Mystery Solved! Re: advair diskus - Discard after 30 days

[Guest guest]

First of all THANK YOU Dahnajeanne for finding this! And I am so happy. While

humidity can 'cake' the powder of Advair Diskus so that less comes out and

reduces teh therapy for the asthma patient, humidity could lend itself to fungal

growth as well, which this study does not mention.  It appears that I was on the

right track with my original hypothesis!

So thank you for confirming this. Also Joy RPh from Florida mentioned humidity!

 

Secondly I did not know about a Google Scholar Search. How do I use this? How do

I find it?

 

Thanks,

 

Jeanetta Mastron CPhT BS

F/O

 

 

From: dahnajeanne <dahnajeanne@...>

Subject: Re: advair diskus -

Date: Thursday, September 24, 2009, 8:58 AM

Seretide is the tradename for combination preparation fluticasone/salmeterol in

Europe & Australia. (Advair in the U.S.)

I found this study through Google Scholar.

Journal of Aerosol Medicine

An In Vivo and In Vitro Comparison of Two Powder Inhalers following Storage at

Hot/Humid Conditions

url: http://www.liebertonline.com/doi/abs/10.1089/jam.2005.18.304

Dry powder inhalers (DPIs) are increasingly being used for the treatment of

asthma and COPD. A potential drawback is that DPIs can be sensitive to humidity.

Two DPIs, Symbicort Turbuhaler and Seretide Diskus, were stored 3 months at

either 25°C/30% RH or 40°C/75% RH. After storage, delivered, as well as fine

particle dose, FPD, were tested in vitro and lung deposition, of the steroid

components, was assessed in vivo. After storage at 40°C/75% RH, delivered dose

as well as FPD from Symbicort Turbuhaler was virtually unchanged while FPD for

Seretide Diskus decreased by about 50% despite no decrease in delivered dose.

For both products, no difference in FPD was seen after storage at 25°C/30% RH.

These in vitro findings were confirmed in the in vivo part of the study. Lung

deposition for Symbicort Turbuhaler was unaffected by 40°C/75% RH storage, while

for Seretide Diskus it was reduced with about 50%. The study extends previous in

vitro observations of

impaired performance of Seretide Diskus and demonstrates that this translates

into decreased drug delivery to the site of action. The clinical importance of

this finding has not been studied but could result in undertreatment.

> " I will attempt to find out why the device must be thrown away after 30 days.

"

>

> i have searched adn searched using google and the following key words: : Why

must the Advair diskus inhalation device be discarded after 30 days? " and other

varions of the same,  but I can not find out why. If any one knows plesae let me

know.

>

> Thank you,

>

> Jeanetta Mastron CPhT BS

> Founder/ Owner

>

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