Age-Related Lymphocyte and Neutrophil Levels in Children of Hepatitis C-Infected Women

[Guest guest]

http://www.pidj.org/pt/re/pidj/abstract.00006454-200809000-00007.htm;jsessionid=\

Lj2CMnhGwxHD4GDP4sSHQn9Sn6PJ7yhNhN0T4n0tZ8SVgBR1ypvz!-1052912739!181195629!8091!\

-1

Age-Related Lymphocyte and Neutrophil Levels in Children of Hepatitis C-Infected

Women.

Original Studies

Pediatric Infectious Disease Journal. 27(9):800-807, September 2008.

Pembrey, Lucy PhD *; Newell, Marie-Louise PhD *+; Tovo, Pier-Angelo MD ++;

European Paediatric Hepatitis C Virus Network

Abstract:

Background: Investigation of immunologic values in children vertically exposed

to hepatitis C virus (HCV) infection could help explain the higher risk of

infection in girls and indicate mechanisms of spontaneous viral clearance and

possible long-term immunologic effects.

Methods: Prospective study of children born to HCV-infected women. Lymphocyte

and neutrophil measurements were age-standardized using the LMS method (this

summarizes the changing age distribution of a variable). Associations between

maternal and infant characteristics and lymphocyte and neutrophil z-scores were

quantified using linear regression allowing for repeated measures.

Results: HCV-infected children, girls, and those born to HCV/human

immunodeficiency virus (HIV)-coinfected women had significantly higher

lymphocyte z-scores than HCV-uninfected children, boys, and children born to

HCV-only-infected women, respectively. Peak absolute lymphocytes were

significantly lower for infected children with evidence of viral clearance than

for persistently infected children. Girls also had significantly higher

neutrophil z-scores than boys but HCV-infected children had significantly lower

neutrophil z-scores than uninfected children.

Conclusions: The gender associations are in line with those observed among

children born to HIV-infected women, suggesting general gender-based differences

in response to infection. Age-related standards for uninfected children could be

used to assess immune function in other pediatric diseases and these results

suggest that gender-specific reference values should be used at least for the

first 2 years of life.

[Guest guest]

http://www.pidj.org/pt/re/pidj/abstract.00006454-200809000-00007.htm;jsessionid=\

Lj2CMnhGwxHD4GDP4sSHQn9Sn6PJ7yhNhN0T4n0tZ8SVgBR1ypvz!-1052912739!181195629!8091!\

-1

Age-Related Lymphocyte and Neutrophil Levels in Children of Hepatitis C-Infected

Women.

Original Studies

Pediatric Infectious Disease Journal. 27(9):800-807, September 2008.

Pembrey, Lucy PhD *; Newell, Marie-Louise PhD *+; Tovo, Pier-Angelo MD ++;

European Paediatric Hepatitis C Virus Network

Abstract:

Background: Investigation of immunologic values in children vertically exposed

to hepatitis C virus (HCV) infection could help explain the higher risk of

infection in girls and indicate mechanisms of spontaneous viral clearance and

possible long-term immunologic effects.

Methods: Prospective study of children born to HCV-infected women. Lymphocyte

and neutrophil measurements were age-standardized using the LMS method (this

summarizes the changing age distribution of a variable). Associations between

maternal and infant characteristics and lymphocyte and neutrophil z-scores were

quantified using linear regression allowing for repeated measures.

Results: HCV-infected children, girls, and those born to HCV/human

immunodeficiency virus (HIV)-coinfected women had significantly higher

lymphocyte z-scores than HCV-uninfected children, boys, and children born to

HCV-only-infected women, respectively. Peak absolute lymphocytes were

significantly lower for infected children with evidence of viral clearance than

for persistently infected children. Girls also had significantly higher

neutrophil z-scores than boys but HCV-infected children had significantly lower

neutrophil z-scores than uninfected children.

Conclusions: The gender associations are in line with those observed among

children born to HIV-infected women, suggesting general gender-based differences

in response to infection. Age-related standards for uninfected children could be

used to assess immune function in other pediatric diseases and these results

suggest that gender-specific reference values should be used at least for the

first 2 years of life.

