Guest guest Posted October 14, 2001 Report Share Posted October 14, 2001 Has anyone tried this? Patty Subject: PREGNENOLONE ========================= http://216.117.138.253/supplements/pregnenolone.html Pregnenolone is the precursor to all the steroid hormones (those made by the ovaries, testicles and adrenal glands), including progesterone, estrogen, testosterone, the cortisones and DHEA. Pregnenolone was used in the 1930's and 40's to successfully treat arthritis in humans, but was neglected when synthetic drugs replaced it. Biochemist Peat, Ph.D., who has experimented with pregnenolone for many years, reports that when you are deficient in pregnenolone, taking it as a supplement can successfully relieve depression, improve memory, reduce skin aging, relieve arthritis symptoms, and reduce stress-induced fatigue. Improved Memory One of the most exciting aspects of pregnenolone is its memory enhancing activities. Studies have shown Pregnenolone to be hundreds of times more powerful than other memory enhancing substances. It also has a powerful effect on improving transmission of nerve impulses. Pregnenolone has shown such great promise that it is now being studied by many prominent researchers. For example, Dr. Bruce , a neurologist at the Harbor - UCLA Medical Center is currently studying pregnenolone's effect on Alzheimer's. Pregnenolone Sublingual Drops Each Bottle Contains: Pregnenolone 1250 mg. per 30ml Dropper Bottle) Part BM15 - Pregnenolone Drops Studies have shown Pregnenolone to be hundreds of times more powerful than other memory enhancing substances. It also has a powerful effect on improving transmission of nerve impulses. More info Price: $24.00 =============================== Pregnenolone What does it do? The functions of pregnenolone in the body are not well known. Pregnenolone serves as a precursor to other hormones, including dehydroepiandrosterone (DHEA) and progesterone.1 It has been suggested that the role of pregnenolone in the body is to serve as a " mother-steroid " (precursor hormone), and that it has no function on its own. More research is needed to determine the functions (if any) of pregnenolone in the body. Many effects of pregnenolone on the nervous system have been studied. Rat studies indicate powerful memory enhancing effects,2 far beyond that of other neuroactive substances.3 4 In healthy men aged twenty to thirty, administration of pregnenolone (1 mg daily) was found to improve sleep quality and decrease intermittent wakefulness.5 It has been suggested that this hormone may play a role in the neuroendocrine response to stress. During periods of stress, the output of adrenal steroids increases. The increased output of these steroids has been associated with increased fatigue in army pilots resulting in poor performance. In a study of pilots under stress, pregnenolone therapy (25 mg, twice daily) improved performance with no adverse side effects.6 In a rat study of the stress response, an increase in anxiety was observed following administration of pregnenolone. It is suggested that this is a beneficial response during a stressful period and is initiated through the nervous system.7 In a rat model of spinal cord injury, pregnenolone administration in conjunction with an anti-inflammatory medication (indomethacin) and an immune modulating medication (bacterial lipopolysaccharide) resulted in a statistically significant improvement in motor function relative to controls. The control groups included rats on other combinations of the medications and other anti-inflammatory medications.8 Pregnenolone appears to exhibit an antagonistic effect on the calming receptors in the brain (GABA receptors), resulting in an excitatory effect. It is possible that this alteration in nervous system transmission could contribute to seizure activity.9 10 It is known that steroid hormones effect mood and behavior through the nervous system. In individuals with either current depression or a history of depression, pregnenolone (in the cerebrospinal fluid) was found to be significantly lower than in healthy people. In addition, it was found that patients with active depression had lower levels of pregnenolone compared with those with a prior history of depression.11 In a double blind placebo-controlled study of elderly women with wrinkles, daily application of a pregnenolone acetate (0.5 percent) cream improved the visible wrinkling of the skin. When the treatment was discontinued, the benefit was not maintained. Because the results were only temporary, it is suggested that the beneficial effect of the cream was due to improved hydration of the skin.12 Researchers have reported on the