Assessment of the combined effect of plasma exchange and plasma perfusion on patients with severe hepatitis awaiting orthotopic liver transplantation

[Guest guest]

IJAO 2004; 27: 40 - 44

Assessment of the combined effect of plasma exchange and plasma perfusion on

patients with severe hepatitis awaiting orthotopic liver transplantation

Y.-J. Wang1, N.-H. He1, Z.-W. Wang1, R.-Z. Niu1, J. Liu1, J.-J. Li1, M.-D.

Li1, Y.-M. Wang1

1Artificial Liver Unit, Southwest Hospital, Third Military Medical

University, Chongqing - China

ABSTRACT

To determine if plasma exchange combined with plasma perfusion is a reliable

and effective temporary liver support treatment for patients on the waiting

list for OLT, we tested this method in 5 patients with end-stage and 3

patients with middle-stage severe hepatitis. Four patients were successfully

controlled until a donor liver was available 4 to 13 days later. In

contrast, the remaining 4 patients were not adequately controlled by this

treatment and experienced aggravated disease progression, dying 3 to 8 days

after treatment while still awaiting OLT. Of those 4 patients who received

OLT, 2 patients died from multi-organ failure caused by hepatic failure,

while the other 2 survived. These findings show that plasma exchange

combined with plasma perfusion provides temporary support for some patients

on the waiting list for OLT. The ability of patients to successfully bridge

to OLT is closely associated with the degree of liver failure,

complications, multi-organ failure, and the length of the waiting period for

a donor liver. (Int J Artif Organs 2004; 27: 40-4)

[Guest guest]

IJAO 2004; 27: 40 - 44

Assessment of the combined effect of plasma exchange and plasma perfusion on

patients with severe hepatitis awaiting orthotopic liver transplantation

Y.-J. Wang1, N.-H. He1, Z.-W. Wang1, R.-Z. Niu1, J. Liu1, J.-J. Li1, M.-D.

Li1, Y.-M. Wang1

1Artificial Liver Unit, Southwest Hospital, Third Military Medical

University, Chongqing - China

ABSTRACT

To determine if plasma exchange combined with plasma perfusion is a reliable

and effective temporary liver support treatment for patients on the waiting

list for OLT, we tested this method in 5 patients with end-stage and 3

patients with middle-stage severe hepatitis. Four patients were successfully

controlled until a donor liver was available 4 to 13 days later. In

contrast, the remaining 4 patients were not adequately controlled by this

treatment and experienced aggravated disease progression, dying 3 to 8 days

after treatment while still awaiting OLT. Of those 4 patients who received

OLT, 2 patients died from multi-organ failure caused by hepatic failure,

while the other 2 survived. These findings show that plasma exchange

combined with plasma perfusion provides temporary support for some patients

on the waiting list for OLT. The ability of patients to successfully bridge

to OLT is closely associated with the degree of liver failure,

complications, multi-organ failure, and the length of the waiting period for

a donor liver. (Int J Artif Organs 2004; 27: 40-4)

[Guest guest]

IJAO 2004; 27: 40 - 44

Assessment of the combined effect of plasma exchange and plasma perfusion on

patients with severe hepatitis awaiting orthotopic liver transplantation

Y.-J. Wang1, N.-H. He1, Z.-W. Wang1, R.-Z. Niu1, J. Liu1, J.-J. Li1, M.-D.

Li1, Y.-M. Wang1

1Artificial Liver Unit, Southwest Hospital, Third Military Medical

University, Chongqing - China

ABSTRACT

To determine if plasma exchange combined with plasma perfusion is a reliable

and effective temporary liver support treatment for patients on the waiting

list for OLT, we tested this method in 5 patients with end-stage and 3

patients with middle-stage severe hepatitis. Four patients were successfully

controlled until a donor liver was available 4 to 13 days later. In

contrast, the remaining 4 patients were not adequately controlled by this

treatment and experienced aggravated disease progression, dying 3 to 8 days

after treatment while still awaiting OLT. Of those 4 patients who received

OLT, 2 patients died from multi-organ failure caused by hepatic failure,

while the other 2 survived. These findings show that plasma exchange

combined with plasma perfusion provides temporary support for some patients

on the waiting list for OLT. The ability of patients to successfully bridge

to OLT is closely associated with the degree of liver failure,

complications, multi-organ failure, and the length of the waiting period for

a donor liver. (Int J Artif Organs 2004; 27: 40-4)

[Guest guest]

IJAO 2004; 27: 40 - 44

Assessment of the combined effect of plasma exchange and plasma perfusion on

patients with severe hepatitis awaiting orthotopic liver transplantation

Y.-J. Wang1, N.-H. He1, Z.-W. Wang1, R.-Z. Niu1, J. Liu1, J.-J. Li1, M.-D.

Li1, Y.-M. Wang1

1Artificial Liver Unit, Southwest Hospital, Third Military Medical

University, Chongqing - China

ABSTRACT

To determine if plasma exchange combined with plasma perfusion is a reliable

and effective temporary liver support treatment for patients on the waiting

list for OLT, we tested this method in 5 patients with end-stage and 3

patients with middle-stage severe hepatitis. Four patients were successfully

controlled until a donor liver was available 4 to 13 days later. In

contrast, the remaining 4 patients were not adequately controlled by this

treatment and experienced aggravated disease progression, dying 3 to 8 days

after treatment while still awaiting OLT. Of those 4 patients who received

OLT, 2 patients died from multi-organ failure caused by hepatic failure,

while the other 2 survived. These findings show that plasma exchange

combined with plasma perfusion provides temporary support for some patients

on the waiting list for OLT. The ability of patients to successfully bridge

to OLT is closely associated with the degree of liver failure,

complications, multi-organ failure, and the length of the waiting period for

a donor liver. (Int J Artif Organs 2004; 27: 40-4)