The Usefulness Of Shear Wave Velocity In Managing Nonalcoholic Steatohepatitis

[Guest guest]

The Usefulness Of Shear Wave Velocity In Managing Nonalcoholic Steatohepatitis

Nonalcoholic steatohepatitis (NASH) is manifestation of metabolic syndrome in the liver and is a pandemic over the globe especially in the developed countries, based on a high calorie diet and sedentary lifestyle. As in the other types of chronic hepatitis, collagen fibers continuously accumulate in the liver through the course of NASH toward cirrhosis and hepatocellular carcinoma development. Histological evaluation is a current gold standard for quantification of the fiber deposition. A tiny biopsy specimen, however, leads to considerable variability and is practically difficult to obtain repeatedly from multiple sites. Several surrogate markers have been developed for evaluation of fiber accumulation in a

noninvasive way. Unfortunately, however, so far no methodology can satisfy both specificity for the liver and applicability for multiple sites. A research article published in the World Journal of Gastroenterology addresses this problem. A research team led by Takeshi Suda, from Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, investigated the efficacy of shear wave velocity (SWV) measurement in the evaluation of NASH pathophysiology using ACUSON S2000 ultrasound system. This research revealed significant positive correlation between SWV and the histological fibrous stages and suggested the possibility to distinguish mild fibrosis from severe fibrosis or cirrhosis with substantial accuracy. Furthermore, the correlations of SWV with biochemical markers such as hyaluronic acid or albumin were presented. This is the first report suggesting that SWV can be reproducibly

measured in NASH and varies through the liver. Due to the non-invasive and easily accessible nature of SWV measurement, this technology makes it possible to conduct a longitudinal evaluation of liver rigidity at multiple sites of the liver in a large cohort. The actual longitudinal evaluation in a larger NAFLD population may prove not only useful for fibrous staging of NASH but also for the process of fiber accumulation and value as a prognostic indicator. Reference: Osaki A, Kubota T, Suda T, Igarashi M, Nagasaki K, Tsuchiya A, Yano M, Tamura Y, Takamura M, Kawai H, Yamagiwa S, Kikuchi T, Nomoto M, Aoyagi Y. Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis. World J Gastroenterol 2010; 16(23): 2918-2925 Source: Ye-Ru Wang World Journal of Gastroenterology

http://www.medicalnewstoday.com/articles/193021.php