use of pregnenolone in a variety of rheumatologic diseases. In a study of pregnenolone therapy (intramuscular injection, 50-600 mg daily) for rheumatoid arthritis, six of eleven individuals experienced moderate to marked improvement in symptoms of joint pain and joint mobility. The symptom improvement was apparent two to four days after therapy was initiated. In a study of thirteen adults with osteoarthritis, pregnenolone therapy reduced the pain and improved the range of motion in seven of the study participants. Pain recurred when therapy was discontinued. In a person who suffered from gouty arthritis and was unresponsive to traditional medications, pregnenolone therapy resulted in a dramatic response within three days of initiating therapy. This patient received 300 mg daily of pregnenolone (by intramuscular injection) for four weeks, followed by 200 mg weekly of pregnenolone as a maintenance dose. This study of pregnenolone therapy in rheumatologic diseases also reports a substantial benefit in patients with systemic lupus erythematosus (SLE), psoriasis, and scleroderma. Of the 59 individuals reported in this paper, the only adverse effect was redness or pain at the site of injection. No systemic adverse effects were reported.13 Where is it found? The cells of the adrenal gland, as well as the central nervous system, synthesize pregnenolone. Human studies show that there are much higher concentrations of pregnenolone in the nervous tissue than in the bloodstream.14 Animal studies indicate that pregnenolone is found in the brain in ten-fold larger concentrations than the other stress-related hormones (including DHEA).15 Pregnenolone is present in the blood as both free pregnenolone and a more stable form, pregnenolone-sulfate. Who is likely to be deficient? Since it is not an essential nutrient, pregnenolone is not associated with a deficiency state. How much is usually taken? Pregnenolone is generally available in amounts of 10 to 30 mg. It is unknown what amount of pregnenolone is necessary for autoimmune diseases, preventive therapy, or memory enhancement, especially since studies were performed primarily on rats, and used an injectable form of the hormone. Many studies have indicated a U-shaped distribution16 in the therapeutic response to pregnenolone therapy. The U-shaped distribution describes a benefit of low dose pregnenolone, a loss of effect with increasing dose of pregnenolone, and a second peak of benefit with higher doses of the steroid. It is unknown what dosage range is represented in either part of the U-shaped curve for humans, and whether or not this curve is altered by disease. Are there any side effects or interactions? Due to its antagonistic effects on the GABA receptor in the central nervous system, pregnenolone therapy may be contraindicated in people with a history of seizures. Pregnenolone may inhibit drugs used to increase GABA activity (i.e., neurontin); these drugs are frequently used in the treatment of epilepsy and depression. Pregnenolone supplementation may increase progesterone levels and consequently other hormones in the body (testosterone and estradiol). Pregnenolone may cause disturbances in the endocrine system, including changes in the menstrual cycle and problems with hormone sensitive diseases, or it may interact with hormone therapy such as oral contraceptives. The side effects and interactions with other therapies are currently unknown. References: 1. Akwa Y, Young J, Kabbadj K, et al. Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain. J Steroid Biochem Molec Biol 1991;40(1-3):71-81. 2. Isaacson RL, Varner JA, Baars JM, de Wied D. The effects of pregnenolone sulfate and ethylestrenol on retention of a passive avoidance task. Brain Res 1995;689:79-84. 3. Flood JF, Morley JE, E. Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: The amygdala is by far the most sensitive. Proc Natl Acad Sci 1995;92:10806-810. 4. Flood JF, Morley JE, E. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci 1992;89:1567-71. 5. Steiger A, Trachsel L, Guldner J, et al. Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation. Brain Res 1993;615:267-74. 6. Pincus G, Hoagland H. Effects of administered pregnenolone on fatiguing psychomotor performance. Aviation Med 1944;April:98-115. 7. Melchior CL, Ritzmann RF. Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze. Pharmacol Biochem Behav 1994;48(4):893-97. 8. Guth L, Zhang Z, E. Key role for pregnenolone in combination therapy that promotes recovery after spinal cord injury. 1994;91:12308-312. 9. Wu FS, Gibbs TT, Farb DH Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol 1991;40(3):333-36. 