Thyroid Disorders and Hepatitis C

[Guest guest]

Thyroid Disorders and Hepatitis C

Thyroid Disorders, Treatment and Hepatitis C

,

Interferon treatment can cause thyroid changes, so you could see a TSH level rise or fall when you are receiving interferon.

,Occasionally, patients on interferon need to take medication to correct their TSH levels.

,Hepatitis C itself also can cause thyroid changes, even without the interferon treatment.

,HCV infected persons show a higher rate of Thyroid disease then the general public.

..

Thyroid problems are common and occur without hepatitis C.,

http://www.hepatitis.va.gov

FFrom Tina @J & F Blog.

Thyroid disorders run in my family; My mother had surgery to remove her overactive thyroid, my daughter, son, niece, brother and myself all have hashimoto's.When I was on Interferon and Ribavirin my thyroid function was further impaired. Even now I am still taking a much higher dose of synthroid (thyroid medication) then I did before treatment.What I find interesting is that researchers have reported people with HCV show a higher risk of having thyroid disorders. The research found that (an underactive or overactive thyroid) is more common in people with HCV than the general public. Among that population it was found that more individuals had an underactive thyroid .

The recommendation is that HCV patients should be periodically screened for thyroid function, in particular hypothyroidism and autoimmune thyroid disease.

Risk Factors With Hypothyroidism and HCV in Women

Posted on May 6, 2009

..Hypothyroidism may increase liver cancer risk in women

“Screening and proper management of thyroid diseases in patients with diabetes or hepatitis C virus infection may help prevent hepatocellular carcinoma.†Data from an ongoing hospital-based case-control study indicate that women with a prior history of hypothyroidism may be at an increased risk for liver cancer. However, researchers are unclear about whether and why hypothyroidism causes liver cancer..

“Although hypothyroidism-associated weight gain may partially explain the association between hypothyroidism and hepatocellular carcinoma, hypothyroidism independent from obesity can also contribute to hepatocellular carcinoma development,†the researchers wrote. “Screening and proper management of thyroid diseases in patients with diabetes or hepatitis C virus infection may help prevent hepatocellular carcinoma.â€

..Researchers from M.D. Cancer Center in Houston examined demographic and liver cancer risk factor data from the records of 420 patients with newly diagnosed liver cancer and compared the data with 1,104 healthy controls.Patients were questioned about their prior history of thyroid disorders. Those with a prior history of thyroid disorders were asked for age at diagnosis, duration of the disorder and treatment exposure

.. Hepatitis C, cigarette use

,A questionnaire about prior history of obesity was administered to 184 patients and 648 controls. Blood samples from 420 patients and 1,104 controls were tested for hepatitis B and hepatitis C.A history of hepatitis C or hepatitis B, cigarette smoking, heavy alcohol consumption or having a family history of cancer or diabetes were significantly associated with liver cancer development, they reported in Hepatology.Fifteen percent of patients with liver cancer had a history of thyroid disease compared with nearly 12% of healthy controls

.. A significant interaction was found between gender and hypothyroidism on the development of liver cancer (P=.02). Women with a history of hypothyroidism had a twofold higher risk for liver cancer. In addition, women with a prior history of hypothyroidism for longer than 10 years had a threefold higher risk for liver cancer when compared with women without a history of thyroid disorders (P=.001)

..The researchers observed a significant risk modification of combined hypothyroidism and hepatitis infection and combined diabetes and hepatitis infection in women.According to the researchers, hypothyroidism may also play a role in the development of nonalcoholic steatohepatitis, further contributing to the susceptibility of liver cancer development.“Further studies among different populations are warranted to confirm the association between hypothyroidism and hepatocellular carcinoma and to identify the underlying biological mechanisms and the genetic predisposition factors that may contribute to susceptibility to hepatocellular carcinoma development in the presence of thyroid disorders,†the researchers said..Hassan M. Hepatology.

2009;49:1563-1570..

How The Thyroid Works

,

TSH is a hormone produced by the pituitary gland in the brain. TSH causes the thyroid gland (located in the neck) to produce thyroid (T4 and T3).

