Video: Avandia Plus Metformin - Both Medicines May Prevent Development of Diabetes

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Video: Avandia Plus Metformin - Both Medicines May Prevent Development of Diabetes

Video: Avandia Plus Metformin - Both Medicines May Prevent Development of Diabetes

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A low dose combination of two antidiabetes medications may help stave off the development of type 2 diabetes among individuals with impaired glucose tolerance (IGT), according to research published online ahead of print in The Lancet.Here is some information about IGT:

• It is a condition in which blood sugar (or glucose) levels are above normal but below those seen among those with diabetes

• It is considered to be a pre-diabetes state, with many who suffer from the condition going on to develop type 2 diabetes

• It is associated with a combination of impaired sensitivity to insulin and reduced release of insulin by the body

Researchers from the University of Toronto randomly assigned over 200 individuals with IGT to receive a daily low dose of the antidiabetes drugs rosiglitazone, commonly known as Avandia, and metformin, commonly known as Glucophage, or a placebo. Treatment continued for an average of about four years, and the participants were regularly assessed for the presence of diabetes.Only 14% of those who took the medications developed diabetes, compared with 39% of those taking a placebo. This means that only four individuals with IGT would need to take the drugs for one case of type 2 diabetes to be prevented. In addition, 80% of those taking the medications actually developed a normal response to glucose, compared with only 53% of those on placebo. And while impaired sensitivity to insulin remained stable among those receiving treatment, it worsened among those taking a placebo.

We spoke with Dr. Bernard Zinman, one of the investigator's of this study, who offered some further insight.

Today’s research suggests that low dose treatment with a combination of antidiabetes drugs that each have different mechanisms of action may help prevent diabetes in at-risk individuals.

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Also See :Type 2 diabetes prevention

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