10. Maione S, Berrino L, Vitagliano S, et al. Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in mice. Eur J Pharmacol 1992;219:477-79. 11. MS, Guidotti A, Rubinow D, et al. CSF neuroactive steroids in affective disorders: pregnenolone, progesterone and DBI. Biol Psychiatry 1994;35(10):775-80. 12. Sternberg TH, LeVan P, ET. The hydrating effects of pregnenolone acetate on the human skin. Curr Ther Res 1961;3(11):469-71. 13. McGavack TH, Chevalley J, Weissberg J. The use of D 5-pregnenolone in various clinical disorders. J Clin Endocrinol 1951;11(6):559-77. 14. Morfin R, Young J, Corpechot C, et al. Neurosteroids: pregnenolone in human sciatic nerves. Proc Natl Acad Sci 1992;89:6790-793. 15. Akwa Y, Young J, Kabbadj K, et al. Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain. J Steroid Biochem Molec Biol 1991;40(1-3):71-81. 16. Isaacson RL, Varner JA, Baars JM, de Wied D. The effects of pregnenolone sulfate and ethylestrenol on retention of a passive avoidance task. Brain Res 1995;689:79-84. ========================== http://www.myvitanet.com/vitanet/pregliq10mtr.html Promotes a woman's natural defense against Estrogen sensitivity An exciting breakthrough in anti-aging is Pregnenolone, a hormone produced by the adrenal glands. Unlike DHEA which converts to estrogen and testosterone, Preg is converted directly to progesterone, and can be an excellent choice for estrogen-sensitive women or testosterone-sensitive men. Pregnenolone has been used for: PMS and menopausal problems. Estrogen sensitivities. Ovarian cysts Arthritis and fatigue. 30, 50 or 150 Count Capsules / 30mg Availability: Usually ships the next business day. 180Regular price: $29.95Sale price: $18.71 ============================= http://www.vitaminusa.com/pregprodlis.html PREGNENOLONE This natural hormone plays a role in memory, mood, energy, PMS, menopause, hormone replacement, stress reduction, immunity, rheumatoid arthritis and other conditions. Pregnenolone or DHEA has to be made in a laboratory. If you want Pregnenolone or DHEA, the bottles you buy must say that they contain actual Pregnenolone or DHEA, not extracts of wild yams. Pregnenolone is made in many organs and tissues that produce steroid hormones. Most common are the adrenal glands, skin and gonads. We now know that the brain has the capacity to use cholesterol to make Pregnenolone and other steroids. There are enzymes in cells that convert cholesterol to Pregnenolone. Pregnenolone is different from DHEA in that it can be metabolized into progesterone which in turn can turn into aldosterone or cortisol. DHEA has been called the " Mother Hormone, but Pregnenolone is called the " Mother of DHEA and the " Grandmother of all steroid hormones " . INDICATIONS: a.. ALZHEIMER'S b.. MEMORY AND THINKING c.. MOOD d.. SLEEP e.. CHOLESTEROL f.. CHRONIC FATIGUE g.. HORMONE REPLACEMENT THERAPY h.. IMMUNE SYSTEM i.. LUPUS j.. MULTIPLE SCLEROSIS k.. PREMENSTRUAL SYNDROME l.. PROSTATE GLAND m.. PSORIASIS n.. RHEUMATOID ARTHRITIS o.. SCLERODERMA p.. SEIZURES q.. STRESS r.. TRAUMA OR INJURIES WHAT IS THE RIGHT DOSE? In studies it has ranged from 1 mg to several hundred mg. It is best to start using low doses before considering higher ones. It is recommended that supervision by a health care practitioner be considered. You may want to start with a low dose of 10 mg taken in the morning before breakfast with water or another liquid. Take 10mg for a few days and if this is not effective, gradually increase the dose to 15 then 20, up to 30mg. If you are taking Pregnenolone for hormone replacement therapy, a low dose of 10 mg may be just right for a start. For relief from Rheumatoid arthritis, higher doses may be needed, so starting with 20 mg may be a better option. Higher doses should not be taken unless a physician has been consulted. SIDE EFFECTS: Common side effects reported thus far on doses greater than 10 mg include insomnia, irritability, and, less frequently, headaches. If you get insomnia or feel over alert, skip a dose and then reduce it on subsequent days. Pregnenolone 10mg Dietary Supplement by Dixie Health Regular price: $10.00 Sale price: $8.00, 2/$14.00, 3/$20.00 Pregnenolone 50mg Dietary Supplement by MRM Regular price: $22.95 Sale price: $19.28 ======================================= http://www.nubrain.com/preg.html PREGNENOLONE Pregnenolone is a steroid precursor hormone produced in the adrenal glands, liver, skin, brain, testicles, ovaries and retina of the eyes. It is made in the body from the bad-rap guy, cholesterol. Naturally, to get pregnenolone, we need adequate amounts of cholesterol plus other nutrients, including vitamin A, thyroid hormone and enzymes. If any of these are