Guest guest Posted January 9, 2006 Report Share Posted January 9, 2006 Oh thank you for this. I have been trying to quit for many years but still smoke when under a lot of presure. And let me tell you with being divorced and having a son in and out of mental hospital and having a son who is severly mentally challenged and all his bad behavior and how much I have to watch him, and then having Jra too I feel so uncapeable at times but then when all turns out good for that day I feel better. I need a good excuse to stop smoking and can't seem to at all. But maybe this will help me. hugs; paulette Georgina <gmckin11@...> wrote: Impact Of Smoking And Genes On Rheumatoid Arthritis Article Date: 05 Jan 2006 http://www.medicalnewstoday.com/medicalnews.php?newsid=35748 Rheumatoid arthritis (RA) is one of the most common systemic autoimmune diseases, and one of the least understood. Smoking is the major known environmental risk factor for RA, though little is known about the mechanisms involved. HLA-DR shared epitope (SE) genes are a widely recognized genetic risk factor for RA, though little is known about how these genes affect autoimmune reactions that lead to chronic inflammation and progressive joint and organ damage. To better understand the interactions between smoking and HLA-DR SE genes in RA, a team of researchers in Sweden focused on the disease's distinctive autoimmune hallmark: citrulline, an amino acid not normally present in protein. While extremely rare in healthy individuals and relatively rare in other inflammatory conditions, citrulline-modified proteins are common in about two-thirds of RA patients and may be an underlying factor in the development of the disease. To investigate whether smoking and SE genes trigger immune reactions to citrullinated proteins, the team conducted a case-control study involving patients with recent-onset RA. The results, featured in the January 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis), suggest that smokers with SE genes are more susceptible to anticitrulline antibody-positive RA. The study's 930 early RA patients, drawn from the Epidemiological Investigation of Rheumatoid Arthritis Study Group, ranged in age from 18 to 70 years. 383 healthy controls, drawn from the blood bank of northern Sweden, were matched for age, gender, and residential area. All participants completed questionnaires about their past and present smoking habits, as well as genotyping profiles. In addition, bronchial fluid was obtained from a representative sample of RA patients, including both current heavy smokers and lifelong non-smokers, and tested with immunostaining for the presence of citrullinated protein in cells. Based on their series of experiments and comparisons, the researchers found that a history of smoking increases the risk for RA, but only for individuals who test positive for anticitrulline antibodies, regardless of the presence of SE genes. Similarly, inheriting HLA-DR SE genes in a single copy, as well as in double copies, increases the risk for RA, but only for individuals who test positive for anticitrulline antibodies, including individuals who have never smoked. Yet, for individuals who test positive for anticitrulline antibodies, the interaction of smoking and carrying 2 copies of the SE gene dramatically increases the risk for developing RA--by 21 times. " The remarkable gene-environment interaction observed in the case-control study, together with the immunostaining for citrullinated proteins, might now provide a clue to the molecular mechanisms of importance for disease development in a subset of RA patients, " notes team spokesperson Dr. Lars Klareskog of Karolinska Institutet, Stockholm. " We may thereby be given some new opportunities to both predict and understand the onset of RA and to interfere with RA-inducing events before clinical symptoms are apparent. " Article: " A New Model for an Etiology of Rheumatoid Arthritis: Smoking May Trigger HLA-DR (Shared Epitope)-Restricted Immune Reactions to Autoantigens Modified by Citrullination, " Lars Klareskog, Patrik Stolt, Karin Lundberg, Henrik Källberg, Camilla Bengtsson, Johan Grunewald, Johan Rönnelid, Helena Erlandsson , Ann- Ulfgren, Solbritt Rantapää-Dahlqvist, Anders Eklund, Leonid Padyukov, Lars Alfredsson, and the Epidemiological Investigation of Rheumatoid Arthritis Study Group, Arthritis & Rheumatism, January 2006, 54:1, pp. 53-61. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 9, 2006 Report Share Posted January 9, 2006 I have to say it will make a difference when you do it. My brother was nearly killed in a work injury in May. Thankfully he has had a miraculous recovery except for a tibia that will not heal. It is crushed and they are going to take him back in to surgery to pull the rod and pins out to roto rooter it and hope it will heal this time. He does not smoke but chews tobacco. The doctor said that his odds of healing were over 70% less with tobacco in his system. I certainly won't be easy with all your stressors but my mom said she couldn't just stop she had to replace it with something so she chewed a ton of gum. Best of luck to you! e Ginger Sunshine <pct777@...> wrote: Oh thank you for this. I have been trying to quit for many years but still smoke when under a lot of presure. And let me tell you with being divorced and having a son in and out of mental hospital and having a son who is severly mentally challenged and all his bad behavior and how much I have to watch him, and then having Jra too I feel so uncapeable at times but then when all turns out good for that day I feel better. I need a good excuse to stop smoking and can't seem to at all. But maybe this will help me. hugs; paulette Georgina <gmckin11@...> wrote: Impact Of Smoking And Genes On Rheumatoid Arthritis Article Date: 05 Jan 2006 http://www.medicalnewstoday.com/medicalnews.php?newsid=35748 Rheumatoid arthritis (RA) is one of the most common systemic autoimmune diseases, and one of the least understood. Smoking is the major known environmental risk factor for RA, though little is known about the mechanisms involved. HLA-DR shared epitope (SE) genes are a widely recognized genetic risk factor for RA, though little is known about how these genes affect autoimmune reactions that lead to chronic inflammation and progressive joint and organ damage. To better understand the interactions between smoking and HLA-DR SE genes in RA, a team of researchers in Sweden focused on the disease's distinctive autoimmune hallmark: citrulline, an amino acid not normally present in protein. While extremely rare in healthy individuals and relatively rare in other inflammatory conditions, citrulline-modified proteins are common in about two-thirds of RA patients and may be an underlying factor in the development of the disease. To investigate whether smoking and SE genes trigger immune reactions to citrullinated proteins, the team conducted a case-control study involving patients with recent-onset RA. The results, featured in the January 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis), suggest that smokers with SE genes are more susceptible to anticitrulline antibody-positive RA. The study's 930 early RA patients, drawn from the Epidemiological Investigation of Rheumatoid Arthritis Study Group, ranged in age from 18 to 70 years. 