NIH FUNDS FIRST NATIONAL SNP GENOTYPING CENTER AT BROAD INSTITUTE

[Guest guest]

> U.S. Department of Health and Human Services

>

> NATIONAL INSTITUTES OF HEALTH

>

> NIH News

>

> National Center for Research Resources (NCRR)

> http://www.ncrr.nih.gov/

>

>

> FOR IMMEDIATE RELEASE

> Tuesday, October 5, 2004

>

>

> CONTACTS:

> Joyce Mc/Ann Puderbaugh, NCRR

> 301-435-0888

>

> Nhuch,

> Broad Institute of MIT and Harvard

> 617-252-1064

>

>

> NIH FUNDS FIRST NATIONAL SNP GENOTYPING CENTER AT BROAD INSTITUTE

>

> BETHESDA, MARYLAND -- The National Center for Research Resources (NCRR), a

> component of the National Institutes of Health (NIH), announced today it

> will

> fund the first national center for high-throughput genotyping dedicated

> solely

> to large-scale SNP (single nucleotide polymorphism) analysis at the Eli

> and

> Edythe L. Broad Institute of MIT and Harvard University in Cambridge,

> Mass.

> A

> five-year cooperative agreement will provide over $14 million to create a

> high-

> capacity resource so that U.S. researchers can quickly and

> cost-effectively

> carry out large-scale studies of genetic variation in humans and animals

> to

> advance disease gene identification.

>

> Research on genetic variation is aimed at improving the diagnosis and

> treatment

> of numerous diseases of humans that may have significant genetic

> components

> --

> such as Type 1 diabetes, schizophrenia, and some types of cancer -- by

> identifying specific genetic markers, or genotypes, that are associated

> with

>

> particular diseases or responses to drug therapies. Studies examining

> genetic

> variation in animals such as mice and rats can identify genetic regions

> that,

> in humans, may contribute to complex diseases such as diabetes and

> hypertension.

>

> " The tremendous potential of genetic research makes it critical that we

> develop this central resource so investigators around the country can

> access

>

> high capacity genotyping with the additional benefits of economies of

> scale,

>

> quality assurance and data sharing, " said NCRR Division for Clinical

> Research

> Resources Director Hayward, M.D., Ph.D. " The demand for genotyping

> will grow exponentially as investigators prioritize potential targets for

> treatment and as members of afflicted families try to better estimate

> their

> risk for a particular condition. "

> Many diseases can be traced to inherited differences in each individual's

> genes. The most common type of variation in the human genome is the single

> nucleotide polymorphism, or SNP (pronounced " snip " ). A SNP is a single DNA

> base pair, or unit of DNA, the sequence of which can vary from individual

> to

>

> individual. It is estimated that there are at least 10 million SNPs in the

> human population, although no two individuals will vary at every such

> position.

> Scientists have found that certain SNP combinations are associated with

> predisposition to particular diseases or adverse drug reactions.

>

> The new center will offer tools to aid in the selection, discovery, and

> analysis of SNPs by providing broad access to flexible, accurate, and

> affordable genotyping and sequencing. Integrated computational tools will

> help

> researchers manage large, well-characterized collections of patient data

> and

>

> design experiments using secure informatics tools for sample management.

> An integrated SNP selection tool will be provided to automate queries and

> create SNP panels. A secure, web-based environment will provide access to

> a

> database linked to an in-house DNA repository and all samples will be

> coded

> to

> assure subject confidentiality. Results will be accessible to the

> investigators

> through a secure database integrated with a suite of data management and

> analytic tools for analysis of correlations among variants and with

> disease

> phenotypes.

>

> Because investigators use different technologies based on the scales and

> configurations needed, a menu of services will be offered using three

> different

> technology platforms. When fully operational, the center will be able to

> process from 200 million to as many as billions of genotypes per year,

> depending on the technology platform used and the needs of outside users.

> The

> cost for genotyping will be on the order of pennies per genotype, varying

> according to the technology platform used. Two decades ago, the cost was

> $10

>

> per genotype, and prices are expected to drop further as technology

> improves. A

> portion of the center's annual budget will be used to partially support

> compelling genotyping research projects, to be selected by a steering

> committee.