inadequate, you will have a less than desired supply of pregnenolone. In a healthy person, the conversion of cholesterol to pregnenolone occurs inside the mitochondria, nicknamed the lungs of the cell because of their role in cell respiration. Once produced, pregnenolone leaves the mitochondria, so it cannot inhibit its own synthesis. In fact, both progesterone and pregnenolone stimulate their own synthesis so that if you take them, the body's ability to synthesize them is not suppressed. Sometimes short term therapy restores the body's ability to produce adequate amounts. In the cytoplasm, enzymes convert pregnenolone into either progesterone or DHEA, depending on the tissue and the need. Brain Function: Including Mood, Memory and Thinking Depressed patients were found to have low levels of pregnenolone in their cerebro- spinal fluid. This fluid circulates throughout the spinal column and brain, any major change in its chemistry is reflected in this spinal fluid. Because the brain concentration decreases from its peak value at age thirty to only 5% of peak value at 90, the need for supplemental pregnenolone increases as we age. In fact, the older and/or sicker you are, the more likely you are to feel an effect from pregnenolone. Pregnenolone may help restore impaired memory, according to neurobiologist Eugene of the City of Hope Medical Center in Los Angeles, and his colleagues, biologist F. Morley, of the St. Louis VA Medical Center. These researchers tested pregnenolone and other steroids on mice. They found that pregnenolone is several hundred times more potent than any memory enhancer that has been tested before. Their report, in the March 1992 Proceedings of the National Academy of Sciences, says that pregnenolone restores normal levels of memory hormones which decline during aging. noted that pregnenolone was used in the late 1940's to treat rheumatoid arthritis but fell into disuse when cortisone was discovered. But, says , pregnenolone was never found to have adverse side effects whereas the toxic effects of cortisone are many and severe. Pregnenolone also acts on NMDA (N-methyl-D-aspartate) receptors which affect learning and memory by regulating the function of the synapses on our neurons. Dr. Flood of the Geriatric Research Education and Clinical Center in St. Louis writes " Pregnenolone is the most potent memory enhancer yet reported " . Alzheimer's, Parkinson's and other forms of dementia and mental deterioration that occurs with everyone as we age may benefit from pregnenolone supplementation. Cholesterol Lowering Drugs: Drugs that are used by patients to lower their cholesterol levels inadvertently also block the production of pregnenolone which may lead to impaired brain function. Pregnenolone has a unique ability to repair the enzymes in the cytochrome P-450 system which are responsible for converting cholesterol into pregnenolone. Therefore, pregnenolone supplementation should be considered essential for anyone using cholesterol lowering drugs. Other enzymes in the P-450 system are vital to certain detoxification processes which are also stabilized by pregnenolone. Pregnenolone doesn't affect the rate of synthesis of these enzymes, but it stabilizes them against the normal proteolytic enzymes, increasing their activity. This stabilizing action is a general feature of these steroids. Protection from cortisone toxicity: The classic effects of toxic levels of cortisol include daytime euphoria, insomnia plus hot flashes at night, osteoporosis, brain aging, atrophy of the skin plus other signs of premature aging and adrenal atrophy (shrinking). Two injections of cortisone can destroy the beta cells of the pancreas in dogs, causing diabetes. Peat believes that stress-inducing elevation in cortisone can cause diabetes in people as well. Peat reports that pregnenolone can be used to withdraw from cortisone therapy over a one month period without developing " " disease symptoms (from adrenal atrophy), because of its normalizing effects on the adrenal gland. In female patients, progesterone therapy may also be indicated. Reduced exophthalmia in Graves' disease patients: In the 1950's pregnenolone was tested on patients with exophthalmis (bulging eyes) from Graves' disease. It was reported that their eyes quickly receded to a more normal position in their sockets. Peat gave pregnenolone to a desperate woman with seriously bulging eyes. After using pregnenolone for just a few weeks, she telephoned him and said that her eyes were completely normal. Since pregnenolone converts both progesterone and DHEA, it is a much safer therapy. Peat recommends it for everyone past the age of 40 and even younger, if persistent health problems occur. This includes even the juvenile diabetic. Why? Because pregnenolone was shown to rejuvenate the beta cells of the pancreas in diabetic animals. If it works on animals, its worth a try in humans. 