- OT (But maybe not...) More info on Fluoride & Thyroid Function

[Guest guest]

This was taken from another group I frequent:

~The Avenging Angel

=========================================================

REFERENCE SET: FLUORIDE & THE THYROID

All Fluoride compounds - inorganic and organic - affect thyroid hormone

activity.

©September 19, 2000 s Schuld, PFPC

Here are several hundred papers with links to a few thousand more. Included

are studies on hormone transport, inhibition of hormone synthesis,

fluorosis and goiter, G protein activation, fluoride concentration in the

thyroid gland, thyroid cancer, fluoride as TSH agonist, fluoride-iodine

antagonism etc.

Ahn CS, Rosenberg IN - " Iodine metabolism in thyroid slices - effects of

TSH, dibutyril cyclic 3',5'-AMP, NaF and prostaglandin E1 " Endocrinology

86(2):396-405 (1970) (Fluoride = TSH)

Amir S, Menezez-Ferreira M, Shimohigashi Y, Chen HC, Nisula B, Weintraub BD

- " Activities of deglycosylated thyrotropin at the thyroid membrane

receptor-adenylate cyclase system " J Endocrinol Invest

8(6):537-41 (1985)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3009595 & fo

rm=6 & db=m & Dopt=b (HF deglycosylates TSH)

Amir SM, Kubota K, Tramontano D, Ingbar SH, Keutmann HT - " The carbohydrate

moiety of bovine thyrotropin is essential for full bioactivity but not for

receptor recognition " Endocrinology 120(1):345-52 (1987)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3023032 & fo

rm=6 & db=m & Dopt=b (HF deglycosylates TSH)

Anbar M, Guttman S, Lewitus Z - " Effect of monofluorosulphanate,

difluorophosphate, and F borate ions on the iodine uptake of the thyroid

gland " Nature 183:1517 (1959) (monofluorosulfonate, difluorophosphate

inhibit iodine transport)

Anbar M, Guttman S, Lewitus Z- " The accumulation of fluoroborate ions in

thyroid glands of rats " Endocrinology 66:888 (1960) (-> fluoroborate

concentrates in thyroid gland, inhibits iodide transport)

Arellano M, Malet-o M, o R, Gires P - " The anti-cancer drug

5-fluorouracil is metabolized by the isolated perfused rat liver and in

rats into highly toxic fluoroacetate " Br J Cancer 7(1):79-86 (1998)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9459149 & fo

rm=6 & db=m & Dopt=b

Auskaps AM, Shaw JH - " Hemoglobin concentration, thyroid weight and growth

rate in rats during minimum fluoride ingestion " J Nutr 55:611-621 (1955)

Ayelli Edgar V, Genaro AM, Cremaschi GA, Sterin Borda L - " Fluoxetine

action upon human T lymphocyte proliferation " Acta Physiol Pharmacol Ther

Latinoam 48(4):191-7 (1998)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/queryd?uid=9914808 & f

orm=6 & db=m & Dopt=b

Bachinskii PP, Gutsalenko OA, Naryzhniuk ND, Sidora VD, Shliakhta AI -

" Action of the body fluorine of healthy persons and thyroidopathy patients

on the function of hypophyseal-thyroid the system " Probl Endokrinol (Mosk)

31(6):25-9 (1985)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4088985 & fo

rm=6 & db=m & Dopt=b (-> reduced T3, increased TSH and I131 uptake)

Balabolkin MI, Mikhailets ND, Lobovskaia RN, Chernousova NV - " The

interrelationship of the thyroid and immune statuses of workers with

long-term fluorine exposure " Ter Arkh 67(1):41-2(1995)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7709355 & fo

rm=6 & db=m & Dopt=b

Ballicu P, Floris M, Frongia L - " Fluoride poisoning and thyroid function "

Minerva Stomatol 5(1):1-5 (1966)

Bartholmes P, Senkel H, Spranger H - " Inhibition of glycolytic enzymes by

fluoride ions " Dtsch Zahnarztl Z 42(10):916-9 (1987)

Banovac K, De Forteza R - " The effect of mast cell chymase on extracellular

matrix: studies in autoimmune thyroiditis and in cultured thyroid cells "

Int Arch Allergy Immunol 99(1):141-9 (1992)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1282841 & fo

rm=6 & db=m & Dopt=b

Baume LJ, Becks H - " Hormonal Control of Tooth Eruption " , Part I , J Dent

Res 33: 80-103 (1954)

Baume LJ, Becks H - " Hormonal Control of Tooth Eruption " , Part III , J Dent

Res 33:104-114 (1954)

Baumgartner A, Dubeyko M, Campos-Barros A, Eravci M, Meinhold H -

" Subchronic administration of fluoxetine to rats affects triiodothyronine

production and deiodination in regions of the cortex and in the limbic

forebrain " Brain Res 635(1-2):68-74 (1994)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8173980 & fo

rm=6 & db=m & Dopt=b (Prozac)