The hypothalamus in the brain releases Thyrotropin-releasing Hormone (TRH). The release of TRH tells the pituitary gland to release Thyroid Stimulating Hormone (TSH). This TSH, circulating in your bloodstream, is what tells the thyroid to make thyroid hormones and release them into your bloodstream.

The thyroid has the only cells in the body capable of absorbing iodine. The thyroid takes in iodine, obtained through food, iodized salt, or supplements, and combines it with the amino acid tyrosine. The thyroid then converts the iodine/tyrosine into the hormones T3 and T4. The "3" and the "4" refer to the number of iodine molecules in each thyroid hormone molecule.

,

,

,

..

Thyroid disorders

Hashimoto's

.. Hashimoto's Thyroiditis is a type of autoimmune thyroid disease in which the immune system attacks and destroys the thyroid gland. The thyroid helps set the rate of metabolism, which is the rate at which the body uses energy. Hashimoto’s stops the gland from making enough thyroid hormones for the body to work the way it should. It is the most common thyroid disease in the U.S.

Hashimoto's disease is a disease, and hypothyroidism is a condition. Hypothyroidism -- An underactive thyroid.Hyperthyroidism -- An overactive thyroid.

..

Graves Disease

,Graves' disease is the most common form of hyperthyroidism, occurring when your immune system mistakenly attacks your thyroid gland and causes it to overproduce the hormone thyroxine. This higher thyroxine level can greatly increase your body's metabolic rate, which may affect you in numerous ways, from your moods to your physical appearance;

Sometimes the thyroid becomes enlarged -- due to Hashimoto's disease, Graves' disease, nutritional deficiencies, or other thyroid imbalances. When the thyroid become enlarged, this is known as a goiter.

..

Goiter -- An enlarged thyroid.

..Some people develop solid or liquid filled cysts, lumps, bumps and tumors -- both benign and cancerous -- in the thyroid gland. These are known as thyroid nodules.

..Thyroid Nodules -- Lumps in the thyroid gland.Thyroid Cancer -- Malignant thyroid nodules or tissue.Thyroiditis -- Inflammation of the thyroid.

,Because thyroid disease is common in HCV infection it is further irritated with the use of interferon therapy. Thyroid disease can manifest during HCV interferon-related therapy. 2010/Thyroid dysfunction in a UK hepatitis C population treated with interferon-alpha and ribavirin combination therapyThyroid dysfunction and interferon-alpha therapy for hepatitis C

An important fact here is to be screened for thyroid dysfunction while treating HCV.

Blood Test Is TSH

(thyroid stimulating hormone)

, Blood tests should be given *during treatment at 12, 24, and 48 weeks

* varies depending on genotype.

,If you are in the small percent of people who developed thyroid dysfunction during treatment you will need on going treatment for thyroid disease.

,

Location

Your thyroid is a small bowtie or butterfly-shaped gland, located in your neck, wrapped around the windpipe, behind and below the Adam's Apple area.

,

Symptoms

One Thyroid disorder, Hashimoto's disease does not have unique signs and symptoms. The disease typically progresses slowly over a number of years and causes chronic thyroid damage, leading to a drop in thyroid hormone levels in your blood.

The signs and symptoms are mainly those of an underactive thyroid gland (hypothyroidism).

,The signs and symptoms of hypothyroidism vary widely, depending on the severity of hormone deficiency. At first, you may barely notice any symptoms, such as fatigue and sluggishness, or you may simply attribute them to getting older. But as the disease progresses, you may develop more obvious signs and symptoms.

Signs and symptoms of hypothyroidism include:.,underactive thyroid

Fatigue and sluggishnessIncreased sensitivity to coldConstipationPale, dry skinA puffy faceHoarse voice

An elevated blood cholesterol levelUnexplained weight gain -

occurring infrequently and rarely more than 10 to 20 pounds, most of which is fluidMuscle aches, tenderness and stiffness, especially in your shoulders and hips

Pain and stiffness in your joints and swelling in your knees or the small joints in your hands and feet

.. , Muscle weakness, especially in your lower extremitiesExcessive or prolonged menstrual bleeding (menorrhagia)

DepressionWithout treatment, signs and symptoms gradually become more severe and your thyroid gland may become enlarged (goiter). In addition, you may become more forgetful, your thought processes may slow, or you may feel depressed.

