RNA interference small RNAs effectively fight viral hepatitis

[Guest guest]

Liver International

Volume 24 Issue 6 Page 526 - December 2004

doi:10.1111/j.1478-3231.2004.0960.x

Review Article

RNA interference small RNAs effectively fight viral hepatitis

Amir Shlomai1,2 and Yosef Shaul1

Abstract:

RNA interference (RNAi) is the process of sequence-specific gene silencing,

initiated by double-stranded RNA that is homologous in sequence to the

target gene. This unique phenomenon has been extensively investigated during

the last few years not only in the context of its mechanism and its possible

role in the regulation of gene expression and cell function, but also as a

potential powerful tool for gene therapy. Targeting essential viral genes or

oncogenic alleles are only some of the possible applications of RNAi in the

field of gene-directed therapy. This review covers the potential use of RNAi

against hepatitis B and hepatitis C viruses, the main pathogens causing

chronic liver disease. The major milestones along the discovery of RNAi will

also be covered.

[Guest guest]

Liver International

Volume 24 Issue 6 Page 526 - December 2004

doi:10.1111/j.1478-3231.2004.0960.x

Review Article

RNA interference small RNAs effectively fight viral hepatitis

Amir Shlomai1,2 and Yosef Shaul1

Abstract:

RNA interference (RNAi) is the process of sequence-specific gene silencing,

initiated by double-stranded RNA that is homologous in sequence to the

target gene. This unique phenomenon has been extensively investigated during

the last few years not only in the context of its mechanism and its possible

role in the regulation of gene expression and cell function, but also as a

potential powerful tool for gene therapy. Targeting essential viral genes or

oncogenic alleles are only some of the possible applications of RNAi in the

field of gene-directed therapy. This review covers the potential use of RNAi

against hepatitis B and hepatitis C viruses, the main pathogens causing

chronic liver disease. The major milestones along the discovery of RNAi will

also be covered.

[Guest guest]

Liver International

Volume 24 Issue 6 Page 526 - December 2004

doi:10.1111/j.1478-3231.2004.0960.x

Review Article

RNA interference small RNAs effectively fight viral hepatitis

Amir Shlomai1,2 and Yosef Shaul1

Abstract:

RNA interference (RNAi) is the process of sequence-specific gene silencing,

initiated by double-stranded RNA that is homologous in sequence to the

target gene. This unique phenomenon has been extensively investigated during

the last few years not only in the context of its mechanism and its possible

role in the regulation of gene expression and cell function, but also as a

potential powerful tool for gene therapy. Targeting essential viral genes or

oncogenic alleles are only some of the possible applications of RNAi in the

field of gene-directed therapy. This review covers the potential use of RNAi

against hepatitis B and hepatitis C viruses, the main pathogens causing

chronic liver disease. The major milestones along the discovery of RNAi will

also be covered.

[Guest guest]

Liver International

Volume 24 Issue 6 Page 526 - December 2004

doi:10.1111/j.1478-3231.2004.0960.x

Review Article

RNA interference small RNAs effectively fight viral hepatitis

Amir Shlomai1,2 and Yosef Shaul1

Abstract:

RNA interference (RNAi) is the process of sequence-specific gene silencing,

initiated by double-stranded RNA that is homologous in sequence to the

target gene. This unique phenomenon has been extensively investigated during

the last few years not only in the context of its mechanism and its possible

role in the regulation of gene expression and cell function, but also as a

potential powerful tool for gene therapy. Targeting essential viral genes or

oncogenic alleles are only some of the possible applications of RNAi in the

field of gene-directed therapy. This review covers the potential use of RNAi

against hepatitis B and hepatitis C viruses, the main pathogens causing

chronic liver disease. The major milestones along the discovery of RNAi will

also be covered.