Guest guest Posted September 8, 2008 Report Posted September 8, 2008 http://www3.interscience.wiley.com/journal/120848818/abstract Liver International Volume 28 Issue 9, Pages 1298 - 1304 Published Online: 25 Jul 2008 CLINICAL STUDIES Changing aetiology of liver dysfunction in the new generation of a hepatitis B and C-endemic area: cross-sectional studies on adolescents born in the first 10 years after universal hepatitis B vaccination Jung-Ta Kao 1 , Jing-Houng Wang 1 , Chao-Hung Hung 1 , Tsung-Hui Hu 1 , Chuan-Mo Lee 1 , Shu-Fen Hung 1 and Sheng-Nan Lu 1 1 Department of Internal Medicine, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Division of Hepato-Gastroenterology, Chang Gung University College of Medicine, Kaohsiung, Taiwan Correspondence Sheng-Nan Lu MD, MPH, PhD, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Division of Hepato-Gastroenterology, #123 Ta Pei Road, Niao Sung 833, Kaohsiung, Taiwan Tel: +886 7 731 7123, ext. 8301 Fax: +886 7 732 2402 e-mail: juten@... ABSTRACT Background/Aim: Geographical variation in viral hepatitis infection complicates various levels of liver diseases. This study elucidates the changing aetiology of alanine transaminase elevation (ALT levels>40 IU/L) in a previously hepatitis-endemic township. Design/Methods: Five cross-sectional screenings were performed on teenagers born from 1984 to 1993. We examined hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (anti-HCV), ALT and body mass index, and additionally checked hepatitis B envelope antigen (HBeAg) for positive HBsAg and HCV RNA for positive anti-HCV. Teenagers with ALT elevation underwent an ultrasonography examination. Results: This study enrolled 1788 (93.7%) of 1909 students, discovering individual prevalence of HBsAg (6.3%), anti-hepatitis B core (anti-HBc) (15.5%), anti-HCV (2.2%), overweight (22.4%), obesity (12.8%) and ALT>40 IU/L (3.7%). HBsAg and anti-HBc prevalence declined with trends, while obesity increased with trends (P Quote
Guest guest Posted September 8, 2008 Report Posted September 8, 2008 http://www3.interscience.wiley.com/journal/120848818/abstract Liver International Volume 28 Issue 9, Pages 1298 - 1304 Published Online: 25 Jul 2008 CLINICAL STUDIES Changing aetiology of liver dysfunction in the new generation of a hepatitis B and C-endemic area: cross-sectional studies on adolescents born in the first 10 years after universal hepatitis B vaccination Jung-Ta Kao 1 , Jing-Houng Wang 1 , Chao-Hung Hung 1 , Tsung-Hui Hu 1 , Chuan-Mo Lee 1 , Shu-Fen Hung 1 and Sheng-Nan Lu 1 1 Department of Internal Medicine, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Division of Hepato-Gastroenterology, Chang Gung University College of Medicine, Kaohsiung, Taiwan Correspondence Sheng-Nan Lu MD, MPH, PhD, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Division of Hepato-Gastroenterology, #123 Ta Pei Road, Niao Sung 833, Kaohsiung, Taiwan Tel: +886 7 731 7123, ext. 8301 Fax: +886 7 732 2402 e-mail: juten@... ABSTRACT Background/Aim: Geographical variation in viral hepatitis infection complicates various levels of liver diseases. This study elucidates the changing aetiology of alanine transaminase elevation (ALT levels>40 IU/L) in a previously hepatitis-endemic township. Design/Methods: Five cross-sectional screenings were performed on teenagers born from 1984 to 1993. We examined hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (anti-HCV), ALT and body mass index, and additionally checked hepatitis B envelope antigen (HBeAg) for positive HBsAg and HCV RNA for positive anti-HCV. Teenagers with ALT elevation underwent an ultrasonography examination. Results: This study enrolled 1788 (93.7%) of 1909 students, discovering individual prevalence of HBsAg (6.3%), anti-hepatitis B core (anti-HBc) (15.5%), anti-HCV (2.2%), overweight (22.4%), obesity (12.8%) and ALT>40 IU/L (3.7%). HBsAg and anti-HBc prevalence declined with trends, while obesity increased with trends (P Quote
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