An interesting chemical is DMSO, made from the sap of trees.
This drug is widely available and very low in toxicity. Apart from its
it is used to enhance the effects of other drugs. It does this by modifying cell
If you pour some ink on you skin you can wash it off, but if you mix DMSO with
and pour it on the skin you may get a permanent tattoo. So DMSO can carry things
I have an interest in the ability of DMSO to carry cancer killing oxygen
like H2O2, into tissues.
Effect of DMSO and DFMO on rat prostate tumor growth.
Carvalho L, Foulkes K, Mickey DD
Department of Surgery, University of North Carolina, Chapel Hill 27599-7235.
An anaplastic, metastatic subline of the Dunning rat tumor was exposed to
non-cytodestructive doses of the cellular differentiation agents
dimethylsulfoxide and difluoromethylornithine. Copenhagen rats hosting prostate
tumors were evaluated by comparing solid tumor growth resulting from injection
of treated cells with solid tumor growth of untreated control cells. Results
showed significantly slower solid tumor growth after a 15 day in vitro exposure
of cells to either agent, after oral treatment of host animals for 20 days with
either agent before injection of untreated tumor cells, and after oral treatment
of host animals with either agent initiated on the day of untreated tumor cell
injection. Treatment of animals with established tumors with either agent also
had an inhibitory effect on tumor growth, and the effect was related to the
length of treatment. Thus, exposure of these highly malignant rat prostate
carcinoma cells to non-cytotoxic doses of either agent induced slower tumor
growth rates. Treatment with either agent could have selected for a slower
growing population of tumor cells. Since a slowing of cell cycle transit times
is an early indicator of cellular differentiation, these results could reflect
an increase in the capacity of the malignant cells to differentiate.
PMID: 2508071, UI: 90017079