383 healthy controls, drawn from the blood bank of northern Sweden, were matched for age, gender, and residential area. All participants completed questionnaires about their past and present smoking habits, as well as genotyping profiles. In addition, bronchial fluid was obtained from a representative sample of RA patients, including both current heavy smokers and lifelong non-smokers, and tested with immunostaining for the presence of citrullinated protein in cells. Based on their series of experiments and comparisons, the researchers found that a history of smoking increases the risk for RA, but only for individuals who test positive for anticitrulline antibodies, regardless of the presence of SE genes. Similarly, inheriting HLA-DR SE genes in a single copy, as well as in double copies, increases the risk for RA, but only for individuals who test positive for anticitrulline antibodies, including individuals who have never smoked. Yet, for individuals who test positive for anticitrulline antibodies, the interaction of smoking and carrying 2 copies of the SE gene dramatically increases the risk for developing RA--by 21 times. " The remarkable gene-environment interaction observed in the case-control study, together with the immunostaining for citrullinated proteins, might now provide a clue to the molecular mechanisms of importance for disease development in a subset of RA patients, " notes team spokesperson Dr. Lars Klareskog of Karolinska Institutet, Stockholm. " We may thereby be given some new opportunities to both predict and understand the onset of RA and to interfere with RA-inducing events before clinical symptoms are apparent. " Article: " A New Model for an Etiology of Rheumatoid Arthritis: Smoking May Trigger HLA-DR (Shared Epitope)-Restricted Immune Reactions to Autoantigens Modified by Citrullination, " Lars Klareskog, Patrik Stolt, Karin Lundberg, Henrik Källberg, Camilla Bengtsson, Johan Grunewald, Johan Rönnelid, Helena Erlandsson , Ann- Ulfgren, Solbritt Rantapää-Dahlqvist, Anders Eklund, Leonid Padyukov, Lars Alfredsson, and the Epidemiological Investigation of Rheumatoid Arthritis Study Group, Arthritis & Rheumatism, January 2006, 54:1, pp. 53-61. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 9, 2006 Report Share Posted January 9, 2006 Thank you e, I am going to try it. Gosh so sorry to hear about your brother. I only wish that my relatives would call me sometimes and just take intrest. But since my mom and dad died I am pretty much all alone now with me and my kids. I guess that;s why I get so stressed out. hugs; paulette bound for london <boundforlondon@...> wrote: I have to say it will make a difference when you do it. My brother was nearly killed in a work injury in May. Thankfully he has had a miraculous recovery except for a tibia that will not heal. It is crushed and they are going to take him back in to surgery to pull the rod and pins out to roto rooter it and hope it will heal this time. He does not smoke but chews tobacco. The doctor said that his odds of healing were over 70% less with tobacco in his system. I certainly won't be easy with all your stressors but my mom said she couldn't just stop she had to replace it with something so she chewed a ton of gum. Best of luck to you! e Ginger Sunshine <pct777@...> wrote: Oh thank you for this. I have been trying to quit for many years but still smoke when under a lot of presure. And let me tell you with being divorced and having a son in and out of mental hospital and having a son who is severly mentally challenged and all his bad behavior and how much I have to watch him, and then having Jra too I feel so uncapeable at times but then when all turns out good for that day I feel better. I need a good excuse to stop smoking and can't seem to at all. But maybe this will help me. hugs; paulette Georgina <gmckin11@...> wrote: Impact Of Smoking And Genes On Rheumatoid Arthritis Article Date: 05 Jan 2006 http://www.medicalnewstoday.com/medicalnews.php?newsid=35748 Rheumatoid arthritis (RA) is one of the most common systemic autoimmune diseases, and one of the least understood. Smoking is the major known environmental risk factor for RA, though little is known about the mechanisms involved. HLA-DR shared epitope (SE) genes are a widely recognized genetic risk factor for RA, though little is known about how these genes affect autoimmune reactions that lead to chronic inflammation and progressive joint and organ damage. To better understand the interactions between smoking and HLA-DR SE genes in RA, a team of researchers in Sweden focused on the disease's distinctive autoimmune hallmark: citrulline, an amino acid not normally present in protein. While extremely rare in healthy individuals and relatively rare in other inflammatory conditions, citrulline-modified proteins are common in about two-thirds of RA patients and may be an underlying factor in the development of the disease. To investigate whether smoking and SE genes trigger immune reactions to citrullinated proteins, the team conducted a case-control study involving patients with recent-onset RA. The results, featured in the January 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis), suggest that smokers with SE genes are more susceptible to anticitrulline antibody-positive RA. The study's 930 early RA patients, drawn from the Epidemiological Investigation of Rheumatoid Arthritis Study Group, ranged in age from 18 to 70 years. 383 healthy controls, drawn from the blood bank of northern Sweden, were matched for age, gender, and residential area. All participants completed questionnaires about their past and present smoking habits, as well as genotyping profiles. In addition, bronchial fluid was obtained from a representative sample of RA patients, including both current heavy smokers and lifelong non-smokers, and tested with immunostaining for the presence of citrullinated protein in cells. Based on their series of experiments and comparisons, the researchers found that a history of smoking increases the risk for RA, but only for individuals who test positive for anticitrulline antibodies, regardless of the presence of SE genes. Similarly, inheriting HLA-DR SE genes in a single copy, as well as in double copies, increases the risk for RA, but only for individuals who test positive for anticitrulline antibodies, including individuals who have never smoked. Yet, for individuals who test positive for anticitrulline antibodies, the interaction of smoking and carrying 2 copies of the SE gene dramatically increases the risk for developing RA--by 21 times. " The remarkable gene-environment interaction observed in the case-control study, together with the immunostaining for citrullinated proteins, might now provide a clue to the molecular mechanisms of importance for disease development in a subset of RA patients, " notes team spokesperson Dr. Lars Klareskog of Karolinska Institutet, Stockholm. " We may thereby be given some new opportunities to both predict and understand the onset of RA and to interfere with RA-inducing events before clinical symptoms are apparent. " Article: " A New Model for an Etiology of Rheumatoid Arthritis: Smoking May Trigger HLA-DR (Shared Epitope)-Restricted Immune Reactions to Autoantigens Modified by Citrullination, " Lars Klareskog, Patrik Stolt, Karin Lundberg, Henrik Källberg, Camilla Bengtsson, Johan Grunewald, Johan Rönnelid, Helena Erlandsson , Ann- Ulfgren, Solbritt Rantapää-Dahlqvist, Anders Eklund, Leonid Padyukov, Lars Alfredsson, and the Epidemiological Investigation of Rheumatoid Arthritis Study Group, Arthritis & Rheumatism, January 2006, 54:1, pp. 53-61. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 9, 2006 Report Share Posted January 9, 2006 ette, Sounds like you have had an awful lot of stress on your plate. Just wanted to let you know that I am rooting for you in your effort to give up smoking. Are you going to try and go cold turkey or a gradual decrease. Thinking of you and praying that you will have success! Blessings, (aundrea 10 systemic jra)-- - In , Ginger Sunshine <pct777@y...> wrote: > > Thank you e, > > I am going to try it. > > Gosh so sorry to hear about your brother. I only wish that my relatives would call me sometimes and just take intrest. But since my mom and dad died I am pretty much all alone now with me and my kids. I guess that;s why I get so stressed out. > > hugs; paulette > > bound for london <boundforlondon@y...> wrote: > I have to say it will make a difference when you do it. My brother was nearly killed in a work injury in May. Thankfully he has had a miraculous recovery except for a tibia that will not heal. It is crushed and they are going to take him back in to surgery to pull the rod and pins out to roto rooter it and hope it will heal this time. He does not smoke but chews tobacco. The doctor said that his odds of healing were over 70% less with tobacco in his system. I certainly won't be easy with all your stressors but my mom said she couldn't just stop she had to replace it with something so she chewed a ton of gum. Best of luck to you! > > e > > Ginger Sunshine <pct777@y...