>

> The first genotyping studies within the NCRR-funded Broad Institute

> genotyping

> center will be performed in early 2005. Researchers interested in access

> to

> the

> center or applying for subsidized genotyping should contact the Broad

> Institute

> at ncrr_gc@... or refer to the Broad Institute Web site,

> www.broad.mit.edu, which will contain details on the application process

> later

> this fall.

>

> Stacey , Ph.D., the new center's principal investigator and

> director,

>

> currently oversees the Broad's Genetic Analysis platform where she manages

> all

> of the genotyping, SNP discovery, and production activities related to

> human

>

> genetics. She also serves as scientific director of Broad Institute's

> portion

> of the International HapMap Project, a collaborative public project

> designed

> to

> advance genetic research and its application to disease gene discovery by

> determining patterns of genetic variation throughout the human genome

> (www.hapmap.org).

>

> " We are thrilled that the NCRR has selected the Broad Institute for this

> important responsibility. Human genetics is undergoing an extraordinary

> transformation, which is leading to the ability to take a comprehensive

> view

> of

> all human genetic variation and its association with disease. The National

> Genotyping Center at the Broad will make this capability accessible to

> many

> biomedical researchers and thereby have a direct impact on the

> understanding

> of

> disease, " said Lander, Ph.D., founding director of the Broad

> Institute.

> High-resolution images of SNP technologies used by the Genotyping Center

> are

>

> available at http://www.ncrr.nih.gov/genotyping.asp.

>

> NCRR is part of the National Institutes of Health, an agency of the

> Department

> of Health and Human Services. NCRR is the nation's leading federal sponsor

> of

> resources that enable advances in many areas of biomedical research. NCRR

> support provides the scientific research community with access to a

> diverse

> array of biomedical research technologies, instrumentation, specialized

> basic

> and clinical research facilities, animal models, genetic stocks, and such

> biomaterials as cell lines, tissues, and organs. Additional information

> about

> NCRR can be found at www.ncrr.nih.gov.

>

>

> ##

>

> This NIH News Release is available online at:

> http://www.nih.gov/news/pr/oct2004/ncrr-05.htm

>

> To subscribe (or unsubscribe) from this list, go to

> http://list.nih.gov/cgi-bin/wa?SUBED1=nihpress & A=1.

>

[Guest guest]

> U.S. Department of Health and Human Services

>

> NATIONAL INSTITUTES OF HEALTH

>

> NIH News

>

> National Center for Research Resources (NCRR)

> http://www.ncrr.nih.gov/

>

>

> FOR IMMEDIATE RELEASE

> Tuesday, October 5, 2004

>

>

> CONTACTS:

> Joyce Mc/Ann Puderbaugh, NCRR

> 301-435-0888

>

> Nhuch,

> Broad Institute of MIT and Harvard

> 617-252-1064

>

>

> NIH FUNDS FIRST NATIONAL SNP GENOTYPING CENTER AT BROAD INSTITUTE

>

> BETHESDA, MARYLAND -- The National Center for Research Resources (NCRR), a

> component of the National Institutes of Health (NIH), announced today it

> will

> fund the first national center for high-throughput genotyping dedicated

> solely

> to large-scale SNP (single nucleotide polymorphism) analysis at the Eli

> and

> Edythe L. Broad Institute of MIT and Harvard University in Cambridge,

> Mass.

> A

> five-year cooperative agreement will provide over $14 million to create a

> high-

> capacity resource so that U.S. researchers can quickly and

> cost-effectively

> carry out large-scale studies of genetic variation in humans and animals

> to

> advance disease gene identification.

>

> Research on genetic variation is aimed at improving the diagnosis and

> treatment

> of numerous diseases of humans that may have significant genetic

> components

> --

> such as Type 1 diabetes, schizophrenia, and some types of cancer -- by

> identifying specific genetic markers, or genotypes, that are associated

> with

>

> particular diseases or responses to drug therapies. Studies examining

> genetic

> variation in animals such as mice and rats can identify genetic regions

> that,

> in humans, may contribute to complex diseases such as diabetes and

> hypertension.

