I think it worths the time reading this article !!! Learn it !!!

July 30, 2010

This article is about how effective is Caspofungin penetrating candida biofilms

but there is important information that we should know. First, candida biofilms

are present in most candida infections. (mucousal or in contact with devices.

The article also speaks about how the azole drugs and Amp B fail to penetrate

candida biofilms. The article speaks how Caspofungin is Fungicidal. (that is

what we need) Unfortunately, the azoles are Fungistatic in the doses we can

tolerate. Another point is how the Echinocandins (Miconazole, Cancidas, and

Anidulafungin) target the 1.3 Beta D Glucan which is the main componet of the

fugus cell wall (60%) We, humans, don't have Glucan in our cells, So, therapies

like this don't affect our cell integrity. This isn't possible using the azoles

( Ketoconazole, Fluconazole, Itraconazole, Voriconazole, and Posoconazole) which

attack Ergosterol very similar to Cholesterol the main part of our cells. Going

to the point, How can we think that using any Azole, which are fungistatics,

(don't kill), have poor Biofilm penetration, we can't take them in high doses

because our sell could be also damaged, we can eradicate a candida infection???

Also, they aren't totally broad spectrum against all candida strains. See how

many limitations. This is the reason because you find many people telling Rx

drugs did nothing for them. See the other part, Echinocandins, are Fungicidal

against most candida strains (kill). Less toxic to the humans because they

target something we don't have in our cells and they penetrate Biofilms a lot

better than other antifungals. I am almost sure if we could have Oral versions

available, most of us could be candida free. Do your own conclusions. Still, we

can use some substances to disrupt biofilms and allow our limited weapons to do

their job better. I will post what we can do according to the available

information. Sorry for the lenght of this post.

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