> wrote: > Oh thank you for this. I have been trying to quit for many years but still smoke when under a lot of presure. And let me tell you with being divorced and having a son in and out of mental hospital and having a son who is severly mentally challenged and all his bad behavior and how much I have to watch him, and then having Jra too I feel so uncapeable at times but then when all turns out good for that day I feel better. I need a good excuse to stop smoking and can't seem to at all. But maybe this will help me. > > hugs; paulette > > Georgina <gmckin11@v...> wrote: > Impact Of Smoking And Genes On Rheumatoid Arthritis > Article Date: 05 Jan 2006 > http://www.medicalnewstoday.com/medicalnews.php?newsid=35748 > > Rheumatoid arthritis (RA) is one of the most common systemic > autoimmune diseases, and one of the least understood. Smoking is the major > known environmental risk factor for RA, though little is known about the > mechanisms involved. HLA-DR shared epitope (SE) genes are a widely > recognized genetic risk factor for RA, though little is known about how > these genes affect autoimmune reactions that lead to chronic inflammation > and progressive joint and organ damage. > > To better understand the interactions between smoking and HLA-DR SE > genes in RA, a team of researchers in Sweden focused on the disease's > distinctive autoimmune hallmark: citrulline, an amino acid not normally > present in protein. While extremely rare in healthy individuals and > relatively rare in other inflammatory conditions, citrulline- modified > proteins are common in about two-thirds of RA patients and may be an > underlying factor in the development of the disease. To investigate whether > smoking and SE genes trigger immune reactions to citrullinated proteins, the > team conducted a case-control study involving patients with recent- onset RA. > The results, featured in the January 2006 issue of Arthritis & Rheumatism > (http://www.interscience.wiley.com/journal/arthritis), suggest that smokers > with SE genes are more susceptible to anticitrulline antibody- positive RA. > > The study's 930 early RA patients, drawn from the Epidemiological > Investigation of Rheumatoid Arthritis Study Group, ranged in age from 18 to > 70 years. 383 healthy controls, drawn from the blood bank of northern > Sweden, were matched for age, gender, and residential area. All participants > completed questionnaires about their past and present smoking habits, as > well as genotyping profiles. In addition, bronchial fluid was obtained from > a representative sample of RA patients, including both current heavy smokers > and lifelong non-smokers, and tested with immunostaining for the presence of > citrullinated protein in cells. > > Based on their series of experiments and comparisons, the researchers > found that a history of smoking increases the risk for RA, but only for > individuals who test positive for anticitrulline antibodies, regardless of > the presence of SE genes. Similarly, inheriting HLA-DR SE genes in a single > copy, as well as in double copies, increases the risk for RA, but only for > individuals who test positive for anticitrulline antibodies, including > individuals who have never smoked. Yet, for individuals who test positive > for anticitrulline antibodies, the interaction of smoking and carrying 2 > copies of the SE gene dramatically increases the risk for developing RA--by > 21 times. > > " The remarkable gene-environment interaction observed in the > case-control study, together with the immunostaining for citrullinated > proteins, might now provide a clue to the molecular mechanisms of importance > for disease development in a subset of RA patients, " notes team spokesperson > Dr. Lars Klareskog of Karolinska Institutet, Stockholm. " We may thereby be > given some new opportunities to both predict and understand the onset of RA > and to interfere with RA-inducing events before clinical symptoms are > apparent. " > > Article: " A New Model for an Etiology of Rheumatoid Arthritis: Smoking > May Trigger HLA-DR (Shared Epitope)-Restricted Immune Reactions to > Autoantigens Modified by Citrullination, " Lars Klareskog, Patrik Stolt, > Karin Lundberg, Henrik Källberg, Camilla Bengtsson, Johan Grunewald, Johan > Rönnelid, Helena Erlandsson , Ann- Ulfgren, Solbritt > Rantapää-Dahlqvist, Anders Eklund, Leonid Padyukov, Lars Alfredsson, and the > Epidemiological Investigation of Rheumatoid Arthritis Study Group, Arthritis > & Rheumatism, January 2006, 54:1, pp. 53-61. > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 9, 2006 Report Share Posted January 9, 2006 ette, Let me tell you from experiance. If you can make it just 14 days without a smoke you will find it outright repulsive. Don't do the gum do the patches.They are expensive but in the long run so much cheaper. You realy can do it.Just try and stay away from people that do smoke in the weaning process. I understand the stress.I had quit for 3 yrs until got sick then started again. I guess I need to take my own advice and quit. Things smell better,food tasts better and lord knows you can breathe better.The first several days are rough while your lungs adjust.You will cough up all kinds of pure nasty crud but then it's gone. I quit duiring both my pregnancys due to a realy good reason not to mention God works in realy mysterious ways and would just get sick. I'll try right along with you!!! Arthurnator@... We can and will do It. Hugs Becki and 7 systemic Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 9, 2006 Report Share Posted January 9, 2006 ette, The very vivid dreams are true while on the patch.They can be good or bad. My mom is trying the patch again and has decided to take the patch off before bed due to the dreams. Mayby the patch while awake and then first thing in the morning chew the gum before you put a new patch on. I swear if you can get through 2 weeks the nicotene craving is gone it's just your hand needs something to do. By some clay and squish it or even playdough.It's rough but you can do it. Hugs Becki and 7 systemic Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 Oh thank you! You don't know what it means to me to know I have someone rooting for me. I thank you for that. I pray I can do it. I thought I would go cold turkey, but then with all this junk I have to contend with, my ex comes by just to bost about his new girlfriend, and the accident and her kids which I told him I don't care and don't need to hear this. He has always told me I was lucky to have him as no one else would ever want me because of my JRA. I need crutches and do have the deformities from this thng. But I think now i will just try the cutting down. I will cut down to every hour and then two and then three and so forth. If that doesn't work I guess I will just throw them in the trash when the trash man comes and be done with it that way. I am going out tomorrow and buy tons of gum! ha ha ha ha Thank you again for the prayer. hugs paulette sonia1md <sonia1md@...> wrote: ette, Sounds like you have had an awful lot of stress on your plate. Just wanted to let you know that I am rooting for you in your effort to give up smoking. Are you going to try and go cold turkey or a gradual decrease. Thinking of you and praying that you will have success! Blessings, (aundrea 10 systemic jra)-- - In , Ginger Sunshine <pct777@y...> wrote: > > Thank you e, > > I am going to try it. > > Gosh so sorry to hear about your brother. I only wish that my relatives would call me sometimes and just take intrest. But since my mom and dad died I am pretty much all alone now with me and my kids. I guess that;s why I get so stressed out. > > hugs; paulette > > bound for london <boundforlondon@y...> wrote: > I have to say it will make a difference when you do it. My brother was nearly killed in a work injury in May. Thankfully he has had a miraculous recovery except for a tibia that will not heal. It is crushed and they are going to take him back in to surgery to pull the rod and pins out to roto rooter it and hope it will heal this time. He does not smoke but chews tobacco. The doctor said that his odds of healing were over 70% less with tobacco in his system. I certainly won't be easy with all your stressors but my mom said she couldn't just stop she had to replace it with something so she chewed a ton of gum. Best of luck to you! > > e > > Ginger Sunshine <pct777@y...