>

> " The tremendous potential of genetic research makes it critical that we

> develop this central resource so investigators around the country can

> access

>

> high capacity genotyping with the additional benefits of economies of

> scale,

>

> quality assurance and data sharing, " said NCRR Division for Clinical

> Research

> Resources Director Hayward, M.D., Ph.D. " The demand for genotyping

> will grow exponentially as investigators prioritize potential targets for

> treatment and as members of afflicted families try to better estimate

> their

> risk for a particular condition. "

> Many diseases can be traced to inherited differences in each individual's

> genes. The most common type of variation in the human genome is the single

> nucleotide polymorphism, or SNP (pronounced " snip " ). A SNP is a single DNA

> base pair, or unit of DNA, the sequence of which can vary from individual

> to

>

> individual. It is estimated that there are at least 10 million SNPs in the

> human population, although no two individuals will vary at every such

> position.

> Scientists have found that certain SNP combinations are associated with

> predisposition to particular diseases or adverse drug reactions.

>

> The new center will offer tools to aid in the selection, discovery, and

> analysis of SNPs by providing broad access to flexible, accurate, and

> affordable genotyping and sequencing. Integrated computational tools will

> help

> researchers manage large, well-characterized collections of patient data

> and

>

> design experiments using secure informatics tools for sample management.

> An integrated SNP selection tool will be provided to automate queries and

> create SNP panels. A secure, web-based environment will provide access to

> a

> database linked to an in-house DNA repository and all samples will be

> coded

> to

> assure subject confidentiality. Results will be accessible to the

> investigators

> through a secure database integrated with a suite of data management and

> analytic tools for analysis of correlations among variants and with

> disease

> phenotypes.

>

> Because investigators use different technologies based on the scales and

> configurations needed, a menu of services will be offered using three

> different

> technology platforms. When fully operational, the center will be able to

> process from 200 million to as many as billions of genotypes per year,

> depending on the technology platform used and the needs of outside users.

> The

> cost for genotyping will be on the order of pennies per genotype, varying

> according to the technology platform used. Two decades ago, the cost was

> $10

>

> per genotype, and prices are expected to drop further as technology

> improves. A

> portion of the center's annual budget will be used to partially support

> compelling genotyping research projects, to be selected by a steering

> committee.

>

> The first genotyping studies within the NCRR-funded Broad Institute

> genotyping

> center will be performed in early 2005. Researchers interested in access

> to

> the

> center or applying for subsidized genotyping should contact the Broad

> Institute

> at ncrr_gc@... or refer to the Broad Institute Web site,

> www.broad.mit.edu, which will contain details on the application process

> later

> this fall.

>

> Stacey , Ph.D., the new center's principal investigator and

> director,

>

> currently oversees the Broad's Genetic Analysis platform where she manages

> all

> of the genotyping, SNP discovery, and production activities related to

> human

>

> genetics. She also serves as scientific director of Broad Institute's

> portion

> of the International HapMap Project, a collaborative public project

> designed

> to

> advance genetic research and its application to disease gene discovery by

> determining patterns of genetic variation throughout the human genome

> (www.hapmap.org).

>

> " We are thrilled that the NCRR has selected the Broad Institute for this

> important responsibility. Human genetics is undergoing an extraordinary

> transformation, which is leading to the ability to take a comprehensive

> view

> of

> all human genetic variation and its association with disease. The National

> Genotyping Center at the Broad will make this capability accessible to

> many

> biomedical researchers and thereby have a direct impact on the

> understanding

> of

> disease, " said Lander, Ph.D., founding director of the Broad

> Institute.

> High-resolution images of SNP technologies used by the Genotyping Center

> are

>

> available at http://www.ncrr.nih.gov/genotyping.asp.

>

> NCRR is part of the National Institutes of Health, an agency of the

> Department

> of Health and Human Services. NCRR is the nation's leading federal sponsor

> of

> resources that enable advances in many areas of biomedical research. NCRR

> support provides the scientific research community with access to a

> diverse

> array of biomedical research technologies, instrumentation, specialized

> basic

> and clinical research facilities, animal models, genetic stocks, and such

> biomaterials as cell lines, tissues, and organs. Additional information

> about

> NCRR can be found at www.ncrr.nih.gov.

>

>

> ##

>

> This NIH News Release is available online at:

> http://www.nih.gov/news/pr/oct2004/ncrr-05.htm

>

> To subscribe (or unsubscribe) from this list, go to

> http://list.nih.gov/cgi-bin/wa?SUBED1=nihpress & A=1.