Bech K, Madsen SN - " Human thyroid adenylate cyclase in non-toxic goitre:

sensitivity to TSH, fluoride and thyroid stimulating immunoglobulins " Clin

Endocrinol (Oxf) 8(6):457-66 (1978)

Beex L, Ross A, Smals P, Kloppenborg P - " 5-Fluorouracil-induced increase of

total thyroxine and triiodothyronine " Cancer Treat Rep

61:1291-1295 (1977)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=589596 & for

m=6 & db=m & Dopt=b (Fluoride increase TBG concentration->Total T4 increased)

also:

Beex LV, Ross A, Smals AG, Kloppenborg PW - " Letter: 5-fluorouracil and the

thyroid " Lancet (7964):866-7 (1976)

Benagiano A, Colasanti A, De Simone G - " Studio della funzionalita tiroidia

in soggetti residenti in zone fluorotiche " Ann Stomatol 1:513 (1959)

Benagiano, A - " The effect of sodium fluoride on thyroid enzymes and basal

metabolism of the rat. " Ann Di Stomatol 14:601-619 (1965)

Benagiano A, Fiorentini S - " Richerche sperimentali e cliniche sui rapporrti

tra fluore e tirodi " li di Stomatol 4:3-16(1955) " Fluorine can produce

considerable functional and anatomic changes in the thyroid under the

following conditions:

1) its action must be prolonged for a period of time inversely proportional

to the administered dose

2) the further this dose is from the toxic level, the longer will it take

for the anatomo-functional manifestations of the thyroid to appear.

3) when the doses are minimal there is a variable period of latency before

the setting up of the thyroid changes

4) at an early period these changes manifest themselves by an increased

function of the thyroid and an altered thyroid-hypophyial balance; later by

a parenchymatous hypertrophy which leads to a hypofunction of the thyroid,

and finally by a strumiform degeneration of the gland "

Berman MI, CG Jr, Manjunath P, Sairam MR, Nayfeh SN - " The role of

the carbohydrate moiety in thyrotropin action " Biochem Biophys Res Commun

133(2):680-7 (1985)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3002351 & fo

rm=6 & db=m & Dopt=b (HF - deglycosylates TSH)

_________________________________________________________________

Chat with friends online, try MSN Messenger: http://messenger.msn.com

[Guest guest]

This was taken from another group I frequent:

~The Avenging Angel

=========================================================

REFERENCE SET: FLUORIDE & THE THYROID

All Fluoride compounds - inorganic and organic - affect thyroid hormone

activity.

©September 19, 2000 s Schuld, PFPC

Here are several hundred papers with links to a few thousand more. Included

are studies on hormone transport, inhibition of hormone synthesis,

fluorosis and goiter, G protein activation, fluoride concentration in the

thyroid gland, thyroid cancer, fluoride as TSH agonist, fluoride-iodine

antagonism etc.

Ahn CS, Rosenberg IN - " Iodine metabolism in thyroid slices - effects of

TSH, dibutyril cyclic 3',5'-AMP, NaF and prostaglandin E1 " Endocrinology

86(2):396-405 (1970) (Fluoride = TSH)

Amir S, Menezez-Ferreira M, Shimohigashi Y, Chen HC, Nisula B, Weintraub BD

- " Activities of deglycosylated thyrotropin at the thyroid membrane

receptor-adenylate cyclase system " J Endocrinol Invest

8(6):537-41 (1985)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3009595 & fo

rm=6 & db=m & Dopt=b (HF deglycosylates TSH)

Amir SM, Kubota K, Tramontano D, Ingbar SH, Keutmann HT - " The carbohydrate

moiety of bovine thyrotropin is essential for full bioactivity but not for

receptor recognition " Endocrinology 120(1):345-52 (1987)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3023032 & fo

rm=6 & db=m & Dopt=b (HF deglycosylates TSH)

Anbar M, Guttman S, Lewitus Z - " Effect of monofluorosulphanate,

difluorophosphate, and F borate ions on the iodine uptake of the thyroid

gland " Nature 183:1517 (1959) (monofluorosulfonate, difluorophosphate

inhibit iodine transport)

Anbar M, Guttman S, Lewitus Z- " The accumulation of fluoroborate ions in

thyroid glands of rats " Endocrinology 66:888 (1960) (-> fluoroborate

concentrates in thyroid gland, inhibits iodide transport)

Arellano M, Malet-o M, o R, Gires P - " The anti-cancer drug

5-fluorouracil is metabolized by the isolated perfused rat liver and in

rats into highly toxic fluoroacetate " Br J Cancer 7(1):79-86 (1998)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9459149 & fo

rm=6 & db=m & Dopt=b

Auskaps AM, Shaw JH - " Hemoglobin concentration, thyroid weight and growth

rate in rats during minimum fluoride ingestion " J Nutr 55:611-621 (1955)

