Vioxx

[Guest guest]

,

I am on vioxx right now and is awesome! My doctor just put me on it and it

(25 mg) once a day. Advil does nothing compared to this drug. If i take

advil i have to take it all day long and it still doesn't really relieve the

pain like vioxx does. ( vioxx isn't really a pain reliever more of an

anti-arthritic pain medicine) I have been on it for about 3 weeks and i am

so glad the doctor put me on it.

good stuff!

david vitanza

Vioxx

Does anyone on the list have any experience with Vioxx? If the past

couple of days are any indication, and if I believe everything I have

read, it is no stronger than high doses of Advil. Has anyone had any

success with it over the long term.

[Guest guest]

Hi ,

I just started taking it recently because Voltaren etc. was really

bothering my stomach. At first I thought it was quite good, but lately

I've been wondering. I seem to have a very " irritated " bowel and still

feel quite flared up. Also, last night I was up again for about 4 to 5

hours, partly back pain but also I couldn't sleep. I started wondering

if there was any connection to taking the Vioxx just before bedtime

because I have been awake a lot lately.

It's still early to tell, so who knows.

Any other opinions?

Diane Popiuk

Leger wrote:

>

>

> Does anyone on the list have any experience with Vioxx? If the past

> couple of days are any indication, and if I believe everything I have

> read, it is no stronger than high doses of Advil. Has anyone had any

> success with it over the long term.

>

>

>

>

[Guest guest]

On Fri, 01 Sep 2000 21:07:15 -0000, Scoliosis Treatmentegroups wrote:

> Does anyone on the list have any experience with Vioxx? If the past

> couple of days are any indication, and if I believe everything I have

> read, it is no stronger than high doses of Advil. Has anyone had any

> success with it over the long term.

>

>

I've taken Vioxx for several months at 25 to 50 mg. per day. I feel the

same way you do. It helps but not as much as I wish it would. I often have

to top it off with extra strength Tylenol or some times Vicodin. I do know

some people, especially those with severe osteoarthritis, who claim vioxx

has helped their pain significantly.

C.P.

_______________________________________________________

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[Guest guest]

Is it as irritating to the stomach as Naprosin/Naproxen, or Ponstel?

I''ve tried both, and they don't take care of the pain.

in the East Bay

At 04:13 PM 09/01/2000 -0500, Vitanza wrote:

>,

>

>I am on vioxx right now and is awesome! My doctor just put me on it and it

>(25 mg) once a day. Advil does nothing compared to this drug. If i take

>advil i have to take it all day long and it still doesn't really relieve the

>pain like vioxx does. ( vioxx isn't really a pain reliever more of an

>anti-arthritic pain medicine) I have been on it for about 3 weeks and i am

>so glad the doctor put me on it.

>

>good stuff!

>

>david vitanza

>

> Vioxx

>

>

>

>Does anyone on the list have any experience with Vioxx? If the past

>couple of days are any indication, and if I believe everything I have

>read, it is no stronger than high doses of Advil. Has anyone had any

>success with it over the long term.

>

>

>

>

>

[Guest guest]

The benefits of Vioxx and Celebrex are supposed to be that they do

not irritate the stomach. Both are supposed to be comparable to high

doses of Advil in strength and they can be taken for long periods

without problems. However since I have a very low tolerance to NSAIDS

my doctor told me to take it only with food. I guess I will try it

for a while but so far it doesn't seem to be strong enough to be

noticeably helpful with me.

Here is what the info sheet says: " Your body produces chemicals

called prostaglandins. Some of these prostaglandins help line the

stomach with a protective layer. In arthritis, other prostaglandins

cause pain and swelling. At prescribed doses, Vioxx does not effect

the type that maintains the protective layer of the stomach, and

reduces the change of bleeding. "

Since I mentioned Advil I would like to make a comment. Advil has

always been my drug of choice for severe pain. However I noticed that

the generic versions are not as good as the real Advil. I asked my

pharmacist about that and he said that it was the way in which they

made the drug that sometimes matters more than the formula. Anyone

else notice any difference between generic and the major brand?

[Guest guest]

Wow, this is scary! I've tried taking Vioxx, but it makes me very sleepy,

and really does no better than Naprosin. I think I'll go back to Naprosin,

although it doesn't handle the pain very well. It doesn't upset my stomach.

Any other drugs that people recomend for the pain?

I'm also concerned because my pre-surgery instructions say to stop taking

medications 3 weeks before. I take Celexa for depression, and Naprosin. How

can I survive 3 weeks without those or any pain pills? Any advice out there?

from the East Bay

At 09:53 AM 09/10/2000 -0700, you wrote:

>Eleven Deaths Among UK Vioxx Users

>

>

>LONDON, Sep 08 (Reuters Health) - Eleven deaths and more than 1,000

>reports of suspected

>adverse reactions to Merck's new osteoarthritis drug Vioxx (rofecoxib)

>have been reported in

>the UK since its launch in June last year, British regulators said on

>Thursday.

