Acute dystonia during pegylated interferon alpha therapy in a case with chronic hepatitis B infection

[Guest guest]

Clin Neuropharmacol. 2004 May-Jun;27(3):105-7.

Acute dystonia during pegylated interferon alpha therapy in a case with

chronic hepatitis B infection.

Atasoy N, Ustundag Y, Konuk N, Atik L.

Department of Psychiatry, Zonguldak Karaelmas University, Faculty of

Medicine, Kozlu/Zonguldak, Turkey. nurayulus@...

Interferon (IFN) is the most widely prescribed drug of choice for chronic

hepatitis B infection, which is a common health problem in our country.

Therapy with IFN-alpha may be associated with a number of neuropsychiatric

symptoms, such as Parkinsonism, akathisia, seizure, and depressive

disorders. In this case report, we present clinical and laboratory findings

of a case with chronic hepatitis B that developed acute dystonia soon after

the first dose of pegylated interferon alpha. As far as we know, this is the

first report in English literature indicating such an adverse effect of

pegylated interferon alpha.

Publication Types:

Case Reports

PMID: 15190230 [PubMed - indexed for MEDLINE]

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What is dystonia?

Dystonia is a state of abnormal (either excessive or inadequate) muscle

tone. There are many forms of dystonia. Dystonia disorders cause involuntary

movements and prolonged muscle contraction, resulting in twisting body

motions, tremor, and abnormal posture. These movements may involve the

entire body, or only an isolated area.

There are several situations that are associated with dystonia, including

medication-induced

[Guest guest]

Clin Neuropharmacol. 2004 May-Jun;27(3):105-7.

Acute dystonia during pegylated interferon alpha therapy in a case with

chronic hepatitis B infection.

Atasoy N, Ustundag Y, Konuk N, Atik L.

Department of Psychiatry, Zonguldak Karaelmas University, Faculty of

Medicine, Kozlu/Zonguldak, Turkey. nurayulus@...

Interferon (IFN) is the most widely prescribed drug of choice for chronic

hepatitis B infection, which is a common health problem in our country.

Therapy with IFN-alpha may be associated with a number of neuropsychiatric

symptoms, such as Parkinsonism, akathisia, seizure, and depressive

disorders. In this case report, we present clinical and laboratory findings

of a case with chronic hepatitis B that developed acute dystonia soon after

the first dose of pegylated interferon alpha. As far as we know, this is the

first report in English literature indicating such an adverse effect of

pegylated interferon alpha.

Publication Types:

Case Reports

PMID: 15190230 [PubMed - indexed for MEDLINE]

-----------

What is dystonia?

Dystonia is a state of abnormal (either excessive or inadequate) muscle

tone. There are many forms of dystonia. Dystonia disorders cause involuntary

movements and prolonged muscle contraction, resulting in twisting body

motions, tremor, and abnormal posture. These movements may involve the

entire body, or only an isolated area.

There are several situations that are associated with dystonia, including

medication-induced

[Guest guest]

Clin Neuropharmacol. 2004 May-Jun;27(3):105-7.

Acute dystonia during pegylated interferon alpha therapy in a case with

chronic hepatitis B infection.

Atasoy N, Ustundag Y, Konuk N, Atik L.

Department of Psychiatry, Zonguldak Karaelmas University, Faculty of

Medicine, Kozlu/Zonguldak, Turkey. nurayulus@...

Interferon (IFN) is the most widely prescribed drug of choice for chronic

hepatitis B infection, which is a common health problem in our country.

Therapy with IFN-alpha may be associated with a number of neuropsychiatric

symptoms, such as Parkinsonism, akathisia, seizure, and depressive

disorders. In this case report, we present clinical and laboratory findings

of a case with chronic hepatitis B that developed acute dystonia soon after

the first dose of pegylated interferon alpha. As far as we know, this is the

first report in English literature indicating such an adverse effect of

pegylated interferon alpha.

Publication Types:

Case Reports

PMID: 15190230 [PubMed - indexed for MEDLINE]

-----------

What is dystonia?

Dystonia is a state of abnormal (either excessive or inadequate) muscle

tone. There are many forms of dystonia. Dystonia disorders cause involuntary

movements and prolonged muscle contraction, resulting in twisting body

motions, tremor, and abnormal posture. These movements may involve the

entire body, or only an isolated area.

There are several situations that are associated with dystonia, including

medication-induced

[Guest guest]

Clin Neuropharmacol. 2004 May-Jun;27(3):105-7.

Acute dystonia during pegylated interferon alpha therapy in a case with

chronic hepatitis B infection.

Atasoy N, Ustundag Y, Konuk N, Atik L.

Department of Psychiatry, Zonguldak Karaelmas University, Faculty of

Medicine, Kozlu/Zonguldak, Turkey. nurayulus@...

Interferon (IFN) is the most widely prescribed drug of choice for chronic

hepatitis B infection, which is a common health problem in our country.

Therapy with IFN-alpha may be associated with a number of neuropsychiatric

symptoms, such as Parkinsonism, akathisia, seizure, and depressive

disorders. In this case report, we present clinical and laboratory findings

of a case with chronic hepatitis B that developed acute dystonia soon after

the first dose of pegylated interferon alpha. As far as we know, this is the

first report in English literature indicating such an adverse effect of

pegylated interferon alpha.

Publication Types:

Case Reports

PMID: 15190230 [PubMed - indexed for MEDLINE]

-----------

What is dystonia?

Dystonia is a state of abnormal (either excessive or inadequate) muscle

tone. There are many forms of dystonia. Dystonia disorders cause involuntary

movements and prolonged muscle contraction, resulting in twisting body

motions, tremor, and abnormal posture. These movements may involve the

entire body, or only an isolated area.

There are several situations that are associated with dystonia, including

medication-induced