>

[Guest guest]

> U.S. Department of Health and Human Services

>

> NATIONAL INSTITUTES OF HEALTH

>

> NIH News

>

> National Center for Research Resources (NCRR)

> http://www.ncrr.nih.gov/

>

>

> FOR IMMEDIATE RELEASE

> Tuesday, October 5, 2004

>

>

> CONTACTS:

> Joyce Mc/Ann Puderbaugh, NCRR

> 301-435-0888

>

> Nhuch,

> Broad Institute of MIT and Harvard

> 617-252-1064

>

>

> NIH FUNDS FIRST NATIONAL SNP GENOTYPING CENTER AT BROAD INSTITUTE

>

> BETHESDA, MARYLAND -- The National Center for Research Resources (NCRR), a

> component of the National Institutes of Health (NIH), announced today it

> will

> fund the first national center for high-throughput genotyping dedicated

> solely

> to large-scale SNP (single nucleotide polymorphism) analysis at the Eli

> and

> Edythe L. Broad Institute of MIT and Harvard University in Cambridge,

> Mass.

> A

> five-year cooperative agreement will provide over $14 million to create a

> high-

> capacity resource so that U.S. researchers can quickly and

> cost-effectively

> carry out large-scale studies of genetic variation in humans and animals

> to

> advance disease gene identification.

>

> Research on genetic variation is aimed at improving the diagnosis and

> treatment

> of numerous diseases of humans that may have significant genetic

> components

> --

> such as Type 1 diabetes, schizophrenia, and some types of cancer -- by

> identifying specific genetic markers, or genotypes, that are associated

> with

>

> particular diseases or responses to drug therapies. Studies examining

> genetic

> variation in animals such as mice and rats can identify genetic regions

> that,

> in humans, may contribute to complex diseases such as diabetes and

> hypertension.

>

> " The tremendous potential of genetic research makes it critical that we

> develop this central resource so investigators around the country can

> access

>

> high capacity genotyping with the additional benefits of economies of

> scale,

>

> quality assurance and data sharing, " said NCRR Division for Clinical

> Research

> Resources Director Hayward, M.D., Ph.D. " The demand for genotyping

> will grow exponentially as investigators prioritize potential targets for

> treatment and as members of afflicted families try to better estimate

> their

> risk for a particular condition. "

> Many diseases can be traced to inherited differences in each individual's

> genes. The most common type of variation in the human genome is the single

> nucleotide polymorphism, or SNP (pronounced " snip " ). A SNP is a single DNA

> base pair, or unit of DNA, the sequence of which can vary from individual

> to

>

> individual. It is estimated that there are at least 10 million SNPs in the

> human population, although no two individuals will vary at every such

> position.

> Scientists have found that certain SNP combinations are associated with

> predisposition to particular diseases or adverse drug reactions.

>

> The new center will offer tools to aid in the selection, discovery, and

> analysis of SNPs by providing broad access to flexible, accurate, and

> affordable genotyping and sequencing. Integrated computational tools will

> help

> researchers manage large, well-characterized collections of patient data

> and

>

> design experiments using secure informatics tools for sample management.

> An integrated SNP selection tool will be provided to automate queries and

> create SNP panels. A secure, web-based environment will provide access to

> a

> database linked to an in-house DNA repository and all samples will be

> coded

> to

> assure subject confidentiality. Results will be accessible to the

> investigators

> through a secure database integrated with a suite of data management and

> analytic tools for analysis of correlations among variants and with

> disease

> phenotypes.

>

> Because investigators use different technologies based on the scales and

> configurations needed, a menu of services will be offered using three

> different

> technology platforms. When fully operational, the center will be able to

> process from 200 million to as many as billions of genotypes per year,

> depending on the technology platform used and the needs of outside users.

> The

> cost for genotyping will be on the order of pennies per genotype, varying

> according to the technology platform used. Two decades ago, the cost was

> $10

>

> per genotype, and prices are expected to drop further as technology

> improves. A

> portion of the center's annual budget will be used to partially support

> compelling genotyping research projects, to be selected by a steering

> committee.