[Guest guest]

http://www.pidj.org/pt/re/pidj/abstract.00006454-200809000-00007.htm;jsessionid=\

Lj2CMnhGwxHD4GDP4sSHQn9Sn6PJ7yhNhN0T4n0tZ8SVgBR1ypvz!-1052912739!181195629!8091!\

-1

Age-Related Lymphocyte and Neutrophil Levels in Children of Hepatitis C-Infected

Women.

Original Studies

Pediatric Infectious Disease Journal. 27(9):800-807, September 2008.

Pembrey, Lucy PhD *; Newell, Marie-Louise PhD *+; Tovo, Pier-Angelo MD ++;

European Paediatric Hepatitis C Virus Network

Abstract:

Background: Investigation of immunologic values in children vertically exposed

to hepatitis C virus (HCV) infection could help explain the higher risk of

infection in girls and indicate mechanisms of spontaneous viral clearance and

possible long-term immunologic effects.

Methods: Prospective study of children born to HCV-infected women. Lymphocyte

and neutrophil measurements were age-standardized using the LMS method (this

summarizes the changing age distribution of a variable). Associations between

maternal and infant characteristics and lymphocyte and neutrophil z-scores were

quantified using linear regression allowing for repeated measures.

Results: HCV-infected children, girls, and those born to HCV/human

immunodeficiency virus (HIV)-coinfected women had significantly higher

lymphocyte z-scores than HCV-uninfected children, boys, and children born to

HCV-only-infected women, respectively. Peak absolute lymphocytes were

significantly lower for infected children with evidence of viral clearance than

for persistently infected children. Girls also had significantly higher

neutrophil z-scores than boys but HCV-infected children had significantly lower

neutrophil z-scores than uninfected children.

Conclusions: The gender associations are in line with those observed among

children born to HIV-infected women, suggesting general gender-based differences

in response to infection. Age-related standards for uninfected children could be

used to assess immune function in other pediatric diseases and these results

suggest that gender-specific reference values should be used at least for the

first 2 years of life.

[Guest guest]

http://www.pidj.org/pt/re/pidj/abstract.00006454-200809000-00007.htm;jsessionid=\

Lj2CMnhGwxHD4GDP4sSHQn9Sn6PJ7yhNhN0T4n0tZ8SVgBR1ypvz!-1052912739!181195629!8091!\

-1

Age-Related Lymphocyte and Neutrophil Levels in Children of Hepatitis C-Infected

Women.

Original Studies

Pediatric Infectious Disease Journal. 27(9):800-807, September 2008.

Pembrey, Lucy PhD *; Newell, Marie-Louise PhD *+; Tovo, Pier-Angelo MD ++;

European Paediatric Hepatitis C Virus Network

Abstract:

Background: Investigation of immunologic values in children vertically exposed

to hepatitis C virus (HCV) infection could help explain the higher risk of

infection in girls and indicate mechanisms of spontaneous viral clearance and

possible long-term immunologic effects.

Methods: Prospective study of children born to HCV-infected women. Lymphocyte

and neutrophil measurements were age-standardized using the LMS method (this

summarizes the changing age distribution of a variable). Associations between

maternal and infant characteristics and lymphocyte and neutrophil z-scores were

quantified using linear regression allowing for repeated measures.

Results: HCV-infected children, girls, and those born to HCV/human

immunodeficiency virus (HIV)-coinfected women had significantly higher

lymphocyte z-scores than HCV-uninfected children, boys, and children born to

HCV-only-infected women, respectively. Peak absolute lymphocytes were

significantly lower for infected children with evidence of viral clearance than

for persistently infected children. Girls also had significantly higher

neutrophil z-scores than boys but HCV-infected children had significantly lower

neutrophil z-scores than uninfected children.

Conclusions: The gender associations are in line with those observed among

children born to HIV-infected women, suggesting general gender-based differences

in response to infection. Age-related standards for uninfected children could be

used to assess immune function in other pediatric diseases and these results

suggest that gender-specific reference values should be used at least for the

first 2 years of life.