Long-term histologic and virologic outcomes of acute self-limited hepatitis B

[Guest guest]

Hepatology. 2003 May;37(5):1172-9.

Long-term histologic and virologic outcomes of acute self-limited hepatitis

B.

Yuki N, Nagaoka T, Yamashiro M, Mochizuki K, Kaneko A, Yamamoto K, Omura M,

Hikiji K, Kato M.

Department of Gastroenterology, Osaka National Hospital, Japan.

yuki@...

The long-term impact of acute self-limited hepatitis B on the liver is

unknown. Fourteen patients were recalled at a median of 4.2 years (range,

1.8-9.5 years) after the onset of acute hepatitis B. All showed clinical and

serologic recovery with circulating hepatitis B surface antigen (HBsAg)

clearance. Antibody to HBsAg (anti-HBs) had developed in 12 patients. Nine

underwent liver biopsies at a median of 7.2 years, and histologic findings

were evaluated using Ishak scores. Serum samples and frozen liver tissue

were subjected to real-time detection polymerase chain reaction (PCR) to

quantify the surface and X regions of the hepatitis B virus (HBV) genome and

qualitative PCR to detect the covalently closed circular (ccc) HBV DNA

replicative intermediate. Three patients had low levels of circulating HBV

DNA up to 8.9 years after the onset, whereas both HBV DNA surface and X

regions were found in the liver of all 9 patients examined, including 7

negative for serum HBV DNA. Liver viral loads assessed by the 2 regions

showed a significant correlation (r = 0.946; P =.008), and all patients

tested positive for ccc HBV DNA. Liver fibrosis and mild inflammation

persisted in 8 patients. The fibrosis stage had relation to peak serum HBV

DNA in the acute phase (P =.046) but not to liver viral loads in the late

convalescent phase. In conclusion, occult HBV infection persists in the

liver and is accompanied by abnormal liver histology for a decade after

complete clinical recovery from acute self-limited hepatitis B.

PMID: 12717399 [PubMed]

[Guest guest]

Hepatology. 2003 May;37(5):1172-9.

Long-term histologic and virologic outcomes of acute self-limited hepatitis

B.

Yuki N, Nagaoka T, Yamashiro M, Mochizuki K, Kaneko A, Yamamoto K, Omura M,

Hikiji K, Kato M.

Department of Gastroenterology, Osaka National Hospital, Japan.

yuki@...

The long-term impact of acute self-limited hepatitis B on the liver is

unknown. Fourteen patients were recalled at a median of 4.2 years (range,

1.8-9.5 years) after the onset of acute hepatitis B. All showed clinical and

serologic recovery with circulating hepatitis B surface antigen (HBsAg)

clearance. Antibody to HBsAg (anti-HBs) had developed in 12 patients. Nine

underwent liver biopsies at a median of 7.2 years, and histologic findings

were evaluated using Ishak scores. Serum samples and frozen liver tissue

were subjected to real-time detection polymerase chain reaction (PCR) to

quantify the surface and X regions of the hepatitis B virus (HBV) genome and

qualitative PCR to detect the covalently closed circular (ccc) HBV DNA

replicative intermediate. Three patients had low levels of circulating HBV

DNA up to 8.9 years after the onset, whereas both HBV DNA surface and X

regions were found in the liver of all 9 patients examined, including 7

negative for serum HBV DNA. Liver viral loads assessed by the 2 regions

showed a significant correlation (r = 0.946; P =.008), and all patients

tested positive for ccc HBV DNA. Liver fibrosis and mild inflammation

persisted in 8 patients. The fibrosis stage had relation to peak serum HBV

DNA in the acute phase (P =.046) but not to liver viral loads in the late

convalescent phase. In conclusion, occult HBV infection persists in the

liver and is accompanied by abnormal liver histology for a decade after

complete clinical recovery from acute self-limited hepatitis B.

PMID: 12717399 [PubMed]

[Guest guest]

Hepatology. 2003 May;37(5):1172-9.

Long-term histologic and virologic outcomes of acute self-limited hepatitis

B.

Yuki N, Nagaoka T, Yamashiro M, Mochizuki K, Kaneko A, Yamamoto K, Omura M,

Hikiji K, Kato M.

Department of Gastroenterology, Osaka National Hospital, Japan.

yuki@...

The long-term impact of acute self-limited hepatitis B on the liver is

unknown. Fourteen patients were recalled at a median of 4.2 years (range,

1.8-9.5 years) after the onset of acute hepatitis B. All showed clinical and

serologic recovery with circulating hepatitis B surface antigen (HBsAg)

clearance. Antibody to HBsAg (anti-HBs) had developed in 12 patients. Nine

underwent liver biopsies at a median of 7.2 years, and histologic findings

were evaluated using Ishak scores. Serum samples and frozen liver tissue

were subjected to real-time detection polymerase chain reaction (PCR) to

quantify the surface and X regions of the hepatitis B virus (HBV) genome and

qualitative PCR to detect the covalently closed circular (ccc) HBV DNA

replicative intermediate. Three patients had low levels of circulating HBV

DNA up to 8.9 years after the onset, whereas both HBV DNA surface and X

regions were found in the liver of all 9 patients examined, including 7

negative for serum HBV DNA. Liver viral loads assessed by the 2 regions

showed a significant correlation (r = 0.946; P =.008), and all patients

tested positive for ccc HBV DNA. Liver fibrosis and mild inflammation

persisted in 8 patients. The fibrosis stage had relation to peak serum HBV

DNA in the acute phase (P =.046) but not to liver viral loads in the late

convalescent phase. In conclusion, occult HBV infection persists in the

liver and is accompanied by abnormal liver histology for a decade after

complete clinical recovery from acute self-limited hepatitis B.

PMID: 12717399 [PubMed]

[Guest guest]

Hepatology. 2003 May;37(5):1172-9.

Long-term histologic and virologic outcomes of acute self-limited hepatitis

B.

Yuki N, Nagaoka T, Yamashiro M, Mochizuki K, Kaneko A, Yamamoto K, Omura M,

Hikiji K, Kato M.

Department of Gastroenterology, Osaka National Hospital, Japan.

yuki@...

The long-term impact of acute self-limited hepatitis B on the liver is

unknown. Fourteen patients were recalled at a median of 4.2 years (range,

1.8-9.5 years) after the onset of acute hepatitis B. All showed clinical and

serologic recovery with circulating hepatitis B surface antigen (HBsAg)

clearance. Antibody to HBsAg (anti-HBs) had developed in 12 patients. Nine

underwent liver biopsies at a median of 7.2 years, and histologic findings

were evaluated using Ishak scores. Serum samples and frozen liver tissue

were subjected to real-time detection polymerase chain reaction (PCR) to

quantify the surface and X regions of the hepatitis B virus (HBV) genome and

qualitative PCR to detect the covalently closed circular (ccc) HBV DNA

replicative intermediate. Three patients had low levels of circulating HBV

DNA up to 8.9 years after the onset, whereas both HBV DNA surface and X

regions were found in the liver of all 9 patients examined, including 7

negative for serum HBV DNA. Liver viral loads assessed by the 2 regions

showed a significant correlation (r = 0.946; P =.008), and all patients

tested positive for ccc HBV DNA. Liver fibrosis and mild inflammation

persisted in 8 patients. The fibrosis stage had relation to peak serum HBV

DNA in the acute phase (P =.046) but not to liver viral loads in the late

convalescent phase. In conclusion, occult HBV infection persists in the

liver and is accompanied by abnormal liver histology for a decade after

complete clinical recovery from acute self-limited hepatitis B.

PMID: 12717399 [PubMed]