> wrote: > Oh thank you for this. I have been trying to quit for many years but still smoke when under a lot of presure. And let me tell you with being divorced and having a son in and out of mental hospital and having a son who is severly mentally challenged and all his bad behavior and how much I have to watch him, and then having Jra too I feel so uncapeable at times but then when all turns out good for that day I feel better. I need a good excuse to stop smoking and can't seem to at all. But maybe this will help me. > > hugs; paulette > > Georgina <gmckin11@v...> wrote: > Impact Of Smoking And Genes On Rheumatoid Arthritis > Article Date: 05 Jan 2006 > http://www.medicalnewstoday.com/medicalnews.php?newsid=35748 > > Rheumatoid arthritis (RA) is one of the most common systemic > autoimmune diseases, and one of the least understood. Smoking is the major > known environmental risk factor for RA, though little is known about the > mechanisms involved. HLA-DR shared epitope (SE) genes are a widely > recognized genetic risk factor for RA, though little is known about how > these genes affect autoimmune reactions that lead to chronic inflammation > and progressive joint and organ damage. > > To better understand the interactions between smoking and HLA-DR SE > genes in RA, a team of researchers in Sweden focused on the disease's > distinctive autoimmune hallmark: citrulline, an amino acid not normally > present in protein. While extremely rare in healthy individuals and > relatively rare in other inflammatory conditions, citrulline- modified > proteins are common in about two-thirds of RA patients and may be an > underlying factor in the development of the disease. To investigate whether > smoking and SE genes trigger immune reactions to citrullinated proteins, the > team conducted a case-control study involving patients with recent- onset RA. > The results, featured in the January 2006 issue of Arthritis & Rheumatism > (http://www.interscience.wiley.com/journal/arthritis), suggest that smokers > with SE genes are more susceptible to anticitrulline antibody- positive RA. > > The study's 930 early RA patients, drawn from the Epidemiological > Investigation of Rheumatoid Arthritis Study Group, ranged in age from 18 to > 70 years. 383 healthy controls, drawn from the blood bank of northern > Sweden, were matched for age, gender, and residential area. All participants > completed questionnaires about their past and present smoking habits, as > well as genotyping profiles. In addition, bronchial fluid was obtained from > a representative sample of RA patients, including both current heavy smokers > and lifelong non-smokers, and tested with immunostaining for the presence of > citrullinated protein in cells. > > Based on their series of experiments and comparisons, the researchers > found that a history of smoking increases the risk for RA, but only for > individuals who test positive for anticitrulline antibodies, regardless of > the presence of SE genes. Similarly, inheriting HLA-DR SE genes in a single > copy, as well as in double copies, increases the risk for RA, but only for > individuals who test positive for anticitrulline antibodies, including > individuals who have never smoked. Yet, for individuals who test positive > for anticitrulline antibodies, the interaction of smoking and carrying 2 > copies of the SE gene dramatically increases the risk for developing RA--by > 21 times. > > " The remarkable gene-environment interaction observed in the > case-control study, together with the immunostaining for citrullinated > proteins, might now provide a clue to the molecular mechanisms of importance > for disease development in a subset of RA patients, " notes team spokesperson > Dr. Lars Klareskog of Karolinska Institutet, Stockholm. " We may thereby be > given some new opportunities to both predict and understand the onset of RA > and to interfere with RA-inducing events before clinical symptoms are > apparent. " > > Article: " A New Model for an Etiology of Rheumatoid Arthritis: Smoking > May Trigger HLA-DR (Shared Epitope)-Restricted Immune Reactions to > Autoantigens Modified by Citrullination, " Lars Klareskog, Patrik Stolt, > Karin Lundberg, Henrik Källberg, Camilla Bengtsson, Johan Grunewald, Johan > Rönnelid, Helena Erlandsson , Ann- Ulfgren, Solbritt > Rantapää-Dahlqvist, Anders Eklund, Leonid Padyukov, Lars Alfredsson, and the > Epidemiological Investigation of Rheumatoid Arthritis Study Group, Arthritis > & Rheumatism, January 2006, 54:1, pp. 53-61. > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 ette, Don't listen to a word that you ex has to say. He is feeding you words of garbage that you just need to toss in the trash along with those cigs! Think about how far you have come dispite having jra. Obviously, you have had to be strong just to cope with the loss of your parents. Perhaps, God brought you to this site so that we could give you words of encouragement and acceptance instead of listening to lies that your ex would like you to believe. Make 2006 the year that you commit to getting healthy in every since of the word. This whole list will only encourage you and when you want to reach for a cig just reach for your keyboard instead! :-) Do you think you should pick up some kind of nicotine patch when your out there getting the gum??? blessings, (Aundrea 10 systemic jra) > > Impact Of Smoking And Genes On Rheumatoid Arthritis > > Article Date: 05 Jan 2006 > > http://www.medicalnewstoday.com/medicalnews.php?newsid=35748 > > > > Rheumatoid arthritis (RA) is one of the most common systemic > > autoimmune diseases, and one of the least understood. Smoking is > the major > > known environmental risk factor for RA, though little is known > about the > > mechanisms involved. HLA-DR shared epitope (SE) genes are a widely > > recognized genetic risk factor for RA, though little is known > about how > > these genes affect autoimmune reactions that lead to chronic > inflammation > > and progressive joint and organ damage. > > > > To better understand the interactions between smoking and > HLA-DR SE > > genes in RA, a team of researchers in Sweden focused on the > disease's > > distinctive autoimmune hallmark: citrulline, an amino acid not > normally > > present in protein. While extremely rare in healthy individuals and > > relatively rare in other inflammatory conditions, citrulline- > modified > > proteins are common in about two-thirds of RA patients and may be > an > > underlying factor in the development of the disease. To > investigate whether > > smoking and SE genes trigger immune reactions to citrullinated > proteins, the > > team conducted a case-control study involving patients with recent- > onset RA. > > The results, featured in the January 2006 issue of Arthritis & > Rheumatism > > (http://www.interscience.wiley.com/journal/arthritis), suggest > that smokers > > with SE genes are more susceptible to anticitrulline antibody- > positive RA. > > > > The study's 930 early RA patients, drawn from the > Epidemiological > > Investigation of Rheumatoid Arthritis Study Group, ranged in age > from 18 to > > 70 years. 383 healthy controls, drawn from the blood bank of > northern > > Sweden, were matched for age, gender, and residential area. All > participants > > completed questionnaires about their past and present smoking > habits, as > > well as genotyping profiles. In addition, bronchial fluid was > obtained from > > a representative sample of RA patients, including both current > heavy smokers > > and lifelong non-smokers, and tested with immunostaining for the > presence of > > citrullinated protein in cells. > > > > Based on their series of experiments and comparisons, the > researchers > > found that a history of smoking increases the risk for RA, but > only for > > individuals who test positive for anticitrulline antibodies, > regardless of > > the presence of SE genes. Similarly, inheriting HLA-DR SE genes in > a single > > copy, as well as in double copies, increases the risk for RA, but > only for > > individuals who test positive for anticitrulline antibodies, > including > > individuals who have never smoked. Yet, for individuals who test > positive > > for anticitrulline antibodies, the interaction of smoking and > carrying 2 > > copies of the SE gene dramatically increases the risk for > developing RA--by > > 21 times. > > > > " The remarkable gene-environment interaction observed in the > > case-control study, together with the immunostaining for > citrullinated > > proteins, might now provide a clue to the molecular