841. Pattern of serial HBV DNA level and HCC development in Patients with Liver Cirrhosis

[Guest guest]

http://www.hbvadvocate.org/news/reports/HBV_AASLD_2008/Abstracts/Nov2%20Disease%\

20Progression.htm#Nov2a841

841. Pattern of serial HBV DNA level and HCC development in Patients with Liver

Cirrhosis

J. Kwon; J. Choi; H. Woo; J. Kim; C. You; S. Bae; S. Yoon; N. Han; C. Lee; Y.

Lee

Aims:

Hepatitis B virus (HBV) DNA level was known to be a strong predictor of

hepatocellular carcinoma (HCC) in REVEAL study. The majority of studies assessed

the one time of HBV DNA level at the time of chronic hepatitis or/and HCC

development. The aim of this study is to know whether the pattern of serial HBV

DNA level is associated with the development of HCC.

Methods:

Among 352 patients who diagnosed a newly HBV related HCC between Jan 2005 and

Dec 2007, 49 cirrhosis patients with serial HBV DNA level over 1 year before the

HCC development was enrolled in the study. 98 consecutive cirrhosis patients

with serial HBV DNA level during the same period were recruited as controls. 29

patients (59.2%) in HCC group and 52 patients (55.1%) in the control have been

treated with antiviral agent. The changing patterns of serial HBV DNA were

arbitrarily classified as follows; Type 1, persistently high pattern (™104

copies/mL (C/mL))of DNA titer without interval change of 1-2 log C/mL, type 2,

fluctuation pattern of DNA titer over the range of 2-3 log C/mL, type 3,

decreasing pattern of DNA titer

[Guest guest]

http://www.hbvadvocate.org/news/reports/HBV_AASLD_2008/Abstracts/Nov2%20Disease%\

20Progression.htm#Nov2a841

841. Pattern of serial HBV DNA level and HCC development in Patients with Liver

Cirrhosis

J. Kwon; J. Choi; H. Woo; J. Kim; C. You; S. Bae; S. Yoon; N. Han; C. Lee; Y.

Lee

Aims:

Hepatitis B virus (HBV) DNA level was known to be a strong predictor of

hepatocellular carcinoma (HCC) in REVEAL study. The majority of studies assessed

the one time of HBV DNA level at the time of chronic hepatitis or/and HCC

development. The aim of this study is to know whether the pattern of serial HBV

DNA level is associated with the development of HCC.

Methods:

Among 352 patients who diagnosed a newly HBV related HCC between Jan 2005 and

Dec 2007, 49 cirrhosis patients with serial HBV DNA level over 1 year before the

HCC development was enrolled in the study. 98 consecutive cirrhosis patients

with serial HBV DNA level during the same period were recruited as controls. 29

patients (59.2%) in HCC group and 52 patients (55.1%) in the control have been

treated with antiviral agent. The changing patterns of serial HBV DNA were

arbitrarily classified as follows; Type 1, persistently high pattern (™104

copies/mL (C/mL))of DNA titer without interval change of 1-2 log C/mL, type 2,

fluctuation pattern of DNA titer over the range of 2-3 log C/mL, type 3,

decreasing pattern of DNA titer

[Guest guest]

http://www.hbvadvocate.org/news/reports/HBV_AASLD_2008/Abstracts/Nov2%20Disease%\

20Progression.htm#Nov2a841

841. Pattern of serial HBV DNA level and HCC development in Patients with Liver

Cirrhosis

J. Kwon; J. Choi; H. Woo; J. Kim; C. You; S. Bae; S. Yoon; N. Han; C. Lee; Y.

Lee

Aims:

Hepatitis B virus (HBV) DNA level was known to be a strong predictor of

hepatocellular carcinoma (HCC) in REVEAL study. The majority of studies assessed

the one time of HBV DNA level at the time of chronic hepatitis or/and HCC

development. The aim of this study is to know whether the pattern of serial HBV

DNA level is associated with the development of HCC.

Methods:

Among 352 patients who diagnosed a newly HBV related HCC between Jan 2005 and

Dec 2007, 49 cirrhosis patients with serial HBV DNA level over 1 year before the

HCC development was enrolled in the study. 98 consecutive cirrhosis patients

with serial HBV DNA level during the same period were recruited as controls. 29

patients (59.2%) in HCC group and 52 patients (55.1%) in the control have been

treated with antiviral agent. The changing patterns of serial HBV DNA were

arbitrarily classified as follows; Type 1, persistently high pattern (™104

copies/mL (C/mL))of DNA titer without interval change of 1-2 log C/mL, type 2,

fluctuation pattern of DNA titer over the range of 2-3 log C/mL, type 3,

decreasing pattern of DNA titer

[Guest guest]

http://www.hbvadvocate.org/news/reports/HBV_AASLD_2008/Abstracts/Nov2%20Disease%\

20Progression.htm#Nov2a841

841. Pattern of serial HBV DNA level and HCC development in Patients with Liver

Cirrhosis

J. Kwon; J. Choi; H. Woo; J. Kim; C. You; S. Bae; S. Yoon; N. Han; C. Lee; Y.

Lee

Aims:

Hepatitis B virus (HBV) DNA level was known to be a strong predictor of

hepatocellular carcinoma (HCC) in REVEAL study. The majority of studies assessed

the one time of HBV DNA level at the time of chronic hepatitis or/and HCC

development. The aim of this study is to know whether the pattern of serial HBV

DNA level is associated with the development of HCC.

Methods:

Among 352 patients who diagnosed a newly HBV related HCC between Jan 2005 and

Dec 2007, 49 cirrhosis patients with serial HBV DNA level over 1 year before the

HCC development was enrolled in the study. 98 consecutive cirrhosis patients

with serial HBV DNA level during the same period were recruited as controls. 29

patients (59.2%) in HCC group and 52 patients (55.1%) in the control have been

treated with antiviral agent. The changing patterns of serial HBV DNA were

arbitrarily classified as follows; Type 1, persistently high pattern (™104

copies/mL (C/mL))of DNA titer without interval change of 1-2 log C/mL, type 2,

fluctuation pattern of DNA titer over the range of 2-3 log C/mL, type 3,

decreasing pattern of DNA titer