Ayelli Edgar V, Genaro AM, Cremaschi GA, Sterin Borda L - " Fluoxetine

action upon human T lymphocyte proliferation " Acta Physiol Pharmacol Ther

Latinoam 48(4):191-7 (1998)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/queryd?uid=9914808 & f

orm=6 & db=m & Dopt=b

Bachinskii PP, Gutsalenko OA, Naryzhniuk ND, Sidora VD, Shliakhta AI -

" Action of the body fluorine of healthy persons and thyroidopathy patients

on the function of hypophyseal-thyroid the system " Probl Endokrinol (Mosk)

31(6):25-9 (1985)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4088985 & fo

rm=6 & db=m & Dopt=b (-> reduced T3, increased TSH and I131 uptake)

Balabolkin MI, Mikhailets ND, Lobovskaia RN, Chernousova NV - " The

interrelationship of the thyroid and immune statuses of workers with

long-term fluorine exposure " Ter Arkh 67(1):41-2(1995)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7709355 & fo

rm=6 & db=m & Dopt=b

Ballicu P, Floris M, Frongia L - " Fluoride poisoning and thyroid function "

Minerva Stomatol 5(1):1-5 (1966)

Bartholmes P, Senkel H, Spranger H - " Inhibition of glycolytic enzymes by

fluoride ions " Dtsch Zahnarztl Z 42(10):916-9 (1987)

Banovac K, De Forteza R - " The effect of mast cell chymase on extracellular

matrix: studies in autoimmune thyroiditis and in cultured thyroid cells "

Int Arch Allergy Immunol 99(1):141-9 (1992)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1282841 & fo

rm=6 & db=m & Dopt=b

Baume LJ, Becks H - " Hormonal Control of Tooth Eruption " , Part I , J Dent

Res 33: 80-103 (1954)

Baume LJ, Becks H - " Hormonal Control of Tooth Eruption " , Part III , J Dent

Res 33:104-114 (1954)

Baumgartner A, Dubeyko M, Campos-Barros A, Eravci M, Meinhold H -

" Subchronic administration of fluoxetine to rats affects triiodothyronine

production and deiodination in regions of the cortex and in the limbic

forebrain " Brain Res 635(1-2):68-74 (1994)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8173980 & fo

rm=6 & db=m & Dopt=b (Prozac)

Bech K, Madsen SN - " Human thyroid adenylate cyclase in non-toxic goitre:

sensitivity to TSH, fluoride and thyroid stimulating immunoglobulins " Clin

Endocrinol (Oxf) 8(6):457-66 (1978)

Beex L, Ross A, Smals P, Kloppenborg P - " 5-Fluorouracil-induced increase of

total thyroxine and triiodothyronine " Cancer Treat Rep

61:1291-1295 (1977)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=589596 & for

m=6 & db=m & Dopt=b (Fluoride increase TBG concentration->Total T4 increased)

also:

Beex LV, Ross A, Smals AG, Kloppenborg PW - " Letter: 5-fluorouracil and the

thyroid " Lancet (7964):866-7 (1976)

Benagiano A, Colasanti A, De Simone G - " Studio della funzionalita tiroidia

in soggetti residenti in zone fluorotiche " Ann Stomatol 1:513 (1959)

Benagiano, A - " The effect of sodium fluoride on thyroid enzymes and basal

metabolism of the rat. " Ann Di Stomatol 14:601-619 (1965)

Benagiano A, Fiorentini S - " Richerche sperimentali e cliniche sui rapporrti

tra fluore e tirodi " li di Stomatol 4:3-16(1955) " Fluorine can produce

considerable functional and anatomic changes in the thyroid under the

following conditions:

1) its action must be prolonged for a period of time inversely proportional

to the administered dose

2) the further this dose is from the toxic level, the longer will it take

for the anatomo-functional manifestations of the thyroid to appear.

3) when the doses are minimal there is a variable period of latency before

the setting up of the thyroid changes

4) at an early period these changes manifest themselves by an increased

function of the thyroid and an altered thyroid-hypophyial balance; later by

a parenchymatous hypertrophy which leads to a hypofunction of the thyroid,

and finally by a strumiform degeneration of the gland "

Berman MI, CG Jr, Manjunath P, Sairam MR, Nayfeh SN - " The role of

the carbohydrate moiety in thyrotropin action " Biochem Biophys Res Commun

133(2):680-7 (1985)

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3002351 & fo

rm=6 & db=m & Dopt=b (HF - deglycosylates TSH)

_________________________________________________________________

Chat with friends online, try MSN Messenger: http://messenger.msn.com