Allergic disease after pediatric liver transplantation with systemic tacrolimus and cyclosporine a therapy

[Guest guest]

57 of 93

Transplantation Proceedings

Volume 35, Issue 8 , December 2003, Pages 3039-3041

doi:10.1016/j.transproceed.2003.10.033 Cite or link using doi

Copyright © 2003 Elsevier Science Inc. All rights reserved.

Liver transplantation: complications

Allergic disease after pediatric liver transplantation with systemic

tacrolimus and cyclosporine a therapy

C. Arikan, , a, M. Kilicb, Y. Tokatb and S. Aydogdua

a Department of Pediatric Gastroenterology, Hepatology and Nutrition (C.A.,

S.A.), Izmir, Turkey

b Department of General Surgery (M.K., Y.T.), Ege University Organ

Transplant and Research Center, Izmir, Turkey

Available online 18 December 2003.

Abstract

Cyclosporine A (CsA) and tacrolimus (Tac), both calcineurin inhibitors, have

been used extensively for immunosuppressive therapy in pediatric liver

transplant recipients. They share a similar mechanism of action, the

inhibition of cytokine gene transcription primarily interleukin-2 (IL-2) in

T lymphocytes. Despite the strong immunosuppressive property, there are

several reports of food allergy in pediatric transplant recipients under Tac

immunosuppression, but not CsA. In this paper we report on 3 of 50 pediatric

liver transplant recipients diagnosed with food allergy and asthma while

receiving systemic Tac/CsA immunosupression and the discuss the role of

calcineurin inhibitors in this situation.

Corresponding author. Address reprint requests to Dr Cigdem Arikan 250.sok

Mustafa Cukur Sitesi B1 Blk. No:6 D:1, 35500 , Izmir, , Turkey

[Guest guest]

57 of 93

Transplantation Proceedings

Volume 35, Issue 8 , December 2003, Pages 3039-3041

doi:10.1016/j.transproceed.2003.10.033 Cite or link using doi

Copyright © 2003 Elsevier Science Inc. All rights reserved.

Liver transplantation: complications

Allergic disease after pediatric liver transplantation with systemic

tacrolimus and cyclosporine a therapy

C. Arikan, , a, M. Kilicb, Y. Tokatb and S. Aydogdua

a Department of Pediatric Gastroenterology, Hepatology and Nutrition (C.A.,

S.A.), Izmir, Turkey

b Department of General Surgery (M.K., Y.T.), Ege University Organ

Transplant and Research Center, Izmir, Turkey

Available online 18 December 2003.

Abstract

Cyclosporine A (CsA) and tacrolimus (Tac), both calcineurin inhibitors, have

been used extensively for immunosuppressive therapy in pediatric liver

transplant recipients. They share a similar mechanism of action, the

inhibition of cytokine gene transcription primarily interleukin-2 (IL-2) in

T lymphocytes. Despite the strong immunosuppressive property, there are

several reports of food allergy in pediatric transplant recipients under Tac

immunosuppression, but not CsA. In this paper we report on 3 of 50 pediatric

liver transplant recipients diagnosed with food allergy and asthma while

receiving systemic Tac/CsA immunosupression and the discuss the role of

calcineurin inhibitors in this situation.

Corresponding author. Address reprint requests to Dr Cigdem Arikan 250.sok

Mustafa Cukur Sitesi B1 Blk. No:6 D:1, 35500 , Izmir, , Turkey

[Guest guest]

57 of 93

Transplantation Proceedings

Volume 35, Issue 8 , December 2003, Pages 3039-3041

doi:10.1016/j.transproceed.2003.10.033 Cite or link using doi

Copyright © 2003 Elsevier Science Inc. All rights reserved.

Liver transplantation: complications

Allergic disease after pediatric liver transplantation with systemic

tacrolimus and cyclosporine a therapy

C. Arikan, , a, M. Kilicb, Y. Tokatb and S. Aydogdua

a Department of Pediatric Gastroenterology, Hepatology and Nutrition (C.A.,

S.A.), Izmir, Turkey

b Department of General Surgery (M.K., Y.T.), Ege University Organ

Transplant and Research Center, Izmir, Turkey

Available online 18 December 2003.

Abstract

Cyclosporine A (CsA) and tacrolimus (Tac), both calcineurin inhibitors, have

been used extensively for immunosuppressive therapy in pediatric liver

transplant recipients. They share a similar mechanism of action, the

inhibition of cytokine gene transcription primarily interleukin-2 (IL-2) in

T lymphocytes. Despite the strong immunosuppressive property, there are

several reports of food allergy in pediatric transplant recipients under Tac

immunosuppression, but not CsA. In this paper we report on 3 of 50 pediatric

liver transplant recipients diagnosed with food allergy and asthma while

receiving systemic Tac/CsA immunosupression and the discuss the role of

calcineurin inhibitors in this situation.

Corresponding author. Address reprint requests to Dr Cigdem Arikan 250.sok

Mustafa Cukur Sitesi B1 Blk. No:6 D:1, 35500 , Izmir, , Turkey

[Guest guest]

57 of 93

Transplantation Proceedings

Volume 35, Issue 8 , December 2003, Pages 3039-3041

doi:10.1016/j.transproceed.2003.10.033 Cite or link using doi

Copyright © 2003 Elsevier Science Inc. All rights reserved.

Liver transplantation: complications

Allergic disease after pediatric liver transplantation with systemic

tacrolimus and cyclosporine a therapy

C. Arikan, , a, M. Kilicb, Y. Tokatb and S. Aydogdua

a Department of Pediatric Gastroenterology, Hepatology and Nutrition (C.A.,

S.A.), Izmir, Turkey

b Department of General Surgery (M.K., Y.T.), Ege University Organ

Transplant and Research Center, Izmir, Turkey

Available online 18 December 2003.

Abstract

Cyclosporine A (CsA) and tacrolimus (Tac), both calcineurin inhibitors, have

been used extensively for immunosuppressive therapy in pediatric liver

transplant recipients. They share a similar mechanism of action, the

inhibition of cytokine gene transcription primarily interleukin-2 (IL-2) in

T lymphocytes. Despite the strong immunosuppressive property, there are

several reports of food allergy in pediatric transplant recipients under Tac

immunosuppression, but not CsA. In this paper we report on 3 of 50 pediatric

liver transplant recipients diagnosed with food allergy and asthma while

receiving systemic Tac/CsA immunosupression and the discuss the role of

calcineurin inhibitors in this situation.

Corresponding author. Address reprint requests to Dr Cigdem Arikan 250.sok

Mustafa Cukur Sitesi B1 Blk. No:6 D:1, 35500 , Izmir, , Turkey