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Re: Can you Answer This?

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Atropine is an antihistamine, decongestant combination me thinks. I cheated

and read about the war thing using Atropine, that I didn't know and found very

interesting.

Thanks for the challenge!

Lori

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Hi Jeanetta,

I think you stumped me here.

I want to say the answer is to prevent bedwetting but I cannot find any facts to

back up my hunch.

This was a good one!!

Still searching,

--

To love what you do and feel that

it matters - how could anything

be more fun? -- Graham

. . . for my heart rejoiced in

all my labour . . . Ecclesiastes

2:10

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Dear ,

While there MAY be some relationship between atropine and bedwetting

I am not familiar with it.

If I can stump you , that says a lot!~ You are the internet

search queen! If anyone could find this I would have bet on you!

Actually I was expecting an experienced retail tech to get this from

experience! I could leave it on a bit longer....but I know you have

ants in your pants about this! Hee!)

I give you credit at least you knew it had something to do with a

discharge or secretion!

Atropine, as you all know, is one of the ingredients in Lomotil, the

other being diphenoxylate. Use together in Lomotil, it causes " low

motility " (yes that is how it got its name) to reduce the cause of

diarrhea. Motility means movement. However within the body, motility

refers to the movement of the smooth muscles of the GI system. High

Motility is the fast movement of the smooth muscles that increase

large intesting (colon) emptying time. The smooth muscles spasm

around the intestines (tighten and release)thus pushing out the

waste into the toilet.Perisralsis is the process of wave-like muscle

contractions of the alimentary tract that moves food along. The

alimentary tract does not include the large intestine whihc has

waste. But the movement in the lower intestinal area is the same but

refered to as motility. Lomotil causes the high motility to slow

down to normal or abnormally low to stop the 'pushing' of waste

through the large intestine. This would slow down the emptying time

and give 'time' to the diarrhea like stool to 'thichken up' so that

a firmer stool will be formed. Emptying time and stool formation go

back to normal.

So what does atropine ii gtts PO qhs used for? ??

Good one isn't it???

Tease Tease Tease!

Jeanetta

> Hi Jeanetta,

>

> I think you stumped me here.

>

> I want to say the answer is to prevent bedwetting but I cannot

find any facts to back up my hunch.

>

> This was a good one!!

>

> Still searching,

>

>

>

>

> --

> To love what you do and feel that

> it matters - how could anything

> be more fun? -- Graham

>

> . . . for my heart rejoiced in

> all my labour . . . Ecclesiastes

> 2:10

>

>

>

>

>

>

>

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Now let me be more precise:

The Mechanism of action or effect of:

Diphenoxylate¡ª A Synthetic opiate agonist, probably acts both

locally and centrally to reduce intestinal motility.

More technically: It is an Opiate Receptor Agonists that stimulate mu

(¦Ì) & gamma (¦Ã) receptors in GI to ¡ýperistalsis & constrict

sphincters

It decreases Ach release from postganglionic cholinergic nerves in

the gut and slows the propulsion through the small and large

intestine.

While...

The Mechanism of action or effect of:

Atropine¡ªHas anticholinergic activity.

ACh or acetylycholine causes the smooth muscle to become more active

or move the contents of the large colon/intestine faster. Blocking

ACh or an anticholinergic drug would slow down the movement of the

smooth muscle.

So what does Atropine do if ordered as: i - ii gtts PO qhs

It is used for excessive drooling at night.

What patient may need this? Perhaps a patient with Parkinson's

Disease.

Did I tease your brain enouhg??

Jeanetta

> Dear ,

>

> While there MAY be some relationship between atropine and

bedwetting

> I am not familiar with it.

>

> If I can stump you , that says a lot!~ You are the internet

> search queen! If anyone could find this I would have bet on you!

>

> Actually I was expecting an experienced retail tech to get this

from

> experience! I could leave it on a bit longer....but I know you

have

> ants in your pants about this! Hee!)

>

> I give you credit at least you knew it had something to do with a

> discharge or secretion!

>

> Atropine, as you all know, is one of the ingredients in Lomotil,

the

> other being diphenoxylate. Use together in Lomotil, it causes " low

> motility " (yes that is how it got its name) to reduce the cause of

> diarrhea. Motility means movement. However within the body,

motility

> refers to the movement of the smooth muscles of the GI system.

High

> Motility is the fast movement of the smooth muscles that increase

> large intesting (colon) emptying time. The smooth muscles spasm

> around the intestines (tighten and release)thus pushing out the

> waste into the toilet.Perisralsis is the process of wave-like

muscle

> contractions of the alimentary tract that moves food along. The

> alimentary tract does not include the large intestine whihc has

> waste. But the movement in the lower intestinal area is the same

but

> refered to as motility. Lomotil causes the high motility to slow

> down to normal or abnormally low to stop the 'pushing' of waste

> through the large intestine. This would slow down the emptying

time

> and give 'time' to the diarrhea like stool to 'thichken up' so

that

> a firmer stool will be formed. Emptying time and stool formation

go

> back to normal.

>

>

> So what does atropine ii gtts PO qhs used for? ??

>

> Good one isn't it???

>

> Tease Tease Tease!

>

> Jeanetta

>

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Okay so what the heck? Right?

Well you would have to know that an increase in ACh occurs at night

along with increase in GI motility and digestion. Along with this is

sleep and increase salivation, urination and defecation etc.

So MAY be absolutely correct that eye drops of atropine MAY

ALSO be used to combat excessive night time urination. However this

particular prescription was in fact ordered for a heavy night time

drooler with PD.

So blocking Ach especially at night causes unusual dryness of the

mouth. But if you are a heavy drooler this may just put you back to

a 'normal' amount of saliva, instead of dryness.

I hope I teased your brain enough!

Now , I expect you are furiously looking (er searching) for the

relationship between atropine eye drops and night time urination.

I would expect nothing less from you. That is why you are a TEXPERT!

So if and when you find this out, let us know!

Jeanetta

>

> So what does Atropine do if ordered as: i - ii gtts PO qhs

>

> It is used for excessive drooling at night.

> What patient may need this? Perhaps a patient with Parkinson's

> Disease.

>

> Did I tease your brain enough??

>

> Jeanetta

>

> ---

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