mechanisms of > importance > > for disease development in a subset of RA patients, " notes team > spokesperson > > Dr. Lars Klareskog of Karolinska Institutet, Stockholm. " We may > thereby be > > given some new opportunities to both predict and understand the > onset of RA > > and to interfere with RA-inducing events before clinical symptoms > are > > apparent. " > > > > Article: " A New Model for an Etiology of Rheumatoid > Arthritis: Smoking > > May Trigger HLA-DR (Shared Epitope)-Restricted Immune Reactions to > > Autoantigens Modified by Citrullination, " Lars Klareskog, Patrik > Stolt, > > Karin Lundberg, Henrik Källberg, Camilla Bengtsson, Johan > Grunewald, Johan > > Rönnelid, Helena Erlandsson , Ann- Ulfgren, Solbritt > > Rantapää-Dahlqvist, Anders Eklund, Leonid Padyukov, Lars > Alfredsson, and the > > Epidemiological Investigation of Rheumatoid Arthritis Study Group, > Arthritis > > & Rheumatism, January 2006, 54:1, pp. 53-61. > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 you are such a Blessing. Thank you. I guess I do listen as I always have had bad feelings for myself. I did talk to my son tonight and he is feeling less and less depressed as I am always glad i can hand him good words of wisdome. I am trying so hard this year to have nothing but positive thoughts about everything. I was going to pick up a patch for the help of quiting but I have heard so much bad things about using them. Like vivid and bad dreams and things. I thought I would just try the gum first and if that didn't help, then maybe i would take the chance. I was reading the artical on Methotrexate (sp) and it shrinks tumors in the utris it said and that is what I have. I called my Oncologist and he made an appoitment for me and yet after talking to my OB who said no it isn't for calisfied fibroids I am all down now. But I am going to be positive about something will be out there to help me. I want to just plain have them out but both my heart doctor and my lung doctor said no way. I am a big big risk. I would hate to think of what would happen if I needed surgery. So here I stay on tons of pills and my two tumors. Thank you so much for being here. hugs; paulette sonia1md <sonia1md@...> wrote: ette, Don't listen to a word that you ex has to say. He is feeding you words of garbage that you just need to toss in the trash along with those cigs! Think about how far you have come dispite having jra. Obviously, you have had to be strong just to cope with the loss of your parents. Perhaps, God brought you to this site so that we could give you words of encouragement and acceptance instead of listening to lies that your ex would like you to believe. Make 2006 the year that you commit to getting healthy in every since of the word. This whole list will only encourage you and when you want to reach for a cig just reach for your keyboard instead! :-) Do you think you should pick up some kind of nicotine patch when your out there getting the gum??? blessings, (Aundrea 10 systemic jra) > > Impact Of Smoking And Genes On Rheumatoid Arthritis > > Article Date: 05 Jan 2006 > > http://www.medicalnewstoday.com/medicalnews.php?newsid=35748 > > > > Rheumatoid arthritis (RA) is one of the most common systemic > > autoimmune diseases, and one of the least understood. Smoking is > the major > > known environmental risk factor for RA, though little is known > about the > > mechanisms involved. HLA-DR shared epitope (SE) genes are a widely > > recognized genetic risk factor for RA, though little is known > about how > > these genes affect autoimmune reactions that lead to chronic > inflammation > > and progressive joint and organ damage. > > > > To better understand the interactions between smoking and > HLA-DR SE > > genes in RA, a team of researchers in Sweden focused on the > disease's > > distinctive autoimmune hallmark: citrulline, an amino acid not > normally > > present in protein. While extremely rare in healthy individuals and > > relatively rare in other inflammatory conditions, citrulline- > modified > > proteins are common in about two-thirds of RA patients and may be > an > > underlying factor in the development of the disease. To > investigate whether > > smoking and SE genes trigger immune reactions to citrullinated > proteins, the > > team conducted a case-control study involving patients with recent- > onset RA. > > The results, featured in the January 2006 issue of Arthritis & > Rheumatism > > (http://www.interscience.wiley.com/journal/arthritis), suggest > that smokers > > with SE genes are more susceptible to anticitrulline antibody- > positive RA. > > > > The study's 930 early RA patients, drawn from the > Epidemiological > > Investigation of Rheumatoid Arthritis Study Group, ranged in age > from 18 to > > 70 years. 383 healthy controls, drawn from the blood bank of > northern > > Sweden, were matched for age, gender, and residential area. All > participants > > completed questionnaires about their past and present smoking > habits, as > > well as genotyping profiles. In addition, bronchial fluid was > obtained from > > a representative sample of RA patients, including both current > heavy smokers > > and lifelong non-smokers, and tested with immunostaining for the > presence of > > citrullinated protein in cells. > > > > Based on their series of experiments and comparisons, the > researchers > > found that a history of smoking increases the risk for RA, but > only for > > individuals who test positive for anticitrulline antibodies, > regardless of > > the presence of SE genes. Similarly, inheriting HLA-DR SE genes in > a single > > copy, as well as in double copies, increases the risk for RA, but > only for > > individuals who test positive for anticitrulline antibodies, > including > > individuals who have never smoked. Yet, for individuals who test > positive > > for anticitrulline antibodies, the interaction of smoking and > carrying 2 > > copies of the SE gene dramatically increases the risk for > developing RA--by > > 21 times. > > > > " The remarkable gene-environment interaction observed in the > > case-control study, together with the immunostaining for > citrullinated > > proteins, might now provide a clue to the molecular mechanisms of > importance > > for disease development in a subset of RA patients, " notes team > spokesperson > > Dr. Lars Klareskog of Karolinska Institutet, Stockholm. " We may > thereby be > > given some new opportunities to both predict and understand the > onset of RA > > and to interfere with RA-inducing events before clinical symptoms > are > > apparent. " > > > > Article: " A New Model for an Etiology of Rheumatoid > Arthritis: Smoking > > May Trigger HLA-DR (Shared Epitope)-Restricted Immune Reactions to > > Autoantigens Modified by Citrullination, " Lars Klareskog, Patrik > Stolt, > > Karin Lundberg, Henrik Källberg, Camilla Bengtsson, Johan > Grunewald, Johan > > Rönnelid, Helena Erlandsson , Ann- Ulfgren, Solbritt > > Rantapää-Dahlqvist, Anders Eklund, Leonid Padyukov, Lars > Alfredsson, and the > > Epidemiological Investigation of Rheumatoid Arthritis Study Group, > Arthritis > > & Rheumatism, January 2006, 54:1, pp. 53-61. > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 ette, best of luck! You can do it! Donna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 ette, wow, you do have a lot to contend with but I must chime in on one thing you mentioned, " He has always told me I was lucky to have him as no one else would ever want me because of my JRA. I need crutches and do have the deformities from this thng. " Well hun if that what he thinks you are much to good for man like that anyway. Let him have his new girlfriend there are better things around the corner! I relate because many years ago I was in a similar situation and ironically was told the very same thing. My ex would hold my (deformed) hands in front of my face and say things like, " Look & *^%$ who else will have you look at you, your a monster, you should feel lucky to have me. " Well his loss, I left him and have moved on and given myself and my kids a much better home. I dated several times and even got married in 2004. We are so much better than that! Never again will another person have the chance to even think about talking to me like that. If this disease does nothing else it makes you strong, compassionate, courageous, brave, tolerant