Guest guest Posted November 25, 2004 Report Share Posted November 25, 2004 http://www.aid-diagnostika.com/english/kits/GenID/rdb_2070e_cyp2c19.htm QUOTE: In Asians the alleles CYP2C19*2 and *3 together accounts for 100% of the defective alleles. In the caucasian population 85% of the poor metabolizer are homozygous for the allele CYP2C19*2. The CYP2C19*3 to *8 alleles are extremly seldom. So for the remainig 15% of PMs additional defective alleles must be present (3,6,7). Other important clinically used drugs that are affected by the CYP2C19 polymorphism are certain antidepressants, barbiturates, the anxiolytic diazepam and the antimalarial proguanil (1,8). The most important substrates of CYP2C19 are summorized in Table 1. UNQUOTE http://www.imm.ki.se/ CYPalleles/ THE CRYSTAL STRUCTURE OF CYP3A4, THE MOST PROLIFIC HUMAN DRUG METABOLISING P450, HAS BEEN SOLVED BY ASTEX. http://drnelson.utmem.edu/CytochromeP450.html http://www.astex-technology.co.uk/ONE/29_37.HTML http://www.astex-technology.co.uk/press_release.jsp?press_release_id=83 QUOTE: CYP450 3A4 is generally regarded as the most important family member of these drug metabolising enzymes; it is estimated that as many as 50% of all known drugs interact with this form of cytochrome P450. However, CYP450 3A4 is also the most poorly understood member with respect to its drug metabolising action and represents a major problem in drug development. Astex’s proprietary P450 structural information enables the company and its collaborators to generate lead compounds with optimal drug metabolism and pharmacokinetic properties and so reduce attrition rates in drug development. UNQUOTE NOTE: You can access other related search result lists by clicking on numbers at the bottom of the following linked webpages... http://www.google.com/search?hl=en & q=p450+asian http://www.google.com/search?q=p450+asian & hl=en & lr= & start=10 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=20 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=30 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=40 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=50 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=60 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=150 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=240 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=330 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=420 & sa=N Connie Mullins <cmull3700@...> wrote: Hi Jim, I have a friend who's son is asian and he reacted bad to, if i remember correctly, Zyprexa. I don't have any data, nor do i know where to get it, but they sure need to know over there. Connie --- Jim wrote: --------------------------------- Hi Group, I think I read someone discussing that Asians don't have the enzyme(s) needed to motabolize some or all of the antidepressants. I would love the data as I have a friend who has an inside line into the biggest Chinese paper in the US and he wants to mention Iris Chang's death and what we know about the antidepressants, this could really get the word out to a large segment of our population and maybe save some lives. Let me know what you got if anything. also I have a new CCHR booklet, bigger than the old ones with some great stuff you might like to know about. It's called " The real crisis in metal health " and is writeen by four M.D.'s Send me your address privately if you want one. Best, Jim __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 25, 2004 Report Share Posted November 25, 2004 http://www.aid-diagnostika.com/english/kits/GenID/rdb_2070e_cyp2c19.htm QUOTE: In Asians the alleles CYP2C19*2 and *3 together accounts for 100% of the defective alleles. In the caucasian population 85% of the poor metabolizer are homozygous for the allele CYP2C19*2. The CYP2C19*3 to *8 alleles are extremly seldom. So for the remainig 15% of PMs additional defective alleles must be present (3,6,7). Other important clinically used drugs that are affected by the CYP2C19 polymorphism are certain antidepressants, barbiturates, the anxiolytic diazepam and the antimalarial proguanil (1,8). The most important substrates of CYP2C19 are summorized in Table 1. UNQUOTE http://www.imm.ki.se/ CYPalleles/ THE CRYSTAL STRUCTURE OF CYP3A4, THE MOST PROLIFIC HUMAN DRUG METABOLISING P450, HAS BEEN SOLVED BY ASTEX. http://drnelson.utmem.edu/CytochromeP450.html http://www.astex-technology.co.uk/ONE/29_37.HTML http://www.astex-technology.co.uk/press_release.jsp?press_release_id=83 QUOTE: CYP450 3A4 is generally regarded as the most important family member of these drug metabolising enzymes; it is estimated that as many as 50% of all known