>

>The Medicines Control Agency (MCA) and the Committee on Safety of

>Medicines (CSM)

>said, " Up to July 2000, the MCA/CSM had received a total of 1,120

>reports, via the Yellow

>Card Scheme, of suspected adverse reactions to rofecoxib. "

>

>Five patients died following gastrointestinal reactions, three following

>cardiac failure and three

>following myocardial infarction, the agencies reported in their

>newsletter " Current Problems. "

>

>An estimated 557,100 prescriptions for Merck's COX-2 inhibitor have been

>dispensed in the

>UK up to the end of May 2000, the agencies said. The rate of reported

>adverse reactions is

>therefore approximately one per 500 prescriptions.

>

> " Gastrointestinal adverse reactions account for almost half (554) of the

>reports, of which the

>majority (84%) were nausea, dyspepsia, diarrhoea and abdominal pain, "

>the agency said.

>

> " However there have been 68 reports (12%) of upper GI perforations,

>ulceration and bleeds

>(PUBs). Forty-four (65%) of the patients with PUBs recovered, although

>five had a fatal

>outcome. "

>

>The agencies also received 177 reports of suspected cardiovascular

>reactions, including 101

>reports of oedema, 31 reports of hypertension and 19 reports of

>palpitations.

>

>There were 15 reports of cardiac failure, three of which had a fatal

>outcome, and nine reports of

>myocardial infarction, three of them fatal. In the majority of these

>cases, the patient had risk

>factors for cardiovascular disease.

>

>Psychiatric reactions were also reported, including 28 reports of

>depression, 14 reports of

>confusion and 11 reports of hallucinations.

>

>Adverse reactions recognised with other NSAIDs were also reported with

>rofecoxib. These

>included angioedema (35 reports), bronchospasm or exacerbation of asthma

>(25), renal failure

>(16), and abnormal hepatic function (12).

>

>The newsletter reminded prescribers that rofecoxib is contraindicated in

>patients with active

>peptic ulceration, GI bleeding, and severe congestive heart failure. It

>also noted that " caution

>should be exercised in patients with a history of cardiac failure, left

>ventricular dysfunction, or

>hypertension and in patients with pre-existing oedema for any other

>reason " .

>

>In conclusion, the agencies said, " As with all new drugs, the safety of

>rofecoxib remains under

>close review. " They pointed out that another COX-2 inhibitor,

>Pharmacia's celecoxib

>(Celebrex), had been launched recently and promised to report on its

>safety profile in a

>forthcoming bulletin.

>

>Merck officials were not immediately available for comment.

>

>

[Guest guest]

I have to recommend Ultradol (In Canada) or Lodine (I think in the

US). It works well although it can upset the stomach. However as an

NSAID it was my favourite. Also Relifen (SP?)is not that bad although

it doesn't work as well as Ultradol. For my normal pain the one and

only drug that has always worked and never failed to work in higher

doses is ADVIL. (Not generic but the real stuff.) It just gets to

your stomach eventually but even there I never had much trouble with

it.

[Guest guest]

Interesting that Naproxen Sodium (generic Aleve) also does not affect my

stomach at all. It could be related to the fact that you could take it 12

hourly.

Relafen, although being promoted in the medical community as something

that does not affect the stomach, messed up my stomach within 2 dosages.

We're all different...eh?

Sanette

On Tue, 12 Sep 2000 16:51:10 -0700 NB <wrdtech@...> writes:

> Wow, this is scary! I've tried taking Vioxx, but it makes me very

> sleepy,

> and really does no better than Naprosin. I think I'll go back to

> Naprosin,

> although it doesn't handle the pain very well. It doesn't upset my

> stomach.

>

On Wed, 13 Sep 2000 00:29:57 -0000 " Leger " <legerpj@...>

writes:

> I have to recommend Ultradol (In Canada) or Lodine (I think in the

> US). It works well although it can upset the stomach. However as an

> NSAID it was my favourite. Also Relifen (SP?)is not that bad...........

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[Guest guest]

Yes Kristi: So far that's what Dr. R recommends. He'd rather we tough anything

out but gave us Vioxx upon discharge. I've had several bad headaches and have

used it maybe 5 times since surgery. But the last time I could swear it hurt my

stomach. So unless I really can't function, I'm not going to take it at all.

Flo from land

> ** Original Subject: RE: Vioxx

> ** Original Sender: Kristi Lent <klent@...>

> ** Original Date: Wed, 13 Jun 2001 13:01:32 -0400

> ** Original Message follows...

>

> Is it Vioxx that is ok for us to take.