More On Hypothyroidism (underactive thyroid) Is a condition in which your thyroid gland doesn't produce enough of certain important hormones.Women, especially those older than 50, are more likely to have hypothyroidism. Hypothyroidism upsets the normal balance of chemical reactions in your body. It seldom causes symptoms in the early stages, but over time, untreated hypothyroidism can cause a number of health problems, such as obesity, joint pain, infertility and heart disease.The good news is that accurate thyroid function tests are available to diagnose hypothyroidism, and treatment of hypothyroidism with synthetic thyroid hormone is usually simple, safe and effective once the proper dosage is established. Hyperthyroidism (overactive thyroid) Is a condition in which your thyroid gland produces too much of the hormone thyroxine. Hyperthyroidism can significantly accelerate your body's metabolism, causing sudden weight loss, a rapid or irregular heartbeat, sweating, and nervousness or irritability.Several treatment options are available if you have hyperthyroidism. Doctors use anti-thyroid medications and radioactive iodine to slow the production of thyroid hormones. Sometimes, treatment of hyperthyroidism involves surgery to remove part of your thyroid gland. Although hyperthyroidism can be serious if you ignore it, most people respond well once hyperthyroidism is diagnosed and treated

http://hepmon.com/view/?id=146

http://www.mayoclinic.com/health/hyperthyroidism/DS00344

http://www.mayoclinic.com/health/thyroid-disease/AN00986

http://qjmed.oxfordjournals.org/cgi/content/extract/103/3/187

http://Hepatitis Cnewdrugs.blogspot.com/2010/05/thyroid-disorders-and-hepatitis-c.html

[Guest guest]

Thanks Don, I have been batteling thyroid problems since treatment I appreciate the site.

From: Christ <ludichrist2000@...>009 - VCHepC <VCHepC >; Hepatitis C <Hepatitis C >; WebWarriors grp < >Sent: Sat, May 15, 2010 6:40:03 PMSubject: [ ] Thyroid Disorders and Hepatitis C

Thyroid Disorders and Hepatitis C

Thyroid Disorders, Treatment and Hepatitis C

,

Interferon treatment can cause thyroid changes, so you could see a TSH level rise or fall when you are receiving interferon.

,Occasionally, patients on interferon need to take medication to correct their TSH levels.

,Hepatitis C itself also can cause thyroid changes, even without the interferon treatment.

,HCV infected persons show a higher rate of Thyroid disease then the general public.

..

Thyroid problems are common and occur without hepatitis C.,

http://www.hepatiti s.va.gov

FFrom Tina @J & F Blog.

Thyroid disorders run in my family; My mother had surgery to remove her overactive thyroid, my daughter, son, niece, brother and myself all have hashimoto's.When I was on Interferon and Ribavirin my thyroid function was further impaired. Even now I am still taking a much higher dose of synthroid (thyroid medication) then I did before treatment.What I find interesting is that researchers have reported people with HCV show a higher risk of having thyroid disorders. The research found that (an underactive or overactive thyroid) is more common in people with HCV than the general public. Among that population it was found that more individuals had an underactive thyroid .

The recommendation is that HCV patients should be periodically screened for thyroid function, in particular hypothyroidism and autoimmune thyroid disease.

Risk Factors With Hypothyroidism and HCV in Women

Posted on May 6, 2009

..Hypothyroidism may increase liver cancer risk in women

“Screening and proper management of thyroid diseases in patients with diabetes or hepatitis C virus infection may help prevent hepatocellular carcinoma.†Data from an ongoing hospital-based case-control study indicate that women with a prior history of hypothyroidism may be at an increased risk for liver cancer. However, researchers are unclear about whether and why hypothyroidism causes liver cancer..