150 - 30mg caps $29 ================================= http://www.gaines.com/html/BioMax/BMX-DHPGinfo.html BioMax Formulations is a manufacturer of professional-quality products. The medical community has long known that oral delivery systems are the most efficient way to make most substances bio-available to the target host. Due to ease of administration, oral preparations are by far the standard way to deliver medication and food supplement products. As a person gets older, the oral bioavailability dminishes to a fraction of the hormone levels when the person was young. As with the two master hormones, DHEA and Pregnenolone, the people who benefit the most from these master hormone augmentations are people over forty years of age, who sadly have the poorest oral absorption characteristics. DHEA has been the subject of over 4,000 studies that have shown that this adrenal hormone has life-rejuvenating properties for all people over forty years of age. Our highest levels of DHEA are when we are in our early twenties. As we grow older, DHEA levels diminish to 9% at age ninety from our highest level in youth. DHEA is a Master Hormone that will convert to testosterone, estrogen or several other needed hormones, based on your body's needs. Pregnenolone is another Master Hormone that has shown dramatic memory enhancement properties in recent medical studies. Pregnenolone is a Master Hormone that converts not only into the DHEA branch of hormones, but also into another branch of hormones that converts to progesterone and several other needed hormones into which DHEA cannot be converted. When we are producing our peak levels of DHEA at age 20, a man produces 31 mg of DHEA per day, while a women products 19 mg of DHEA per day. We should not take any more DHEA than our maximum production, unless under the care of a health professional. Women especially need the balanced hormone replacement of DHEA and Pregnenolone to balance their estrogen and progesterone levels for optimum health and revitalization. Each bottle (1300 mg) contains: DHEA (dehydroepiandrosterone) 1000 mg Pregenolone glycerine 300 mg With alcohol as a preservative. Recommended Usage: Take 1 to 3 droppersful per day under the tongue, or as directed by a health care professional. One bottle at maximum dosage for men per day (31 mg, or 2-3/4 droppersful per day) will last 32 days. One bottle at maximum dosage for women (19 mg, or 1-3/4 droppersful per day) will last 52 days. =============== Grow Younger! Discover the New Miracle Cream That Erases Years, Balances Hormones and Reverses Aging! ================================================ Wouldn't it be nice if there was something that would allow your own body to produce just the right amount of all the hormones you need -- naturally, in just the perfect balance? For both men and women? Until now, there wasn't anything available that could do that. But now there is, PrenoloneT cream. This amazing cream contains pregnenalone, the master hormone from which all other steroid hormones in your body are created. It can be called the parent compound of all hormones, such as progesterone, estrogen, testosterone, DHEA, cortisol, and aldosterone. After all, how can one know how much progesterone or estrogen is really needed. It becomes a game of guesswork and inevitably, a good balance is not achieved. Now, there is no more need for guessing. The pregnenolone in PrenoloneT cream lets your body take care of itself. Naturally and without side-effects! Pregnenalone is natural substance normally manufactured in your body from cholesterol. In PrenoloneT cream, it is derived from soy and the Mexican wild yam. It can be used as a dietary supplement, since it is not a controlled substance like progesterone and estrogen. What's even better, is that it does not function like synthetic hormones, which can cause debilitating side effects. Instead, it has hormone-balancing effects throughout the body as well as other powerful anti-inflammatory effects. Pregnenolone is also involved in emotional health, proper sleep, and reduced stress. Clinical studies have examined its role in relieving depression, improving memory, reducing stress, treating arthritis and increasing longevity. It is even being studied for Alzheimer's Disease, ADD and skin conditions. We're all born with plenty of Pregnenolone. The trouble is, it declines with age, along with all the other steroid hormones in your