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Detoxification of Biotoxins in Chronic Neurotoxic Syndromes

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linda i am new to this group soi have been reading all the messages

to catch up on enzymes. when i read this i coudnt beleive my eyes.

this sounds like me and other people in my family. half of it i dont

understand but the evry thing else i had! specialy the infertility

thing. i tried like crazy to get knocjed up this last time but the

doctorsaid i was alergic to my husbands sperm [can i say that] i

never had a rash or any thing.i have a probelm with fat too! do you

know how i can get the vision test that tells me my toxins? i am

going to by some enzymes for me and my autism kid. i am worried

because karen said they wont work if you have mercury. my daughter

broke a thermomter in half with her teeth when she was 2. i gave her

3 slices of wonder bread to make sure the glass was not in her mouth

cause it lokks like a sponge. someone said she has mercury to from

this. i hope the vitamins from huoston work.

nice to meet you.

nancy.

> Reprinted with permission from:

> Allergy Research Group Newsletter: Focus August 2002

>

> Detoxification of Biotoxins in Chronic Neurotoxic Syndromes

>

> Kane, Ph.D.

>

> The following is an excerpt from the work of , M.D,

> Kane, Ph.D. and Neal Speight, MD, who have

> established a medical protocol to treat chronically ill patients in

> their clinics who are suffering from hypercoagulable

> states related to neurotoxin exposure. The patient population

affected

> includes those with CFIDS, Fibromyalgia, MS,

> Cardiovascular Disease, Depression, Rheumatoid Arthritis, IBS,

> Infertility, ALS, Parkinsons, Lyme, Stroke, Toxic

> Building Syndrome, Estuary Associated Syndrome, Diabetes without

family

> Hx, Optic Neuritis, Refractory Heavy Metal

> Toxicity, Autism, Pulmonary Hemorrhage. Patients diagnosed with

these

> chronic illnesses may be potentially

> classified as 'Neurotoxic Membrane Syndrome' (NMS) with the

endothelial

> cell membrane as the target of degeneration.

> While hypercoagulation involves a myriad of proteins, it is

ultimately a

> membrane event, essentially disrupting the

> phospholipids that structure the membrane. Agglomeration (blocked

> cellular exposure to blood flow/nutrients and

> impaired cell-to-cell communication) indicates elevation of

> phospholipase A2 and the uncoupling of eicosanoids from

> the cell membrane causing inflammation.

>

> The recent pioneering work of Ritchie Shoemaker, M.D. as

communicated in

> his book Desperation Medicine and his

> peer reviewed work (Residential and recreational acquisition of

possible

> estuary associated syndrome - a new approach

> to successful diagnosis and treatment, Environmental Health

Perspectives

> 2001 Oct; 109-Suppl 5:791-6) lends strong

> support to a connection between Chronic Fatigue Syndrome,

Fibromyalgia,

> Lyme Disease, Pfiesteria infection and that

> of numerous Neurotoxic Syndromes.

>

> Neurotoxins are minute compounds between 200-1000 KD (kilodaltons)

that

> are comprised of oxygen, nitrogen and

> sulfate atoms arranged in such a way as to make the outside of the

> molecule fat loving and water hating. As such, once

> it enters the body, it tends to bind to structures that are rich in

fat

> such as most of our cells, especially the liver, kidney,

> and brain. Neurotoxins are capable of dissolving in fatty tissue and

> moving through it, crossing cell membranes, and

> transporting against a gradient, particularly with potassium,

disrupting

> the electrical balance of the cell itself.

>

> As fat soluble neurotoxins move through the cells of the body from

the

> GI tract to sinus to lung to eye to muscle, to joint

> to nerve, etc, they eventually enter the liver and the bile. Once

> neurotoxins bind with bile they have access to the liver,

> the body is poisoned over and over again as the bile is re-

circulated

> (first released into the intestine to digest fats and

> then reabsorbed).

>

> Neurotoxins cause damage by disrupting sodium and calcium channel

> receptors, attacking enzyme reactions involved

> in glucose production thereby disrupting energy metabolism in the

cell,

> manufacturing renegade fatty acids as saturated

> very long chain, odd chain and branched chain fatty acids impairing

> membrane function, stimulating enzymes (PLA2)

> which uncouple essential fatty acids from the cell membrane and

> impairing the function of the nuclear receptor PPAR

> gamma which controls transcription (the conversion of instructions

held

> in our DNA to RNA which then leads to

> translation or protein production in the cell).

>

> Once neurotoxins get into the cell they move toward the nucleus

turning

> on indirectly the production of cytokines such

> as TNF alpha,IL6, and IL-1Beta. TNF alpha will cause the garbage

cells

> in the body(macrophages) to become active.

> The white cells are also induced to gather in the area of the

cytokine

> (TNF alpha) release. TNF alpha also induces

> endothelial cell adhesion. Endothelial cells which line the blood

> vessels of the body become " sticky " in conjunction with

> the increase in white cells. Increased blood viscosity results in

> restricted blood flow in neurotoxic patients leading to

> fatigue and discomfort.

>

> Hypercoagulation is predominantly an unwanted mass of proteins

> disrupting function. When referencing the artery;

> hypercoagulation invariably involves the plasmic side of the cell

and if

> endothelial cells of the vascular system are

> targeted by a toxin (virus, neurotoxin, heavy metal, antibody, etc),

> restriction of blood flow ultimately results. If a neuron

> is targeted then signaling is disrupted. The presence of neurotoxins

> involvesPLA2, which is the " sergeant at arms "

> monitoring cell membrane health. A membrane disturbance(unwanted

> mass)would trigger the release of eicosanoids,

> which would then induce inflammation and call to attention the

clean-up

> committee, i.e. macrophages.

>

> Our approach is to first confirm that neurotoxin mediated illness

could

> in fact be a problem for the patient via the Visual

> Contrast Sensitivity test that isolates deficits in velocity of

flow in

> retinal capillaries. If the patient scores poorly on this

> test then the evaluation may include screening for cytokine

elevations

> followed by Coagulation and Red Cell lipid testing

> through BodyBio /s Hopkins.

>

> In both of our satellite clinics in PA and NC we initiate treatment

with

> changing the patients overall diet, addressing the

> outer lipid leaflet of the cell membrane through fatty acid therapy

and

> the addition of supplementation targeted towards

> dissolving fibrin, clearing the liver/biliary tree, and healing the

cell

> membrane. The patients' progress is evaluated

> through the visual contrast test and repeatlab evaluation.

>

> Additionally, binding therapy with the cholesterol lowering drug

> Cholestyramine is an option in treating some of these

> patients. This drug has a complimentary positive charge to the

> generally negative charge of the neurotoxin and as the

> neurotoxin-bile complex passes the Sphincter of Oddi where bile is

> released from the gallbladder, it binds neurotoxins

> linked to bile which can then not be reabsorbed. Prolonged use of

> Cholestyramine has proven to be disappointing in

> patient outcomes whereby the infection is of a chronic nature.

Cycling

> of Cholestyramine has been utilized (5 days on,

> 10 days off)or an early AM single dose for several months.

>

> In our clinical experience we have found that venous Phospholipid

> Exchange is one of the most efficient ways of

> clearing the liver and biliary tree which are paramount in

addressing

> neurotoxic syndromes. Oral use of phospholipids in

> a Liver Flush is also an effective intervention.

>

> Blood thinning agents such as Heparin and Warfarin increase blood

flow

> around the damaged endothelium, however,

> reconstituting membrane fluidity can directly address coagulation

in a

> natural restorative way. Vibrant healthy

> membranes will not permit agglomeration. The high POLYunsaturated

> lipids with a preponderance of

> phosphatidylcholine on the plasmic surface precludes undesirable

> clumping to occur. Treatment modalities should

> address dissolving fibrin and healing the cell membrane.

>

> Unhealthy bacteria have been known to colonize the liver and its

biliary

> system. These bacteria cansynthesize very

> long chain saturated or renegade fats that lead to liver toxicity,

> biliary congestion and impairment of prostaglandin

> synthesis. Lipids vibrate in the cell at millions oftimes/second.

The

> double bonds of the omega 6 and omega 3 lipids

> are the singing backbone of life expressed through their high energy

> level. These bonds are their vibratory song, and

> they absolutely carry a tune befitting every act and function in the

> exercise of life, providing all 70 trillion of our cells their

> flexible nature. When renegade fats are over represented in the cell

> membrane they result in off key expression, and if

> strong enough, may spell cellular death and apoptosis. Healing the

outer

> leaflet of the membrane, comprised primarily of

> phosphatidylcholine, with phospholipid therapy, is our highest

priority

> in addressing chronic illness and

> hypercoagulation.

>

> Neal Speight, M.D. is at the Center For Wellness in Charlotte, NC.

> Contact , M.D. and Kane, Ph.D.

> at the WellSpring Clinic in Wayne, PA to obtain the 'The Detoxx

Book:

> Detoxification of Biotoxins in Chronic Neurotoxic

> Syndromes' or a Visual Contrast kit at 856-825-8338.

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Hi Again ,

I'm not , so hope you don't mind if I comment too.

As background information, I know very little about enzymes,

and a lot about heavy metal detoxification. Or so I think, LOL.

Everyone reading this list for long already realizes this, since

most of my posts are about mercury poisoning and/or detox.

It is very common (VERY common!) for kids with autism/aspergers/

etc/etc/etc to have toxic metals in their bodies. Many people

(including me) speculate that there is a genetic component to

metal toxicity

> linda i am new to this group soi have been reading all the messages

> to catch up on enzymes. when i read this i coudnt beleive my eyes.

> this sounds like me and other people in my family. half of it i dont

> understand but the evry thing else i had! specialy the infertility

> thing. i tried like crazy to get knocjed up this last time but the

> doctorsaid i was alergic to my husbands sperm [can i say that] i

> never had a rash or any thing.i have a probelm with fat too! do you

> know how i can get the vision test that tells me my toxins?

here is info on a good way to look for heavy metal toxicity:

/files/HOW_TO_hair_test

i am

> going to by some enzymes for me and my autism kid. i am worried

> because karen said they wont work if you have mercury.

they will still work. they may not work as well. in fact, it may

be that it is because of mercury that your kid NEEDS the enzymes.

don't worry too much about if they will work. try them and

see. be very observant. make notes. enzymes don't " work " for

everyone. and you may even have some " bad " things.... so it

is always important to PAY ATTENTION ;)

my daughter

> broke a thermomter in half with her teeth when she was 2. i gave her

> 3 slices of wonder bread to make sure the glass was not in her mouth

> cause it lokks like a sponge. someone said she has mercury to from

> this.

this is ONE way she could get too much mercury. there are also

other ways, including:

--mercury in many vaccines (in the preservative thimerosal)

--mercury from your body (gestation or breasmilk), such as

from your dental filling, RhoGam or other shots you got

during pregnancy, dental work you got during pregnancy,

fish you ate during pregnancy

I consider the " big 2 " sources of mercury poisoning to be:

vaccines (children) and amalgam (adults). But there is lots

of crossover for both. (Adults get flu shots with mercury in

them. Children can get poisoned by mom's amalgams.)