“Although hypothyroidism- associated weight gain may partially explain the association between hypothyroidism and hepatocellular carcinoma, hypothyroidism independent from obesity can also contribute to hepatocellular carcinoma development,†the researchers wrote. “Screening and proper management of thyroid diseases in patients with diabetes or hepatitis C virus infection may help prevent hepatocellular carcinoma.â€

..Researchers from M.D. Cancer Center in Houston examined demographic and liver cancer risk factor data from the records of 420 patients with newly diagnosed liver cancer and compared the data with 1,104 healthy controls.Patients were questioned about their prior history of thyroid disorders. Those with a prior history of thyroid disorders were asked for age at diagnosis, duration of the disorder and treatment exposure

.. Hepatitis C, cigarette use

,A questionnaire about prior history of obesity was administered to 184 patients and 648 controls. Blood samples from 420 patients and 1,104 controls were tested for hepatitis B and hepatitis C.A history of hepatitis C or hepatitis B, cigarette smoking, heavy alcohol consumption or having a family history of cancer or diabetes were significantly associated with liver cancer development, they reported in Hepatology.Fifteen percent of patients with liver cancer had a history of thyroid disease compared with nearly 12% of healthy controls

.. A significant interaction was found between gender and hypothyroidism on the development of liver cancer (P=.02). Women with a history of hypothyroidism had a twofold higher risk for liver cancer. In addition, women with a prior history of hypothyroidism for longer than 10 years had a threefold higher risk for liver cancer when compared with women without a history of thyroid disorders (P=.001)

..The researchers observed a significant risk modification of combined hypothyroidism and hepatitis infection and combined diabetes and hepatitis infection in women.According to the researchers, hypothyroidism may also play a role in the development of nonalcoholic steatohepatitis, further contributing to the susceptibility of liver cancer development.“Further studies among different populations are warranted to confirm the association between hypothyroidism and hepatocellular carcinoma and to identify the underlying biological mechanisms and the genetic predisposition factors that may contribute to susceptibility to hepatocellular carcinoma development in the presence of thyroid disorders,†the researchers said..Hassan M.

Hepatology. 2009;49:1563- 1570..

How The Thyroid Works

,

TSH is a hormone produced by the pituitary gland in the brain. TSH causes the thyroid gland (located in the neck) to produce thyroid (T4 and T3).

The hypothalamus in the brain releases Thyrotropin- releasing Hormone (TRH). The release of TRH tells the pituitary gland to release Thyroid Stimulating Hormone (TSH). This TSH, circulating in your bloodstream, is what tells the thyroid to make thyroid hormones and release them into your bloodstream.

The thyroid has the only cells in the body capable of absorbing iodine. The thyroid takes in iodine, obtained through food, iodized salt, or supplements, and combines it with the amino acid tyrosine. The thyroid then converts the iodine/tyrosine into the hormones T3 and T4. The "3" and the "4" refer to the number of iodine molecules in each thyroid hormone molecule.

,

,

,

..

Thyroid disorders

Hashimoto's . Hashimoto's Thyroiditis is a type of autoimmune thyroid disease in which the immune system attacks and destroys the thyroid gland. The thyroid helps set the rate of metabolism, which is the rate at which the body uses energy. Hashimoto’s stops the gland from making enough thyroid hormones for the body to work the way it should. It is the most common thyroid disease in the U.S. Hashimoto's disease is a disease, and hypothyroidism is a condition. Hypothyroidism -- An underactive thyroid.Hyperthyroidism -- An overactive thyroid.

..

Graves Disease

,Graves' disease is the most common form of hyperthyroidism, occurring when your immune system mistakenly attacks your thyroid gland and causes it to overproduce the hormone thyroxine. This higher thyroxine level can greatly increase your body's metabolic rate, which may affect you in numerous ways, from your moods to your physical appearance;

Sometimes the thyroid becomes enlarged -- due to Hashimoto's disease, Graves' disease, nutritional deficiencies, or other thyroid imbalances. When the thyroid become enlarged, this is known as a goiter.

..

Goiter -- An enlarged thyroid.

..Some people develop solid or liquid filled cysts, lumps, bumps and tumors -- both benign and cancerous -- in the thyroid gland. These are known as thyroid nodules.