and patient and oh yeah..vocal. Hang tight and hang tough my friend! Also I quit smoking in a day! I through my cigarettes out in the road, seen the pack get run over and have never smoked again! Smiles! Donna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 >ette, If you don't mind me adding my 2 cents in I quit smoking before I got pregnant cold turkey. It was so hard. I started smoking again after my kids were born. My dr. prescribed me Wellbutrin to help me quit. The 1st 2 weeks the smell of smoke would make we gag. The hardest part was learing to do something else with my hands besides hold a cigarette. I can't believe how much easier it was to quit. If you have a prescription plan maybe you could check that out. Good luck!!! and (9 poly) > ette, > The very vivid dreams are true while on the patch.They can be good or bad. > My mom is trying the patch again and has decided to take the patch off before > bed due to the dreams. > Mayby the patch while awake and then first thing in the morning chew the gum > before you put a new patch on. > I swear if you can get through 2 weeks the nicotene craving is gone it's just > your hand needs something to do. > By some clay and squish it or even playdough.It's rough but you can do it. > Hugs > Becki and 7 systemic > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 That's right, you and those kids should be your world! best of luck and you will always have friends here. Donna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 Another thing to keep your hands buisy is popping bubble wrap. Who can't resist poping that stuff when it comes in packaging and I know you can buy it. I don't recall being tired.Just cranky a bit for the first 2 weeks,after that it was a breeze until the stress of all stress hit.A chronicly ill child. Good luck Becki and 7 systemic Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 Donna you are awesome! (drea 10 systemic jra)--- In , ajaoky@a... wrote: > > ette, wow, you do have a lot to contend with but I must chime in on one > thing you mentioned, " He has always told me I was lucky to have him as no one > else would ever want me because of my JRA. I need crutches and do have the > deformities from this thng. " Well hun if that what he thinks you are much to > good for man like that anyway. Let him have his new girlfriend there are better > things around the corner! I relate because many years ago I was in a similar > situation and ironically was told the very same thing. My ex would hold my > (deformed) hands in front of my face and say things like, " Look & *^%$ who > else will have you look at you, your a monster, you should feel lucky to have > me. " Well his loss, I left him and have moved on and given myself and my kids a > much better home. I dated several times and even got married in 2004. We are > so much better than that! Never again will another person have the chance to > even think about talking to me like that. If this disease does nothing else > it makes you strong, compassionate, courageous, brave, tolerant and patient > and oh yeah..vocal. Hang tight and hang tough my friend! Also I quit smoking in > a day! I through my cigarettes out in the road, seen the pack get run over > and have never smoked again! > Smiles! > Donna > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 I'd like to add that Arthur gives us a unique perspective/ opportunity while dating. While others are going out with the Asshole, bitch (pardon my language), high maintenance sorority girl/ Frat guy... And failing miserably. Arthur has given us a way to QUICKLY weed out those awful types of people that aren't worth your time. If they don't want to be part of your life because of deformities, doctors visits, a little extra time getting out of the car... Then you DON'T want them either. It is that simple. He or she is out there... I promise. Fischer DPA Architects, Inc. pfischer@... Re: OT: Impact Of Smoking And Genes On Rheumatoid Arthritis ette, wow, you do have a lot to contend with but I must chime in on one thing you mentioned, " He has always told me I was lucky to have him as no one else would ever want me because of my JRA. I need crutches and do have the deformities from this thng. " Well hun if that what he thinks you are much to good for man like that anyway. Let him have his new girlfriend there are better things around the corner! I relate because many years ago I was in a similar situation and ironically was told the very same thing. My ex would hold my (deformed) hands in front of my face and say things like, " Look & *^%$ who else will have you look at you, your a monster, you should feel lucky to have me. " Well his loss, I left him and have moved on and given myself and my kids a much better home. I dated several times and even got married in 2004. We are so much better than that! Never again will another person have the chance to even think about talking to me like that. If this disease does nothing else it makes you strong, compassionate, courageous, brave, tolerant and patient and oh yeah..vocal. Hang tight and hang tough my friend! Also I quit smoking in a day! I through my cigarettes out in the road, seen the pack get run over and have never smoked again! Smiles! Donna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 Yes I guess your right! My mom used to say to me when I first went out with this man, why does he want you? You are so sick and he is a healthy normal cute man what does he want you for? I guess she was right! She always said stick to your own kind. Well we have no other JRA's around here but me! ha ha ha ha Thank you, I will keep this all in mind when he keeps coming by while working with his truck. hugs and many thanks to you. paulette Fischer <pfischer@...> wrote: I'd like to add that Arthur gives us a unique perspective/ opportunity while dating. While others are going out with the Asshole, bitch (pardon my language), high maintenance sorority girl/ Frat guy... And failing miserably. Arthur has given us a way to QUICKLY weed out those awful types of people that aren't worth your time. If they don't want to be part of your life because of deformities, doctors visits, a little extra time getting out of the car... Then you DON'T want them either. It is that simple. He or she is out there... I promise. Fischer DPA Architects, Inc. pfischer@... Re: OT: Impact Of Smoking And Genes On Rheumatoid Arthritis ette, wow, you do have a lot to contend with but I must chime in on one thing you mentioned, " He has always told me I was lucky to have him as no one else would ever want me because of my JRA. I need crutches and do have the deformities from this thng. " Well hun if that what he thinks you are much to good for man like that anyway. Let him have his new girlfriend there are better things around the corner! I relate because many years ago I was in a similar situation and ironically was told the very same thing. My ex would hold my (deformed) hands in front of my face and say things like, " Look & *^%$ who else will have you look at you, your a monster, you should feel lucky to have me. " Well his loss, I left him and have moved on and given myself and my kids a much better home. I dated several times and even got married in 2004. We are so much better than that! Never again will another person have the chance to even think about talking to me like that. If this disease does nothing else it makes you strong, compassionate, courageous, brave, tolerant and patient and oh yeah..vocal. Hang tight and hang tough my friend! Also I quit smoking in a day! I through my cigarettes out in the road, seen the pack get run over and have never smoked again! Smiles! Donna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 Donna he would also say, " are you just stupid or stupid? " this was his favorate thing to say when he would try and tell me something about something and used a very low tone one I could not hear and then asked what did you say I couldn't hear you. Sometimes he would say things like you have a big butt or hey scumbag. I mean if this is his feelings why drop by? I thank you Donna for sharing with me and a lot of what your ex said is the same as mine. I never felt so ugly in my life. But, i am back on my feet again and my first and most important thing in life is to take good care of my kids. hugs; paulette ajaoky@... wrote: ette, wow, you do have a lot to contend with but I must chime in on one thing you mentioned, " He has always told me I was lucky to have him as no one else would ever want me because of my JRA. I need crutches and do have the deformities from this thng. " Well hun if that what he thinks you are much to good for man like that anyway. Let him have his new girlfriend there are better things around the corner! I relate because many years ago I was in a similar situation and ironically was told the very same thing. My ex would hold my (deformed) hands in front of my face and say things like, " Look & *^%$ who else will have you look at you, your a monster, you should feel lucky to have me. " Well his loss, I left him and have moved on and given myself and my kids a much better home. I dated several times and even got married in 2004. We are so much better than that! Never again will another person have the chance to even think about talking to me like that. If this disease does nothing else it makes you strong, compassionate, courageous, brave, tolerant and patient and oh yeah..vocal. Hang tight and hang tough my friend! Also I quit smoking in a day! I through my cigarettes out in the road, seen the pack get run over and have never smoked again! Smiles! Donna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 Oh man I sure hope so as right now I am craving one. hugs; paulette ajaoky@... wrote: ette, best of luck! You can do it! Donna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 Hi , Oh I know it will be hard as I have tried to stop many times. Then my ex would say something or my boy would call and say he is back in the hospital and these things would make me run to have one again and again. I thought wellburrin was for something else? Did it work? Was it easier? Thank you for the advice! I may just ask my doctor. Which doctor did you get it from? I have a lung doctor and more maybe I should ask one of them. hugs; paulette shelbert416 <michellecoomes@...> wrote: >ette, If you don't mind me adding my 2 cents in I quit smoking before I got pregnant cold turkey. It was so hard. I started smoking again after my kids were born. My dr. prescribed me Wellbutrin to help me quit. The 1st 2 weeks the smell of smoke would make we gag. The hardest part was learing to do something else with my hands besides hold a cigarette. I can't believe how much easier it was to quit. If you have a prescription plan maybe you could check that out. Good luck!!! and (9 poly) > ette, > The very vivid dreams are true while on the patch.They can be good or bad. > My mom is trying the patch again and has decided to take the patch off before > bed due to the dreams. > Mayby the patch while awake and then first thing in the morning chew the gum > before you put a new patch on. > I swear if you can get through 2 weeks the nicotene craving is gone it's just > your hand needs something to do. > By some clay and squish it or even playdough.It's rough but you can do it. > Hugs > Becki and 7 systemic > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 There are people out there who will love you despite the fact that you have a chronic disease. Honestly that really shocked me! I didn't even want to be around me most of the time, I'm pretty boring when I'm sick, yet somehow at 18 (which i considered pretty young to fall in love) I met a guy who despite everything still loved me and wanted to hang out with me. We've been together for two and half years. He use to hang out with me on methotrexate nights (not to mention he never drank alcohol during the time I was on mtx because I wasn't allowed to and he never wanted me to feel different when we were at parties) even though I felt like crap and most of the time fell asleep during whatever movie we were watching, despite his fear of needles he learned how to give me my enbrel shots, he has always been there to offer a massage when I was in pain, and in the two and half years that i have been sick he has stayed by my side through hospitilizations, one surgery, and a lot of uncertainty, I feel very lucky and I know now that I have this because I deserve this as does every person. Maybe me and my boyfriend wont be together forever or maybe we will, but I realize now how lucky I am to have such a caring and understanding boyfriend. I can't believe your mom would say that to you, or that either of your boyfriends would ever say such hurtful things, I know being 21 my life experience doesn't rank up there that much especially in the love department but I do know that we all deserve people who love and understand us, and it breaks my heart that anyone would ever act that way towards you. We are so much better then that! Donna I am so glad that you found the amazing husband that you have, and ette I'm glad you dumped that ass (pardon my language I'm not much for swearing but it definitely was the only word that fit)! Ginger Sunshine <pct777@...> wrote: Yes I guess your right! My mom used to say to me when I first went out with this man, why does he want you? You are so sick and he is a healthy normal cute man what does he want you for? I guess she was right! She always said stick to your own kind. Well we have no other JRA's around here but me! ha ha ha ha Thank you, I will keep this all in mind when he keeps coming by while working with his truck. hugs and many thanks to you. paulette Fischer <pfischer@...> wrote: I'd like to add that Arthur gives us a unique perspective/ opportunity while dating. While others are going out with the Asshole, bitch (pardon my language), high maintenance sorority girl/ Frat guy... And failing miserably. Arthur has given us a way to QUICKLY weed out those awful types of people that aren't worth your time. If they don't want to be part of your life because of deformities, doctors visits, a little extra time getting out of the car... Then you DON'T want them either. It is that simple. He or she is out there... I promise. Fischer DPA Architects, Inc. pfischer@... Re: OT: Impact Of Smoking And Genes On Rheumatoid Arthritis ette, wow, you do have a lot to contend with but I must chime in on one thing you mentioned, " He has always told me I was lucky to have him as no one else would ever want me because of my JRA. I need crutches and do have the deformities from this thng. " Well hun if that what he thinks you are much to good for man like that anyway. Let him have his new girlfriend there are better things around the corner! I relate because many years ago I was in a similar situation and ironically was told the very same thing. My ex would hold my (deformed) hands in front of my face and say things like, " Look & *^%$ who else will have you look at you, your a monster, you should feel lucky to have me. " Well his loss, I left him and have moved on and given myself and my kids a much better home. I dated several times and even got married in 2004. We are so much better than that! Never again will another person have the chance to even think about talking to me like that. If this disease does nothing else it makes you strong, compassionate, courageous, brave, tolerant and patient and oh yeah..vocal. Hang tight and hang tough my friend! Also I quit smoking in a day! I through my cigarettes out in the road, seen the pack get run over and have never smoked again! Smiles! Donna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 Oh yes I know all too well about the dreams. Good grief, I thought hey maybe it's better to just smoke. ha ha ha I don't blame your mom for trying again. I think I tried about three times and just gave up the patch. I even tried during the day with the patch instead of night but I would go through depression and alot more things seemed to bother me. Did you get very very tired when you stopped? I seem to be able to fall asleep on a dime and can do this anytime in the afternoon. If I quit I will not drive for a while until I know how I feel during the afternoon. Hey now the play dough is a good thing. I have that as i have kids. ha ha ha Maybe I will give that a try. I know my daughter always loves it when we both make things with it. Maybe she will even lend me some to keep with me just to squish. Thank you Becki for the wonderful help here. paulette Arthurnator@... wrote: ette, The very vivid dreams are true while on the patch.They can be good or bad. My mom is trying