More than 375 & not effective for some

[Guest guest]

Hi all,

I fill out a form when I get my shots that asks different questions

but at the bottom it states " It is not effective in all people "

I am better on the Xolair but I am still couphing even right after I

get my shots. It has only been four days today. I use Flovent 220

and Singular and Neb with Xopenex. I am on the 375mg of Xolair and

my IGE is through the roof at 1273.

I sent a link before that talks about using both the Xolair and

Immunotherapy. I am going to the doc next week to talk about doing

this. He has mentioned it before but I was confused about how that

would work like they might counteract each other. Link

http://www.ccjm.org/PDFFILES/Rambasek304.pdf

It says: Omalizumab is most effective in people with low body

weight, lower IGE levels, and frequent hospitalizations in spite of

multidrug therapy. It also states that the IgE level should not

exceed 700 IU/ml because the volume of the injection would likely be

too large. So... this to me means with my weight of 196 and my IgE

of 1273 So does this mean I shouldn't be taking Omalizumb? Wow! It

does help though. I stopped for a couple of months and was worse. I

still need help so I am looking toward the Allergy Shots too. Next I

read this below so I am confused.

Omalizumab has not been well studied at

doses above 750 mg per month and is not

FDA-approved above this dose. This is primarily

because using doses greater than 750

mg per month would be cost-prohibitive (see

above discussion) and would require more

than two injections per month because technical

issues limit how much this drug can be

concentrated.

I couldn't find the place where I read about combining Allergy Shots

with Xolair. It said something to the effect that the IgE that does

not get bound by the Xolair is treated with the Allergy Shots. Like

when all of the Xolair is used up there is still IgE to deal with.

I will continue trying to find this info. I thought it was on that

site I sent in but there is a lot of reading to do so maybe I missed

it. Anyone have info on this?

In Hope,

[Guest guest]

Hi ,

Toward the end of the article (p. 260) under Topics for Future

Research, it says:

" Will it facilitate immunotherapy? Some patients with asthma or

allergic rhinitis currently receive allergen vaccines ( " allergy

shots " ). Occasionally, patients receiving immunotherapy exhibit a

tendency for serious IgE-mediated (anaphylactic) reactions. Such

patients may be unable to advance the dose of immunotherapy

injections to therapeutic levels. Omalizumab, by decreasing the

severity or frequency of these reactions, may enable these patients

to achieve therapeutic ( " maintenance " ) doses of immunotherapy. "

I did of the search of the document (CTRL+F) and didn't see anything

else regarding immunotherapy. Do you think it was from another

article?

Hope this helps a little!

> I couldn't find the place where I read about combining Allergy

Shots

> with Xolair. It said something to the effect that the IgE that does

> not get bound by the Xolair is treated with the Allergy Shots. Like

> when all of the Xolair is used up there is still IgE to deal with.

>

> I will continue trying to find this info. I thought it was on that

> site I sent in but there is a lot of reading to do so maybe I

missed

> it. Anyone have info on this?

>

> In Hope,

>

>

>

[Guest guest]

Hi ,

If it makes you feel better, I am far from cured despite the Xolair. I have not

had the miraculous, life-altering effect that some have described. I am better

(less pred, fewer hosp) but I am still ++ symptomatic. In fact, I am on a sick

day from work today (I am a nurse) since I am too sob to walk around much.

As for allergy shots, I am not sure about combining them with xolair but I do

know the evidence that they work for severe asthma is poor. In fact, my pulmo

was so not convinced, he put it up to me to decide to try it or not. I didn't.

I do have lower IgE than you but I was measured while on pred so that can mask

the results.

The only advice I have is that if there is no exhorbitant cost for you (co-pays

etc...) and since Xolair has few if any side effects, I would stick with it for

a couple of years to see....

ps the way I figure it, a little bit better is still an improvement...