Guest guest Posted January 8, 2004 Report Share Posted January 8, 2004 - Forgive my knowledge, I'm new here, but what is this drug used for? -- In , foxhillers@a... wrote: > http://www.medscape.com/viewarticle/466612 > > Medscape Alert > Topiramate Decreases Serum Bicarbonate > > > Medscape Staff ReportDec. 30, 2003 †" Topiramate (Topamax) causes > hyperchloremic, non-anion gap metabolic acidosis (decreased serum bicarbonate), > Ortho-McNeil warned healthcare professionals in a letter mailed this month. Measurement > of baseline and periodic serum bicarbonate during topiramate treatment is > recommended.According to the letter, the rate of occurrence of persistently > decreased serum bicarbonate ranged from 23% to 67% for patients treated with > topiramate and 1% to 10% for placebo in clinical trial. Incidence of markedly low > serum bicarbonate ranged from 3% to 11% for topiramate and 0 to less than 1% for > placebo. " Conditions or therapies that predispose to acidosis (such as renal > disease, severe respiratory disorders, status epilepticus, diarrhea, surgery, > ketogenic diet, or drugs) may be additive to the bicarbonate lowering effects of > topiramate, " the letter added.MedWatch, the U.S. Food and Drug > Administration's safety information > > > > > MJH > " The Basil Book " > http://foxhillfarm.us/FireBasil > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 9, 2004 Report Share Posted January 9, 2004 Topamax is one of many antiepileptic drugs (AEDs). These drugs as used with folks with seizures. mjh > > http://www.medscape.com/viewarticle/466612 > > > > Medscape Alert > > Topiramate Decreases Serum Bicarbonate > > > > > > Medscape Staff ReportDec. 30, 2003 †" Topiramate (Topamax) causes > > hyperchloremic, non-anion gap metabolic acidosis (decreased serum > bicarbonate), > > Ortho-McNeil warned healthcare professionals in a letter mailed > this month. Measurement > > of baseline and periodic serum bicarbonate during topiramate > treatment is > > recommended.According to the letter, the rate of occurrence of > persistently > > decreased serum bicarbonate ranged from 23% to 67% for patients > treated with > > topiramate and 1% to 10% for placebo in clinical trial. Incidence > of markedly low > > serum bicarbonate ranged from 3% to 11% for topiramate and 0 to > less than 1% for > > placebo. " Conditions or therapies that predispose to acidosis (such > as renal > > disease, severe respiratory disorders, status epilepticus, > diarrhea, surgery, > > ketogenic diet, or drugs) may be additive to the bicarbonate > lowering effects of > > topiramate, " the letter added.MedWatch, the U.S. Food and Drug > > Administration's safety information > > > > > > > > > > MJH > > " The Basil Book " > > http://foxhillfarm.us/FireBasil > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2004 Report Share Posted January 14, 2004 Hello I am a lurker cum newby and i really would be grateful for you good peoples advice. My 11yr old sons consultant is suggesting that he should supplement or replace [??] his current tegretol retard medication with Topamax. > http://www.medscape.com/viewarticle/466612 > > Medscape Alert > Topiramate Decreases Serum Bicarbonate> > Medscape Staff ReportDec. 30, 2003 †" Topiramate (Topamax) causes > hyperchloremic, non-anion gap metabolic acidosis (decreased serum bicarbonate), > Ortho-McNeil warned healthcare professionals...... What is hyperchloremic, non-anion gap metabolic acidosis and or serum bicarbinate? The Medscape Alert goes on to say Conditions or therapies that predispose to acidosis (such as renal > disease, severe respiratory disorders, status epilepticus, diarrhea, surgery, > ketogenic diet, or drugs) may be additive to the bicarbonate lowering effects of > topiramate, " Can anyone explain what this means? has does have status epilepticus attacks and during the last year we have found that the only thing which is effective for controlling headaches and nausea which have persisted [and been wholly unresponsive to any conventional medication] for up to about 6+ weeks at a time and caused him to miss a lot of schooling..has been a ketone inducing low carb Atkins diet. Although the Consultant seems to have a seizure himself when the word 'diet' is mentionned , we are convinced that restriction of certain foods and/or putting into ketosis is the only way of improving the quality of his life. Please come back to me quickly. I am desperately worried. Since thomas went into a major seizure he has been and still is in hospital for 7 days at the consultants insistance for 'investigations'.To date these have consisted of 2 blood tests [negative], one urine test [negative save bit low on the carbamazapine levels] and a lot of questions [from a student nurse and in a half an hour with psychyatrist] asking if he is stressed because of his diet and could he not do more exercise instead! i have also seen a dietician and we have had 2 talks with the consultant who seems not to have read the notes. He is totally obsessed with this diet thing [although T was not any 'diet' when he has this or any other seizure!] He has also has queried whether he is faking the seizures and whether we have not been giving T his medication! We are clearly under investigation and it is extremely stressful. > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2004 Report Share Posted January 22, 2004 You know what is strange about a lot of these meds, alternative meds (keto diet), they all alter the metabolic acid/alkaline balance. One of the mom's two years ago said she gave her daughter sodium bicarbonate (baking soda) to calm an upset stomach and she had a seizure. My own daughter craves acidic foods, ie. pickles, sauerkraut, etc. It makes you wonder if a lot of these children suffer metabolic alkosis, maybe a slight imbalance (nothing drastic enough to have other symptoms). Just pondering or sluthing as someone called it last year. Quote Link to comment Share on other sites More sharing options...
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