I would suggest you might read this info on mercury and its

connection to autism:

/files/Mercury-Autism%20FAQ

I will also just mention here that a number of people who

are using enzymes for their kids/themselves are ALSO involved

with detoxing for heavy metals. This is not an " either/or "

thing where you are only allowed to do one or the other.

I think the enzymes are easier to start out on, since it is

a pill you take and you can see how it goes. For the detoxing,

most people need to read about it for a while to get the

picture. Doing a hair test (see info above) is a good place

to start. So is reading..... Feel free to ask questions.

There are a number of people on this list who are doing

mercury detox.

best wishes,

Moria

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A pediatrician is likely to order a blood test in which case it would

only show recent exposure, especially for mercury. My child's blood

test showed normal mercury levels. His hair analysis showed low-

normal mercury levels BUT it had the characteristic disordered

mineral transport as well as other metals that were high.

Apparently, mercury is among the last to leave the body during

chelation and so it is common NOT to see it high on the hair analysis

at first. Are you on the board-- they have a file

there that tells how to get a hair test WITH or WITHOUT a doctor's

prescription and you can order it yourself, do it, and then ask for

help on that board. It is a good starting point.

W

> Can a childs pediatrician test for metal toxicity? Or is it better

to

> go through a company on our own?

>

> Penny

>

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> Can a childs pediatrician test for metal toxicity? Or is it better to

> go through a company on our own?

>

> Penny

Hello Penny,

Would you like a short answer or the real answer?? hahahah.

the real answers always seem so long ;)

The short answer:

Do a hair elements test through DDI. Complete details are here:

/files/HOW_TO_hair_test

It doesn't matter if you order it through DLS or if your doctor

signs. Do whatever is more convenient or expedient for you.

Longer answer:

There are a number of ways that people test for heavy metals.

Some of which are actually not helpful. This means that your

doctor MAY possibly think your kid is not metal toxic and be

incorrect about it. Testing for mercury is actually pretty

darned tricky. But even for lead (which is " easier " ) some

physicians do blood tests (which is inappropriate since it

only shows RECENT exposure). If you want to read about some

other ways to test besides the hair test, you can go here:

/files/ANDY_INDEX

and read the 3 sections on " determining toxicity " .

But a hair test is simple, not painful, and seems to work

well for people.

Having your doctor order the test for you MAY be a " better "

way, since you may want your doctor to be involved. Then again,

if your doctor is going to be not-helpful, then it may NOT

be " better " . As far as the TEST though, it doesn't matter

who orders it. It DOES matter that you get a DDI hair elements

test AND NOT SOMETHING ELSE.

best wishes,

Moria

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Can a childs pediatrician test for metal toxicity? Or is it better to

go through a company on our own?

Penny

moriamerri wrote:

> Hi Again ,

>

> I'm not , so hope you don't mind if I comment too.

> As background information, I know very little about enzymes,

> and a lot about heavy metal detoxification. Or so I think, LOL.

> Everyone reading this list for long already realizes this, since

> most of my posts are about mercury poisoning and/or detox.

> It is very common (VERY common!) for kids with autism/aspergers/

> etc/etc/etc to have toxic metals in their bodies. Many people

> (including me) speculate that there is a genetic component to

> metal toxicity

> > linda i am new to this group soi have been reading all the messages

> > to catch up on enzymes. when i read this i coudnt beleive my eyes.

> > this sounds like me and other people in my family. half of it i dont

> > understand but the evry thing else i had! specialy the infertility

> > thing. i tried like crazy to get knocjed up this last time but the

> > doctorsaid i was alergic to my husbands sperm [can i say that] i

> > never had a rash or any thing.i have a probelm with fat too! do you

> > know how i can get the vision test that tells me my toxins?

>

> here is info on a good way to look for heavy metal toxicity:

> /files/HOW_TO_hair_test

>

>

> i am

> > going to by some enzymes for me and my autism kid. i am worried

> > because karen said they wont work if you have mercury.

>

> they will still work. they may not work as well. in fact, it may

> be that it is because of mercury that your kid NEEDS the enzymes.

> don't worry too much about if they will work. try them and

> see. be very observant. make notes. enzymes don't " work " for

> everyone. and you may even have some " bad " things.... so it

> is always important to PAY ATTENTION ;)

>

> my daughter

> > broke a thermomter in half with her teeth when she was 2. i gave her

> > 3 slices of wonder bread to make sure the glass was not in her mouth

> > cause it lokks like a sponge. someone said she has mercury to from

> > this.

>

> this is ONE way she could get too much mercury. there are also

> other ways, including:

> --mercury in many vaccines (in the preservative thimerosal)

> --mercury from your body (gestation or breasmilk), such as

> from your dental filling, RhoGam or other shots you got

> during pregnancy, dental work you got during pregnancy,

> fish you ate during pregnancy

>

> I consider the " big 2 " sources of mercury poisoning to be:

> vaccines (children) and amalgam (adults). But there is lots

> of crossover for both. (Adults get flu shots with mercury in

> them. Children can get poisoned by mom's amalgams.)

>

> I would suggest you might read this info on mercury and its

> connection to autism:

> /files/Mercury-Autism%20FAQ

>

> I will also just mention here that a number of people who

> are using enzymes for their kids/themselves are ALSO involved

> with detoxing for heavy metals. This is not an " either/or "

> thing where you are only allowed to do one or the other.

> I think the enzymes are easier to start out on, since it is

> a pill you take and you can see how it goes. For the detoxing,

> most people need to read about it for a while to get the

> picture. Doing a hair test (see info above) is a good place

> to start. So is reading..... Feel free to ask questions.

> There are a number of people on this list who are doing

> mercury detox.

>

> best wishes,

> Moria

>

>

>

>

>

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Just my .02. If you do the test on your own, you 'own' the results...does that

make sense? In other words, the dr can't keep the record and not let you have a

copy. I know that sounds odd but being in the military (or married to it), you

don't own your records, the military does. If you want to get your records and

copy them you can but it has to be done 'at your own risk' and it has to be done

periodically so you can get caught up to date...the dr keeps your record at the

end of the appt and turns them in to records and it is considered a felony or

misdemeanor if you maintain your own records. It's the most bizarre part of the

military (well, one of the most bizarre).

Anyway, if you have a situation like that, you might want to do it yourself so

you can show who you want, when you want.

Tonya Dillingham

Mothersheart1996@...

Re: Detoxification of Biotoxins in Chronic Neurotoxic

Syndromes

> Can a childs pediatrician test for metal toxicity? Or is it better to

> go through a company on our own?

>

> Penny

Hello Penny,

Would you like a short answer or the real answer?? hahahah.

the real answers always seem so long ;)

The short answer:

Do a hair elements test through DDI. Complete details are here:

/files/HOW_TO_hair_test

It doesn't matter if you order it through DLS or if your doctor

signs. Do whatever is more convenient or expedient for you.

Longer answer:

There are a number of ways that people test for heavy metals.

Some of which are actually not helpful. This means that your

doctor MAY possibly think your kid is not metal toxic and be

incorrect about it. Testing for mercury is actually pretty

darned tricky. But even for lead (which is " easier " ) some

physicians do blood tests (which is inappropriate since it

only shows RECENT exposure). If you want to read about some

other ways to test besides the hair test, you can go here:

/files/ANDY_INDEX

and read the 3 sections on " determining toxicity " .

But a hair test is simple, not painful, and seems to work

well for people.

Having your doctor order the test for you MAY be a " better "

way, since you may want your doctor to be involved. Then again,

if your doctor is going to be not-helpful, then it may NOT

be " better " . As far as the TEST though, it doesn't matter

who orders it. It DOES matter that you get a DDI hair elements

test AND NOT SOMETHING ELSE.

best wishes,

Moria

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Share on other sites

, Sorry! As you can see I am behind in my mail! Why don't

you call them. Or e-mail them from here, I am sure they could

answer your questions. Best, (Nice to meet you too!!)

And good luck, e-mail me carltonl citadel.edu, if you have a

problem and I will ask Dr.Kane.

General inquiries should be addressed to:

Customer Service

45 Reese Road

PO Box 809

Millville, NJ 08332

USA

Telephone:

888.320.8338 (toll free)

856.825.8338 (outside the US)

Fax:

856.825.2143

E-mail:

custservice@...

nkcellular wrote:

>

> linda i am new to this group soi have been reading all the messages

> to catch up on enzymes. when i read this i coudnt beleive my eyes.

> this sounds like me and other people in my family. half of it i dont

> understand but the evry thing else i had! specialy the infertility

> thing. i tried like crazy to get knocjed up this last time but the

> doctorsaid i was alergic to my husbands sperm [can i say that] i

> never had a rash or any thing.i have a probelm with fat too! do you

> know how i can get the vision test that tells me my toxins? i am

> going to by some enzymes for me and my autism kid. i am worried

> because karen said they wont work if you have mercury. my daughter

> broke a thermomter in half with her teeth when she was 2. i gave her

> 3 slices of wonder bread to make sure the glass was not in her mouth

> cause it lokks like a sponge. someone said she has mercury to from

> this. i hope the vitamins from huoston work.

>

> nice to meet you.

>

> nancy.

>

>

> > Reprinted with permission from:

> > Allergy Research Group Newsletter: Focus August 2002

> >

> > Detoxification of Biotoxins in Chronic Neurotoxic Syndromes

> >

> > Kane, Ph.D.

> >

> > The following is an excerpt from the work of , M.D,

>

> > Kane, Ph.D. and Neal Speight, MD, who have

> > established a medical protocol to treat chronically ill patients in

> > their clinics who are suffering from hypercoagulable

> > states related to neurotoxin exposure. The patient population

> affected

> > includes those with CFIDS, Fibromyalgia, MS,

> > Cardiovascular Disease, Depression, Rheumatoid Arthritis, IBS,

> > Infertility, ALS, Parkinsons, Lyme, Stroke, Toxic

> > Building Syndrome, Estuary Associated Syndrome, Diabetes without

> family

> > Hx, Optic Neuritis, Refractory Heavy Metal

> > Toxicity, Autism, Pulmonary Hemorrhage. Patients diagnosed with

> these

> > chronic illnesses may be potentially

> > classified as 'Neurotoxic Membrane Syndrome' (NMS) with the

> endothelial

> > cell membrane as the target of degeneration.