drugs interact with this form of cytochrome P450. However, CYP450 3A4 is also the most poorly understood member with respect to its drug metabolising action and represents a major problem in drug development. Astex’s proprietary P450 structural information enables the company and its collaborators to generate lead compounds with optimal drug metabolism and pharmacokinetic properties and so reduce attrition rates in drug development. UNQUOTE NOTE: You can access other related search result lists by clicking on numbers at the bottom of the following linked webpages... http://www.google.com/search?hl=en & q=p450+asian http://www.google.com/search?q=p450+asian & hl=en & lr= & start=10 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=20 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=30 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=40 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=50 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=60 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=150 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=240 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=330 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=420 & sa=N Connie Mullins <cmull3700@...> wrote: Hi Jim, I have a friend who's son is asian and he reacted bad to, if i remember correctly, Zyprexa. I don't have any data, nor do i know where to get it, but they sure need to know over there. Connie --- Jim wrote: --------------------------------- Hi Group, I think I read someone discussing that Asians don't have the enzyme(s) needed to motabolize some or all of the antidepressants. I would love the data as I have a friend who has an inside line into the biggest Chinese paper in the US and he wants to mention Iris Chang's death and what we know about the antidepressants, this could really get the word out to a large segment of our population and maybe save some lives. Let me know what you got if anything. also I have a new CCHR booklet, bigger than the old ones with some great stuff you might like to know about. It's called " The real crisis in metal health " and is writeen by four M.D.'s Send me your address privately if you want one. Best, Jim __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 25, 2004 Report Share Posted November 25, 2004 http://www.aid-diagnostika.com/english/kits/GenID/rdb_2070e_cyp2c19.htm QUOTE: In Asians the alleles CYP2C19*2 and *3 together accounts for 100% of the defective alleles. In the caucasian population 85% of the poor metabolizer are homozygous for the allele CYP2C19*2. The CYP2C19*3 to *8 alleles are extremly seldom. So for the remainig 15% of PMs additional defective alleles must be present (3,6,7). Other important clinically used drugs that are affected by the CYP2C19 polymorphism are certain antidepressants, barbiturates, the anxiolytic diazepam and the antimalarial proguanil (1,8). The most important substrates of CYP2C19 are summorized in Table 1. UNQUOTE http://www.imm.ki.se/ CYPalleles/ THE CRYSTAL STRUCTURE OF CYP3A4, THE MOST PROLIFIC HUMAN DRUG METABOLISING P450, HAS BEEN SOLVED BY ASTEX. http://drnelson.utmem.edu/CytochromeP450.html http://www.astex-technology.co.uk/ONE/29_37.HTML http://www.astex-technology.co.uk/press_release.jsp?press_release_id=83 QUOTE: CYP450 3A4 is generally regarded as the most important family member of these drug metabolising enzymes; it is estimated that as many as 50% of all known drugs interact with this form of cytochrome P450. However, CYP450 3A4 is also the most poorly understood member with respect to its drug metabolising action and represents a major problem in drug development. Astex’s proprietary P450 structural information enables the company and its collaborators to generate lead compounds with optimal drug metabolism and pharmacokinetic properties and so reduce attrition rates in drug development. UNQUOTE NOTE: You can access other related search result lists by clicking on numbers at the bottom of the following linked webpages... http://www.google.com/search?hl=en & q=p450+asian http://www.google.com/search?q=p450+asian & hl=en & lr= & start=10 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=20 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=30 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=40 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=50 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=60 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=150 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=240 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=330 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=420 & sa=N Connie Mullins <cmull3700@...