> Kristi in AL

>

>

>

>

[Guest guest]

Hi Kate: I too avoid taking Vioxx or anything else unless I'm truly desperate.

I can't afford to mess with my liver. I really think that's why Dr. R wants us

to tough it out whenever possible. And that's why he doesn't want us to take

Tylenol.

I had antibiotics twice since surgery. The first time it was a precautionary

measure following foot surgery, the second was recenlty for an ear infection.

They presented no problem and I felt perfectly normal while taking antibiotics.

As to having the flu, etc. I have not had it since surgery and have had the flu

only once in my whole 58 years. I just don't get the flu and viruses.

I too have arthritis but the reduction in pain since surgery is such that I no

longer need medication for it. I do notice however that as soon as I run out of

my hormone patches, the pain sets back in again. I've run out twice and twice

my joints were painful. I'm toughing it out watching my mailbox for my patches

to come right now.

It's tough to get old. Sigh.

Flo from land

> ** Original Subject: Re: Vioxx

> ** Original Sender: Plumeria38@...

> ** Original Date: Wed, 13 Jun 2001 21:03:25 -0400

> ** Original Message follows...

>

> Hi Flo,

>

> I have osteoarthritis, and have had a few headaches too in the last seven

> months since my surgery. Dr R told me it was fine for me to take Vioxx too,

> and it really helps; however, I am afraid to take it every day as I have high

> liver enzyme levels, and my pcp told me that Vioxx breaks down in the liver,

> and she thought it could be dangerous for me. I just try not to take

> anything, and many times just rest a lot if I have a lot of pain.

>

> In fact, would love to know from you, and other MGB patients, what do you all

> do when you have the flu or a virus? Are there any drugs that are safe, and

> is the inability to take drugs a permanent problem, or will it be ok to take

> antiobiotics after a year along with other drugs? Thanks for the replies.

>

> Love,

> Kate in Louisburg, NC

>

>

>

>

[Guest guest]

No Jude, It wasn't on an empty stomach. And I'm not even sure that the Vioxx was

the culprit. Although I suspect it was. I'll try it again if I absolutely can't

stand the headache and I'll make sure that I have plenty of food in my stomach.

As I recall I'd had just orange juice and 1/2 piece of toast.

Now what was this about me being " oldish " ? Hmmmm.....let's be honest here.

Let's take the ish off and that's what I really am! LOL

Flo

> ** Original Subject: RE: Vioxx

> ** Original Sender: Judyh1022@...

> ** Original Date: Wed, 13 Jun 2001 21:55:07 -0400

> ** Original Message follows...

>

> I just want to add here, Please y'all, take your Vioxx after eating. Always

> after eating! Flo, you said your tummy hurt last time. Was it empty?

> Please remeber that any antiinflammatory can mess up your tummy, even these

> newer generation ones. Better safe, as they say. We can't have our Flo

> getting sick! She's had enough already, and like she says over and over, she

> is . . .well. . .. getting oldish!

> Smiling at a safe distance, PhillyJude

>

>

>

[Guest guest]

Yes!

Vioxx

> Is it Vioxx that is ok for us to take.

> Kristi in AL

>

>

>

>

[Guest guest]

> Is it Vioxx that is ok for us to take.

> Kristi in AL

Yes. I take it everyday for arthritic pain relief.

[Guest guest]

Yes, vioxx is ok but I just talked to Dr. R today about pain meds and he said

take them all with great care. Our tummies are fragile and if you can live

without it you should!

[Guest guest]

Yes, Kristi. Vioxx is okay to take.

Rebekah Shirley

Mobile, Alabama

3/15/01

[Guest guest]

Hi Flo,

I have osteoarthritis, and have had a few headaches too in the last seven

months since my surgery. Dr R told me it was fine for me to take Vioxx too,

and it really helps; however, I am afraid to take it every day as I have high

liver enzyme levels, and my pcp told me that Vioxx breaks down in the liver,

and she thought it could be dangerous for me. I just try not to take

anything, and many times just rest a lot if I have a lot of pain.

In fact, would love to know from you, and other MGB patients, what do you all

do when you have the flu or a virus? Are there any drugs that are safe, and

is the inability to take drugs a permanent problem, or will it be ok to take

antiobiotics after a year along with other drugs? Thanks for the replies.

Love,

Kate in Louisburg, NC

[Guest guest]

I just want to add here, Please y'all, take your Vioxx after eating. Always

after eating! Flo, you said your tummy hurt last time. Was it empty?

Please remeber that any antiinflammatory can mess up your tummy, even these

newer generation ones. Better safe, as they say. We can't have our Flo

getting sick! She's had enough already, and like she says over and over, she

is . . .well. . .. getting oldish!

