Serum levels of tumor necrosis factor- correlate with severity of hepatic encephalopathy due to chronic liver failure

[Guest guest]

Liver International

Volume 24 Issue 2 Page 110 - April 2004

doi:10.1111/j.1478-3231.2004.0894.x

Clinical Studies

Serum levels of tumor necrosis factor- correlate with severity of hepatic

encephalopathy due to chronic liver failure

M. Odeh1, E. Sabo2, I. Srugo3 and A. Oliven1

Background: Several studies have shown that serum levels of tumor necrosis

factor- (TNF) are significantly elevated in patients with acute and chronic

liver diseases, where these elevations are independent of the etiology of

the underlying disease. Serum levels of TNF are significantly higher in

patients with cirrhosis than in those without cirrhosis, reaching the

highest levels in decompensated cirrhosis. It has also been shown that

plasma levels of TNF correlate with the severity of hepatic encephalopathy

(HE) in fulminant hepatic failure. However, still there are no published

data regarding the relationship between blood levels of TNF and the presence

or severity of HE in patients with chronic liver failure.

Aim: The aim of this study is to determine the relationship between serum

levels of TNF and clinical grades of HE in patients with liver cirrhosis.

Methods: Using a commercially available high-sensitivity enzyme-linked

immunosorbent assay kit, serum levels of TNF were measured in 74 patients

with liver cirrhosis in various clinical grades of HE (grades 0-4).

Results: The mean±SEM values of serum levels of TNF at presentation in

patients with grade 0 of HE (n=23), grade 1 (n=12), grade 2 (n=14), grade 3

(n=16), and grade 4 (n=9) were 4.50±0.46, 9.10±1.0, 12.98±1.22, 21.51±2.63,

and 58.26±19.7 pg/ml, respectively. A significant positive correlation was

found between serum levels of TNF and the severity of HE (P<0.0001).

Conclusion: Serum levels of TNF correlate positively with the severity of HE

in patients with chronic liver failure.

[Guest guest]

Liver International

Volume 24 Issue 2 Page 110 - April 2004

doi:10.1111/j.1478-3231.2004.0894.x

Clinical Studies

Serum levels of tumor necrosis factor- correlate with severity of hepatic

encephalopathy due to chronic liver failure

M. Odeh1, E. Sabo2, I. Srugo3 and A. Oliven1

Background: Several studies have shown that serum levels of tumor necrosis

factor- (TNF) are significantly elevated in patients with acute and chronic

liver diseases, where these elevations are independent of the etiology of

the underlying disease. Serum levels of TNF are significantly higher in

patients with cirrhosis than in those without cirrhosis, reaching the

highest levels in decompensated cirrhosis. It has also been shown that

plasma levels of TNF correlate with the severity of hepatic encephalopathy

(HE) in fulminant hepatic failure. However, still there are no published

data regarding the relationship between blood levels of TNF and the presence

or severity of HE in patients with chronic liver failure.

Aim: The aim of this study is to determine the relationship between serum

levels of TNF and clinical grades of HE in patients with liver cirrhosis.

Methods: Using a commercially available high-sensitivity enzyme-linked

immunosorbent assay kit, serum levels of TNF were measured in 74 patients

with liver cirrhosis in various clinical grades of HE (grades 0-4).

Results: The mean±SEM values of serum levels of TNF at presentation in

patients with grade 0 of HE (n=23), grade 1 (n=12), grade 2 (n=14), grade 3

(n=16), and grade 4 (n=9) were 4.50±0.46, 9.10±1.0, 12.98±1.22, 21.51±2.63,

and 58.26±19.7 pg/ml, respectively. A significant positive correlation was

found between serum levels of TNF and the severity of HE (P<0.0001).

Conclusion: Serum levels of TNF correlate positively with the severity of HE

in patients with chronic liver failure.

[Guest guest]

Liver International

Volume 24 Issue 2 Page 110 - April 2004

doi:10.1111/j.1478-3231.2004.0894.x

Clinical Studies

Serum levels of tumor necrosis factor- correlate with severity of hepatic

encephalopathy due to chronic liver failure

M. Odeh1, E. Sabo2, I. Srugo3 and A. Oliven1

Background: Several studies have shown that serum levels of tumor necrosis

factor- (TNF) are significantly elevated in patients with acute and chronic

liver diseases, where these elevations are independent of the etiology of

the underlying disease. Serum levels of TNF are significantly higher in

patients with cirrhosis than in those without cirrhosis, reaching the

highest levels in decompensated cirrhosis. It has also been shown that

plasma levels of TNF correlate with the severity of hepatic encephalopathy

(HE) in fulminant hepatic failure. However, still there are no published

data regarding the relationship between blood levels of TNF and the presence

or severity of HE in patients with chronic liver failure.

Aim: The aim of this study is to determine the relationship between serum

levels of TNF and clinical grades of HE in patients with liver cirrhosis.

Methods: Using a commercially available high-sensitivity enzyme-linked

immunosorbent assay kit, serum levels of TNF were measured in 74 patients

with liver cirrhosis in various clinical grades of HE (grades 0-4).

Results: The mean±SEM values of serum levels of TNF at presentation in

patients with grade 0 of HE (n=23), grade 1 (n=12), grade 2 (n=14), grade 3

(n=16), and grade 4 (n=9) were 4.50±0.46, 9.10±1.0, 12.98±1.22, 21.51±2.63,

and 58.26±19.7 pg/ml, respectively. A significant positive correlation was

found between serum levels of TNF and the severity of HE (P<0.0001).

Conclusion: Serum levels of TNF correlate positively with the severity of HE

in patients with chronic liver failure.

[Guest guest]

Liver International

Volume 24 Issue 2 Page 110 - April 2004

doi:10.1111/j.1478-3231.2004.0894.x

Clinical Studies

Serum levels of tumor necrosis factor- correlate with severity of hepatic

encephalopathy due to chronic liver failure

M. Odeh1, E. Sabo2, I. Srugo3 and A. Oliven1

Background: Several studies have shown that serum levels of tumor necrosis

factor- (TNF) are significantly elevated in patients with acute and chronic

liver diseases, where these elevations are independent of the etiology of

the underlying disease. Serum levels of TNF are significantly higher in

patients with cirrhosis than in those without cirrhosis, reaching the

highest levels in decompensated cirrhosis. It has also been shown that

plasma levels of TNF correlate with the severity of hepatic encephalopathy

(HE) in fulminant hepatic failure. However, still there are no published

data regarding the relationship between blood levels of TNF and the presence

or severity of HE in patients with chronic liver failure.

Aim: The aim of this study is to determine the relationship between serum

levels of TNF and clinical grades of HE in patients with liver cirrhosis.

Methods: Using a commercially available high-sensitivity enzyme-linked

immunosorbent assay kit, serum levels of TNF were measured in 74 patients

with liver cirrhosis in various clinical grades of HE (grades 0-4).

Results: The mean±SEM values of serum levels of TNF at presentation in

patients with grade 0 of HE (n=23), grade 1 (n=12), grade 2 (n=14), grade 3

(n=16), and grade 4 (n=9) were 4.50±0.46, 9.10±1.0, 12.98±1.22, 21.51±2.63,

and 58.26±19.7 pg/ml, respectively. A significant positive correlation was

found between serum levels of TNF and the severity of HE (P<0.0001).

Conclusion: Serum levels of TNF correlate positively with the severity of HE

in patients with chronic liver failure.