> > While hypercoagulation involves a myriad of proteins, it is

> ultimately a

> > membrane event, essentially disrupting the

> > phospholipids that structure the membrane. Agglomeration (blocked

> > cellular exposure to blood flow/nutrients and

> > impaired cell-to-cell communication) indicates elevation of

> > phospholipase A2 and the uncoupling of eicosanoids from

> > the cell membrane causing inflammation.

> >

> > The recent pioneering work of Ritchie Shoemaker, M.D. as

> communicated in

> > his book Desperation Medicine and his

> > peer reviewed work (Residential and recreational acquisition of

> possible

> > estuary associated syndrome - a new approach

> > to successful diagnosis and treatment, Environmental Health

> Perspectives

> > 2001 Oct; 109-Suppl 5:791-6) lends strong

> > support to a connection between Chronic Fatigue Syndrome,

> Fibromyalgia,

> > Lyme Disease, Pfiesteria infection and that

> > of numerous Neurotoxic Syndromes.

> >

> > Neurotoxins are minute compounds between 200-1000 KD (kilodaltons)

> that

> > are comprised of oxygen, nitrogen and

> > sulfate atoms arranged in such a way as to make the outside of the

> > molecule fat loving and water hating. As such, once

> > it enters the body, it tends to bind to structures that are rich in

> fat

> > such as most of our cells, especially the liver, kidney,

> > and brain. Neurotoxins are capable of dissolving in fatty tissue and

> > moving through it, crossing cell membranes, and

> > transporting against a gradient, particularly with potassium,

> disrupting

> > the electrical balance of the cell itself.

> >

> > As fat soluble neurotoxins move through the cells of the body from

> the

> > GI tract to sinus to lung to eye to muscle, to joint

> > to nerve, etc, they eventually enter the liver and the bile. Once

> > neurotoxins bind with bile they have access to the liver,

> > the body is poisoned over and over again as the bile is re-

> circulated

> > (first released into the intestine to digest fats and

> > then reabsorbed).

> >

> > Neurotoxins cause damage by disrupting sodium and calcium channel

> > receptors, attacking enzyme reactions involved

> > in glucose production thereby disrupting energy metabolism in the

> cell,

> > manufacturing renegade fatty acids as saturated

> > very long chain, odd chain and branched chain fatty acids impairing

> > membrane function, stimulating enzymes (PLA2)

> > which uncouple essential fatty acids from the cell membrane and

> > impairing the function of the nuclear receptor PPAR

> > gamma which controls transcription (the conversion of instructions

> held

> > in our DNA to RNA which then leads to

> > translation or protein production in the cell).

> >

> > Once neurotoxins get into the cell they move toward the nucleus

> turning

> > on indirectly the production of cytokines such

> > as TNF alpha,IL6, and IL-1Beta. TNF alpha will cause the garbage

> cells

> > in the body(macrophages) to become active.

> > The white cells are also induced to gather in the area of the

> cytokine

> > (TNF alpha) release. TNF alpha also induces

> > endothelial cell adhesion. Endothelial cells which line the blood

> > vessels of the body become " sticky " in conjunction with

> > the increase in white cells. Increased blood viscosity results in

> > restricted blood flow in neurotoxic patients leading to

> > fatigue and discomfort.

> >

> > Hypercoagulation is predominantly an unwanted mass of proteins

> > disrupting function. When referencing the artery;

> > hypercoagulation invariably involves the plasmic side of the cell

> and if

> > endothelial cells of the vascular system are

> > targeted by a toxin (virus, neurotoxin, heavy metal, antibody, etc),

> > restriction of blood flow ultimately results. If a neuron

> > is targeted then signaling is disrupted. The presence of neurotoxins

> > involvesPLA2, which is the " sergeant at arms "

> > monitoring cell membrane health. A membrane disturbance(unwanted

> > mass)would trigger the release of eicosanoids,

> > which would then induce inflammation and call to attention the

> clean-up

> > committee, i.e. macrophages.

> >

> > Our approach is to first confirm that neurotoxin mediated illness

> could

> > in fact be a problem for the patient via the Visual

> > Contrast Sensitivity test that isolates deficits in velocity of

> flow in

> > retinal capillaries. If the patient scores poorly on this

> > test then the evaluation may include screening for cytokine

> elevations

> > followed by Coagulation and Red Cell lipid testing

> > through BodyBio /s Hopkins.

> >

> > In both of our satellite clinics in PA and NC we initiate treatment

> with

> > changing the patients overall diet, addressing the

> > outer lipid leaflet of the cell membrane through fatty acid therapy

> and

> > the addition of supplementation targeted towards

> > dissolving fibrin, clearing the liver/biliary tree, and healing the

> cell

> > membrane. The patients' progress is evaluated

> > through the visual contrast test and repeatlab evaluation.

> >

> > Additionally, binding therapy with the cholesterol lowering drug

> > Cholestyramine is an option in treating some of these

> > patients. This drug has a complimentary positive charge to the

> > generally negative charge of the neurotoxin and as the

> > neurotoxin-bile complex passes the Sphincter of Oddi where bile is

> > released from the gallbladder, it binds neurotoxins

> > linked to bile which can then not be reabsorbed. Prolonged use of

> > Cholestyramine has proven to be disappointing in

> > patient outcomes whereby the infection is of a chronic nature.

> Cycling

> > of Cholestyramine has been utilized (5 days on,

> > 10 days off)or an early AM single dose for several months.

> >

> > In our clinical experience we have found that venous Phospholipid

> > Exchange is one of the most efficient ways of

> > clearing the liver and biliary tree which are paramount in

> addressing

> > neurotoxic syndromes. Oral use of phospholipids in

> > a Liver Flush is also an effective intervention.

> >

> > Blood thinning agents such as Heparin and Warfarin increase blood

> flow

> > around the damaged endothelium, however,

> > reconstituting membrane fluidity can directly address coagulation

> in a

> > natural restorative way. Vibrant healthy

> > membranes will not permit agglomeration. The high POLYunsaturated

> > lipids with a preponderance of

> > phosphatidylcholine on the plasmic surface precludes undesirable

> > clumping to occur. Treatment modalities should

> > address dissolving fibrin and healing the cell membrane.

> >

> > Unhealthy bacteria have been known to colonize the liver and its

> biliary

> > system. These bacteria cansynthesize very

> > long chain saturated or renegade fats that lead to liver toxicity,

> > biliary congestion and impairment of prostaglandin

> > synthesis. Lipids vibrate in the cell at millions oftimes/second.

> The

> > double bonds of the omega 6 and omega 3 lipids

> > are the singing backbone of life expressed through their high energy

> > level. These bonds are their vibratory song, and

> > they absolutely carry a tune befitting every act and function in the

> > exercise of life, providing all 70 trillion of our cells their

> > flexible nature. When renegade fats are over represented in the cell

> > membrane they result in off key expression, and if

> > strong enough, may spell cellular death and apoptosis. Healing the

> outer

> > leaflet of the membrane, comprised primarily of

> > phosphatidylcholine, with phospholipid therapy, is our highest

> priority

> > in addressing chronic illness and

> > hypercoagulation.

> >

> > Neal Speight, M.D. is at the Center For Wellness in Charlotte, NC.

> > Contact , M.D. and Kane, Ph.D.

> > at the WellSpring Clinic in Wayne, PA to obtain the 'The Detoxx

> Book:

> > Detoxification of Biotoxins in Chronic Neurotoxic

> > Syndromes' or a Visual Contrast kit at 856-825-8338.

>

>

>

>

>

Link to comment
Share on other sites

thankyou linda. i know how it is with all the email. i cant beleive

how many i am getting now tha i joined this group. every one is nice

hear. do you think doctor kane can give help. let me tell you my

problems. i have the cronic fatique i am so tired i cant get out of

bed some time not godd with children crying all the time. the house

is in bad shape but i dont have time to care. i have a skin infecton

that looks like i got burned with gas. just my arms and stomache. i

think my eyes started goeing bad around the time i found a lttle tick

hiding under my left boob[can i say that]i know you get limes from

ticks but i never had the red cricles. do you and doctor kane help

grownups or just autism children. can you tell me what to do where do

i go? i never had toxic syndrome [dont use tampons] but id have

arhtritis in the toes and fingers and elbows and knee. i dont

drink so tha livers good. i dont eat liver thow ha ha!!!! not sure

about the other stuff in your letter. maybe the oil digetion i a

problem. some times their is oarnge drops of oil in the toilet. i eat

some oiley foods bu mostly health foods like granola for snacks and

friut rollups and no steak ever. my greta uncle had parkinsins. i

think thats about it!! i think my husband is alittle crazy but only

after playing poker. ha ha] he is a good man. i dont think my autism

daughter emma has trouble with calcium becase she drinks plenty a

milk!and saltines are her favrites.

nice to meet you to!!

nacy

> > > Reprinted with permission from:

> > > Allergy Research Group Newsletter: Focus August 2002

> > >

> > > Detoxification of Biotoxins in Chronic Neurotoxic Syndromes

> > >

> > > Kane, Ph.D.

> > >

> > > The following is an excerpt from the work of , M.D,

> >

> > > Kane, Ph.D. and Neal Speight, MD, who have

> > > established a medical protocol to treat chronically ill

patients in

> > > their clinics who are suffering from hypercoagulable

> > > states related to neurotoxin exposure. The patient population

> > affected

> > > includes those with CFIDS, Fibromyalgia, MS,

> > > Cardiovascular Disease, Depression, Rheumatoid Arthritis, IBS,

> > > Infertility, ALS, Parkinsons, Lyme, Stroke, Toxic

> > > Building Syndrome, Estuary Associated Syndrome, Diabetes

without

> > family

> > > Hx, Optic Neuritis, Refractory Heavy Metal

> > > Toxicity, Autism, Pulmonary Hemorrhage. Patients diagnosed with

> > these

> > > chronic illnesses may be potentially

> > > classified as 'Neurotoxic Membrane Syndrome' (NMS) with the

> > endothelial

> > > cell membrane as the target of degeneration.

> > > While hypercoagulation involves a myriad of proteins, it is

> > ultimately a

> > > membrane event, essentially disrupting the

> > > phospholipids that structure the membrane. Agglomeration

(blocked

> > > cellular exposure to blood flow/nutrients and

> > > impaired cell-to-cell communication) indicates elevation of

> > > phospholipase A2 and the uncoupling of eicosanoids from

> > > the cell membrane causing inflammation.