Smiling at a safe distance, PhillyJude

[Guest guest]

Thanks for the reply. I had some major problems with my fingers. Doctor said

he thinks it might be atritis, but he wanted me to take Vioxx. I took one today

and it has already helped. I am not going to take another one unless it gets

bad again which I don't think it will cause it was such a freaky thing. (that's

me!)

Thanks for the replies!

Kristi in AL

[Guest guest]

I had to take some for the first time since my surgery 10 months ago,

and the leaflet that came with it from the pharmacy also said not to

lay down for at least 30 minutes after taking Vioxx. I guess that

would be so that it has a chance to leave your stomach.

> I just want to add here, Please y'all, take your Vioxx after

eating. Always

> after eating! Flo, you said your tummy hurt last time.

[Guest guest]

, I have until recently been on vioxx for arthritis. It has

not seem to make a difference in my spasms at all.

I just stopped it about a week ago when I discovered I had an

internal bleeding. I have no idea yet what is causing the bleeding.

I once had a malformed vein in the small intestine which required

a small bowel resection. I wonder if another has shown up. I

understand that if you have one, then you are more prone to have

others. Time and testing will tell. It took 4 years and several

transfusions to find the last one. I pray this will not take that long.

I am sure you are aware that vioxx can effect the liver, so if you

take it be sure to keep check on that.

[Guest guest]

Hi . I cannot take any kind of anti inflammitory

medications at all, no motrin, aleve, vioxx, etc. It

irritates my esoph. and creates spasms. Strange isn't

it?!!

--- lindwoodwebtv <lindwood@...> wrote:

> ANyone in here take vioxx? I take it occasionally

> for aches and pains. I always swallow food after

> taking it, and plenty of water. I have wondered if

> it effects my spasms. It might be that I hve more

> when I take that. Hmm...what's good for me is bad

> for me?

>

>

__________________________________________________

[Guest guest]

, I took vioxx for a little while and stopped because I was having

increased spasms and heartburn.

--

>From: Wickman <kellywickman@...>

>Reply-achalasia

>achalasia

>Subject: Re: vioxx

>Date: Thu, 18 Apr 2002 12:32:43 -0700 (PDT)

>

>Hi . I cannot take any kind of anti inflammitory

>medications at all, no motrin, aleve, vioxx, etc. It

>irritates my esoph. and creates spasms. Strange isn't

>it?!!

>

>

>

>--- lindwoodwebtv <lindwood@...> wrote:

> > ANyone in here take vioxx? I take it occasionally

> > for aches and pains. I always swallow food after

> > taking it, and plenty of water. I have wondered if

> > it effects my spasms. It might be that I hve more

> > when I take that. Hmm...what's good for me is bad

> > for me?

> >

> >

>

>

>__________________________________________________

>

[Guest guest]

I still think that stomach problems are LESS likely to happen with

vioxx/celebrex than Aleve, Iburofin, etc. For now, I am going to continue

taking it, as I have injured my achiles tendon a bit, and it helps me a lot. It

IS making it heal up. I am going to reserve it for BAD pain days, though. I

don't want to abuse something that works so well!! Man, it's a miracle drug for

me for pain. ANd funny thing, celebrex did NOTHING for me. I thought since

they were both cox 2 inhibitors that one would pretty much be like the other.

Not for me. Oh well....careful careful careful I will be. I hope your bleeding

abates and that you don't have to go through some further ordeal over it.

THat's scary.

[Guest guest]

When I take vioxx, I can usually count on a 2-3 pound increase in my weight

for several days. It is fluid. When I was 288, it was 8-10 pounds of fluid.

Feel your pain and my 16 yo does not have a cell phone...and if his grades

continue like they are, he won't have his license either! LOL

in SC

[Guest guest]

Hi Kettye,

I took Celebrex and Vioxx for about six years. They did a very good job as

I found out after I quit taking them. I quit when one evening I began to

believe that I was having a heart attack. The pain subsided for the rest of

the night. The next morning I took another Vioxx and the pain returned. The

pain took most of the day to subside. I then decided that the meds were the

cause. I took the final one the following morning with the pain again

returning. I informed my doctor about it. He sent me to be scoped where

they found three bleeding ulcers. It turns out that it was a combination of

the nsaids and Aleve that caused my problem. I am now in pain management

and am doing fairly well. In retrospect I should have went to the emergency

room immediately since I thought that I was having a heart attack. I

suppose that I was wishing that I would have a lethal one at the time. I am

out of that stage now and I am glad that it was just ulcers. Be careful

with other meds as they can cause other serious problems.

Steve

At 05:56 AM 7/6/2003, you wrote:

>

>Message: 1

> Date: Sat, 5 Jul 2003 14:20:48 -0500

> From: " Kettye Voltz " <mom@...>

>Subject: Re: Viox

>has anyone tryed vioxx?

>