>

> The first genotyping studies within the NCRR-funded Broad Institute

> genotyping

> center will be performed in early 2005. Researchers interested in access

> to

> the

> center or applying for subsidized genotyping should contact the Broad

> Institute

> at ncrr_gc@... or refer to the Broad Institute Web site,

> www.broad.mit.edu, which will contain details on the application process

> later

> this fall.

>

> Stacey , Ph.D., the new center's principal investigator and

> director,

>

> currently oversees the Broad's Genetic Analysis platform where she manages

> all

> of the genotyping, SNP discovery, and production activities related to

> human

>

> genetics. She also serves as scientific director of Broad Institute's

> portion

> of the International HapMap Project, a collaborative public project

> designed

> to

> advance genetic research and its application to disease gene discovery by

> determining patterns of genetic variation throughout the human genome

> (www.hapmap.org).

>

> " We are thrilled that the NCRR has selected the Broad Institute for this

> important responsibility. Human genetics is undergoing an extraordinary

> transformation, which is leading to the ability to take a comprehensive

> view

> of

> all human genetic variation and its association with disease. The National

> Genotyping Center at the Broad will make this capability accessible to

> many

> biomedical researchers and thereby have a direct impact on the

> understanding

> of

> disease, " said Lander, Ph.D., founding director of the Broad

> Institute.

> High-resolution images of SNP technologies used by the Genotyping Center

> are

>

> available at http://www.ncrr.nih.gov/genotyping.asp.

>

> NCRR is part of the National Institutes of Health, an agency of the

> Department

> of Health and Human Services. NCRR is the nation's leading federal sponsor

> of

> resources that enable advances in many areas of biomedical research. NCRR

> support provides the scientific research community with access to a

> diverse

> array of biomedical research technologies, instrumentation, specialized

> basic

> and clinical research facilities, animal models, genetic stocks, and such

> biomaterials as cell lines, tissues, and organs. Additional information

> about

> NCRR can be found at www.ncrr.nih.gov.

>

>

> ##

>

> This NIH News Release is available online at:

> http://www.nih.gov/news/pr/oct2004/ncrr-05.htm

>

> To subscribe (or unsubscribe) from this list, go to

> http://list.nih.gov/cgi-bin/wa?SUBED1=nihpress & A=1.

>

[Guest guest]

> U.S. Department of Health and Human Services

>

> NATIONAL INSTITUTES OF HEALTH

>

> NIH News

>

> National Center for Research Resources (NCRR)

> http://www.ncrr.nih.gov/

>

>

> FOR IMMEDIATE RELEASE

> Tuesday, October 5, 2004

>

>

> CONTACTS:

> Joyce Mc/Ann Puderbaugh, NCRR

> 301-435-0888

>

> Nhuch,

> Broad Institute of MIT and Harvard

> 617-252-1064

>

>

> NIH FUNDS FIRST NATIONAL SNP GENOTYPING CENTER AT BROAD INSTITUTE

>

> BETHESDA, MARYLAND -- The National Center for Research Resources (NCRR), a

> component of the National Institutes of Health (NIH), announced today it

> will

> fund the first national center for high-throughput genotyping dedicated

> solely

> to large-scale SNP (single nucleotide polymorphism) analysis at the Eli

> and

> Edythe L. Broad Institute of MIT and Harvard University in Cambridge,

> Mass.

> A

> five-year cooperative agreement will provide over $14 million to create a

> high-

> capacity resource so that U.S. researchers can quickly and

> cost-effectively

> carry out large-scale studies of genetic variation in humans and animals

> to

> advance disease gene identification.

>

> Research on genetic variation is aimed at improving the diagnosis and

> treatment

> of numerous diseases of humans that may have significant genetic

> components

> --

> such as Type 1 diabetes, schizophrenia, and some types of cancer -- by

> identifying specific genetic markers, or genotypes, that are associated

> with

>

> particular diseases or responses to drug therapies. Studies examining

> genetic

> variation in animals such as mice and rats can identify genetic regions

> that,

> in humans, may contribute to complex diseases such as diabetes and

> hypertension.