the patch again and has decided to take the patch off before bed due to the dreams. Mayby the patch while awake and then first thing in the morning chew the gum before you put a new patch on. I swear if you can get through 2 weeks the nicotene craving is gone it's just your hand needs something to do. By some clay and squish it or even playdough.It's rough but you can do it. Hugs Becki and 7 systemic Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 Oh wow just 14 days. Well ha ha ha that may not seem like too long but for someone who smokes it's a liftime. ha ha. But you know I will count the days. Well speaking of repulsive, I can't stand the smell of someones smoke but mine doesn't bother me, and then to smell it on my hand bothers me and I have to wash and wash. Yet i crave it in me. Man who ever invented these things sure got alot of people hooked. Oh wow ok you and I both. Oh man just talking about it makes me want one. I am going to go get some gum. Hugs' paulette Arthurnator@... wrote: ette, Let me tell you from experiance. If you can make it just 14 days without a smoke you will find it outright repulsive. Don't do the gum do the patches.They are expensive but in the long run so much cheaper. You realy can do it.Just try and stay away from people that do smoke in the weaning process. I understand the stress.I had quit for 3 yrs until got sick then started again. I guess I need to take my own advice and quit. Things smell better,food tasts better and lord knows you can breathe better.The first several days are rough while your lungs adjust.You will cough up all kinds of pure nasty crud but then it's gone. I quit duiring both my pregnancys due to a realy good reason not to mention God works in realy mysterious ways and would just get sick. I'll try right along with you!!! Arthurnator@... We can and will do It. Hugs Becki and 7 systemic Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2006 Report Share Posted January 10, 2006 ette, Wellbutrin is an anti depressant. From what my Dr. explained it makes the same chemical reaction in your brain as smoking would. It also helps lose weight because of that same reaction. I would guess any of your doctors could prescribe it to you as long as it doesn't react with any other meds you take. I got it from my Gyno. It was far easier to quit on the meds for me. When I quit cold turkey I was sick, nervous and well quite frankly a maniac for several weeks. It always amazed me that my ex stuck with me through that but bailed when we had the twins but that's a whole other story :-). Whatever way you do it, you will find the strength you need. It sounds like your plate is full right now but you'll feel so much better. As for men - what is it they say about us? Can't live with them, can't shoot them. Seems fitting for them , too. lol. Seriously, I love men and there are some great ones out there who wouldn't dream of talking to a woman like that. You deserve far better. Women are such strong creatures but we never do give ourselves the credit we deserve. Stay strong. Ginger Sunshine <pct777@...> wrote: Hi , Oh I know it will be hard as I have tried to stop many times. Then my ex would say something or my boy would call and say he is back in the hospital and these things would make me run to have one again and again. I thought wellburrin was for something else? Did it work? Was it easier? Thank you for the advice! I may just ask my doctor. Which doctor did you get it from? I have a lung doctor and more maybe I should ask one of them. hugs; paulette shelbert416 <michellecoomes@...> wrote: >ette, If you don't mind me adding my 2 cents in I quit smoking before I got pregnant cold turkey. It was so hard. I started smoking again after my kids were born. My dr. prescribed me Wellbutrin to help me quit. The 1st 2 weeks the smell of smoke would make we gag. The hardest part was learing to do something else with my hands besides hold a cigarette. I can't believe how much easier it was to quit. If you have a prescription plan maybe you could check that out. Good luck!!! and (9 poly) > ette, > The very vivid dreams are true while on the patch.They can be good or bad. > My mom is trying the patch again and has decided to take the patch off before > bed due to the dreams. > Mayby the patch while awake and then first thing in the morning chew the gum > before you put a new patch on. > I swear if you can get through 2 weeks the nicotene craving is gone it's just > your hand needs something to do. > By some clay and squish it or even playdough.It's rough but you can do it. > Hugs > Becki and 7 systemic > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2006 Report Share Posted January 11, 2006 Oh wow now I could sure use something like that. Not just to stop smoking as I have had a few still today, but to lose a few pounds. I will have to ask at my next appoitment. Oh yes I too am that way. My ex stayed wirh me during those hig fever's and all that but when I had breast cancer and had to have kemo, he left out of here the day before. I think he just couldn't cope with all the stress and he never has or will smoke. I have not been on a date since the divorce. It sure made me feel he may be right about no one will want me looking the way I do, but you know what? I feel like now I know myself so much better. I did every thing for him. My hair my clothes and just everything and lost who i was and what i liked but now I know myself again and it's fun. I still do have times of lonleyness for someone to care about me, but hey, that too shall pass. Hugs; paulette Coomes <michellecoomes@...> wrote: ette, Wellbutrin is an anti depressant. From what my Dr. explained it makes the same chemical reaction in your brain as smoking would. It also helps lose weight because of that same reaction. I would guess any of your doctors could prescribe it to you as long as it doesn't react with any other meds you take. I got it from my Gyno. It was far easier to quit on the meds for me. When I quit cold turkey I was sick, nervous and well quite frankly a maniac for several weeks. It always amazed me that my ex stuck with me through that but bailed when we had the twins but that's a whole other story :-). Whatever way you do it, you will find the strength you need. It sounds like your plate is full right now but you'll feel so much better. As for men - what is it they say about us? Can't live with them, can't shoot them. Seems fitting for them , too. lol. Seriously, I love men and there are some great ones out there who wouldn't dream of talking to a woman like that. You deserve far better. Women are such strong creatures but we never do give ourselves the credit we deserve. Stay strong. Ginger Sunshine <pct777@...> wrote: Hi , Oh I know it will be hard as I have tried to stop many times. Then my ex would say something or my boy would call and say he is back in the hospital and these things would make me run to have one again and again. I thought wellburrin was for something else? Did it work? Was it easier? Thank you for the advice! I may just ask my doctor. Which doctor did you get it from? I have a lung doctor and more maybe I should ask one of them. hugs; paulette shelbert416 <michellecoomes@...> wrote: >ette, If you don't mind me adding my 2 cents in I quit smoking before I got pregnant cold turkey. It was so hard. I started smoking again after my kids were born. My dr. prescribed me Wellbutrin to help me quit. The 1st 2 weeks the smell of smoke would make we gag. The hardest part was learing to do something else with my hands besides hold a cigarette. I can't believe how much easier it was to quit. If you have a prescription plan maybe you could check that out. Good luck!!! and (9 poly) > ette, > The very vivid dreams are true while on the patch.They can be good or bad. > My mom is trying the patch again and has decided to take the patch off before > bed due to the dreams. > Mayby the patch while awake and then first thing in the morning chew the gum > before you put a new patch on. > I swear if you can get through 2 weeks the nicotene craving is gone it's just > your hand needs something to do. > By some clay and squish it or even playdough.It's rough but you can do it. > Hugs > Becki and 7 systemic > > > Quote Link to comment Share on other sites More sharing options...
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