused by hepatitis > C virus (HCV) genotype 1 (G1) were 34% and 29%, respectively (P > =.004).3> - Weight-based ribavirin dosing was associated with higher rates of > dose reduction for anemia but not with higher rates of > discontinuation.3> Everyone is raving about the all-new beta. 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Guest guest Posted November 9, 2006 Report Share Posted November 9, 2006 Valeant Pharmaceuticals, headquarters Costa Mesa, CA! http://www.valeant.com/products/infectiousDisease/index.jspf Sheena <marvindamartian05@...> wrote: Who makes Infergen?> >> > PegIntron/RBV Effective for >65 Year Olds> > > > Reported by Jules Levin> > AASLD, Oct 27-31, 2006, Boston, MA> > > > â?oPegylated Interferon alfa-2b + Ribavirin Is Equally Efficacious > > and Well Tolerated in Patients >65 Years Old in Comparison to Other > > Age Groups: Subanalysis of a Randomized, Controlled Study (WIN-R > > Trial)â?> > > > S. L. Flamm,1 I. M. son,2 R. S. Brown,3 B. Freilich,4 N. > > Afdhal,5 P. Kwo,6 J. Santoro,7 S. Becker,8 A. Wakil,9 D. Pound,10 J. > > Harvey,11 L. H. Griffel,11 C. A. Brass11> > 1Northwestern University, Chicago, Illinois; 2Weill Medical College > > of Cornell University, New York, New York; 3Columbia University > > College of Medicine, New York, New York; 4Baptist Medical Center, > > Kansas City, Missouri;> > 5Beth Israel Deaconness Medical Center, Boston, Massachusetts; > > 6Indiana University School of Medicine, Indianapolis, Indiana; > > 7Atlantic Gastroenterology, Egg Harbor Township, New Jersey; 8Austin > > Gastroenterology, PA, Austin, Texas;> > 9California Pacific Medical Center, San Francisco, California; > > 10Indianapolis Gastroenterology, RSCH, Indianapolis, Indiana; > > 11Schering-Plough Research Institute, Kenilworth, New Jersey> > > > AUTHOR CONCLUSIONS> > Patients 18 to 25 years of age had the highest SVR rate (57%) among > > the 6 age groups.> > > > The SVR rate in patients older than 65 years (46%) was similar to the > > SVR rates observed in younger age groups (41%-57%).> > > > Although elderly patients tended to experience more AEs, the rate of > > SAEs was similar in all groups, and the incidence of treatment > > discontinuation in elderly patients was similar to or less than that > > of younger patients.> > > > Data from this subanalysis of the WIN-R trial strongly suggest that > > patients should not be denied antiviral therapy based on age alone.> > > > > > Abstract*> > Background: Peg interferon (IFN) + ribavirin are the standard of care > > for chronic HCV. There is reluctance to administer anti-viral > > medications to older populations due to a fear of side effects and > > possible decreased efficacy. Limited data is available on pts. age > > >65 due to ineligibility for clinical trials. The role of age in > > determining response to IFN-based antiviral therapy for chronic HCV > > has not been clearly defined.> > > > Aim: To determine if age is an independent predictor of sustained > > virological response (SVR) or medication tolerability within a > > randomized, controlled clinical trial of treatment-naive pts. with > > HCV. Patient age grps studied: 18-25 yrs., n=69; 26-35 yrs., n=350; > > 36-45 yrs., n=1866; 46-55 yrs., n=2200; 56-65 yrs., n=368; and >65 > > yrs., n=55.> > > > Methods: A retrospective review of the multi-center WIN-R trial > > database was undertaken. Pts. were randomized to receive PEG IFN 2b > > (1.5 g/kg/wk) + either ribavirin 800 mg/d or ribavirin 800mg-1400 > > mg/d based on body wt. Pts. with HCV GT1/4 received 48 wks of therapy > > while pts with HCV GT 2/3 were randomized to 24 or 48 wks of therapy. > > 4913 pts. received at least 1 dose of medication and are included in > > this analysis. Although pts. age >65 yrs. were ineligible, 55 such > > pts. Were enrolled as protocol exceptions. Logistic regression > > analyses of SVR comparing two age categories were performed. The > > potential influence of demographic variables on SVR was evaluated > > using the chi square test (two-way frequency table).> > > > Results: > > The overall SVR was 44%. > > > > SVR rates for the grps were: > > 18-25 yrs. = 57%, > > 26-35 yrs. = 41% (p=0.02 vs 18-25),> > 36-45 yrs. = 44% (p=0.03 vs 18-25), > > 46-55 yrs. = 42%, > > 56-65 yrs. = 40% (p=0.01 vs 18-25) and for > > >65 yrs. SVR = 45%.