> > >

> > > The recent pioneering work of Ritchie Shoemaker, M.D. as

> > communicated in

> > > his book Desperation Medicine and his

> > > peer reviewed work (Residential and recreational acquisition of

> > possible

> > > estuary associated syndrome - a new approach

> > > to successful diagnosis and treatment, Environmental Health

> > Perspectives

> > > 2001 Oct; 109-Suppl 5:791-6) lends strong

> > > support to a connection between Chronic Fatigue Syndrome,

> > Fibromyalgia,

> > > Lyme Disease, Pfiesteria infection and that

> > > of numerous Neurotoxic Syndromes.

> > >

> > > Neurotoxins are minute compounds between 200-1000 KD

(kilodaltons)

> > that

> > > are comprised of oxygen, nitrogen and

> > > sulfate atoms arranged in such a way as to make the outside of

the

> > > molecule fat loving and water hating. As such, once

> > > it enters the body, it tends to bind to structures that are

rich in

> > fat

> > > such as most of our cells, especially the liver, kidney,

> > > and brain. Neurotoxins are capable of dissolving in fatty

tissue and

> > > moving through it, crossing cell membranes, and

> > > transporting against a gradient, particularly with potassium,

> > disrupting

> > > the electrical balance of the cell itself.

> > >

> > > As fat soluble neurotoxins move through the cells of the body

from

> > the

> > > GI tract to sinus to lung to eye to muscle, to joint

> > > to nerve, etc, they eventually enter the liver and the bile.

Once

> > > neurotoxins bind with bile they have access to the liver,

> > > the body is poisoned over and over again as the bile is re-

> > circulated

> > > (first released into the intestine to digest fats and

> > > then reabsorbed).

> > >

> > > Neurotoxins cause damage by disrupting sodium and calcium

channel

> > > receptors, attacking enzyme reactions involved

> > > in glucose production thereby disrupting energy metabolism in

the

> > cell,

> > > manufacturing renegade fatty acids as saturated

> > > very long chain, odd chain and branched chain fatty acids

impairing

> > > membrane function, stimulating enzymes (PLA2)

> > > which uncouple essential fatty acids from the cell membrane and

> > > impairing the function of the nuclear receptor PPAR

> > > gamma which controls transcription (the conversion of

instructions

> > held

> > > in our DNA to RNA which then leads to

> > > translation or protein production in the cell).

> > >

> > > Once neurotoxins get into the cell they move toward the nucleus

> > turning

> > > on indirectly the production of cytokines such

> > > as TNF alpha,IL6, and IL-1Beta. TNF alpha will cause the garbage

> > cells

> > > in the body(macrophages) to become active.

> > > The white cells are also induced to gather in the area of the

> > cytokine

> > > (TNF alpha) release. TNF alpha also induces

> > > endothelial cell adhesion. Endothelial cells which line the

blood

> > > vessels of the body become " sticky " in conjunction with

> > > the increase in white cells. Increased blood viscosity results

in

> > > restricted blood flow in neurotoxic patients leading to

> > > fatigue and discomfort.

> > >

> > > Hypercoagulation is predominantly an unwanted mass of proteins

> > > disrupting function. When referencing the artery;

> > > hypercoagulation invariably involves the plasmic side of the

cell

> > and if

> > > endothelial cells of the vascular system are

> > > targeted by a toxin (virus, neurotoxin, heavy metal, antibody,

etc),

> > > restriction of blood flow ultimately results. If a neuron

> > > is targeted then signaling is disrupted. The presence of

neurotoxins

> > > involvesPLA2, which is the " sergeant at arms "

> > > monitoring cell membrane health. A membrane disturbance

(unwanted

> > > mass)would trigger the release of eicosanoids,

> > > which would then induce inflammation and call to attention the

> > clean-up

> > > committee, i.e. macrophages.

> > >

> > > Our approach is to first confirm that neurotoxin mediated

illness

> > could

> > > in fact be a problem for the patient via the Visual

> > > Contrast Sensitivity test that isolates deficits in velocity of

> > flow in

> > > retinal capillaries. If the patient scores poorly on this

> > > test then the evaluation may include screening for cytokine

> > elevations

> > > followed by Coagulation and Red Cell lipid testing

> > > through BodyBio /s Hopkins.

> > >

> > > In both of our satellite clinics in PA and NC we initiate

treatment

> > with

> > > changing the patients overall diet, addressing the

> > > outer lipid leaflet of the cell membrane through fatty acid

therapy

> > and

> > > the addition of supplementation targeted towards

> > > dissolving fibrin, clearing the liver/biliary tree, and healing

the

> > cell

> > > membrane. The patients' progress is evaluated

> > > through the visual contrast test and repeatlab evaluation.

> > >

> > > Additionally, binding therapy with the cholesterol lowering drug

> > > Cholestyramine is an option in treating some of these

> > > patients. This drug has a complimentary positive charge to the

> > > generally negative charge of the neurotoxin and as the

> > > neurotoxin-bile complex passes the Sphincter of Oddi where bile

is

> > > released from the gallbladder, it binds neurotoxins

> > > linked to bile which can then not be reabsorbed. Prolonged use

of

> > > Cholestyramine has proven to be disappointing in

> > > patient outcomes whereby the infection is of a chronic nature.

> > Cycling

> > > of Cholestyramine has been utilized (5 days on,

> > > 10 days off)or an early AM single dose for several months.

> > >

> > > In our clinical experience we have found that venous

Phospholipid

> > > Exchange is one of the most efficient ways of

> > > clearing the liver and biliary tree which are paramount in

> > addressing

> > > neurotoxic syndromes. Oral use of phospholipids in

> > > a Liver Flush is also an effective intervention.

> > >

> > > Blood thinning agents such as Heparin and Warfarin increase

blood

> > flow

> > > around the damaged endothelium, however,

> > > reconstituting membrane fluidity can directly address

coagulation

> > in a

> > > natural restorative way. Vibrant healthy

> > > membranes will not permit agglomeration. The high

POLYunsaturated

> > > lipids with a preponderance of

> > > phosphatidylcholine on the plasmic surface precludes undesirable

> > > clumping to occur. Treatment modalities should

> > > address dissolving fibrin and healing the cell membrane.

> > >

> > > Unhealthy bacteria have been known to colonize the liver and its

> > biliary

> > > system. These bacteria cansynthesize very

> > > long chain saturated or renegade fats that lead to liver

toxicity,

> > > biliary congestion and impairment of prostaglandin

> > > synthesis. Lipids vibrate in the cell at millions

oftimes/second.

> > The

> > > double bonds of the omega 6 and omega 3 lipids

> > > are the singing backbone of life expressed through their high

energy

> > > level. These bonds are their vibratory song, and

> > > they absolutely carry a tune befitting every act and function

in the

> > > exercise of life, providing all 70 trillion of our cells their

> > > flexible nature. When renegade fats are over represented in the

cell

> > > membrane they result in off key expression, and if

> > > strong enough, may spell cellular death and apoptosis. Healing

the

> > outer

> > > leaflet of the membrane, comprised primarily of

> > > phosphatidylcholine, with phospholipid therapy, is our highest

> > priority

> > > in addressing chronic illness and

> > > hypercoagulation.

> > >

> > > Neal Speight, M.D. is at the Center For Wellness in Charlotte,

NC.

> > > Contact , M.D. and Kane, Ph.D.

> > > at the WellSpring Clinic in Wayne, PA to obtain the 'The Detoxx

> > Book:

> > > Detoxification of Biotoxins in Chronic Neurotoxic

> > > Syndromes' or a Visual Contrast kit at 856-825-8338.

> >

> >

> >

> >

> >

Link to comment
Share on other sites

, I think very highly of Dr.Kane, that is because she helped

my child so much, and we still, our whole family try to stick

to the diet that she gave my son. She is a nutritionist, and

I believe that is she is the best that there is! Just go

to www.bodybio.com, and get familiar with her successes.

Best,

nkcellular wrote:

>

> thankyou linda. i know how it is with all the email. i cant beleive

> how many i am getting now tha i joined this group. every one is nice

> hear. do you think doctor kane can give help. let me tell you my

> problems. i have the cronic fatique i am so tired i cant get out of

> bed some time not godd with children crying all the time. the house

> is in bad shape but i dont have time to care. i have a skin infecton

> that looks like i got burned with gas. just my arms and stomache. i

> think my eyes started goeing bad around the time i found a lttle tick

> hiding under my left boob[can i say that]i know you get limes from

> ticks but i never had the red cricles. do you and doctor kane help

> grownups or just autism children. can you tell me what to do where do

> i go? i never had toxic syndrome [dont use tampons] but id have

> arhtritis in the toes and fingers and elbows and knee. i dont

> drink so tha livers good. i dont eat liver thow ha ha!!!! not sure

> about the other stuff in your letter. maybe the oil digetion i a

> problem. some times their is oarnge drops of oil in the toilet. i eat

> some oiley foods bu mostly health foods like granola for snacks and

> friut rollups and no steak ever. my greta uncle had parkinsins. i

> think thats about it!! i think my husband is alittle crazy but only

> after playing poker. ha ha] he is a good man. i dont think my autism

> daughter emma has trouble with calcium becase she drinks plenty a

> milk!and saltines are her favrites.

> nice to meet you to!!

>

> nacy

>

>

> > > > Reprinted with permission from:

> > > > Allergy Research Group Newsletter: Focus August 2002

> > > >

> > > > Detoxification of Biotoxins in Chronic Neurotoxic Syndromes

> > > >

> > > > Kane, Ph.D.

> > > >

> > > > The following is an excerpt from the work of , M.D,

> > >

> > > > Kane, Ph.D. and Neal Speight, MD, who have

> > > > established a medical protocol to treat chronically ill

> patients in

> > > > their clinics who are suffering from hypercoagulable

> > > > states related to neurotoxin exposure. The patient population

> > > affected

> > > > includes those with CFIDS, Fibromyalgia, MS,

> > > > Cardiovascular Disease, Depression, Rheumatoid Arthritis, IBS,

> > > > Infertility, ALS, Parkinsons, Lyme, Stroke, Toxic

> > > > Building Syndrome, Estuary Associated Syndrome, Diabetes

> without

> > > family

> > > > Hx, Optic Neuritis, Refractory Heavy Metal

> > > > Toxicity, Autism, Pulmonary Hemorrhage. Patients diagnosed with

> > > these

> > > > chronic illnesses may be potentially

> > > > classified as 'Neurotoxic Membrane Syndrome' (NMS) with the

> > > endothelial

> > > > cell membrane as the target of degeneration.