> wrote: Hi Jim, I have a friend who's son is asian and he reacted bad to, if i remember correctly, Zyprexa. I don't have any data, nor do i know where to get it, but they sure need to know over there. Connie --- Jim wrote: --------------------------------- Hi Group, I think I read someone discussing that Asians don't have the enzyme(s) needed to motabolize some or all of the antidepressants. I would love the data as I have a friend who has an inside line into the biggest Chinese paper in the US and he wants to mention Iris Chang's death and what we know about the antidepressants, this could really get the word out to a large segment of our population and maybe save some lives. Let me know what you got if anything. also I have a new CCHR booklet, bigger than the old ones with some great stuff you might like to know about. It's called " The real crisis in metal health " and is writeen by four M.D.'s Send me your address privately if you want one. Best, Jim __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 25, 2004 Report Share Posted November 25, 2004 http://www.aid-diagnostika.com/english/kits/GenID/rdb_2070e_cyp2c19.htm QUOTE: In Asians the alleles CYP2C19*2 and *3 together accounts for 100% of the defective alleles. In the caucasian population 85% of the poor metabolizer are homozygous for the allele CYP2C19*2. The CYP2C19*3 to *8 alleles are extremly seldom. So for the remainig 15% of PMs additional defective alleles must be present (3,6,7). Other important clinically used drugs that are affected by the CYP2C19 polymorphism are certain antidepressants, barbiturates, the anxiolytic diazepam and the antimalarial proguanil (1,8). The most important substrates of CYP2C19 are summorized in Table 1. UNQUOTE http://www.imm.ki.se/ CYPalleles/ THE CRYSTAL STRUCTURE OF CYP3A4, THE MOST PROLIFIC HUMAN DRUG METABOLISING P450, HAS BEEN SOLVED BY ASTEX. http://drnelson.utmem.edu/CytochromeP450.html http://www.astex-technology.co.uk/ONE/29_37.HTML http://www.astex-technology.co.uk/press_release.jsp?press_release_id=83 QUOTE: CYP450 3A4 is generally regarded as the most important family member of these drug metabolising enzymes; it is estimated that as many as 50% of all known drugs interact with this form of cytochrome P450. However, CYP450 3A4 is also the most poorly understood member with respect to its drug metabolising action and represents a major problem in drug development. Astex’s proprietary P450 structural information enables the company and its collaborators to generate lead compounds with optimal drug metabolism and pharmacokinetic properties and so reduce attrition rates in drug development. UNQUOTE NOTE: You can access other related search result lists by clicking on numbers at the bottom of the following linked webpages... http://www.google.com/search?hl=en & q=p450+asian http://www.google.com/search?q=p450+asian & hl=en & lr= & start=10 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=20 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=30 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=40 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=50 & sa=N http://www.google.com/search?q=p450+asian & hl=en & lr= & start=60 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=150 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=240 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=330 & sa=N .... http://www.google.com/search?q=p450+asian & hl=en & lr= & start=420 & sa=N Connie Mullins <cmull3700@...> wrote: Hi Jim, I have a friend who's son is asian and he reacted bad to, if i remember correctly, Zyprexa. I don't have any data, nor do i know where to get it, but they sure need to know over there. Connie --- Jim wrote: --------------------------------- Hi Group, I think I read someone discussing that Asians don't have the enzyme(s) needed to motabolize some or all of the antidepressants. I would love the data as I have a friend who has an inside line into the biggest Chinese paper in the US and he wants to mention Iris Chang's death and what we know about the antidepressants, this could really get the word out to a large segment of our population and maybe save some lives. Let me know what you got if anything. also I have a new CCHR booklet, bigger than the old ones with some great stuff you might like to know about. It's called " The real crisis in metal health " and is writeen by four M.D.'s Send me your address privately if you want one. Best, Jim __________________________________________________ Quote Link to comment Share on other sites More sharing options...
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