> > > > There was no difference in SVR in any other pt. age grps including > > pts. age >65 yrs. > > > > There were no differences in SAEs between all age groups. Pts. age 26-> > 35 yrs., 36-45 yrs. and 46-55 yrs. had fewer AEs than those in the 56-> > 65 yrs. and the >65 yrs. age groups. > > > > Treatment discontinuations were significantly higher among the 26-35 > > yrs. group when compared to two groups but there was no difference in > > the treatment discontinuations in the >65 yrs. group compared with > > any other.> > > > Conclusions: > > 1) Adults age 18-25 yrs. had significantly increased chances of > > obtaining SVR than most other age groups.> > 2) Pts. >65 had similar SVR to all other age groups. > > 3) Although there were more AEs in the older age groups, the rate of > > SAEs was the same and treatment drop-outs were the same or less than > > the younger age groups. > > 4) Pts. should not be denied anti-viral therapy based upon age alone.> > > > *Poster presents data updated since abstract submission.> > > > > > The Weight-Based Dosing of Peginterferon alfa-2b and Ribavirin (WIN-> > R) study was a prospective, multicenter, community and academic-> > based, open-label, investigator-initiated, US clinical trial that > > evaluated the efficacy and safety of PEG-IFN alfa-2b plus flat-dose > > or weight-based ribavirin in treatment-naive patients with chronic > > hepatitis C.> > - Overall SVR rates were 44% in the weight-based ribavirin arm and > > 41% in the flat-dose ribavirin arm (P = .020).3> > - SVR rates in patients with chronic hepatitis C caused by hepatitis > > C virus (HCV) genotype 1 (G1) were 34% and 29%, respectively (P > > =.004).3> > - Weight-based ribavirin dosing was associated with higher rates of > > dose reduction for anemia but not with higher rates of > > discontinuation.3> >> > > > > > > --------------------------------------------------------------------> Everyone is raving about the all-new beta.> Everyone is raving about the all-new beta. 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Guest guest Posted November 9, 2006 Report Share Posted November 9, 2006 Ha! Then we should get it cheap because they don't have to ship it very far. LOL, yeah right! > > > > > > PegIntron/RBV Effective for >65 Year Olds > > > > > > Reported by Jules Levin > > > AASLD, Oct 27-31, 2006, Boston, MA > > > > > > â?oPegylated Interferon alfa-2b + Ribavirin Is Equally > Efficacious > > > and Well Tolerated in Patients >65 Years Old in Comparison to > Other > > > Age Groups: Subanalysis of a Randomized, Controlled Study > (WIN-R > > > Trial)â? > > > > > > S. L. Flamm,1 I. M. son,2 R. S. Brown,3 B. Freilich,4 N. > > > Afdhal,5 P. Kwo,6 J. Santoro,7 S. Becker,8 A. Wakil,9 D. > Pound,10 J. > > > Harvey,11 L. H. Griffel,11 C. A. Brass11 > > > 1Northwestern University, Chicago, Illinois; 2Weill Medical > College > > > of Cornell University, New York, New York; 3Columbia > University > > > College of Medicine, New York, New York; 4Baptist Medical > Center, > > > Kansas City, Missouri; > > > 5Beth Israel Deaconness Medical Center, Boston, > Massachusetts; > > > 6Indiana University School of Medicine, Indianapolis, > Indiana; > > > 7Atlantic Gastroenterology, Egg Harbor Township, New Jersey; > 8Austin > > > Gastroenterology, PA, Austin, Texas; > > > 9California Pacific Medical Center, San Francisco, > California; > > > 10Indianapolis Gastroenterology, RSCH, Indianapolis, Indiana; > > > 11Schering-Plough Research Institute, Kenilworth, New Jersey > > > > > > AUTHOR CONCLUSIONS > > > Patients 18 to 25 years of age had the highest SVR rate (57%) > among > > > the 6 age groups. > > > > > > The SVR rate in patients older than 65 years (46%) was > similar to the > > > SVR rates observed in younger age groups (41%-57%). > > > > > > Although elderly patients tended to experience more AEs, the > rate of > > > SAEs was similar in all groups, and the incidence of > treatment > > > discontinuation in elderly patients was similar to or less > than that > > > of younger patients. > > > > > > Data from this subanalysis of the WIN-R trial strongly > suggest that > > > patients should not be denied antiviral therapy based on age > alone. > > > > > > > > > Abstract* > > > Background: Peg interferon (IFN) + ribavirin are the standard > of care > > > for chronic HCV. There is reluctance to administer anti-viral > > > medications to older populations due to a fear of side > effects and > > > possible decreased efficacy. Limited data is available on > pts. age > > > >65 due to ineligibility for clinical trials. The role of age > in > > > determining response to IFN-based antiviral therapy for > chronic HCV > > > has not been clearly defined. > > > > > > Aim: To determine if age is an independent predictor of > sustained > > > virological response (SVR) or medication tolerability within > a > > > randomized, controlled clinical trial of treatment-naive pts. > with > > > HCV. Patient age grps studied: 18-25 yrs., n=69; 26-35 yrs., > n=350; > > > 36-45 yrs., n=1866; 46-55 yrs., n=2200; 56-65 yrs., n=368; > and >65 > > > yrs., n=55. > > > > > > Methods: A retrospective review of the multi-center WIN-R > trial > > > database was undertaken. Pts. were randomized to receive PEG > IFN 2b > > > (1.5 g/kg/wk) + either ribavirin 800 mg/d or ribavirin 800mg- > 1400 > > > mg/d based on body wt. Pts. with HCV GT1/4 received 48 wks of > therapy > > > while pts with HCV GT 2/3 were randomized to 24 or 48 wks of > therapy. > > > 4913 pts. received at least 1 dose of medication and are > included in > > > this analysis. Although pts. age >65 yrs. were ineligible, 55 > such > > > pts. Were enrolled as protocol exceptions. Logistic > regression > > > analyses of SVR comparing two age categories were performed. > The > > > potential influence of demographic variables on SVR was > evaluated > > > using the chi square test (two-way frequency table). > > > > > > Results: > > > The overall SVR was 44%. > > > > > > SVR rates for the grps were: > > > 18-25 yrs. = 57%, > > > 26-35 yrs. = 41% (p=0.02 vs 18-25), > > > 36-45 yrs. = 44% (p=0.03 vs 18-25), > > > 46-55 yrs. = 42%, > > > 56-65 yrs. = 40% (p=0.01 vs 18-25) and for > > > >65 yrs. SVR = 45%. > > > > > > There was no difference in SVR in any other pt. age grps > including > > > pts. age >65 yrs. > > > > > > There were no differences in SAEs between all age groups. > Pts. age 26- > > > 35 yrs., 36-45 yrs. and 46-55 yrs. had fewer AEs than those > in the 56- > > > 65 yrs. and the >65 yrs. age groups. > > > > > > Treatment discontinuations were significantly higher among > the 26-35 > > > yrs. group when compared to two groups but there was no > difference in > > > the treatment discontinuations in the >65 yrs. group compared > with > > > any other. > > > > > > Conclusions: > > > 1) Adults age 18-25 yrs. had significantly increased chances > of > > > obtaining SVR than most other age groups. > > > 2) Pts. >65 had similar SVR to all other age groups. > > > 3) Although there were more AEs in the older age groups, the > rate of > > > SAEs was the same and treatment drop-outs were the same or > less than > > > the younger age groups. > > > 4) Pts. should not be denied anti-viral therapy based upon > age alone. > > > > > > *Poster presents data updated since abstract submission. > > > > > > > > > The Weight-Based Dosing of Peginterferon alfa-2b and > Ribavirin (WIN- > > > R) study was a prospective, multicenter, community and > academic- > > > based, open-label, investigator-initiated, US clinical trial > that > > > evaluated the efficacy and safety of PEG-IFN alfa-2b plus > flat-dose > > > or weight-based ribavirin in treatment-naive patients with > chronic > > > hepatitis C. > > > - Overall SVR rates were 44% in the weight-based ribavirin > arm and > > > 41% in the flat-dose ribavirin arm (P = .020).3 > > > - SVR rates in patients with chronic hepatitis C caused by > hepatitis > > > C virus (HCV) genotype 1 (G1) were 34% and 29%, respectively > (P > > > =.004).3 > > > - Weight-based ribavirin dosing was associated with higher > rates of > > > dose reduction for anemia but not with higher rates of > > > discontinuation.3 > > > > > > > > > > > > > > > > > ---------------------------------------------------------- > ---------- > > Everyone is raving about the all-new beta. > > > > > > > > > --------------------------------- > Everyone is raving about the all-new beta. > Quote Link to comment Share on other sites More sharing options...
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