Effect of iron depletion on serum markers of fibrogenesis, oxidative stress and

[Guest guest]

Effect of iron depletion on serum markers of fibrogenesis, oxidative stress

and serum liver enzymes in chronic hepatitis C: results of a pilot study

Authors: , 1; Tung, Bruce Y.1; Croghan, Anne1; Kowdley, Kris

V.1

Source: Liver International, Volume 27, Number 2, March 2007, pp. 268-273(6)

Publisher: Blackwell Publishing

Abstract:

Background:

Hepatic iron deposition has been associated with decreased response to

interferon-á monotherapy, and has been speculated to contribute to disease

progression in chronic hepatitis C (CHC). We performed this study to

evaluate the effect of iron depletion on biochemical and virologic markers,

and markers of lipid peroxidation and fibrogenesis. Materials and Methods:

Eighteen patients with CHC who did not have a virologic response to

interferon monotherapy underwent weekly phlebotomies until iron depletion

(serum ferritin <50 & #8201;ng/ml). Serum levels of alanine transaminase

(ALT), hepatitis C virus-RNA, transferrin saturation, ferritin,

8-isoprostane, hylauronic acid, amino-terminal procollagen III peptide and

YKL-40 were measured before and after iron depletion. Results:

There was a statistically significant reduction of serum ALT, transferrin

saturation and serum ferritin after iron depletion (range 4-11

phlebotomies). Serum ALT returned to normal after iron depletion in four

(22%) patients. There was a significant reduction in serum procollagen III

peptide level among patients who achieved biochemical response. No

significant reduction was noted in serum levels of other markers.

Conclusions:

Iron depletion was associated with a biochemical response in 22% of patients

who did not respond to interferon monotherapy. There was a significant

reduction in a key marker of fibrogenesis among patients with biochemical

response. These data support longer-term studies of iron depletion in CHC.

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_________________________________________________________________

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[Guest guest]

Effect of iron depletion on serum markers of fibrogenesis, oxidative stress

and serum liver enzymes in chronic hepatitis C: results of a pilot study

Authors: , 1; Tung, Bruce Y.1; Croghan, Anne1; Kowdley, Kris

V.1

Source: Liver International, Volume 27, Number 2, March 2007, pp. 268-273(6)

Publisher: Blackwell Publishing

Abstract:

Background:

Hepatic iron deposition has been associated with decreased response to

interferon-á monotherapy, and has been speculated to contribute to disease

progression in chronic hepatitis C (CHC). We performed this study to

evaluate the effect of iron depletion on biochemical and virologic markers,

and markers of lipid peroxidation and fibrogenesis. Materials and Methods:

Eighteen patients with CHC who did not have a virologic response to

interferon monotherapy underwent weekly phlebotomies until iron depletion

(serum ferritin <50 & #8201;ng/ml). Serum levels of alanine transaminase

(ALT), hepatitis C virus-RNA, transferrin saturation, ferritin,

8-isoprostane, hylauronic acid, amino-terminal procollagen III peptide and

YKL-40 were measured before and after iron depletion. Results:

There was a statistically significant reduction of serum ALT, transferrin

saturation and serum ferritin after iron depletion (range 4-11

phlebotomies). Serum ALT returned to normal after iron depletion in four

(22%) patients. There was a significant reduction in serum procollagen III

peptide level among patients who achieved biochemical response. No

significant reduction was noted in serum levels of other markers.

Conclusions:

Iron depletion was associated with a biochemical response in 22% of patients

who did not respond to interferon monotherapy. There was a significant

reduction in a key marker of fibrogenesis among patients with biochemical

response. These data support longer-term studies of iron depletion in CHC.

http://www.ingentaconnect.com/content/mksg/liv/2007/00000027/00000002/art00015;j\

sessionid=febeo1tam2jfa.victoria

_________________________________________________________________

Mortgage refinance is hot 1) Rates near 30-yr lows 2) Good credit get

intro-rate 4.625%*

https://www2.nextag.com/goto.jsp?product=100000035 & url=%2fst.jsp & tm=y & search=mor\

tgage_text_links_88_h2a5f & s=4056 & p=5117 & disc=y & vers=743