> > > > While hypercoagulation involves a myriad of proteins, it is

> > > ultimately a

> > > > membrane event, essentially disrupting the

> > > > phospholipids that structure the membrane. Agglomeration

> (blocked

> > > > cellular exposure to blood flow/nutrients and

> > > > impaired cell-to-cell communication) indicates elevation of

> > > > phospholipase A2 and the uncoupling of eicosanoids from

> > > > the cell membrane causing inflammation.

> > > >

> > > > The recent pioneering work of Ritchie Shoemaker, M.D. as

> > > communicated in

> > > > his book Desperation Medicine and his

> > > > peer reviewed work (Residential and recreational acquisition of

> > > possible

> > > > estuary associated syndrome - a new approach

> > > > to successful diagnosis and treatment, Environmental Health

> > > Perspectives

> > > > 2001 Oct; 109-Suppl 5:791-6) lends strong

> > > > support to a connection between Chronic Fatigue Syndrome,

> > > Fibromyalgia,

> > > > Lyme Disease, Pfiesteria infection and that

> > > > of numerous Neurotoxic Syndromes.

> > > >

> > > > Neurotoxins are minute compounds between 200-1000 KD

> (kilodaltons)

> > > that

> > > > are comprised of oxygen, nitrogen and

> > > > sulfate atoms arranged in such a way as to make the outside of

> the

> > > > molecule fat loving and water hating. As such, once

> > > > it enters the body, it tends to bind to structures that are

> rich in

> > > fat

> > > > such as most of our cells, especially the liver, kidney,

> > > > and brain. Neurotoxins are capable of dissolving in fatty

> tissue and

> > > > moving through it, crossing cell membranes, and

> > > > transporting against a gradient, particularly with potassium,

> > > disrupting

> > > > the electrical balance of the cell itself.

> > > >

> > > > As fat soluble neurotoxins move through the cells of the body

> from

> > > the

> > > > GI tract to sinus to lung to eye to muscle, to joint

> > > > to nerve, etc, they eventually enter the liver and the bile.

> Once

> > > > neurotoxins bind with bile they have access to the liver,

> > > > the body is poisoned over and over again as the bile is re-

> > > circulated

> > > > (first released into the intestine to digest fats and

> > > > then reabsorbed).

> > > >

> > > > Neurotoxins cause damage by disrupting sodium and calcium

> channel

> > > > receptors, attacking enzyme reactions involved

> > > > in glucose production thereby disrupting energy metabolism in

> the

> > > cell,

> > > > manufacturing renegade fatty acids as saturated

> > > > very long chain, odd chain and branched chain fatty acids

> impairing

> > > > membrane function, stimulating enzymes (PLA2)

> > > > which uncouple essential fatty acids from the cell membrane and

> > > > impairing the function of the nuclear receptor PPAR

> > > > gamma which controls transcription (the conversion of

> instructions

> > > held

> > > > in our DNA to RNA which then leads to

> > > > translation or protein production in the cell).

> > > >

> > > > Once neurotoxins get into the cell they move toward the nucleus

> > > turning

> > > > on indirectly the production of cytokines such

> > > > as TNF alpha,IL6, and IL-1Beta. TNF alpha will cause the garbage

> > > cells

> > > > in the body(macrophages) to become active.

> > > > The white cells are also induced to gather in the area of the

> > > cytokine

> > > > (TNF alpha) release. TNF alpha also induces

> > > > endothelial cell adhesion. Endothelial cells which line the

> blood

> > > > vessels of the body become " sticky " in conjunction with

> > > > the increase in white cells. Increased blood viscosity results

> in

> > > > restricted blood flow in neurotoxic patients leading to

> > > > fatigue and discomfort.

> > > >

> > > > Hypercoagulation is predominantly an unwanted mass of proteins

> > > > disrupting function. When referencing the artery;

> > > > hypercoagulation invariably involves the plasmic side of the

> cell

> > > and if

> > > > endothelial cells of the vascular system are

> > > > targeted by a toxin (virus, neurotoxin, heavy metal, antibody,

> etc),

> > > > restriction of blood flow ultimately results. If a neuron

> > > > is targeted then signaling is disrupted. The presence of

> neurotoxins

> > > > involvesPLA2, which is the " sergeant at arms "

> > > > monitoring cell membrane health. A membrane disturbance

> (unwanted

> > > > mass)would trigger the release of eicosanoids,

> > > > which would then induce inflammation and call to attention the

> > > clean-up

> > > > committee, i.e. macrophages.

> > > >

> > > > Our approach is to first confirm that neurotoxin mediated

> illness

> > > could

> > > > in fact be a problem for the patient via the Visual

> > > > Contrast Sensitivity test that isolates deficits in velocity of

> > > flow in

> > > > retinal capillaries. If the patient scores poorly on this

> > > > test then the evaluation may include screening for cytokine

> > > elevations

> > > > followed by Coagulation and Red Cell lipid testing

> > > > through BodyBio /s Hopkins.

> > > >

> > > > In both of our satellite clinics in PA and NC we initiate

> treatment

> > > with

> > > > changing the patients overall diet, addressing the

> > > > outer lipid leaflet of the cell membrane through fatty acid

> therapy

> > > and

> > > > the addition of supplementation targeted towards

> > > > dissolving fibrin, clearing the liver/biliary tree, and healing

> the

> > > cell

> > > > membrane. The patients' progress is evaluated

> > > > through the visual contrast test and repeatlab evaluation.

> > > >

> > > > Additionally, binding therapy with the cholesterol lowering drug

> > > > Cholestyramine is an option in treating some of these

> > > > patients. This drug has a complimentary positive charge to the

> > > > generally negative charge of the neurotoxin and as the

> > > > neurotoxin-bile complex passes the Sphincter of Oddi where bile

> is

> > > > released from the gallbladder, it binds neurotoxins

> > > > linked to bile which can then not be reabsorbed. Prolonged use

> of

> > > > Cholestyramine has proven to be disappointing in

> > > > patient outcomes whereby the infection is of a chronic nature.

> > > Cycling

> > > > of Cholestyramine has been utilized (5 days on,

> > > > 10 days off)or an early AM single dose for several months.

> > > >

> > > > In our clinical experience we have found that venous

> Phospholipid

> > > > Exchange is one of the most efficient ways of

> > > > clearing the liver and biliary tree which are paramount in

> > > addressing

> > > > neurotoxic syndromes. Oral use of phospholipids in

> > > > a Liver Flush is also an effective intervention.

> > > >

> > > > Blood thinning agents such as Heparin and Warfarin increase

> blood

> > > flow

> > > > around the damaged endothelium, however,

> > > > reconstituting membrane fluidity can directly address

> coagulation

> > > in a

> > > > natural restorative way. Vibrant healthy

> > > > membranes will not permit agglomeration. The high

> POLYunsaturated

> > > > lipids with a preponderance of

> > > > phosphatidylcholine on the plasmic surface precludes undesirable

> > > > clumping to occur. Treatment modalities should

> > > > address dissolving fibrin and healing the cell membrane.

> > > >

> > > > Unhealthy bacteria have been known to colonize the liver and its

> > > biliary

> > > > system. These bacteria cansynthesize very

> > > > long chain saturated or renegade fats that lead to liver

> toxicity,

> > > > biliary congestion and impairment of prostaglandin

> > > > synthesis. Lipids vibrate in the cell at millions

> oftimes/second.

> > > The

> > > > double bonds of the omega 6 and omega 3 lipids

> > > > are the singing backbone of life expressed through their high

> energy

> > > > level. These bonds are their vibratory song, and

> > > > they absolutely carry a tune befitting every act and function

> in the

> > > > exercise of life, providing all 70 trillion of our cells their

> > > > flexible nature. When renegade fats are over represented in the

> cell

> > > > membrane they result in off key expression, and if

> > > > strong enough, may spell cellular death and apoptosis. Healing

> the

> > > outer

> > > > leaflet of the membrane, comprised primarily of

> > > > phosphatidylcholine, with phospholipid therapy, is our highest

> > > priority

> > > > in addressing chronic illness and

> > > > hypercoagulation.

> > > >

> > > > Neal Speight, M.D. is at the Center For Wellness in Charlotte,

> NC.

> > > > Contact , M.D. and Kane, Ph.D.

> > > > at the WellSpring Clinic in Wayne, PA to obtain the 'The Detoxx

> > > Book:

> > > > Detoxification of Biotoxins in Chronic Neurotoxic

> > > > Syndromes' or a Visual Contrast kit at 856-825-8338.

> > >

> > >

> > >

> > >

> > >

Link to comment
Share on other sites

,

What kind of diet is your son on?

Re: Re: Detoxification of Biotoxins in Chronic Neurotoxic

Syndromes

, I think very highly of Dr.Kane, that is because she helped

my child so much, and we still, our whole family try to stick

to the diet that she gave my son. She is a nutritionist, and

I believe that is she is the best that there is! Just go

to www.bodybio.com, and get familiar with her successes.

Best,

nkcellular wrote:

>

> thankyou linda. i know how it is with all the email. i cant beleive

> how many i am getting now tha i joined this group. every one is nice

> hear. do you think doctor kane can give help. let me tell you my

> problems. i have the cronic fatique i am so tired i cant get out of

> bed some time not godd with children crying all the time. the house

> is in bad shape but i dont have time to care. i have a skin infecton

> that looks like i got burned with gas. just my arms and stomache. i

> think my eyes started goeing bad around the time i found a lttle tick

> hiding under my left boob[can i say that]i know you get limes from

> ticks but i never had the red cricles. do you and doctor kane help

> grownups or just autism children. can you tell me what to do where do

> i go? i never had toxic syndrome [dont use tampons] but id have

> arhtritis in the toes and fingers and elbows and knee. i dont

> drink so tha livers good. i dont eat liver thow ha ha!!!! not sure

> about the other stuff in your letter. maybe the oil digetion i a

> problem. some times their is oarnge drops of oil in the toilet. i eat

> some oiley foods bu mostly health foods like granola for snacks and

> friut rollups and no steak ever. my greta uncle had parkinsins. i

> think thats about it!! i think my husband is alittle crazy but only

> after playing poker. ha ha] he is a good man. i dont think my autism

> daughter emma has trouble with calcium becase she drinks plenty a

> milk!and saltines are her favrites.

> nice to meet you to!!

>

> nacy

>

>

> > > > Reprinted with permission from:

> > > > Allergy Research Group Newsletter: Focus August 2002

> > > >

> > > > Detoxification of Biotoxins in Chronic Neurotoxic Syndromes

> > > >

> > > > Kane, Ph.D.