body. Between the ages of 20 and 60, levels of pregnenolone, testosterone, estrogen, progesterone and DHEA drop by 50 percent or more. Unfortunately, pregnenolone drops over 60 percent between the ages of 35 and 75. DHEA declines even more dramatically, dropping by over 80 percent between ages 25 and 75. The declines of these hormones have been linked to accelerated aging, shortened life expectancy, and many age-related diseases. A rising tide of clinical research is just beginning to show the powerful therapeutic benefits of natural pregnenolone. Benefits that can reverse decline. It has been shown to greatly reduce PMS and menopausal symptoms, relieve arthritis pain, fight stress and fatigue, improve memory, energy, and motivation, and can lift depression at the same time. Not only that, it has been shown to regenerate nerves. And what's amazing is that this completely natural substance is non-toxic and virtually without side effects! By now you must be wondering why you haven't heard about pregnenolone before. The truth is, it was heavily researched in the l940s. But then, in 1949, the drug Premarin was manufactured. When that happened, all funding for pregnenolone research ended and all attention turned to steroid drugs - after all, that's where the money was. Chemical drugs could be patented and sold for high prices. But a patent could not be taken out on Pregnenolone, since it's a natural substance. Pharmaceutical companies were free to research natural substances, but there was little profit in it. Dr. Ray Sahelian, in his book, Pregnenolone: Nature's Feel Good Hormone, quotes physician Dr. Arnold Fox: " I remember pregnenolone from the 1950s, when it was mentioned in medical school as a form of therapy for arthritis. PREG, at that time, was being sold without a prescription. But then cortisone emerged on the scene, and that changed everything - pregnenolone vanished from the public eye. However, few people realized that although cortisone gave remarkable short-term improvements, it was later discovered that it also unleashed terrible side effects, including immune suppression and osteoporosis. " Luckily, in l994, Congress passed the Dietary Supplement and Health Education Act, allowing vitamins, minerals, herbs, food extracts, or derivatives to be sold without FDA approval. So pregnenolone, considered a food derivative, is once again the subject of intense research. Studies show pregnenolone plays a vital role in: · Improving hormone balance · Promoting mood elevation · Improving energy and motivation · Relieving arthritis · Regenerating nerves · Enhancing memory · Promoting longevity · Reducing stress It's hard to believe that a single substance can do so much. Dr. Hans Selye, who virtually created the field of neuroendocrinology, wrote that pregnenolone " .possesses - at least in traces - every independent main pharmacological action which has hitherto been shown to be exhibited by any steroid hormone. " Dr. Eugene adds: " Generally, the clinical reports of yesteryear indicated that pregnenolone could exert marked improvements on various symptoms of rheumatoid arthritis. It also seemed to affect other autoimmune conditions, e.g., lupus. " And for hormonal balance, it is many times more powerful than progesterone alone. Surprisingly, men benefit just as much as women do from pregnenolone, but in different ways. A study conducted by Rahmawhati Sih, Ph.D. on the effect of pregnenolone on mental function, showed that, although all subjects who had taken pregnenolone showed improvement, there were gender variations. This suggests that pregnenolone is broken down differently by men and women. It appears to have a testosterone-like effect in men and an estrogen-like effect in women. This is really quite remarkable when you think of what it would take for a chemist to program a formulated drug to be adapted by the body as naturally as pregnenolone is. You can rest assured that pregnenolone is well tolerated and its safety has been well documented. Regelson, M. D., and Carol Colman stated in their book, The Super-Hormone Promise: Nature's Antidote to Aging, Pocket Books, 1996, " We know that pregnenolone is safe, well tolerated, and causes no know side effects. " It makes sense to let your body take care of itself naturally. After all, your own body can produce the perfect balance of hormones for you, if you give it a chance. Give it Prenolone Cream with pregnenolone and watch wonderful things happen. PrenoloneT is available as a cream with DHEA (in Prenolone PlusT) or without Quote Link to comment Share on other sites More sharing options...
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