possible under dosage?

[Guest guest]

Hi Pat et al.,

I seem to recall a while back you had commented on the possibility of being

under-dosed for your Xolair. I am taking 225 mg every 2 weeks with corresponds

to an IgE of 367 I believe. However, I know that IgE values are reduced while on

pred and this measurement was taken when I was in the midst of a massive flare

and receiving IV solumedrol. I have been on the magic glue for 1 year already

and I have begun to see very small improvements. VERY small. I can now make it

down to 7mg of pred before I flare again when previously it was 12.5 and I

recover faster. This is all good. But I wonder if I am being under-dosed because

I have had had no improvement in my sinus allergies and I still had a massive

flare post intense cat exposure. I am also now the proud owner of a productive

cough for the last 9 months when I previously never coughed (CT, chest xray,

sputum samples all show nada - nothing but white cells in the sputum). The cough

is new since I started on Xolair. My pulmo

attributes it to " a change in your asthma - no one can really explain it "

My insurance is very slack (I am Canadian for some reason they just foot the

bill and ask no questions) so I could easily get my dose increased and paid for.

I know you had said some of your patients benefited from more Xolair so I am

debating asking my pulmo if we can up the dose for a couple months to see if I

can speed up the improvements.

Any comments you have on my idea would be greatly apprecaited. Obviously, after

a year of Xolair, re-measuring IgE would not be useful.

Thanks so much for your valuable input!