>

> " The tremendous potential of genetic research makes it critical that we

> develop this central resource so investigators around the country can

> access

>

> high capacity genotyping with the additional benefits of economies of

> scale,

>

> quality assurance and data sharing, " said NCRR Division for Clinical

> Research

> Resources Director Hayward, M.D., Ph.D. " The demand for genotyping

> will grow exponentially as investigators prioritize potential targets for

> treatment and as members of afflicted families try to better estimate

> their

> risk for a particular condition. "

> Many diseases can be traced to inherited differences in each individual's

> genes. The most common type of variation in the human genome is the single

> nucleotide polymorphism, or SNP (pronounced " snip " ). A SNP is a single DNA

> base pair, or unit of DNA, the sequence of which can vary from individual

> to

>

> individual. It is estimated that there are at least 10 million SNPs in the

> human population, although no two individuals will vary at every such

> position.

> Scientists have found that certain SNP combinations are associated with

> predisposition to particular diseases or adverse drug reactions.

>

> The new center will offer tools to aid in the selection, discovery, and

> analysis of SNPs by providing broad access to flexible, accurate, and

> affordable genotyping and sequencing. Integrated computational tools will

> help

> researchers manage large, well-characterized collections of patient data

> and

>

> design experiments using secure informatics tools for sample management.

> An integrated SNP selection tool will be provided to automate queries and

> create SNP panels. A secure, web-based environment will provide access to

> a

> database linked to an in-house DNA repository and all samples will be

> coded

> to

> assure subject confidentiality. Results will be accessible to the

> investigators

> through a secure database integrated with a suite of data management and

> analytic tools for analysis of correlations among variants and with

> disease

> phenotypes.

>

> Because investigators use different technologies based on the scales and

> configurations needed, a menu of services will be offered using three

> different

> technology platforms. When fully operational, the center will be able to

> process from 200 million to as many as billions of genotypes per year,

> depending on the technology platform used and the needs of outside users.

> The

> cost for genotyping will be on the order of pennies per genotype, varying

> according to the technology platform used. Two decades ago, the cost was

> $10

>

> per genotype, and prices are expected to drop further as technology

> improves. A

> portion of the center's annual budget will be used to partially support

> compelling genotyping research projects, to be selected by a steering

> committee.

>

> The first genotyping studies within the NCRR-funded Broad Institute

> genotyping

> center will be performed in early 2005. Researchers interested in access

> to

> the

> center or applying for subsidized genotyping should contact the Broad

> Institute

> at ncrr_gc@... or refer to the Broad Institute Web site,

> www.broad.mit.edu, which will contain details on the application process

> later

> this fall.

>

> Stacey , Ph.D., the new center's principal investigator and

> director,

>

> currently oversees the Broad's Genetic Analysis platform where she manages

> all

> of the genotyping, SNP discovery, and production activities related to

> human

>

> genetics. She also serves as scientific director of Broad Institute's

> portion

> of the International HapMap Project, a collaborative public project

> designed

> to

> advance genetic research and its application to disease gene discovery by

> determining patterns of genetic variation throughout the human genome

> (www.hapmap.org).

>

> " We are thrilled that the NCRR has selected the Broad Institute for this

> important responsibility. Human genetics is undergoing an extraordinary

> transformation, which is leading to the ability to take a comprehensive

> view

> of

> all human genetic variation and its association with disease. The National

> Genotyping Center at the Broad will make this capability accessible to

> many

> biomedical researchers and thereby have a direct impact on the

> understanding

> of

> disease, " said Lander, Ph.D., founding director of the Broad

> Institute.

> High-resolution images of SNP technologies used by the Genotyping Center

> are

>

> available at http://www.ncrr.nih.gov/genotyping.asp.

>

> NCRR is part of the National Institutes of Health, an agency of the

> Department

> of Health and Human Services. NCRR is the nation's leading federal sponsor

> of

> resources that enable advances in many areas of biomedical research. NCRR

> support provides the scientific research community with access to a

> diverse

> array of biomedical research technologies, instrumentation, specialized

> basic

> and clinical research facilities, animal models, genetic stocks, and such

> biomaterials as cell lines, tissues, and organs. Additional information

> about

> NCRR can be found at www.ncrr.nih.gov.

>

>

> ##

>

> This NIH News Release is available online at:

> http://www.nih.gov/news/pr/oct2004/ncrr-05.htm

>

> To subscribe (or unsubscribe) from this list, go to

> http://list.nih.gov/cgi-bin/wa?SUBED1=nihpress & A=1.

>