> > > >

> > > > The following is an excerpt from the work of , M.D,

> > >

> > > > Kane, Ph.D. and Neal Speight, MD, who have

> > > > established a medical protocol to treat chronically ill

> patients in

> > > > their clinics who are suffering from hypercoagulable

> > > > states related to neurotoxin exposure. The patient population

> > > affected

> > > > includes those with CFIDS, Fibromyalgia, MS,

> > > > Cardiovascular Disease, Depression, Rheumatoid Arthritis, IBS,

> > > > Infertility, ALS, Parkinsons, Lyme, Stroke, Toxic

> > > > Building Syndrome, Estuary Associated Syndrome, Diabetes

> without

> > > family

> > > > Hx, Optic Neuritis, Refractory Heavy Metal

> > > > Toxicity, Autism, Pulmonary Hemorrhage. Patients diagnosed with

> > > these

> > > > chronic illnesses may be potentially

> > > > classified as 'Neurotoxic Membrane Syndrome' (NMS) with the

> > > endothelial

> > > > cell membrane as the target of degeneration.

> > > > While hypercoagulation involves a myriad of proteins, it is

> > > ultimately a

> > > > membrane event, essentially disrupting the

> > > > phospholipids that structure the membrane. Agglomeration

> (blocked

> > > > cellular exposure to blood flow/nutrients and

> > > > impaired cell-to-cell communication) indicates elevation of

> > > > phospholipase A2 and the uncoupling of eicosanoids from

> > > > the cell membrane causing inflammation.

> > > >

> > > > The recent pioneering work of Ritchie Shoemaker, M.D. as

> > > communicated in

> > > > his book Desperation Medicine and his

> > > > peer reviewed work (Residential and recreational acquisition of

> > > possible

> > > > estuary associated syndrome - a new approach

> > > > to successful diagnosis and treatment, Environmental Health

> > > Perspectives

> > > > 2001 Oct; 109-Suppl 5:791-6) lends strong

> > > > support to a connection between Chronic Fatigue Syndrome,

> > > Fibromyalgia,

> > > > Lyme Disease, Pfiesteria infection and that

> > > > of numerous Neurotoxic Syndromes.

> > > >

> > > > Neurotoxins are minute compounds between 200-1000 KD

> (kilodaltons)

> > > that

> > > > are comprised of oxygen, nitrogen and

> > > > sulfate atoms arranged in such a way as to make the outside of

> the

> > > > molecule fat loving and water hating. As such, once

> > > > it enters the body, it tends to bind to structures that are

> rich in

> > > fat

> > > > such as most of our cells, especially the liver, kidney,

> > > > and brain. Neurotoxins are capable of dissolving in fatty

> tissue and

> > > > moving through it, crossing cell membranes, and

> > > > transporting against a gradient, particularly with potassium,

> > > disrupting

> > > > the electrical balance of the cell itself.

> > > >

> > > > As fat soluble neurotoxins move through the cells of the body

> from

> > > the

> > > > GI tract to sinus to lung to eye to muscle, to joint

> > > > to nerve, etc, they eventually enter the liver and the bile.

> Once

> > > > neurotoxins bind with bile they have access to the liver,

> > > > the body is poisoned over and over again as the bile is re-

> > > circulated

> > > > (first released into the intestine to digest fats and

> > > > then reabsorbed).

> > > >

> > > > Neurotoxins cause damage by disrupting sodium and calcium

> channel

> > > > receptors, attacking enzyme reactions involved

> > > > in glucose production thereby disrupting energy metabolism in

> the

> > > cell,

> > > > manufacturing renegade fatty acids as saturated

> > > > very long chain, odd chain and branched chain fatty acids

> impairing

> > > > membrane function, stimulating enzymes (PLA2)

> > > > which uncouple essential fatty acids from the cell membrane and

> > > > impairing the function of the nuclear receptor PPAR

> > > > gamma which controls transcription (the conversion of

> instructions

> > > held

> > > > in our DNA to RNA which then leads to

> > > > translation or protein production in the cell).

> > > >

> > > > Once neurotoxins get into the cell they move toward the nucleus

> > > turning

> > > > on indirectly the production of cytokines such

> > > > as TNF alpha,IL6, and IL-1Beta. TNF alpha will cause the garbage

> > > cells

> > > > in the body(macrophages) to become active.

> > > > The white cells are also induced to gather in the area of the

> > > cytokine

> > > > (TNF alpha) release. TNF alpha also induces

> > > > endothelial cell adhesion. Endothelial cells which line the

> blood

> > > > vessels of the body become " sticky " in conjunction with

> > > > the increase in white cells. Increased blood viscosity results

> in

> > > > restricted blood flow in neurotoxic patients leading to

> > > > fatigue and discomfort.

> > > >

> > > > Hypercoagulation is predominantly an unwanted mass of proteins

> > > > disrupting function. When referencing the artery;

> > > > hypercoagulation invariably involves the plasmic side of the

> cell

> > > and if

> > > > endothelial cells of the vascular system are

> > > > targeted by a toxin (virus, neurotoxin, heavy metal, antibody,

> etc),

> > > > restriction of blood flow ultimately results. If a neuron

> > > > is targeted then signaling is disrupted. The presence of

> neurotoxins

> > > > involvesPLA2, which is the " sergeant at arms "

> > > > monitoring cell membrane health. A membrane disturbance

> (unwanted

> > > > mass)would trigger the release of eicosanoids,

> > > > which would then induce inflammation and call to attention the

> > > clean-up

> > > > committee, i.e. macrophages.

> > > >

> > > > Our approach is to first confirm that neurotoxin mediated

> illness

> > > could

> > > > in fact be a problem for the patient via the Visual

> > > > Contrast Sensitivity test that isolates deficits in velocity of

> > > flow in

> > > > retinal capillaries. If the patient scores poorly on this

> > > > test then the evaluation may include screening for cytokine

> > > elevations

> > > > followed by Coagulation and Red Cell lipid testing

> > > > through BodyBio /s Hopkins.

> > > >

> > > > In both of our satellite clinics in PA and NC we initiate

> treatment

> > > with

> > > > changing the patients overall diet, addressing the

> > > > outer lipid leaflet of the cell membrane through fatty acid

> therapy

> > > and

> > > > the addition of supplementation targeted towards

> > > > dissolving fibrin, clearing the liver/biliary tree, and healing

> the

> > > cell

> > > > membrane. The patients' progress is evaluated

> > > > through the visual contrast test and repeatlab evaluation.

> > > >

> > > > Additionally, binding therapy with the cholesterol lowering drug

> > > > Cholestyramine is an option in treating some of these

> > > > patients. This drug has a complimentary positive charge to the

> > > > generally negative charge of the neurotoxin and as the

> > > > neurotoxin-bile complex passes the Sphincter of Oddi where bile

> is

> > > > released from the gallbladder, it binds neurotoxins

> > > > linked to bile which can then not be reabsorbed. Prolonged use

> of

> > > > Cholestyramine has proven to be disappointing in

> > > > patient outcomes whereby the infection is of a chronic nature.

> > > Cycling

> > > > of Cholestyramine has been utilized (5 days on,

> > > > 10 days off)or an early AM single dose for several months.

> > > >

> > > > In our clinical experience we have found that venous

> Phospholipid

> > > > Exchange is one of the most efficient ways of

> > > > clearing the liver and biliary tree which are paramount in

> > > addressing

> > > > neurotoxic syndromes. Oral use of phospholipids in

> > > > a Liver Flush is also an effective intervention.

> > > >

> > > > Blood thinning agents such as Heparin and Warfarin increase

> blood

> > > flow

> > > > around the damaged endothelium, however,

> > > > reconstituting membrane fluidity can directly address

> coagulation

> > > in a

> > > > natural restorative way. Vibrant healthy

> > > > membranes will not permit agglomeration. The high

> POLYunsaturated

> > > > lipids with a preponderance of

> > > > phosphatidylcholine on the plasmic surface precludes undesirable

> > > > clumping to occur. Treatment modalities should

> > > > address dissolving fibrin and healing the cell membrane.

> > > >

> > > > Unhealthy bacteria have been known to colonize the liver and its

> > > biliary

> > > > system. These bacteria cansynthesize very

> > > > long chain saturated or renegade fats that lead to liver

> toxicity,

> > > > biliary congestion and impairment of prostaglandin

> > > > synthesis. Lipids vibrate in the cell at millions

> oftimes/second.

> > > The

> > > > double bonds of the omega 6 and omega 3 lipids

> > > > are the singing backbone of life expressed through their high

> energy

> > > > level. These bonds are their vibratory song, and

> > > > they absolutely carry a tune befitting every act and function

> in the

> > > > exercise of life, providing all 70 trillion of our cells their

> > > > flexible nature. When renegade fats are over represented in the

> cell

> > > > membrane they result in off key expression, and if

> > > > strong enough, may spell cellular death and apoptosis. Healing

> the

> > > outer

> > > > leaflet of the membrane, comprised primarily of

> > > > phosphatidylcholine, with phospholipid therapy, is our highest

> > > priority

> > > > in addressing chronic illness and

> > > > hypercoagulation.

> > > >

> > > > Neal Speight, M.D. is at the Center For Wellness in Charlotte,

> NC.

> > > > Contact , M.D. and Kane, Ph.D.

> > > > at the WellSpring Clinic in Wayne, PA to obtain the 'The Detoxx

> > > Book:

> > > > Detoxification of Biotoxins in Chronic Neurotoxic

> > > > Syndromes' or a Visual Contrast kit at 856-825-8338.

> > >

> > >

> > >

> > >

> > >

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, a combination of the SCDiet and the bodybio diet. Although

I am not being true to either of them, I want it to be that way,

but son will hold out for carbs, and we end up giving in.

In his diet is pecans, almonds (almond oil, almond flour),

sunflower seeds (sunflower oil, sunflower flour). I used the

nuts and seeds to replace any other type of flour, like rice

flour or gluten flour. I just grind them up, until I can use

them like a flour. He gets eggs, just about any kind of meat,

except for canned meat. Any kind of vegetable, except potatoes,

which is hard, he will fight to get those. I use coconut oil,

butter, or sometimes olive oil, if the heat is not to high

to fry or sauté foods. He gets lots of bananas, and yogurt,

and I do give him half and half milk, or buttermilk. There are

recipes that I have been going by in Dr.Kane's detox book,

there are meals for breakfast, lunch, and supper. The main

things that we are suppose to (we are trying to) cut out are

things like bread (other than made with a nut or seed flour),

noodles, potatoes, and some corn like chips. Bodybio is more

like getting stuff into the diet, whereas the SCDiet is taking

some things away, but it is just mainly carbs, that have to go.

Bodybio allows more sweeteners than the SCDiet, but since they

agree on honey, I have just been using that. Actually I can

bring the two diet together and there isn't a conflict, they

both restrict canola oil, margarine, and other hydrogenated

fats. I know I am leaving out a lot of things, but at least

that gives you some idea. Best,

Griffiths wrote:

>

> ,

>

> What kind of diet is your son on?