..Thyroid Nodules -- Lumps in the thyroid gland.Thyroid Cancer -- Malignant thyroid nodules or tissue.Thyroiditis -- Inflammation of the thyroid.

,Because thyroid disease is common in HCV infection it is further irritated with the use of interferon therapy. Thyroid disease can manifest during HCV interferon-related therapy. 2010/Thyroid dysfunction in a UK hepatitis C population treated with interferon-alpha and ribavirin combination therapyThyroid dysfunction and interferon-alpha therapy for hepatitis C

An important fact here is to be screened for thyroid dysfunction while treating HCV.

Blood Test Is TSH

(thyroid stimulating hormone) , Blood tests should be given *during treatment at 12, 24, and 48 weeks * varies depending on genotype. ,If you are in the small percent of people who developed thyroid dysfunction during treatment you will need on going treatment for thyroid disease.

,

Location

Your thyroid is a small bowtie or butterfly-shaped gland, located in your neck, wrapped around the windpipe, behind and below the Adam's Apple area.

,

Symptoms

One Thyroid disorder, Hashimoto's disease does not have unique signs and symptoms. The disease typically progresses slowly over a number of years and causes chronic thyroid damage, leading to a drop in thyroid hormone levels in your blood.

The signs and symptoms are mainly those of an underactive thyroid gland (hypothyroidism) .

,The signs and symptoms of hypothyroidism vary widely, depending on the severity of hormone deficiency. At first, you may barely notice any symptoms, such as fatigue and sluggishness, or you may simply attribute them to getting older. But as the disease progresses, you may develop more obvious signs and symptoms.

Signs and symptoms of hypothyroidism include:.,underactive thyroid

Fatigue and sluggishnessIncreased sensitivity to coldConstipationPale, dry skinA puffy faceHoarse voice

An elevated blood cholesterol levelUnexplained weight gain -

occurring infrequently and rarely more than 10 to 20 pounds, most of which is fluidMuscle aches, tenderness and stiffness, especially in your shoulders and hips

Pain and stiffness in your joints and swelling in your knees or the small joints in your hands and feet

.. , Muscle weakness, especially in your lower extremitiesExcessive or prolonged menstrual bleeding (menorrhagia)

DepressionWithout treatment, signs and symptoms gradually become more severe and your thyroid gland may become enlarged (goiter). In addition, you may become more forgetful, your thought processes may slow, or you may feel depressed.

More On Hypothyroidism (underactive thyroid) Is a condition in which your thyroid gland doesn't produce enough of certain important hormones.Women, especially those older than 50, are more likely to have hypothyroidism. Hypothyroidism upsets the normal balance of chemical reactions in your body. It seldom causes symptoms in the early stages, but over time, untreated hypothyroidism can cause a number of health problems, such as obesity, joint pain, infertility and heart disease.The good news is that accurate thyroid function tests are available to diagnose hypothyroidism, and treatment of hypothyroidism with synthetic thyroid hormone is usually simple, safe and effective once the proper dosage is established. Hyperthyroidism (overactive thyroid) Is a condition in which your thyroid gland produces too much of the hormone thyroxine. Hyperthyroidism can significantly accelerate your body's metabolism, causing sudden weight loss, a rapid or irregular heartbeat, sweating, and nervousness or irritability.Several treatment options are available if you have hyperthyroidism. Doctors use anti-thyroid medications and radioactive iodine to slow the production of thyroid hormones. Sometimes, treatment of hyperthyroidism involves surgery to remove part of your thyroid gland. Although hyperthyroidism can be serious if you ignore it, most people respond well once hyperthyroidism is diagnosed and treated

http://hepmon. com/view/ ?id=146

http://www.mayoclin ic.com/health/ hyperthyroidism/ DS00344

http://www.mayoclin ic.com/health/ thyroid-disease/ AN00986

http://qjmed. oxfordjournals. org/cgi/content/ extract/103/ 3/187

http://Hepatitis Cne wdrugs.blogspot. com/2010/ 05/thyroid- disorders- and-hepatitis- c.html