>

>

> Re: Re: Detoxification of Biotoxins in Chronic Neurotoxic

Syndromes

>

> , I think very highly of Dr.Kane, that is because she helped

> my child so much, and we still, our whole family try to stick

> to the diet that she gave my son. She is a nutritionist, and

> I believe that is she is the best that there is! Just go

> to www.bodybio.com, and get familiar with her successes.

> Best,

>

> nkcellular wrote:

> >

> > thankyou linda. i know how it is with all the email. i cant beleive

> > how many i am getting now tha i joined this group. every one is nice

> > hear. do you think doctor kane can give help. let me tell you my

> > problems. i have the cronic fatique i am so tired i cant get out of

> > bed some time not godd with children crying all the time. the house

> > is in bad shape but i dont have time to care. i have a skin infecton

> > that looks like i got burned with gas. just my arms and stomache. i

> > think my eyes started goeing bad around the time i found a lttle tick

> > hiding under my left boob[can i say that]i know you get limes from

> > ticks but i never had the red cricles. do you and doctor kane help

> > grownups or just autism children. can you tell me what to do where do

> > i go? i never had toxic syndrome [dont use tampons] but id have

> > arhtritis in the toes and fingers and elbows and knee. i dont

> > drink so tha livers good. i dont eat liver thow ha ha!!!! not sure

> > about the other stuff in your letter. maybe the oil digetion i a

> > problem. some times their is oarnge drops of oil in the toilet. i eat

> > some oiley foods bu mostly health foods like granola for snacks and

> > friut rollups and no steak ever. my greta uncle had parkinsins. i

> > think thats about it!! i think my husband is alittle crazy but only

> > after playing poker. ha ha] he is a good man. i dont think my autism

> > daughter emma has trouble with calcium becase she drinks plenty a

> > milk!and saltines are her favrites.

> > nice to meet you to!!

> >

> > nacy

> >

> >

> > > > > Reprinted with permission from:

> > > > > Allergy Research Group Newsletter: Focus August 2002

> > > > >

> > > > > Detoxification of Biotoxins in Chronic Neurotoxic Syndromes

> > > > >

> > > > > Kane, Ph.D.

> > > > >

> > > > > The following is an excerpt from the work of , M.D,

> > > >

> > > > > Kane, Ph.D. and Neal Speight, MD, who have

> > > > > established a medical protocol to treat chronically ill

> > patients in

> > > > > their clinics who are suffering from hypercoagulable

> > > > > states related to neurotoxin exposure. The patient population

> > > > affected

> > > > > includes those with CFIDS, Fibromyalgia, MS,

> > > > > Cardiovascular Disease, Depression, Rheumatoid Arthritis, IBS,

> > > > > Infertility, ALS, Parkinsons, Lyme, Stroke, Toxic

> > > > > Building Syndrome, Estuary Associated Syndrome, Diabetes

> > without

> > > > family

> > > > > Hx, Optic Neuritis, Refractory Heavy Metal

> > > > > Toxicity, Autism, Pulmonary Hemorrhage. Patients diagnosed with

> > > > these

> > > > > chronic illnesses may be potentially

> > > > > classified as 'Neurotoxic Membrane Syndrome' (NMS) with the

> > > > endothelial

> > > > > cell membrane as the target of degeneration.

> > > > > While hypercoagulation involves a myriad of proteins, it is

> > > > ultimately a

> > > > > membrane event, essentially disrupting the

> > > > > phospholipids that structure the membrane. Agglomeration

> > (blocked

> > > > > cellular exposure to blood flow/nutrients and

> > > > > impaired cell-to-cell communication) indicates elevation of

> > > > > phospholipase A2 and the uncoupling of eicosanoids from

> > > > > the cell membrane causing inflammation.

> > > > >

> > > > > The recent pioneering work of Ritchie Shoemaker, M.D. as

> > > > communicated in

> > > > > his book Desperation Medicine and his

> > > > > peer reviewed work (Residential and recreational acquisition of

> > > > possible

> > > > > estuary associated syndrome - a new approach

> > > > > to successful diagnosis and treatment, Environmental Health

> > > > Perspectives

> > > > > 2001 Oct; 109-Suppl 5:791-6) lends strong

> > > > > support to a connection between Chronic Fatigue Syndrome,

> > > > Fibromyalgia,

> > > > > Lyme Disease, Pfiesteria infection and that

> > > > > of numerous Neurotoxic Syndromes.

> > > > >

> > > > > Neurotoxins are minute compounds between 200-1000 KD

> > (kilodaltons)

> > > > that

> > > > > are comprised of oxygen, nitrogen and

> > > > > sulfate atoms arranged in such a way as to make the outside of

> > the

> > > > > molecule fat loving and water hating. As such, once

> > > > > it enters the body, it tends to bind to structures that are

> > rich in

> > > > fat

> > > > > such as most of our cells, especially the liver, kidney,

> > > > > and brain. Neurotoxins are capable of dissolving in fatty

> > tissue and

> > > > > moving through it, crossing cell membranes, and

> > > > > transporting against a gradient, particularly with potassium,

> > > > disrupting

> > > > > the electrical balance of the cell itself.

> > > > >

> > > > > As fat soluble neurotoxins move through the cells of the body

> > from

> > > > the

> > > > > GI tract to sinus to lung to eye to muscle, to joint

> > > > > to nerve, etc, they eventually enter the liver and the bile.

> > Once

> > > > > neurotoxins bind with bile they have access to the liver,

> > > > > the body is poisoned over and over again as the bile is re-

> > > > circulated

> > > > > (first released into the intestine to digest fats and

> > > > > then reabsorbed).

> > > > >

> > > > > Neurotoxins cause damage by disrupting sodium and calcium

> > channel

> > > > > receptors, attacking enzyme reactions involved

> > > > > in glucose production thereby disrupting energy metabolism in

> > the

> > > > cell,

> > > > > manufacturing renegade fatty acids as saturated

> > > > > very long chain, odd chain and branched chain fatty acids

> > impairing

> > > > > membrane function, stimulating enzymes (PLA2)

> > > > > which uncouple essential fatty acids from the cell membrane and

> > > > > impairing the function of the nuclear receptor PPAR

> > > > > gamma which controls transcription (the conversion of

> > instructions

> > > > held

> > > > > in our DNA to RNA which then leads to

> > > > > translation or protein production in the cell).

> > > > >

> > > > > Once neurotoxins get into the cell they move toward the nucleus

> > > > turning

> > > > > on indirectly the production of cytokines such

> > > > > as TNF alpha,IL6, and IL-1Beta. TNF alpha will cause the garbage

> > > > cells

> > > > > in the body(macrophages) to become active.

> > > > > The white cells are also induced to gather in the area of the

> > > > cytokine

> > > > > (TNF alpha) release. TNF alpha also induces

> > > > > endothelial cell adhesion. Endothelial cells which line the

> > blood

> > > > > vessels of the body become " sticky " in conjunction with

> > > > > the increase in white cells. Increased blood viscosity results

> > in

> > > > > restricted blood flow in neurotoxic patients leading to

> > > > > fatigue and discomfort.

> > > > >

> > > > > Hypercoagulation is predominantly an unwanted mass of proteins

> > > > > disrupting function. When referencing the artery;

> > > > > hypercoagulation invariably involves the plasmic side of the

> > cell

> > > > and if

> > > > > endothelial cells of the vascular system are

> > > > > targeted by a toxin (virus, neurotoxin, heavy metal, antibody,

> > etc),

> > > > > restriction of blood flow ultimately results. If a neuron

> > > > > is targeted then signaling is disrupted. The presence of

> > neurotoxins

> > > > > involvesPLA2, which is the " sergeant at arms "

> > > > > monitoring cell membrane health. A membrane disturbance

> > (unwanted

> > > > > mass)would trigger the release of eicosanoids,

> > > > > which would then induce inflammation and call to attention the

> > > > clean-up

> > > > > committee, i.e. macrophages.

> > > > >

> > > > > Our approach is to first confirm that neurotoxin mediated

> > illness

> > > > could

> > > > > in fact be a problem for the patient via the Visual

> > > > > Contrast Sensitivity test that isolates deficits in velocity of

> > > > flow in

> > > > > retinal capillaries. If the patient scores poorly on this

> > > > > test then the evaluation may include screening for cytokine

> > > > elevations

> > > > > followed by Coagulation and Red Cell lipid testing

> > > > > through BodyBio /s Hopkins.

> > > > >

> > > > > In both of our satellite clinics in PA and NC we initiate

> > treatment

> > > > with

> > > > > changing the patients overall diet, addressing the

> > > > > outer lipid leaflet of the cell membrane through fatty acid

> > therapy

> > > > and

> > > > > the addition of supplementation targeted towards

> > > > > dissolving fibrin, clearing the liver/biliary tree, and healing

> > the

> > > > cell

> > > > > membrane. The patients' progress is evaluated

> > > > > through the visual contrast test and repeatlab evaluation.

> > > > >

> > > > > Additionally, binding therapy with the cholesterol lowering drug

> > > > > Cholestyramine is an option in treating some of these

> > > > > patients. This drug has a complimentary positive charge to the

> > > > > generally negative charge of the neurotoxin and as the

> > > > > neurotoxin-bile complex passes the Sphincter of Oddi where bile

> > is

> > > > > released from the gallbladder, it binds neurotoxins

> > > > > linked to bile which can then not be reabsorbed. Prolonged use

> > of

> > > > > Cholestyramine has proven to be disappointing in

> > > > > patient outcomes whereby the infection is of a chronic nature.

> > > > Cycling

> > > > > of Cholestyramine has been utilized (5 days on,

> > > > > 10 days off)or an early AM single dose for several months.

> > > > >

> > > > > In our clinical experience we have found that venous

> > Phospholipid

> > > > > Exchange is one of the most efficient ways of

> > > > > clearing the liver and biliary tree which are paramount in

> > > > addressing

> > > > > neurotoxic syndromes. Oral use of phospholipids in

> > > > > a Liver Flush is also an effective intervention.

> > > > >

> > > > > Blood thinning agents such as Heparin and Warfarin increase

> > blood

> > > > flow

> > > > > around the damaged endothelium, however,

> > > > > reconstituting membrane fluidity can directly address

> > coagulation

> > > > in a

> > > > > natural restorative way. Vibrant healthy

> > > > > membranes will not permit agglomeration. The high

> > POLYunsaturated

> > > > > lipids with a preponderance of

> > > > > phosphatidylcholine on the plasmic surface precludes undesirable

> > > > > clumping to occur. Treatment modalities should

> > > > > address dissolving fibrin and healing the cell membrane.

> > > > >

> > > > > Unhealthy bacteria have been known to colonize the liver and its

> > > > biliary

> > > > > system. These bacteria cansynthesize very

> > > > > long chain saturated or renegade fats that lead to liver

> > toxicity,

> > > > > biliary congestion and impairment of prostaglandin

> > > > > synthesis. Lipids vibrate in the cell at millions

> > oftimes/second.

> > > > The

> > > > > double bonds of the omega 6 and omega 3 lipids

> > > > > are the singing backbone of life expressed through their high

> > energy

> > > > > level. These bonds are their vibratory song, and

> > > > > they absolutely carry a tune befitting every act and function

> > in the

> > > > > exercise of life, providing all 70 trillion of our cells their

> > > > > flexible nature. When renegade fats are over represented in the

> > cell

> > > > > membrane they result in off key expression, and if

> > > > > strong enough, may spell cellular death and apoptosis. Healing

> > the

> > > > outer

> > > > > leaflet of the membrane, comprised primarily of

> > > > > phosphatidylcholine, with phospholipid therapy, is our highest

> > > > priority

> > > > > in addressing chronic illness and

> > > > > hypercoagulation.

> > > > >

> > > > > Neal Speight, M.D. is at the Center For Wellness in Charlotte,

> > NC.

> > > > > Contact , M.D. and Kane, Ph.D.

> > > > > at the WellSpring Clinic in Wayne, PA to obtain the 'The Detoxx

> > > > Book:

> > > > > Detoxification of Biotoxins in Chronic Neurotoxic

> > > > > Syndromes' or a Visual Contrast kit at 856-825-8338.

> > > >

> > > >

> > > >

> > > >

> > > >

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  • 2 years later...

Here are some snippets from a very long and fascinating

article, with some novel approaches to detoxification.

I note that the authors put special emphasis on arachidonic

acid -- the unsaturated fatty acid that is supplied most

abundantly by animal foods such as meat, eggs, butter and

liver (see: Arachidonic Acids in Food

http://www.vaskulitis.org/e/e-arachidon.html )

There is also an emphasis on glutathione, the detoxifying

and protective tripeptide found in raw foods, especially

raw meat and liver.

There is also a mention of the efficacy of butyric acid

for clearing " renegade fatty acids " and " biotoxins " .

Butter is the richest food source of butyric acid.

Interesting. Perhaps raw animal foods -- meat, eggs, butter,

liver -- contain a unique blend of detoxifying elements.

Cooking would damage the glutathione, but might (?) leave

the arachidonate and butyrate unscathed.

FWIW, here is my " practicals review " of the article

(personal health/experimentation notes):

- glutathione for metals detox (raw foods)

- oral phospholipids for detox

- avoid peanuts, canola; " renegade fats " ; VLCFAs

- bile salts and lipase supplements

- increase dietary arachidonate

- heavy metals are lipid soluble; need bile, arachidonate

- avoid excess antioxidants

- oral butyrate very effective in zapping VLCFAs, clearing biotoxins

..... only FWIW.

--AEL

----------------------

SNIPPETS:

http://www.townsendletter.com/Nov_2002/detoxxsystem1102.htm

From the Townsend Letter for Doctors & Patients, November 2002

The Detoxxâ„¢ System: Detoxification of Biotoxins in Chronic

Neurotoxic Syndromes

by , MD, Kane, PhD, and Neal Speight, MD

Chronically ill individuals suffering from neurotoxin exposure

[include] patient populations with CFIDS, Fibromyalgia, MS,

Cardiovascular Disease, Depression, Rheumatoid Arthritis, IBS,

Infertility, ALS, Parkinson's, Lyme, Toxic Building Syndrome,

Estuary Associated Syndrome, Psychosis, Diabetes without

family Hx, Optic Neuritis, Refractory Heavy Metal Toxicity,

Autism, Pulmonary Hemorrhage, Stroke. Patients diagnosed with

these chronic illnesses may be potentially classified as

`Neurotoxic Membrane Syndrome' (NMS) with the endothelial cell

membrane as the target of degeneration.

[.....]

Abnormalities of the hepatobiliary system may involve biliary

stasis whereby infectious material or biotoxins reside within the

liver, biliary tree and gallbladder, as a viscous suspension in

biliary sludge. Biotoxins as bacteria, viruses, parasites,

spirochetes, dinoflagelletes, and fungus may be within biliary

sludge often creating neurotoxins impacting the CNS via the ENS,

or the Second Brain (gut). The occurrence of biliary sludge may be

due to prolonged fasting, low fat intake, high carbohydrate diets

or exposure to pathogens. Restriction of dietary fat may impair

biliary flow which would be contraindicated in attempting to clear

toxicity as bile is paramount to cleansing the body and getting

biotoxins and heavy metals excreted into the fecal matter.

[.....]

HEAVY METALS ARE ALSO LIPID SOLUBLE and often compound the removal

of biotoxins (Aschner et al. 1990, 1998; Dutzak 1991). As has been

observed by many clinicians, often as the patients' heavy metal

toxicity is addressed they are faced with the additional

complication of the presence of biotoxins.... GSH [glutathione]

INFUSION BY FAST IV PUSH has been a remarkable tool to unload the

body burden of heavy metals and neurotoxins in both pediatric and

adult populations, without side effects.

[.....]

Although Arachidonic acid (AA) has been given a negative

association, it is the most prominent essential fatty acid in the

red cell and comprises 12% of the total brain and 15.5% of the

body lipid content. If AA is depleted by overdosing with marine or

flax oil establishing the balance of the EFAs is profoundly

impaired. Often both prostaglandin one and two series relating to

omega six metabolism are compromised when flax and marine oils are

overdosed or lipid intake is insufficient. When AA, the lead

eicosanoid [precursor] of the body, is suppressed due to excess

intake of omega 3, toxicity or disease, the control circuitry of

the body is impaired as is clearly viewed in the patient's

presentation. Arachidonic acid is preferentially wasted in states

of heavy metal toxicity (Tiin and Lin, 1998) and has been observed

to be sharply suppressed in RBC lipid analysis in states of heavy

metal toxicity (Kane, clinical observation 1997-2002).

[.....]

Unhealthy bacteria have been known to colonize the liver and its

biliary system. These bacteria as well as viruses, spirochetes,

dinoflagellates, and the like can synthesize very long chain

saturated or renegade fats that lead to liver toxicity, biliary

congestion, impairment of prostaglandin synthesis and the release

of glutathione.... When renegade fats are over represented in the

cell membrane they result in off key expression, and if strong

enough, may spell cellular death and apoptosis. Healing the outer

leaflet of the membrane (Schachter et al. 1983), comprised

primarily of phosphatidylcholine, with phospholipid therapy, is

our highest priority in addressing chronic illness and

hypercoagulation.

[.....]

The cellular impact of biotoxin and heavy metal burdens results in

disturbed prostaglandin synthesis, poor cellular integrity,

decreased GSH levels.... Biotoxins and heavy metals are lipid

soluble thus the effect upon cellular processes and hepatobiliary

function is often gravely deranged. Often, patients do not possess

a gross burden of toxins but rather a burden that has a finite

impact upon the cell by blocking receptor sites such as G

proteins, which act as a relay system through the cell.

[.....]

Peroxisomes, most prevalent in the liver and kidney, are

organelles within the cell that play a crucial role in clearing

xenobiotics and the third phase of detoxification. Peroxisomes are

intimately involved in cellular lipid metabolism as in the

biosynthesis of fatty acids via á-oxidation involving

physiologically important substrates for VLCFAs, thromboxanes,

leukotrienes and prostaglandins. The creation of a prostaglandin

is an oxidative event (Diczfalusy 1994). Inappropriate use of

antioxidants (mega-dosing) will inhibit á-oxidation, the

production of prostaglandins and cellular metabolism, thus the

liberal use of potent antioxidants would be contraindicated in the

buildup of Renegade fats as VLCFAs, Odd Chain and Branched Chains

which are the hallmark of toxicity.... Inadequate stores of

arachidonic acid can compromise P450 function (McGiff 1991). Oral

application of hormones such as pregnenolone, DHEA (Di Santo et

al. 1996, Ram et al. 1994, Rao et al. 1993) or thyroid stimulate

peroxisomal proliferation and the á-oxidation of Renegade fats as

would nutrients (riboflavin, pyruvate, manganese) and oxidative

therapies. Anti-oxidants slow cellular metabolism and must remain

in the proper balance with all the essential nutrients and

substrates (lipids, protein) to maintain metabolic equilibrium.

Removal of renegade fats in the diet is accomplished by the

avoidance of mustard, canola oil (Naito et al. 2000), peanuts and

peanut oil which contain VLCSFAs that can challenge patients with

liver and CNS toxicity. The oral use of butyrate, a short 4-carbon

chain fatty acid, is of striking benefit (Fusunyan et al. 1998,

Segain et al. 1983, Yin et al. 2001) in mobilizing renegade fats,

lowering TNFalpha, sequestering ammonia, and clearing biotoxins.

[.....]

In states of toxicity it is paramount to stabilize omega 6 fatty

acids and the lead eicosanoid (Attwell et al. 1993) [precursor]

Arachidonic acid (AA) before introducing omega 3 lipids. There

exists a crucial balance between omega 6 and omega 3 fatty acids

in human lipid metabolism which has only recently been brought

into clearer focus through the work of Yehuda (1993, 1994, 1995,

1998, 2000, 2002). His development of the SR-3 (specific ratio of

omega 6 to omega 3) has revealed that the optimum ratio of omega 6

to omega 3 FAs is 4:1. AA, the lead eicosanoid [precursor], must

be stable first along with the other w6 EFAs before w3 fatty acids

are introduced and balanced. Clinicians are often met with poor

patient outcomes when merely administering omega 3 lipids without

first introducing omega 6 fatty acids, stabilizing the structural

lipids, increasing the fat content of the diet, stimulating the

á-oxidation of renegade fatty acids, flushing of the gall

bladder/biliary tree and supporting digestion of fats with bile

salts and lipase.

[.....]

By stabilizing lipid status with intravenous Phospholipid

exchange [iV Phosphatidyl choline] and oral EFA

supplementation we have remarkable tools to unload the body

burden of neurotoxins ( et al. 1982, Cariso et al.

1983, Jaeschke et al. 1987, Kolde et al. 1992) in both

pediatric and adult populations, without side effects. Oral

use of phospholipids in a Liver Flush is also an effective

intervention in addressing neurotoxic syndromes.

[.....]

_____________________________________________________________________

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